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Report error Found 3 Enz. Inhib. hit(s) with all data for entry = 5689
TargetTyrosine-protein kinase SYK(Human)
Pfizer

LigandPNGBDBM92626(Pyrido analog, 3)
Affinity DataIC50:  2.10nMpH: 7.4 T: 25°CAssay Description:A Lance TR-FRET assay (Perkin Elmer) was used to measure and compare the potency of compounds against Syk kinase domain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetTyrosine-protein kinase SYK(Human)
Pfizer

LigandPNGBDBM92625(Dimethoxyquinoline, 2)
Affinity DataIC50:  100nMpH: 7.4 T: 25°CAssay Description:A Lance TR-FRET assay (Perkin Elmer) was used to measure and compare the potency of compounds against Syk kinase domain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetTyrosine-protein kinase SYK(Human)
Pfizer

LigandPNGBDBM92624(Dimethoxyquinoline, 1)
Affinity DataIC50:  320nMpH: 7.4 T: 25°CAssay Description:A Lance TR-FRET assay (Perkin Elmer) was used to measure and compare the potency of compounds against Syk kinase domain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)