Compile Data Set for Download or QSAR
Report error Found 35 Enz. Inhib. hit(s) with all data for entry = 50022582
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataKi:  0.600nMAssay Description:ATP competitive inhibition of recombinant human N-terminal GST-fused CDK4 (S4 to E303 residues)/cyclin D1 expressed in Sf9 insect cells using C-termi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human N-terminal GST-fused CDK4 (S4 to E303 residues)/cyclin D1 expressed in Sf9 insect cells using C-terminal Rb fragment ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataKi:  2.40nMAssay Description:ATP competitive inhibition of recombinant human full-length N-terminal GST-fused CDK6 (M1 to A326 residues)/cyclin D1 (Q4 to I295 residues) expressed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 9.90nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-fused CDK6 (M1 to A326 residues)/cyclin D1 (Q4 to I295 residues) expressed in Sf9 insect c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM384357(US9932327, Compound Flavopiridol)
Affinity DataIC50: 11nMAssay Description:Inhibition of human CDK9/cyclin T1More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 31nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged HIPK2 (165 to 564 residues) expressed in baculovirus infected Sf21 insect cells using MBP as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM384357(US9932327, Compound Flavopiridol)
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant human N-terminal GST-fused CDK4 (S4 to E303 residues)/cyclin D1 expressed in Sf9 insect cells using C-terminal Rb fragment ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 50nMAssay Description:Inhibition of human PIM1More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM384357(US9932327, Compound Flavopiridol)
Affinity DataEC50:  55nMAssay Description:Inhibition of CDK4/CDK6 in human COLO 205 cells assessed as reduction in Rb phosphorylation at S780 residue measured after 24 hrs by laser-scanning f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 57nMAssay Description:Inhibition of human CDK9/cyclin T1More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 60nMAssay Description:Inhibition of CDK4/CDK6 in human MDA-MB-361 cells assessed as reduction in Rb phosphorylation at S780 residue measured after 6 days by laser-scanning...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 61nMAssay Description:Inhibition of recombinant human full-length 6His-tagged DYRK2 expressed in baculovirus infected Sf21 insect cells using casein as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 120nMAssay Description:Inhibition of CDK4/CDK6 in human COLO 205 cells assessed as reduction in Rb phosphorylation at S780 residue measured after 24 hrs by laser-scanning f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM384357(US9932327, Compound Flavopiridol)
Affinity DataIC50: 177nMAssay Description:Inhibition of CDK9 in human U2OS cells assessed as reduction in CTD phosphorylation at Ser2 residue measured after 16 hrs by propidium iodide stainin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 192nMAssay Description:Inhibition of human GSK3betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 287nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged cdk5/N-terminal GST-tagged p35 expressed in baculovirus infected Sf21 cells using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 355nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged cdk5/N-terminal GST-tagged p25 expressed in baculovirus infected Sf21 cells using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 389nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged JNK3 expressed in baculovirus infected Sf21 insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 403nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged FLT3 D835Y mutant (564 to end residues) expressed in baculovirus infected Sf21 insect cells usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 504nMAssay Description:Inhibition of human CDK2/cyclin EMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 659nMAssay Description:Inhibition of recombinant human full-length N-terminal 6His-tagged DRAK1 expressed in baculovirus infected Sf21 cells using ZIPtide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of recombinant human N-terminal 6His-tagged TRKA (440 to end residues) expressed in baculovirus infected Sf21 cells using KKKSPGEYVNIEFG a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 1.63E+3nMAssay Description:Inhibition of human CDK1/cyclin B1More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of human PIM2More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 3.51E+3nMAssay Description:Inhibition of CDK9 in human U2OS cells assessed as reduction in CTD phosphorylation at Ser2 residue measured after 16 hrs by propidium iodide stainin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 3.91E+3nMAssay Description:Inhibition of human CDK7/Mat1/Cyclin H1More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 3.96E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged FLT3 (564 to end residues) expressed in baculovirus infected Sf21 cells using Abltide as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 6.33E+3nMAssay Description:Inhibition of human BRAFMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetAurora kinase B(Human)TBA
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human Aurora BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetAurora kinase A(Human)TBA
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human Aurora AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human ERK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human PLK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human PLK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human cRAFMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed