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Report error Found 42 Enz. Inhib. hit(s) with all data for entry = 50034639
LigandPNGBDBM50365495(CHEMBL1957460)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50365480(CHEMBL1957366)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50365481(CHEMBL1957367)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50365487(CHEMBL1957375)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50365484(CHEMBL1955881)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50209531((R)-2-[3-cyano-2-(2'-ethoxy-biphenyl-4-yl)-6-fluor...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM50365483(CHEMBL1957369)
Affinity DataIC50:  8nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50365486(CHEMBL1957374)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50365476(CHEMBL1957361)
Affinity DataIC50:  12nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM50365500(CHEMBL1957462)
Affinity DataIC50:  13nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50365479(CHEMBL1957364)
Affinity DataIC50:  13nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50365485(CHEMBL1957373)
Affinity DataIC50:  21nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50365482(CHEMBL1957368)
Affinity DataIC50:  22nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50365494(CHEMBL1957381)
Affinity DataIC50:  27nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50365496(CHEMBL1957370)
Affinity DataIC50:  31nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM31589(triaryl imidazole, 1)
Affinity DataIC50:  35nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB


LigandPNGBDBM14754(1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoq...)
Affinity DataIC50:  36nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

LigandPNGBDBM50365492(CHEMBL1957379)
Affinity DataIC50:  52nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50365478(CHEMBL1957363)
Affinity DataIC50:  65nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50365490(CHEMBL1957377)
Affinity DataIC50:  67nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50365493(CHEMBL1957380)
Affinity DataIC50:  97nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50365488(CHEMBL1957365)
Affinity DataIC50:  108nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50365489(CHEMBL1957376)
Affinity DataIC50:  144nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50365480(CHEMBL1957366)
Affinity DataIC50:  200nMAssay Description:Inhibition of human recombinant DHODH transmembrane domain using 2,6-dichloroindophenol sodium, L-Dihydroorotic acid, and decylubiquinone as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50365477(CHEMBL1957362)
Affinity DataIC50:  315nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50365491(CHEMBL1957378)
Affinity DataIC50:  456nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50365475(CHEMBL1957360)
Affinity DataIC50:  561nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50365499(CHEMBL1957461)
Affinity DataIC50:  608nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50365497(CHEMBL1957372)
Affinity DataIC50:  746nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50365500(CHEMBL1957462)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human recombinant DHODH transmembrane domain using 2,6-dichloroindophenol sodium, L-Dihydroorotic acid, and decylubiquinone as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50365495(CHEMBL1957460)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of human recombinant DHODH transmembrane domain using 2,6-dichloroindophenol sodium, L-Dihydroorotic acid, and decylubiquinone as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50365474(CHEMBL1957359)
Affinity DataIC50:  1.72E+3nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50365498(CHEMBL1957371)
Affinity DataIC50:  1.77E+3nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50365480(CHEMBL1957366)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of human recombinant full length PDE2A3 using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50365493(CHEMBL1957380)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of human recombinant DHODH transmembrane domain using 2,6-dichloroindophenol sodium, L-Dihydroorotic acid, and decylubiquinone as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50365496(CHEMBL1957370)
Affinity DataIC50:  6.30E+3nMAssay Description:Inhibition of human recombinant DHODH transmembrane domain using 2,6-dichloroindophenol sodium, L-Dihydroorotic acid, and decylubiquinone as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50365480(CHEMBL1957366)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of human recombinant PDE4B catalytic domain using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50365499(CHEMBL1957461)
Affinity DataIC50: >9.90E+3nMAssay Description:Inhibition of human recombinant DHODH transmembrane domain using 2,6-dichloroindophenol sodium, L-Dihydroorotic acid, and decylubiquinone as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50365498(CHEMBL1957371)
Affinity DataIC50: >9.90E+3nMAssay Description:Inhibition of human recombinant DHODH transmembrane domain using 2,6-dichloroindophenol sodium, L-Dihydroorotic acid, and decylubiquinone as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50365497(CHEMBL1957372)
Affinity DataIC50: >9.90E+3nMAssay Description:Inhibition of human recombinant DHODH transmembrane domain using 2,6-dichloroindophenol sodium, L-Dihydroorotic acid, and decylubiquinone as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50365494(CHEMBL1957381)
Affinity DataIC50: >9.90E+3nMAssay Description:Inhibition of human recombinant DHODH transmembrane domain using 2,6-dichloroindophenol sodium, L-Dihydroorotic acid, and decylubiquinone as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50365492(CHEMBL1957379)
Affinity DataIC50: >9.90E+3nMAssay Description:Inhibition of human recombinant DHODH transmembrane domain using 2,6-dichloroindophenol sodium, L-Dihydroorotic acid, and decylubiquinone as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed