Compile Data Set for Download or QSAR
Report error Found 42 Enz. Inhib. hit(s) with all data for entry = 50039736
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50383031BDBM50383031(CHEMBL2031290)
Affinity DataIC50: 5nMAssay Description:Displacement of BODIPY-labelled cyclopamine from human Smo receptor expressed in HEK293 cells after 2 hrs by fluorescence microscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249522BDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)
Affinity DataIC50: 7nMAssay Description:Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249522BDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)
Affinity DataIC50: 7nMAssay Description:Displacement of BODIPY-labelled cyclopamine from human Smo receptor expressed in HEK293 cells after 2 hrs by fluorescence microscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50383020BDBM50383020(CHEMBL2031277)
Affinity DataIC50: 13nMAssay Description:Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50383029BDBM50383029(CHEMBL2031288)
Affinity DataIC50: 14nMAssay Description:Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50383031BDBM50383031(CHEMBL2031290)
Affinity DataIC50: 15nMAssay Description:Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50383020BDBM50383020(CHEMBL2031277)
Affinity DataIC50: 24nMAssay Description:Displacement of BODIPY-labelled cyclopamine from human Smo receptor expressed in HEK293 cells after 2 hrs by fluorescence microscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50383015BDBM50383015(CHEMBL2031263)
Affinity DataIC50: 29nMAssay Description:Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50383028BDBM50383028(CHEMBL2031287)
Affinity DataIC50: 33nMAssay Description:Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50383016BDBM50383016(CHEMBL2031268)
Affinity DataIC50: 41nMAssay Description:Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50383016BDBM50383016(CHEMBL2031268)
Affinity DataIC50: 63nMAssay Description:Displacement of BODIPY-labelled cyclopamine from human Smo receptor expressed in HEK293 cells after 2 hrs by fluorescence microscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50232973BDBM50232973(CHEMBL254129 | CYCLOPAMINE)
Affinity DataIC50: 64nMAssay Description:Displacement of BODIPY-labelled cyclopamine from human Smo receptor expressed in HEK293 cells after 2 hrs by fluorescence microscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50383024BDBM50383024(CHEMBL2031283)
Affinity DataIC50: 70nMAssay Description:Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50383030BDBM50383030(CHEMBL2031289)
Affinity DataIC50: 70nMAssay Description:Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50383022BDBM50383022(CHEMBL2031077)
Affinity DataIC50: 80nMAssay Description:Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50383036BDBM50383036(CHEMBL2031098)
Affinity DataIC50: 90nMAssay Description:Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50383037BDBM50383037(CHEMBL2031245)
Affinity DataIC50: 100nMAssay Description:Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50383019BDBM50383019(CHEMBL2031273)
Affinity DataIC50: 107nMAssay Description:Displacement of BODIPY-labelled cyclopamine from human Smo receptor expressed in HEK293 cells after 2 hrs by fluorescence microscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50383032BDBM50383032(CHEMBL2031291)
Affinity DataIC50: 110nMAssay Description:Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50383021BDBM50383021(CHEMBL2031281)
Affinity DataIC50: 110nMAssay Description:Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50383041BDBM50383041(CHEMBL2031267)
Affinity DataIC50: 130nMAssay Description:Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249519BDBM50249519(N-((3S,5S)-1-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(p...)
Affinity DataIC50: 140nMAssay Description:Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50383042BDBM50383042(CHEMBL2031295)
Affinity DataIC50: 160nMAssay Description:Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50383019BDBM50383019(CHEMBL2031273)
Affinity DataIC50: 160nMAssay Description:Antagonist activity at Smo receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50383019BDBM50383019(CHEMBL2031273)
Affinity DataIC50: 160nMAssay Description:Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50383038BDBM50383038(CHEMBL2031253)
Affinity DataIC50: 180nMAssay Description:Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50383035BDBM50383035(CHEMBL2031294)
Affinity DataIC50: 190nMAssay Description:Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50383014BDBM50383014(CHEMBL2031258)
Affinity DataIC50: 190nMAssay Description:Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50383025BDBM50383025(CHEMBL2031284)
Affinity DataIC50: 220nMAssay Description:Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50383023BDBM50383023(CHEMBL2031282)
Affinity DataIC50: 290nMAssay Description:Antagonist activity at Smo receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50383023BDBM50383023(CHEMBL2031282)
Affinity DataIC50: 290nMAssay Description:Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50383034BDBM50383034(CHEMBL2031084)
Affinity DataIC50: 300nMAssay Description:Displacement of BODIPY-labelled cyclopamine from human Smo receptor expressed in HEK293 cells after 2 hrs by fluorescence microscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50232973BDBM50232973(CHEMBL254129 | CYCLOPAMINE)
Affinity DataIC50: 300nMAssay Description:Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50383033BDBM50383033(CHEMBL2031292)
Affinity DataIC50: 370nMAssay Description:Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50383017BDBM50383017(CHEMBL2031080)
Affinity DataIC50: 520nMAssay Description:Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50383026BDBM50383026(CHEMBL2031285)
Affinity DataIC50: 640nMAssay Description:Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50383034BDBM50383034(CHEMBL2031084)
Affinity DataIC50: 650nMAssay Description:Antagonist activity at Smo receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50383034BDBM50383034(CHEMBL2031084)
Affinity DataIC50: 650nMAssay Description:Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50383039BDBM50383039(CHEMBL2031254)
Affinity DataIC50: 820nMAssay Description:Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50383027BDBM50383027(CHEMBL2031286)
Affinity DataIC50: 900nMAssay Description:Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50383040BDBM50383040(CHEMBL2031256)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Siena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50383018BDBM50383018(CHEMBL2031079)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed