Compile Data Set for Download or QSAR
Report error Found 31 Enz. Inhib. hit(s) with all data for entry = 50022515
TargetRAC-beta serine/threonine-protein kinase(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 1nMAssay Description:Inhibition of AKT2 (unknown origin) in the presence of [33P]ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 1nMAssay Description:Inhibition of AKT1 (unknown origin) in the presence of [33P]ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 1nMAssay Description:Inhibition of JAK2 (unknown origin) in the presence of [33P]ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PDGFRalpha (unknown origin) in the presence of [33P]ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 1nMAssay Description:Inhibition of LYN (unknown origin) in the presence of [33P]ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetRAC-gamma serine/threonine-protein kinase(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 1nMAssay Description:Inhibition of AKT3 (unknown origin) in the presence of [33P]ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PIM1 (unknown origin) in the presence of [33P]ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase Chk1(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 1nMAssay Description:Inhibition of CHK1 (unknown origin) in the presence of [33P]ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase Lck(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of LCK (unknown origin) in the presence of [33P]ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase Sgk1(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of SGK1 (unknown origin) in the presence of [33P]ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of AXL (unknown origin) in the presence of [33P]ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of GSK3alpha (unknown origin) in the presence of [33P]ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase receptor TYRO3(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 8nMAssay Description:Inhibition of TYRO3 (unknown origin) in the presence of [33P]ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 8.60nMAssay Description:Inhibition of BTK (unknown origin) in the presence of [33P]ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 10nMAssay Description:Inhibition of IGF1R (unknown origin) in the presence of [33P]ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetActivated CDC42 kinase 1(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 11nMAssay Description:Inhibition of Ack1 (unknown origin) in the presence of [33P]ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetInsulin receptor(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 17nMAssay Description:Inhibition of IR (unknown origin) in the presence of [33P]ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 18nMAssay Description:Inhibition of VEGFR2 (unknown origin) in the presence of [33P]ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetActivated CDC42 kinase 1(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM50204589((S)-5,6-diphenyl-N-((tetrahydrofuran-2-yl)methyl)f...)
Affinity DataIC50: 22nMAssay Description:Inhibition of Ack1 (unknown origin) in the presence of [33P]ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 30nMAssay Description:Inhibition of ABL1 (unknown origin) in the presence of [33P]ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 73nMAssay Description:Inhibition of HER2 (unknown origin) in the presence of [33P]ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 77nMAssay Description:Inhibition of IKKalpha (unknown origin) in the presence of [33P]ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM50204589((S)-5,6-diphenyl-N-((tetrahydrofuran-2-yl)methyl)f...)
Affinity DataIC50: 347nMAssay Description:Inhibition of LYN (unknown origin) in the presence of [33P]ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM12915(CHEMBL98350 | 2-(morpholin-4-yl)-8-phenyl-4H-chrom...)
Affinity DataIC50: 363nMAssay Description:Inhibition of PI3Kbeta (unknown origin) in the presence of [33P]ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase Lck(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM50204589((S)-5,6-diphenyl-N-((tetrahydrofuran-2-yl)methyl)f...)
Affinity DataIC50: 432nMAssay Description:Inhibition of LCK (unknown origin) in the presence of [33P]ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM12915(CHEMBL98350 | 2-(morpholin-4-yl)-8-phenyl-4H-chrom...)
Affinity DataIC50: 668nMAssay Description:Inhibition of PI3Kalpha (unknown origin) in the presence of [33P]ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM50204589((S)-5,6-diphenyl-N-((tetrahydrofuran-2-yl)methyl)f...)
Affinity DataIC50: 706nMAssay Description:Inhibition of ABL1 (unknown origin) in the presence of [33P]ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM50204589((S)-5,6-diphenyl-N-((tetrahydrofuran-2-yl)methyl)f...)
Affinity DataIC50: 872nMAssay Description:Inhibition of BTK (unknown origin) in the presence of [33P]ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetWee1-like protein kinase(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of WEE1 (unknown origin) in the presence of [33P]ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 3(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 3.73E+3nMAssay Description:Inhibition of ERK1 (unknown origin) in the presence of [33P]ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of MAP3K8 (unknown origin) in the presence of [33P]ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed