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Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 50045130
TargetCytochrome P450 3A4(Human)
Viamet Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50181473(4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)met...)
Affinity DataIC50:  50nMAssay Description:Inhibition of CYP3A4 in human hepatocytes using testosterone as substrate by HPLC/MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Viamet Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50127138(2-(butan-2-yl)-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlor...)
Affinity DataIC50:  70nMAssay Description:Inhibition of CYP3A4 in human hepatocytes using testosterone as substrate by HPLC/MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetCytochrome P450 3A4(Human)
Viamet Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046178(CHEMBL3310994)
Affinity DataIC50:  800nMAssay Description:Inhibition of CYP3A4 in human hepatocytes using testosterone as substrate by HPLC/MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Viamet Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046176(CHEMBL3310992)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of CYP3A4 in human hepatocytes using testosterone as substrate by HPLC/MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Viamet Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50333117((2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-tr...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of CYP3A4 in human hepatocytes using testosterone as substrate by HPLC/MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetCytochrome P450 3A4(Human)
Viamet Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM124182(US10221160, Example 1 | US11247981, Example 1 | US...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of CYP3A4 in human hepatocytes using testosterone as substrate by HPLC/MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Viamet Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046177(CHEMBL3310993)
Affinity DataIC50:  3.20E+4nMAssay Description:Inhibition of CYP3A4 in human hepatocytes using testosterone as substrate by HPLC/MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Viamet Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046184(CHEMBL3311225)
Affinity DataIC50:  3.60E+4nMAssay Description:Inhibition of CYP3A4 in human hepatocytes using testosterone as substrate by HPLC/MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Viamet Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046179(CHEMBL3309278)
Affinity DataIC50:  4.60E+4nMAssay Description:Inhibition of CYP3A4 in human hepatocytes using testosterone as substrate by HPLC/MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Viamet Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046175(CHEMBL3358963)
Affinity DataIC50:  5.10E+4nMAssay Description:Inhibition of CYP3A4 in human hepatocytes using testosterone as substrate by HPLC/MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Viamet Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046183(CHEMBL3311222)
Affinity DataIC50:  5.30E+4nMAssay Description:Inhibition of CYP3A4 in human hepatocytes using testosterone as substrate by HPLC/MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Viamet Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046185(CHEMBL3311226)
Affinity DataIC50:  5.40E+4nMAssay Description:Inhibition of CYP3A4 in human hepatocytes using testosterone as substrate by HPLC/MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Viamet Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM124183(US10221160, Example 2 | US11247981, Example 2 | US...)
Affinity DataIC50: >6.00E+4nMAssay Description:Inhibition of CYP3A4 in human hepatocytes using testosterone as substrate by HPLC/MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Viamet Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046187(CHEMBL3311228)
Affinity DataIC50:  6.50E+4nMAssay Description:Inhibition of CYP3A4 in human hepatocytes using testosterone as substrate by HPLC/MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2C19(Human)
Viamet Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046187(CHEMBL3311228)
Affinity DataIC50:  7.20E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Viamet Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046182(CHEMBL3311221)
Affinity DataIC50:  7.20E+4nMAssay Description:Inhibition of CYP3A4 in human hepatocytes using testosterone as substrate by HPLC/MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Viamet Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046181(CHEMBL3358962)
Affinity DataIC50:  7.40E+4nMAssay Description:Inhibition of CYP3A4 in human hepatocytes using testosterone as substrate by HPLC/MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Viamet Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046186(CHEMBL3311227)
Affinity DataIC50:  7.90E+4nMAssay Description:Inhibition of CYP3A4 in human hepatocytes using testosterone as substrate by HPLC/MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2C9(Human)
Viamet Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046187(CHEMBL3311228)
Affinity DataIC50:  9.90E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Viamet Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046180(CHEMBL3310995)
Affinity DataIC50:  1.36E+5nMAssay Description:Inhibition of CYP3A4 in human hepatocytes using testosterone as substrate by HPLC/MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed