Compile Data Set for Download or QSAR
maximum 50k data
Found 14 Enz. Inhib. hit(s) with all data for entry = 50001962
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Eberhard-Karls-University Tuebingen

Curated by ChEMBL
LigandPNGBDBM153159(BDBM153160 | US8993756, 4-1)
Affinity DataIC50:  0.150nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged JAK3 (781 to 1124 residues) expressed in baculovirus expression system using FITC-KGGEEEEYFELVK...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Eberhard-Karls-University Tuebingen

Curated by ChEMBL
LigandPNGBDBM209866(PF-06651600 | US11111242, Example 5 | US2023034848...)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Eberhard-Karls-University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50450984(CHEMBL4209692)
Affinity DataIC50:  0.430nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Eberhard-Karls-University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50450982(CHEMBL4209458)
Affinity DataIC50:  7nMAssay Description:Time-dependent inhibition of recombinant human N-terminal His-tagged JAK3 catalytic domain (795 to 1124 residues) expressed in sf21 cells using bioti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
Eberhard-Karls-University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50450983(CHEMBL4204801)
Affinity DataIC50:  22nMAssay Description:Inhibition of BLK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Eberhard-Karls-University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50121209(CHEMBL3622376)
Affinity DataIC50:  35nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Eberhard-Karls-University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50450982(CHEMBL4209458)
Affinity DataIC50:  40nMAssay Description:Time-dependent inhibition of recombinant human N-terminal His-tagged JAK2 (826 to 1132 residues) expressed in sf21 cells using biotinylated peptide s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Eberhard-Karls-University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50450983(CHEMBL4204801)
Affinity DataIC50:  44nMAssay Description:Inhibition of ERBB4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Eberhard-Karls-University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50450983(CHEMBL4204801)
Affinity DataIC50:  49nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1/JAK3(Mus musculus)
Eberhard-Karls-University Tuebingen

Curated by ChEMBL
LigandPNGBDBM153159(BDBM153160 | US8993756, 4-1)
Affinity DataIC50:  70nMAssay Description:Inhibition of JAK3/JAK1 in mouse CTLL-2 cells assessed as reduction in IL2-stimulated STAT5 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Eberhard-Karls-University Tuebingen

Curated by ChEMBL
LigandPNGBDBM81346(CHEMBL538798 | M9440 (Me-3,4-dephostatin))
Affinity DataIC50:  80nMAssay Description:Inhibition of JAK3 (unknown origin) by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Eberhard-Karls-University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50450983(CHEMBL4204801)
Affinity DataIC50:  220nMAssay Description:Inhibition of ITK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetJAK3/JAK1(Homo sapiens (Human))
Eberhard-Karls-University Tuebingen

Curated by ChEMBL
LigandPNGBDBM153159(BDBM153160 | US8993756, 4-1)
Affinity DataIC50:  280nMAssay Description:Inhibition of JAK1/JAK3 in human PBMC CD3+/CD8+ T cells assessed as reduction in IL7-stimulated STAT5 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetJAK3/JAK1(Homo sapiens (Human))
Eberhard-Karls-University Tuebingen

Curated by ChEMBL
LigandPNGBDBM153159(BDBM153160 | US8993756, 4-1)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibition of JAK1/JAK3 in human whole blood CD3+/CD4+ T cells assessed as reduction in IL7-stimulated STAT5 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed