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Report error Found 218 Enz. Inhib. hit(s) with all data for entry = 50045707
LigandPNGBDBM50077646(CHEMBL3417041)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077856(CHEMBL3416921)
Affinity DataIC50:  2nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50051073(CHEMBL3318132)
Affinity DataIC50:  3nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077781(CHEMBL3416942)
Affinity DataIC50:  3nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077471(CHEMBL3416886)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of NaV1.7 in C57BL/6 mouse DRG neurons held at voltage yielding 20% inactivation and depolarized to -10 mV for 40 ms every 10 s by whole-c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077780(CHEMBL3416943)
Affinity DataIC50:  4nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077787(CHEMBL3416937)
Affinity DataIC50:  4nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077803(CHEMBL3416933)
Affinity DataIC50:  4nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077833(CHEMBL3416926)
Affinity DataIC50:  4nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077715(CHEMBL3417038)
Affinity DataIC50:  4nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077777(CHEMBL3416946)
Affinity DataIC50:  4nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077779(CHEMBL3416944)
Affinity DataIC50:  5nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077854(CHEMBL3416923)
Affinity DataIC50:  5nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077832(CHEMBL3416927)
Affinity DataIC50:  5nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077815(CHEMBL3416928)
Affinity DataIC50:  6nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077471(CHEMBL3416886)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of NaV1.7 in C57BL/6 mouse DRG neurons at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077665(CHEMBL3417040)
Affinity DataIC50:  8nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077776(CHEMBL3417035)
Affinity DataIC50:  8nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077805(CHEMBL3416931)
Affinity DataIC50:  8nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077860(CHEMBL3416917)
Affinity DataIC50:  9nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077855(CHEMBL3416922)
Affinity DataIC50:  9nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077786(CHEMBL3416938)
Affinity DataIC50:  10nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077471(CHEMBL3416886)
Affinity DataIC50:  10nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077714(CHEMBL3417039)
Affinity DataIC50:  11nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077784(CHEMBL3416940)
Affinity DataIC50:  13nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077464(CHEMBL3416893)
Affinity DataIC50:  13nMAssay Description:Inhibition of human NaV1.7 assessed as reduction in peak inward current at -10 mV by manual whole cell patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077802(CHEMBL3416934)
Affinity DataIC50:  19nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077857(CHEMBL3416920)
Affinity DataIC50:  19nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077469(CHEMBL3416888)
Affinity DataIC50:  20nMAssay Description:Inhibition of human NaV1.4 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077471(CHEMBL3416886)
Affinity DataIC50:  20nMAssay Description:Inhibition of human NaV1.3 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077800(CHEMBL3416936)
Affinity DataIC50:  23nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077464(CHEMBL3416893)
Affinity DataIC50:  23nMAssay Description:Inhibition of NaV1.7 in C57BL/6 mouse DRG neurons at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077804(CHEMBL3416932)
Affinity DataIC50:  24nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077834(CHEMBL3416925)
Affinity DataIC50:  24nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077835(CHEMBL3416924)
Affinity DataIC50:  25nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077464(CHEMBL3416893)
Affinity DataIC50:  27nMAssay Description:Inhibition of human NaV1.7 by patchXpress 700A electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077785(CHEMBL3416939)
Affinity DataIC50:  28nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077717(CHEMBL3417036)
Affinity DataIC50:  29nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50051073(CHEMBL3318132)
Affinity DataIC50:  30nMAssay Description:Inhibition of human NaV1.4 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077470(CHEMBL3416887)
Affinity DataIC50:  33nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077778(CHEMBL3416945)
Affinity DataIC50:  34nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077858(CHEMBL3416919)
Affinity DataIC50:  39nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077716(CHEMBL3417037)
Affinity DataIC50:  54nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077783(CHEMBL3416941)
Affinity DataIC50:  59nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077801(CHEMBL3416935)
Affinity DataIC50:  63nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077805(CHEMBL3416931)
Affinity DataIC50:  70nMAssay Description:Inhibition of human NaV1.4 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077859(CHEMBL3416918)
Affinity DataIC50:  79nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077810(CHEMBL3416930)
Affinity DataIC50:  86nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50077609(CHEMBL3416902)
Affinity DataIC50:  90nMAssay Description:Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50051073(CHEMBL3318132)
Affinity DataIC50:  90nMAssay Description:Inhibition of human NaV1.5 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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