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Report error Found 16 Enz. Inhib. hit(s) with all data for entry = 50043292
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50368628(ABT-569 | Abbott-70569 | Abbott-70569.1 | Gabitril...)
Affinity DataIC50:  49nMAssay Description:Inhibition of human GAT1 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

TargetSodium- and chloride-dependent GABA transporter 3(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50039246((S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piper...)
Affinity DataIC50:  1.12E+3nMAssay Description:Inhibition of human GAT3 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent betaine transporter(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50419338(CHEMBL1446457)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibition of human BGT1 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent betaine transporter(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50438758(CHEMBL2415009)
Affinity DataIC50:  5.48E+3nMAssay Description:Inhibition of human BGT1 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 1(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50020883((R)-Piperidine-3-carboxylic acid | (R)-nipecotic a...)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibition of human GAT1 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetSodium- and chloride-dependent GABA transporter 2(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50039246((S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piper...)
Affinity DataIC50:  1.19E+4nMAssay Description:Inhibition of human GAT2 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 3(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50438758(CHEMBL2415009)
Affinity DataIC50:  1.39E+4nMAssay Description:Inhibition of human GAT3 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 2(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50438758(CHEMBL2415009)
Affinity DataIC50:  3.69E+4nMAssay Description:Inhibition of human GAT2 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 3(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50000102(3-aminopropanoic acidbeta-alanine | Alanine-beta |...)
Affinity DataIC50:  4.12E+4nMAssay Description:Inhibition of human GAT3 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 3(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50020883((R)-Piperidine-3-carboxylic acid | (R)-nipecotic a...)
Affinity DataIC50:  5.10E+4nMAssay Description:Inhibition of human GAT3 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent betaine transporter(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50039246((S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piper...)
Affinity DataIC50:  7.17E+4nMAssay Description:Inhibition of human BGT1 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 1(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50438758(CHEMBL2415009)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human GAT1 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 1(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50020888((S)-Piperidine-3-carboxylic acid | (S)-nipecotic a...)
Affinity DataIC50:  1.16E+5nMAssay Description:Inhibition of human GAT1 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 1(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50039246((S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piper...)
Affinity DataIC50:  1.70E+5nMAssay Description:Inhibition of human GAT1 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 2(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50000102(3-aminopropanoic acidbeta-alanine | Alanine-beta |...)
Affinity DataIC50:  2.09E+5nMAssay Description:Inhibition of human GAT2 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 3(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50020888((S)-Piperidine-3-carboxylic acid | (S)-nipecotic a...)
Affinity DataIC50:  2.32E+6nMAssay Description:Inhibition of human GAT3 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed