Found 12 Enz. Inhib. hit(s) with Target = 'NAD-dependent protein deacetylase sirtuin-1' and Ligand = 'BDBM27507' TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Nagoya City University
Curated by ChEMBL
Nagoya City University
Curated by ChEMBL
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of recombinant human C-terminal His6-tagged SIRT1 (Met1 to Ser747 residues) defatty-acylase activity expressed in Escherichia coli using S...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Nagoya City University
Curated by ChEMBL
Nagoya City University
Curated by ChEMBL
Affinity DataIC50: <5.00E+4nMAssay Description:Non-competitive inhibition of recombinant human SIRT1 using acetylated histone as substrate measured after 30 mins by fluorimetric analysisMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Nagoya City University
Curated by ChEMBL
Nagoya City University
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant SIRT1 using ZMAL substrate after 4 hrs by homogeneous fluorescence assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Nagoya City University
Curated by ChEMBL
Nagoya City University
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human SIRT1 using MPSDKTIGG as substrate by liquid scintillation counting analysis in presence of [3H]-acetic acidMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Nagoya City University
Curated by ChEMBL
Nagoya City University
Curated by ChEMBL
Affinity DataIC50: 7.30E+4nMAssay Description:Inhibition of full length human SIRT1 expressed in Escherichia coli BL21 (DE3) cells using fluorogenic 7-amino-4-methylcoumarin (AMC)-labeled peptide...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Nagoya City University
Curated by ChEMBL
Nagoya City University
Curated by ChEMBL
Affinity DataIC50: 8.80E+4nMAssay Description:Inhibition of human SIRT1More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Nagoya City University
Curated by ChEMBL
Nagoya City University
Curated by ChEMBL
Affinity DataIC50: 9.04E+4nMAssay Description:Inhibition of N-terminal His6-tagged SIRT1 coding region (156-664) (unknown origin) expressed in Escherichia coli BL21(DE3) using 31.25 uM ac-RHKKac-...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Nagoya City University
Curated by ChEMBL
Nagoya City University
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant SIRT1 after 60 mins by fluorimetric analysisMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Nagoya City University
Curated by ChEMBL
Nagoya City University
Curated by ChEMBL
Affinity DataIC50: 1.18E+5nMAssay Description:Inhibition of human SIRT1 in presence of NAD+ by fluorimetric methodMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Nagoya City University
Curated by ChEMBL
Nagoya City University
Curated by ChEMBL
Affinity DataIC50: 1.49E+5nMAssay Description:Inhibition of human recombinant SIRT1 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Nagoya City University
Curated by ChEMBL
Nagoya City University
Curated by ChEMBL
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of human full length SIRT1 expressed in DE3 cells by fluorimetric assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Nagoya City University
Curated by ChEMBL
Nagoya City University
Curated by ChEMBL
Affinity DataIC50: 5.20E+5nMAssay Description:Inhibition of human SIRT1More data for this Ligand-Target Pair
