Compile Data Set for Download or QSAR
Report error Found 37 Enz. Inhib. hit(s) with all data for entry = 50045608
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
National University of Singapore

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178769BDBM50178769(6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxa...)
Affinity DataIC50: 330nMAssay Description:Inhibition of human recombinant SIRT1 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
National University of Singapore

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50070588BDBM50070588(CHEMBL3408821)
Affinity DataKi:  2.28E+3nMAssay Description:Non-competitive inhibition of human recombinant SIRT2 using Z-QPK(Me)2K(Ac) as substrate assessed as decrease in maximal enzyme activity preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
National University of Singapore

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50070588BDBM50070588(CHEMBL3408821)
Affinity DataKi:  3.70E+3nMAssay Description:Non-competitive inhibition of human recombinant SIRT2 using Z-QPK(Me)2K(Ac) as substrate assessed as decrease in maximal enzyme activity preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
National University of Singapore

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50070588BDBM50070588(CHEMBL3408821)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
National University of Singapore

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50070590BDBM50070590(CHEMBL3408819)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
National University of Singapore

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50070589BDBM50070589(CHEMBL3408820)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
National University of Singapore

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50070582BDBM50070582(CHEMBL3408829)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
National University of Singapore

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 27507BDBM27507(pyridine-3-carboxamide | nicotinamide | 3-Pyridine...)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
National University of Singapore

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50070584BDBM50070584(CHEMBL3408826)
Affinity DataIC50: 7.80E+3nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
National University of Singapore

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50070581BDBM50070581(CHEMBL3408830)
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
National University of Singapore

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50070580BDBM50070580(CHEMBL3408831)
Affinity DataIC50: 1.01E+4nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
National University of Singapore

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50070583BDBM50070583(CHEMBL3408827)
Affinity DataIC50: 1.12E+4nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
National University of Singapore

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50070591BDBM50070591(CHEMBL3408815)
Affinity DataIC50: 1.18E+4nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
National University of Singapore

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50216689BDBM50216689(2-cyano-3-(5-(2,5-dichlorophenyl)furan-2-yl)-N-(qu...)
Affinity DataIC50: 1.39E+4nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
National University of Singapore

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50070592BDBM50070592(CHEMBL3408814)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
National University of Singapore

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50070588BDBM50070588(CHEMBL3408821)
Affinity DataIC50: 1.67E+4nMAssay Description:Inhibition of human recombinant SIRT1 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
National University of Singapore

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50070593BDBM50070593(CHEMBL3408833)
Affinity DataIC50: 1.79E+4nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
National University of Singapore

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50070580BDBM50070580(CHEMBL3408831)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant SIRT1 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
National University of Singapore

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50070594BDBM50070594(CHEMBL3408980)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
National University of Singapore

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50070602BDBM50070602(CHEMBL3408817)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
National University of Singapore

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50070582BDBM50070582(CHEMBL3408829)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of human recombinant SIRT1 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
National University of Singapore

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50070583BDBM50070583(CHEMBL3408827)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of human recombinant SIRT1 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
National University of Singapore

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50070590BDBM50070590(CHEMBL3408819)
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of human recombinant SIRT1 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
National University of Singapore

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50070591BDBM50070591(CHEMBL3408815)
Affinity DataIC50: 3.80E+4nMAssay Description:Inhibition of human recombinant SIRT1 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
National University of Singapore

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50070594BDBM50070594(CHEMBL3408980)
Affinity DataIC50: 5.60E+4nMAssay Description:Inhibition of human recombinant SIRT1 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
National University of Singapore

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50070592BDBM50070592(CHEMBL3408814)
Affinity DataIC50: 6.30E+4nMAssay Description:Inhibition of human recombinant SIRT1 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
National University of Singapore

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50070586BDBM50070586(CHEMBL3408824)
Affinity DataIC50: 8.30E+4nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
National University of Singapore

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50070587BDBM50070587(CHEMBL3408823)
Affinity DataIC50: 9.60E+4nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
National University of Singapore

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50070593BDBM50070593(CHEMBL3408833)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant SIRT1 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
National University of Singapore

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50070584BDBM50070584(CHEMBL3408826)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant SIRT1 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
National University of Singapore

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50070585BDBM50070585(CHEMBL3408825)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
National University of Singapore

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50070581BDBM50070581(CHEMBL3408830)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant SIRT1 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
National University of Singapore

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50070604BDBM50070604(CHEMBL3408984)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
National University of Singapore

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 27507BDBM27507(pyridine-3-carboxamide | nicotinamide | 3-Pyridine...)
Affinity DataIC50: 1.49E+5nMAssay Description:Inhibition of human recombinant SIRT1 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
National University of Singapore

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50070603BDBM50070603(CHEMBL3408983)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
National University of Singapore

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50070589BDBM50070589(CHEMBL3408820)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of human recombinant SIRT1 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
National University of Singapore

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50070601BDBM50070601(CHEMBL3408818)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed