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Report error Found 65 Enz. Inhib. hit(s) with all data for entry = 50049271
LigandPNGBDBM50150119(CHEMBL3769414)
Affinity DataIC50:  0.0580nMAssay Description:Inhibition of PDE1B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM289647(11,11-Difluoro-6-(4-methoxybenzyl)-9-((tetrahydro-...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against chymotrypsinogen; Range 1-10 uMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

LigandPNGBDBM289671(9-(2,2-Difluorocyclopropanecarbonyl)-6-(4-methoxyb...)
Affinity DataIC50:  11nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed

LigandPNGBDBM289653(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)
Affinity DataIC50:  26nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

LigandPNGBDBM289621(6-(4-Methoxybenzyl)-9-((tetrahydro-2H-pyran-4-yl)m...)
Affinity DataIC50:  27nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM289641(6-(4-Chloro-2-fluorobenzyl)-9-((tetrahydro-2H-pyra...)
Affinity DataIC50:  31nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50059033((11aS,11bS)-11a-Ethyl-2,3,4,5,11a,11b-hexahydro-1H...)
Affinity DataIC50:  39nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM289617(6-(4-Chlorobenzyl)-9-((tetrahydro-2H-pyran-4-yl)me...)
Affinity DataIC50:  41nMAssay Description:Inhibitory activity against chymotrypsinogen; Range 1-10 uMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

LigandPNGBDBM50059026(5'-Methyl-2'-(biphenylmethyl)-3'-(phenylmethyl)spi...)
Affinity DataIC50:  48nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM289669(6-(4-Chlorobenzyl)-9-(cyclopropanecarbonyl)-8,9,10...)
Affinity DataIC50:  53nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

LigandPNGBDBM289671(9-(2,2-Difluorocyclopropanecarbonyl)-6-(4-methoxyb...)
Affinity DataIC50:  59nMAssay Description:Inhibition of Cyclin-dependent kinase 2 cyclin AMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50237791(CHEMBL1628659 | SCH-51866)
Affinity DataIC50:  60nMAssay Description:In vitro inhibitory activity against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM289613(6-(4-Chlorobenzyl)-9-methyl-8,9,10,11-tetrahydropy...)
Affinity DataIC50:  69nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

LigandPNGBDBM50237799(CHEMBL4069196)
Affinity DataIC50:  150nMAssay Description:Binding affinity to human sphingosine 1-phosphate receptor 2 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM289618(6-(4-Chlorobenzyl)-9-(oxetan-3-yl)-8,9,10,11-tetra...)
Affinity DataIC50:  150nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM289615(6-(4-Chlorobenzyl)-9-(cyclopropylmethyl)-8,9,10,11...)
Affinity DataIC50:  160nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

LigandPNGBDBM289614(6-(4-Chlorobenzyl)-9-benzyl-8,9,10,11-tetrahydropy...)
Affinity DataIC50:  190nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

LigandPNGBDBM289615(6-(4-Chlorobenzyl)-9-(cyclopropylmethyl)-8,9,10,11...)
Affinity DataIC50:  210nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM289653(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)
Affinity DataIC50:  260nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE5A1 expressed in Baculovirus infected Sf9 insect cells assessed as decrease in F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM289653(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)
Affinity DataIC50:  280nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE11A4 expressed in Baculovirus infected Sf9 insect cells assessed as decrease in ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM289617(6-(4-Chlorobenzyl)-9-((tetrahydro-2H-pyran-4-yl)me...)
Affinity DataIC50:  350nMAssay Description:Inhibition of Cyclin-dependent kinase 2 cyclin AMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50:  370nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE5A1 expressed in Baculovirus infected Sf9 insect cells assessed as decrease in F...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50:  460nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE6C expressed in Baculovirus infected Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50:  460nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM289669(6-(4-Chlorobenzyl)-9-(cyclopropanecarbonyl)-8,9,10...)
Affinity DataIC50:  490nMAssay Description:Inhibition of Cyclin-dependent kinase 2 cyclin AMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM289614(6-(4-Chlorobenzyl)-9-benzyl-8,9,10,11-tetrahydropy...)
Affinity DataIC50:  490nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50237799(CHEMBL4069196)
Affinity DataIC50:  570nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM289641(6-(4-Chloro-2-fluorobenzyl)-9-((tetrahydro-2H-pyra...)
Affinity DataIC50:  610nMAssay Description:Inhibition of Cyclin-dependent kinase 2 cyclin AMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

LigandPNGBDBM289653(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)
Affinity DataIC50:  690nMAssay Description:Binding affinity to human sphingosine 1-phosphate receptor 5 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM289618(6-(4-Chlorobenzyl)-9-(oxetan-3-yl)-8,9,10,11-tetra...)
Affinity DataIC50:  980nMAssay Description:Binding affinity to human sphingosine 1-phosphate receptor 5 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

LigandPNGBDBM289613(6-(4-Chlorobenzyl)-9-methyl-8,9,10,11-tetrahydropy...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro inhibitory activity against recombinant human calpain 1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

LigandPNGBDBM289669(6-(4-Chlorobenzyl)-9-(cyclopropanecarbonyl)-8,9,10...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of PDE10A1 (unknown origin) assessed as decrease in FAM-cAMP hydrolysis after 1 hr by IMAP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

LigandPNGBDBM289621(6-(4-Methoxybenzyl)-9-((tetrahydro-2H-pyran-4-yl)m...)
Affinity DataIC50:  1.60E+3nMAssay Description:Affinity towards human 5-hydroxytryptamine 3 serotonin receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed

LigandPNGBDBM289647(11,11-Difluoro-6-(4-methoxybenzyl)-9-((tetrahydro-...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of PDE10A1 (unknown origin) assessed as decrease in FAM-cAMP hydrolysis after 1 hr by IMAP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM289621(6-(4-Methoxybenzyl)-9-((tetrahydro-2H-pyran-4-yl)m...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibitory activity against chymotrypsinogen; Range 1-10 uMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed

TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE11A4 expressed in Baculovirus infected Sf9 insect cells assessed as decrease in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM289653(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50:  3.50E+3nMAssay Description:Binding affinity to human Sphingosine 1-phosphate receptor 1 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of PDE4D3 (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP addition measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of PDE2A1 (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP addition measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM289671(9-(2,2-Difluorocyclopropanecarbonyl)-6-(4-methoxyb...)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50:  6.30E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM289653(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)
Affinity DataIC50:  7.90E+3nMAssay Description:Binding affinity to human sphingosine 1-phosphate receptor 2 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

LigandPNGBDBM289653(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)
Affinity DataIC50:  8.40E+3nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE8A1 expressed in Baculovirus infected Sf9 insect cells assessed as decrease in F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM289647(11,11-Difluoro-6-(4-methoxybenzyl)-9-((tetrahydro-...)
Affinity DataIC50:  9.20E+3nMAssay Description:Binding affinity to human sphingosine 1-phosphate receptor 2 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM289653(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)
Affinity DataIC50:  9.30E+3nMAssay Description:Inhibition of PDE4D3 (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP addition measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDE3A (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP addition measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM289653(6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyr...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to human sphingosine 1-phosphate receptor 2 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

LigandPNGBDBM289613(6-(4-Chlorobenzyl)-9-methyl-8,9,10,11-tetrahydropy...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDE10A1 (unknown origin) assessed as decrease in FAM-cAMP hydrolysis after 1 hr by IMAP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE8A1 expressed in Baculovirus infected Sf9 insect cells assessed as decrease in F...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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