Compile Data Set for Download or QSAR
maximum 50k data
Found 12 Enz. Inhib. hit(s) with all data for entry = 50040451
TargetBile acid receptor(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50394415(CHEMBL2158166)
Affinity DataIC50:  3.77E+3nMAssay Description:Antagonist activity at GST-tagged FXRalpha ligand binding domain assessed as inhibition of CDCA-induced biotinylated SRC1 binding after 30 mins by HT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50394416(CHEMBL2158165)
Affinity DataIC50:  8.23E+3nMAssay Description:Antagonist activity at GST-tagged FXRalpha ligand binding domain assessed as inhibition of CDCA-induced biotinylated SRC1 binding after 30 mins by HT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50394413(CHEMBL2158162)
Affinity DataEC50:  36nMAssay Description:Agonist activity at FXRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50167176((E)-3-{3-[(4-Benzo[1,3]dioxol-5-yl-benzyl)-cyclohe...)
Affinity DataEC50:  38nMAssay Description:Agonist activity at FXRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50167161((E)-3-{3-[Cyclohexanecarbonyl-(4'-dimethylamino-bi...)
Affinity DataEC50:  25nMAssay Description:Agonist activity at FXRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetBile acid receptor(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM21724(3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(1...)
Affinity DataEC50:  15nMAssay Description:Agonist activity at FXRMore data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50394414(CHEMBL2158163)
Affinity DataEC50:  1.29E+4nMAssay Description:Agonist activity at GST-tagged FXRalpha ligand binding domain assessed as biotinylated SRC1 binding after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50167245((E)-3-{3-[Cyclohexanecarbonyl-(8-methoxy-2,2-dimet...)
Affinity DataEC50:  358nMAssay Description:Agonist activity at FXRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50394417(CHEMBL2158164)
Affinity DataEC50:  94nMAssay Description:Agonist activity at FXRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50394412(CHEMBL2158161)
Affinity DataEC50:  377nMAssay Description:Agonist activity at FXRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50394411(CHEMBL2158160)
Affinity DataEC50:  343nMAssay Description:Agonist activity at FXRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50394414(CHEMBL2158163)
Affinity DataEC50:  2.60E+3nMAssay Description:Agonist activity at FXRalpha expressed in HEK293 cells assessed as increase in transcriptional activity after 18 hrs by luciferase reporter gene assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed