Compile Data Set for Download or QSAR
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Found 37 Enz. Inhib. hit(s) with all data for entry = 50045017
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041691(CHEMBL3358920 | US11149292, Compound (R)-2-(7-(4-c...)
Affinity DataIC50:  1.90nMAssay Description:Induction of internalization of HA-tagged human S1P1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041691(CHEMBL3358920 | US11149292, Compound (R)-2-(7-(4-c...)
Affinity DataIC50:  3.30E+3nMAssay Description:Binding affinity to human adenosine A3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041691(CHEMBL3358920 | US11149292, Compound (R)-2-(7-(4-c...)
Affinity DataIC50: >3.00E+4nMAssay Description:Displacement of [3H]astemizole from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041691(CHEMBL3358920 | US11149292, Compound (R)-2-(7-(4-c...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041691(CHEMBL3358920 | US11149292, Compound (R)-2-(7-(4-c...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041691(CHEMBL3358920 | US11149292, Compound (R)-2-(7-(4-c...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041691(CHEMBL3358920 | US11149292, Compound (R)-2-(7-(4-c...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041691(CHEMBL3358920 | US11149292, Compound (R)-2-(7-(4-c...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041691(CHEMBL3358920 | US11149292, Compound (R)-2-(7-(4-c...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041697(CHEMBL3358915)
Affinity DataEC50:  0.490nMAssay Description:Agonist activity at human S1P1 receptor assessed as cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041698(CHEMBL3358914)
Affinity DataEC50:  3.70nMAssay Description:Agonist activity at human S1P1 receptor assessed as cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041699(CHEMBL3358913)
Affinity DataEC50:  0.450nMAssay Description:Agonist activity at human S1P1 receptor assessed as cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041703(CHEMBL3358912)
Affinity DataEC50:  0.0730nMAssay Description:Agonist activity at human S1P1 receptor assessed as cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041704(CHEMBL3358911)
Affinity DataEC50:  0.0770nMAssay Description:Agonist activity at human S1P1 receptor assessed as cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041705(CHEMBL3358910)
Affinity DataEC50:  0.0870nMAssay Description:Agonist activity at human S1P1 receptor assessed as cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041706(CHEMBL3358909)
Affinity DataEC50:  159nMAssay Description:Agonist activity at human S1P1 receptor assessed as cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041707(CHEMBL3358908)
Affinity DataEC50:  141nMAssay Description:Agonist activity at human S1P1 receptor assessed as cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041708(CHEMBL3358907)
Affinity DataEC50:  120nMAssay Description:Agonist activity at human S1P1 receptor assessed as cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041811(CHEMBL3358906)
Affinity DataEC50:  1.70nMAssay Description:Agonist activity at human S1P1 receptor assessed as cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041812(CHEMBL3358905)
Affinity DataEC50:  26nMAssay Description:Agonist activity at human S1P1 receptor assessed as cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041813(CHEMBL3358904)
Affinity DataEC50:  16nMAssay Description:Agonist activity at human S1P1 receptor assessed as cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041691(CHEMBL3358920 | US11149292, Compound (R)-2-(7-(4-c...)
Affinity DataEC50:  6.10nMAssay Description:Agonist activity at human S1P1 receptor by beta-arrestin recruitment assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Macaca mulatta)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041691(CHEMBL3358920 | US11149292, Compound (R)-2-(7-(4-c...)
Affinity DataEC50:  0.320nMAssay Description:Agonist activity at monkey S1P1 receptor assessed as cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Canis lupus familiaris)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041691(CHEMBL3358920 | US11149292, Compound (R)-2-(7-(4-c...)
Affinity DataEC50:  0.340nMAssay Description:Agonist activity at dog S1P1 receptor assessed as cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Rattus norvegicus)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041691(CHEMBL3358920 | US11149292, Compound (R)-2-(7-(4-c...)
Affinity DataEC50:  0.320nMAssay Description:Agonist activity at rat S1P1 receptor assessed as cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Mus musculus (Mouse))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041691(CHEMBL3358920 | US11149292, Compound (R)-2-(7-(4-c...)
Affinity DataEC50:  0.440nMAssay Description:Agonist activity at mouse S1P1 receptor assessed as cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM23165(CHEMBL366208 | FTY720-phosphate, (S)-2 | [(2S)-2-a...)
Affinity DataEC50:  0.00600nMAssay Description:Agonist activity at human S1P1 receptor assessed as cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041695(CHEMBL3358916)
Affinity DataEC50:  56nMAssay Description:Agonist activity at human S1P1 receptor assessed as cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041694(CHEMBL3358917)
Affinity DataEC50:  0.440nMAssay Description:Agonist activity at human S1P1 receptor assessed as cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041693(CHEMBL3358918)
Affinity DataEC50:  4.60nMAssay Description:Agonist activity at human S1P1 receptor assessed as cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041692(CHEMBL3358919)
Affinity DataEC50:  0.0900nMAssay Description:Agonist activity at human S1P1 receptor assessed as cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041691(CHEMBL3358920 | US11149292, Compound (R)-2-(7-(4-c...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human S1P2 receptor by beta-arrestin recruitment assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041691(CHEMBL3358920 | US11149292, Compound (R)-2-(7-(4-c...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human S1P3 receptor by beta-arrestin recruitment assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041691(CHEMBL3358920 | US11149292, Compound (R)-2-(7-(4-c...)
Affinity DataEC50:  147nMAssay Description:Agonist activity at human S1P4 receptor by beta-arrestin recruitment assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041691(CHEMBL3358920 | US11149292, Compound (R)-2-(7-(4-c...)
Affinity DataEC50:  24nMAssay Description:Agonist activity at human S1P5 receptor by beta-arrestin recruitment assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataEC50:  0.0620nMAssay Description:Agonist activity at human S1P1 receptor assessed as cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041691(CHEMBL3358920 | US11149292, Compound (R)-2-(7-(4-c...)
Affinity DataEC50:  0.0400nMAssay Description:Agonist activity at human S1P1 receptor assessed as cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed