Compile Data Set for Download or QSAR
maximum 50k data
Found 37 Enz. Inhib. hit(s) with all data for entry = 50045608
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50070588(CHEMBL3408821)
Affinity DataKi:  2.28E+3nMAssay Description:Non-competitive inhibition of human recombinant SIRT2 using Z-QPK(Me)2K(Ac) as substrate assessed as decrease in maximal enzyme activity preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50070588(CHEMBL3408821)
Affinity DataKi:  3.70E+3nMAssay Description:Non-competitive inhibition of human recombinant SIRT2 using Z-QPK(Me)2K(Ac) as substrate assessed as decrease in maximal enzyme activity preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50178769((+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-c...)
Affinity DataIC50:  330nMAssay Description:Inhibition of human recombinant SIRT1 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50070588(CHEMBL3408821)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50070590(CHEMBL3408819)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50070589(CHEMBL3408820)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50070582(CHEMBL3408829)
Affinity DataIC50:  6.20E+3nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM27507(3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)
Affinity DataIC50:  6.30E+3nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50070584(CHEMBL3408826)
Affinity DataIC50:  7.80E+3nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50070581(CHEMBL3408830)
Affinity DataIC50:  8.20E+3nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50070580(CHEMBL3408831)
Affinity DataIC50:  1.01E+4nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50070583(CHEMBL3408827)
Affinity DataIC50:  1.12E+4nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50070591(CHEMBL3408815)
Affinity DataIC50:  1.18E+4nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50216689(2-cyano-3-(5-(2,5-dichlorophenyl)furan-2-yl)-N-(qu...)
Affinity DataIC50:  1.39E+4nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50070592(CHEMBL3408814)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50070588(CHEMBL3408821)
Affinity DataIC50:  1.67E+4nMAssay Description:Inhibition of human recombinant SIRT1 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50070593(CHEMBL3408833)
Affinity DataIC50:  1.79E+4nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50070602(CHEMBL3408817)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50070580(CHEMBL3408831)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of human recombinant SIRT1 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50070594(CHEMBL3408980)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50070582(CHEMBL3408829)
Affinity DataIC50:  2.10E+4nMAssay Description:Inhibition of human recombinant SIRT1 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50070583(CHEMBL3408827)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of human recombinant SIRT1 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50070590(CHEMBL3408819)
Affinity DataIC50:  2.80E+4nMAssay Description:Inhibition of human recombinant SIRT1 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50070591(CHEMBL3408815)
Affinity DataIC50:  3.80E+4nMAssay Description:Inhibition of human recombinant SIRT1 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50070594(CHEMBL3408980)
Affinity DataIC50:  5.60E+4nMAssay Description:Inhibition of human recombinant SIRT1 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50070592(CHEMBL3408814)
Affinity DataIC50:  6.30E+4nMAssay Description:Inhibition of human recombinant SIRT1 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50070586(CHEMBL3408824)
Affinity DataIC50:  8.30E+4nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50070587(CHEMBL3408823)
Affinity DataIC50:  9.60E+4nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50070593(CHEMBL3408833)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant SIRT1 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50070585(CHEMBL3408825)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50070581(CHEMBL3408830)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant SIRT1 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50070584(CHEMBL3408826)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant SIRT1 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50070604(CHEMBL3408984)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM27507(3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)
Affinity DataIC50:  1.49E+5nMAssay Description:Inhibition of human recombinant SIRT1 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50070601(CHEMBL3408818)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50070603(CHEMBL3408983)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50070589(CHEMBL3408820)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of human recombinant SIRT1 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed