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Patent
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59
1-ALKYL-5-ARYLIDENE-2-SELENOXOIMIDAZOLIDINE-4-ON AND DERIVATIVE THEREOF, PREPARATION METHOD THEREFOR, AND COMPOSITION COMPRISING SAME FOR PREVENTING, ALLEVIATING OR TREATING NEURODEGENERATIVE DISEASES
DUKSUNG WOMEN''S UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION; KNU-INDUSTRY COOPERATION FOUNDATION; INDUSTRY ACADEMIC COOPERATION FOUNDATION OF YEUNGNAM UNIVERSITY; EWHA UNIVERSITY - INDUSTRY COLLABORATION FOUNDATION
10/23/23
-
96
ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE
Petra Pharma Corporation
10/23/23
-
120
BCL6 INHIBITORS
Cancer Research Technology Limited; The Institute of Cancer Research:
Royal Cancer Hospital
10/23/23
-
90
Compositions and Methods of Modulating Short-Chain Dehydrogenase Activity
BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM; CASE WESTERN RESERVE UNIVERSITY
10/23/23
-
56
HALOALKYLPYRIDYL TRIAZOLE MLL1-WDR5 PROTEIN-PROTEIN INTERACTION INHIBITOR
HUYABIO International, LLC
10/23/23
-
139
IL-17A MODULATORS
SANOFI
10/23/23
-
13
INDAZOLE DERIVATIVES AS INHIBITORS OF SARM1
Disarm Therapeutics, Inc.
10/23/23
-
238
ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF
Biosplice Therapeutics, Inc.
10/23/23
-
47
KCNT1 INHIBITORS AND METHODS OF USE
Praxis Precision Medicines, Inc.
10/23/23
-
10
METHOD FOR TREATING GRAFT VERSUS HOST DISEASE CAUSED BY HEMATOPOIETIC STEM CELL TRANSPLANTATION
BEIJING TIDE PHARMACEUTICAL CO., LTD.
10/23/23
-
58
NEPRILYSIN INHIBITORS
THERAVANCE BIOPHARMA R&D IP, LLC
10/23/23
-
417
NOVEL OXADIAZOLE-BASED SELECTIVE HDAC6 INHIBITORS
ITALFARMACO S.P.A.
10/23/23
-
33
PHENYL TRIAZOLE MLL1-WDR5 PROTEIN-PROTEIN INTERACTION INHIBITOR
HUYABIO International, LLC; CHINA PHARMACEUTICAL UNIVERSITY
10/23/23
-
185
PLASMA KALLIKREIN INHIBITORS
Merck Sharp & Dohme LLC
10/23/23
-
32
QUINAZOLINONE HSD17B13 INHIBITORS AND USES THEREOF
INIPHARM, INC.
10/23/23
-
3
SALT OF DIHYDROPYRIDO[2,3-D]PYRIMIDINONE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF
NANJING CHIA TAI TIANQING PHARMACEUTICAL CO., LTD.
10/23/23
-
30
Disulfiram derivatives as ALDH1A1 and MAGL inhibitors
BATTERJEE MEDICAL COLLEGE
10/20/23
-
295
EIF4E inhibitors and uses thereof
PIC Therapeutics, Inc.
10/20/23
-
34
Muscarinic acetylcholine M1 receptor antagonists
Pipeline Therapeutics, Inc.
10/20/23
-
55
Protease inhibitors as antivirals
ACEA Therapeutics, Inc.
10/20/23
-
137
Treating primary or idiopathic hyperoxaluria with small molecule inhibitors of lactate dehydrogenase
VANDERBILT UNIVERSITY; THE UAB RESEARCH FOUNDATION; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
10/20/23
-
57
Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders
Rugen Holdings (Cayman) Limited
10/20/23
-
187
DICHLOROPHENOL HSD17B13 INHIBITORS AND USES THEREOF
INIPHARM, INC.
10/18/23
-
54
Benzimidazole Derivative Compounds and Uses Thereof
Pfizer Inc.
10/17/23
-
1030
CARM1 INHIBITORS AND USES THEREOF
Epizyme, Inc.
10/17/23
-
37
CERTAIN (2S)-N-[(1S)-1-CYANO-2-PHENYLETHYL]-1,4-OXAZEPANE-2-CARBOXAMIDES AS DIPEPTIDYL PEPTIDASE 1 INHIBITORS
AstraZeneca AB
10/17/23
-
207
COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
Plexxikon Inc.
10/17/23
-
143
Compound containing structure of a five-membered heteroaromatic ring, pharmaceutical compositions thereof and applications thereof
280 Bio, Inc.
10/17/23
-
5
DIARYL AND ARYLHETEROARYL UREA DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO
Arena Pharmaceuticals, Inc.
10/17/23
-
34
ENPP1 Inhibitors and Their Use for the Treatment of Cancer
The Board of Trustees of the Leland Stanford Junior University
10/17/23
-
4
IMIDAZO[1,2-A]PYRIDINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE
Hoffmann-La Roche Inc.
10/17/23
-
90
INDOLE DERIVATIVES AND USES THEREOF FOR TREATING A CANCER
Universite Claude Bernard Lyon 1; Institut National de la Sante et de la Recherche Madicale; Centre National de la Recherche Scientifique; Ecole Normale Superieure de Lyon; Commissariat à l''Energie Atomique et aux Energies AlternativesS; Centre Leon Berard
10/17/23
-
461
KRAS G12D INHIBITORS
Mirati Therapeutics, Inc.; Array BioPharma Inc.
10/17/23
-
160
N/O-Linked Degrons and Degronimers for Protein Degradation
C4 Therapeutics, Inc.
10/17/23
-
7
NOVEL TRICYCLIC AROMATIC HETEROCYCLIC COMPOUND AND PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF
SHANGHAI LONGWOOD BIOPHARMACEUTICALS CO., LTD.
10/17/23
-
26
PTGR2 INHIBITORS AND THEIR USE
National Health Research Institutes; National Taiwan University
10/17/23
-
20
ROR-GAMMA MODULATORS
Escalier Biosciences B.V.
10/17/23
-
29
TRIAZINE COMPOUND AND COMPOSITION AND USE THEREOF
BEIJING FINDCURE BIOSCIENCES, LTD.
10/17/23
-
188
YKL-40 INHIBITORS AND THEIR THERAPEUTIC APPLICATIONS
Molecure S.A.
10/17/23
-
98
5-AMINO-8-(4-PYRIDYL)-[1,2,4]TRIAZOLO[4,3-C]PYRIMIDIN-3-ONE COMPOUNDS FOR USE AGAINST CANCER
ASTRAZENECA AB
10/16/23
-
100
AMIDE DERIVATIVES
Merck Patent GmbH; RYVU THERAPEUTICS S.A.
10/16/23
-
144
AMINO ACID COMPOUNDS AND METHODS OF USE
Pliant Therapeutics, Inc.
10/16/23
-
44
COMPOUND HAVING KDM5 INHIBITORY ACTIVITY AND PHARMACEUTICAL USE THEREOF
ONO PHARMACEUTICAL CO., LTD.
10/16/23
-
549
COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE
Vertex Pharmaceuticals Incorporated
10/16/23
-
250
COMPOUNDS USEFUL AS T CELL ACTIVATORS
Gossamer Bio Services, Inc.
10/16/23
-
20
CONDENSED PYRAZOLE DERIVATIVES AS INHIBITORS OF SARM1
Disarm Therapeutics, Inc.
10/16/23
-
5
PRPK INHIBITORS
Dana-Farber Cancer Institute, Inc.
10/16/23
-
24
PYRAZOLOPYRIMIDINE COMPOUND USED AS ATR KINASE INHIBITOR
BEIJING TIDE PHARMACEUTICAL CO., LTD.
10/16/23
-
3
SALT AND CRYSTAL FORM OF DIHYDROPYRIDO[2,3-d]PYRIMIDINE DERIVATE
NANJING CHIA TAI TIANQING PHARMACEUTICAL CO., LTD.
10/16/23
-
42
4-ETHYNYLPYRIDINE DERIVATIVES USEFUL AS GCN2 INHIBITORS
IP2IPO INNOVATIONS LIMITED
10/15/23
-
210
BENZODIAZEPINE DERIVATIVES USEFUL IN TREATING A RESPIRATORY SYNCYTIAL VIRUS INFECTION
REVIRAL LIMITED
10/15/23
-
164
CARBOXYLIC ACID AROMATIC AMIDES AS ANTAGONISTS OF BRADYKININ B1 RECEPTOR
Bayer Pharma Aktiengesellschaft
10/15/23
-
176
COMPOSITION CONTAINING ARYLAMIDE DERIVATIVE
Chugai Seiyaku Kabushiki Kaisha
10/15/23
-
124
COMPOUNDS ACTIVE TOWARDS NUCLEAR RECEPTORS
NUEVOLUTION A/S
10/15/23
-
76
COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY
IFM Due, Inc.
10/15/23
-
412
GLP-1R MODULATING COMPOUNDS
ASCLETIS BIOSCIENCE CO., LTD.
10/15/23
-
129
INHIBITORS OF APOL1 AND METHODS OF USING SAME
Vertex Pharmaceuticals Incorporated
10/15/23
-
135
SUBSTITUTED PYRROLIZINE COMPOUNDS AND USES THEREOF
Gilead Sciences, Inc.
10/15/23
-
172
2-amino-3-carbonyl imidazopyridine and pyrazolopyridine compounds
1ST Biotherapeutics, Inc.
10/06/23
-
99
ALK-5 inhibitors and uses thereof
Sumitomo Pharma Oncology, Inc.
10/06/23
-
16
Alkynyl (hetero) aromatic ring compounds used for inhibiting protein kinase activity
Shenzhen TargetRx, Inc.
10/06/23
-
99
Labelled cannabinergic ligands and related analogs
TBA
10/06/23
-
172
Method of increasing platelet counts of a subject
KOREA BASIC SCIENCE INSTITUTE; University of Louisville Research Foundation, Inc.; Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
10/06/23
-
58
Acetamido-phenyltetrazole derivatives and methods of using the same
Athenex, Inc.
10/01/23
-
125
Methods of inhibiting kinases
Insilico Medicine IP Limited
10/01/23
-
58
Small molecule inhibitors of ubiquitin specific protease 1 (USP1) and uses thereof
Insilico Medicine IP Limited
10/01/23
-
10
Substituted pyrazlo[3,4-c]pyridines as selective BTK kinase inhibitors
JUMBO DRUG BANK CO., LTD.
10/01/23
-
58
Substituted pyrazolopyrazines, imidazopyrazines and [1,2,4]triazolopyrazines as allosteric SHP2 inhibitors
REVOLUTION MEDICINES, INC.
10/01/23
-
105
Carboxamide compounds and uses thereof
Incyte Corporation
09/26/23
-
36
Histone demethylase inhibitors
TBA
09/26/23
-
47
N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists
Ogeda SA
09/26/23
-
93
SARS-CoV-2 inhibitors for treating coronavirus infections
Insilico Medicine IP Limited
09/26/23
-
58
Spiro compounds as glycosidase inhibitors
Asceneuron SA
09/26/23
-
106
Substituted 1,2,4-triazoles as intermediates in the synthesis of TYK2 inhibitors
Alumis Inc.
09/26/23
-
31
Substituted pyrazolo[3,4-d]pyrimidines as mTOR inhibitors
GALDERMA RESEARCH & DEVELOPMENT
09/26/23
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41
HDAC inhibitor compounds and methods of treatment
University of Florida Research Foundation, Inc.
09/25/23
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298
Therapeutic compounds, compositions and methods of use thereof
Genentech, Inc.
09/25/23
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20
(Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles
Centrexion Therapeutics Corporation
09/23/23
-
253
Bicyclic compound and use thereof
SK BIOPHARMACEUTICALS CO., LTD.
09/23/23
-
3
Bicyclic urea kinase inhibitors and uses thereof
THE GENERAL HOSPITAL CORPORATION; DANA-FARBER CANCER INSTITUTE, INC.; THE BROAD INSTITUTE, INC.
09/23/23
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43
Compositions and methods for inhibiting kinases
Inhibikase Therapeutics, Inc.
09/23/23
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151
Polyheterocyclic compounds as METTL3 inhibitors
Storm Therapeutics Limited
09/23/23
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415
Apoptosis inhibitors
National Institute of Biological Sciences, Beijing
09/21/23
-
176
Compounds and compositions for treating conditions associated with NLRP activity
Novartis AG
09/21/23
-
80
MCT4 inhibitors for treating disease
Vettore, LLC
09/21/23
-
49
Methods of improving cell-based therapy
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
09/21/23
-
52
Quinazoline derivatives as antitumor agents
SUZHOU ZANRONG PHARMA LIMITED
09/21/23
-
222
Heterocyclic adenosine receptor antagonists
Exelixis Inc.
09/17/23
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63
Isoxazolyl-carbonyloxy azabicyclo[3.2.1]octanyl compounds as FXR activators
Ardelyx, Inc.
09/17/23
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27
JAK kinase inhibitor compounds for treatment of respiratory disease
Theravance Biopharma R&D IP, LLC
09/17/23
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223
Macrocyclic compounds for treatment of medical disorders
Achillion Pharmaceuticals, Inc.
09/17/23
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19
N-(phenylsulfonyl)benzamides and related compounds as Bcl-2 inhibitors
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
09/17/23
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106
Substituted pyrido[2,1-a]isoquinolines as VMAT2 inhibitors
Neurocrine Biosciences, Inc.
09/17/23
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1
Benzenesulfonylbenazamide compound for inhibiting BCL-2 protein and composition and use thereof
Shenzhen TargetRx, Inc.
09/15/23
-
570
CDK2 inhibitors
PFIZER INC.
09/15/23
-
164
Compositions and methods of modulating short-chain dehydrogenase
Case Western Reserve University; Board of Regents of the University of Texas System
09/15/23
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25
Heparanase inhibitors and use thereof
BETA THERAPEUTICS PTY LTD
09/15/23
-
13
Heterocyclic compounds as immunomodulators
Incyte Corporation
09/15/23
-
70
Inhibitors of receptor interacting protein kinase I for the treatment of disease
Board of Regents, The University of Texas System
09/15/23
-
3
Treatment of spondyloarthritis
PHARMACYL AB
09/15/23
-
107
Azole derivatives as apelin receptor agonist
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
09/08/23
-
5
Bismuth(III) compounds and methods thereof
THE UNIVERSITY OF HONG KONG
09/08/23
-
3
Crystal form, salt type of substituted 2-hydro-pyrazole derivative and preparation method therefor
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.
09/08/23
-
187
Cyanotriazole compounds
OTSUKA PHARMACEUTICAL CO., LTD.
09/08/23
-
9
Heterocyclic indoles for use in influenza virus infection
JANSSEN SCIENCES IRELAND UC
09/08/23
-
420
Heterocyclic sulfonamide derivative and medicine comprising same
EA PHARMA CO., LTD.
09/08/23
-
117
Inhibitor of lysine specific demethylase-1
CELGENE QUANTICEL RESEARCH, INC.
09/08/23
-
332
Inhibitors of low molecular weight protein tyrosine phosphatase and uses thereof
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; LA JOLLA INSTITUTE OF ALLERGY & IMMUNOLOGY
09/08/23
-
42
Peptide derivatives and uses thereof
Nosopharm
09/08/23
-
14
Phosphodiesterase inhibitors and uses thereof
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
09/08/23
-
216
2,4,5-trisubstituted 1,2,4-triazolones useful as inhibitors of DHODH
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION
09/04/23
-
12
5 to 7 membered heterocyclic amides as JAK inhibitors
Theravance Biopharma R&D IP, LLC
09/04/23
-
143
5-heteroaryl substituted indazole-3-carboxamides and preparation and use thereof
BioSplice Therapeutics, Inc.
09/04/23
-
39
5-substituted difluoropiperidine compounds with blood-brain barrier penetrable capability
WAYSHINE BIOPHARM HOLDING LIMITED
09/04/23
-
44
GSK-3 inhibitors
Bristol-Myers Squibb Company
09/04/23
-
26
Heteroaryl heterocyclyl compounds for the treatment of autoimmune disease
Hoffmann-La Roche Inc.
09/04/23
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102
Heteroaryl-biphenyl amides for the treatment of PD-L1 diseases
CHEMOCENTRYX, INC.
09/04/23
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44
Inhibitors of NEK7 kinase
HALIA THERAPEUTICS, INC.
09/04/23
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218
Fused 1,4-dihydrodioxin derivatives as inhibitors of heat shock transcription factor 1
CANCER RESEARCH TECHNOLOGY LIMITED
08/31/23
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44
Hydroxyalkyl-piperazine derivatives as CXCR3 receptor modulators
IDORSIA PHARMACEUTICALS LTD.
08/31/23
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267
Protein kinase modulators
Cylene Pharmaceuticals, Inc.
08/31/23
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563
Aryl, heteroaryl, and heterocyclic pharmaceutical compounds for treatment of medical disorders
Achillion Pharmaceuticals, Inc.
08/27/23
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92
Azaindole derivatives and their use as ERK kinase inhibitors
AGV Discovery; Institut National de la Sante et de la Recherche Medicale (INSERM); Centre National de la Recherche Scientifique (CNRS); Universite De Montpellier
08/27/23
-
30
Compounds for the treatment of kinase-dependent disorders
EXELIXIS, INC.
08/27/23
-
34
ENPP1 inhibitors and their use for the treatment of cancer
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
08/27/23
-
89
FAP-targeted radiopharmaceuticals and imaging agents, and uses related thereto
Trustees of Tufts College
08/27/23
-
34
Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof
Novartis AG
08/27/23
-
250
Human plasma kallikrein inhibitors
BioCryst Pharmaceuticals, Inc.
08/27/23
-
410
Immunomodulator compounds
CHEMOCENTRYX, INC.
08/27/23
-
122
Monoacylglycerol lipase modulators
Janssen Pharmaceutica NV
08/27/23
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536
Substituted benzofuran, benzopyrrole, benzothiophene, and structurally related complement inhibitors
BioCryst Pharmaceuticals, Inc.
08/27/23
-
98
1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins
Incyte Corporation; Incyte Holdings Corporation
08/18/23
-
364
Bicyclic-fused heteroaryl or aryl compounds
Pfizer Inc.
08/18/23
-
8
Composition for inducing differentiation and protection of neural stem cells and method for inducing neuro-regeneration using the same composition
GENUV Inc.
08/18/23
-
36
Compounds and methods of use
Medivation Technologies LLC
08/18/23
-
2
Crystalline hydrate of a JAK inhibitor compound
Theravance Biopharma R&D IP, LLC
08/18/23
-
34
ENPP1 inhibitors and their use for the treatment of cancer
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
08/18/23
-
647
Methods, compositions, and uses of novel FYN kinase inhibitors
Pathways Neuro Pharma, Inc.
08/18/23
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42
Pyrazolo[3,4-b]pyrazine derivatives as SHP2 phosphatase inhibitors
D. E. Shaw Research, LLC; Relay Therapeutics, Inc.
08/18/23
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94
Pyrazolyl derivatives useful as anti-cancer agents
NOVARTIS AG
08/18/23
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34
Pyridine, pyrazine, and triazine compounds as allosteric SHP2 inhibitors
REVOLUTION MEDICINES, INC.
08/18/23
-
143
Pyrimidinone derivatives as SHP2 antagonists
Merck Patent GmbH
08/18/23
-
365
SOS1 inhibitors
MIRATI THERAPEUTICS, INC.
08/18/23
-
9
Substituted bicyclic compounds
Bristol-Myers Squibb Company
08/18/23
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303
Thiadiazole IRAK4 inhibitors
Gilead Sciences, Inc.
08/18/23
-
79
Agent enhancing antitumor effect using pyrazolo[3,4-d]pyrimidine compound
TAIHO PHARMACEUTICAL CO., LTD.
08/11/23
-
100
Carboxamide-pyrimidine derivatives as SHP2 antagonists
Merck Patent GmbH
08/11/23
-
42
Compounds having tetrahydroindolizine-1-carboxamide as BCL-2 inhibitors
Eil Therapeutics, Inc.
08/11/23
-
264
Fused pyrimidine pyridinone compounds as JAK inhibitors
THERAVANCE BIOPHARMA R&D IP, LLC
08/11/23
-
318
Substituted benzamides
Hoffmann-La Roche Inc.
08/11/23
-
15
2-[thiophen-2-yl)formamido]-N-(phenyl)-2-methylpropanamide derivatives and the use thereof as medicament
Boehringer Ingelheim International GmbH
08/06/23
-
234
6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors
Ajax Therapeutics, Inc.
08/06/23
-
44
Compound having KDM5 inhibitory activity and pharmaceutical use thereof
ONO PHARMACEUTICAL CO., LTD.
08/06/23
-
82
Cyclic ether derivatives of pyrazolo[1,5-A]pyrimidine-3-carboxyamide
Boehringer Ingelheim International GmbH
08/06/23
-
80
Heterocyclic compounds, preparation methods therefor, and methods of uses thereof
INVENTISBIO CO., LTD.
08/06/23
-
101
Inhibitors of receptor interacting protein kinase I for the treatment of disease
Board of Regents, The University of Texas System
08/06/23
-
93
Isoindoline compositions and methods for treating neurodegenerative disease
Cognition Therapeutics, Inc.
08/06/23
-
21
Isoquinoline-steroid conjugates and uses thereof
Aerie Pharmaceuticals, Inc.
08/06/23
-
25
MAGL inhibitors
H. LUNDBECKA/S
08/06/23
-
25
Macrocyclic immunomodulators
CHEMOCENTRYX, INC.
08/06/23
-
51
Macrocyclic indoles as Mcl-1 inhibitors
ASCENTAGE PHARMA (SUZHOU) CO., LTD.; THE REGENTS OF THE UNIVERSITY OF MICHIGAN; ASCENTAGE PHARMA GROUP CORP LIMITED
08/06/23
-
1
Method for preparing pyrrolidinyl urea derivative
ZHANGZHOU PIEN TZE HUANG PHARMACEUTICAL CO., LTD.
08/06/23
-
24
Naphthyridinone compounds as JAK2 V617F inhibitors
Incyte Corporation
08/06/23
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96
Pyridazinones as PARP7 inhibtors
Ribon Therapeutics, Inc.
08/06/23
-
217
Therapeutic compounds and compositions
EXITHERA PHARMACEUTICALS, INC.
08/06/23
-
121
ATM kinase inhibitors and compositions and methods of use thereof
CHDI Foundation, Inc.
07/31/23
-
106
Azalactam compounds as HPK1 inhibitors
PFIZER INC.
07/31/23
-
82
C5a receptor modulators
IDORSIA PHARMACEUTICALS LTD.
07/31/23
-
123
CDK inhibitors and their use as pharmaceuticals
Prelude Therapeutics Incorporated
07/31/23
-
14
Fluorinated tetrahydronaphthyridinyl nonanoic acid derivatives and uses thereof
OcuTerra Therapeutics, Inc.
07/31/23
-
245
Human plasma kallikrein inhibitors
BioCryst Pharmaceuticals, Inc.
07/31/23
-
491
MYST family histone acetyltransferase inhibitors
Epizyme, Inc.
07/31/23
-
24
Pyridinone MK2 inhibitors and uses thereof
XINTHERA, INC.
07/31/23
-
385
Substituted benzoxazole and benzofuran compounds as PDE7 inhibitors
Dart Neuroscience, LLC
07/31/23
-
138
Bicycloheptane pyrrolidine orexin receptor agonists
Merck Sharp & Dohme LLC
07/25/23
-
37
Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors
AstraZeneca AB
07/25/23
-
22
Compounds and compositions as protein kinase inhibitors
ARRAY BIOPHARMA INC.
07/25/23
-
55
Compounds useful as RET inhibitors
Cancer Research Technology Limited
07/25/23
-
82
MK2 inhibitors and uses thereof
XINTHERA, INC.
07/25/23
-
2
Methods of treating disorders using CSF1R inhibitors
Deciphera Pharmaceuticals, LLC
07/25/23
-
16
Substituted aminobenzyl heteroaryl compounds as EGFR and/or PI3K inhibitors
Mekanistic Therapeutics LLC
07/19/23
-
155
5-membered and bicyclic heterocyclic amides as inhibitors of ROCK
Bristol-Myers Squibb Company
07/16/23
-
40
Amino pyrimidine derivatives
Novartis AG
07/16/23
-
17
Bicyclic compounds as ATX inhibitors
Hoffmann-La Roche Inc.
07/16/23
-
88
CDK inhibitors and their use as pharmaceuticals
Prelude Therapeutics Incorporated
07/16/23
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35
Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors
AstraZeneca AB
07/16/23
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11
Compounds for the treatment of kinase-dependent disorders
Exelixis, Inc.
07/16/23
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51
Heterocyclic compounds as immunomodulators
Incyte Corporation
07/16/23
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13
Histone deacetylase inhibitors for immunomodulation in tumor microenvironment
Great Novel Therapeutics Biotech & Medicals Corporation
07/16/23
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96
Imidazopyrimidines and triazolopyrimidines as A2A / A2B inhibitors
Incyte Corporation
07/16/23
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303
Isoquinolin-3-yl carboxamides and preparation and use thereof
BioSplice Therapeutics, Inc.
07/16/23
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12
Matrix metalloproteinase (MMP) inhibitors and methods of use thereof
Foresee Pharmaceuticals Co., Inc.
07/16/23
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21
Pharmaceutical compounds
SAREUM LIMITED
07/16/23
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82
Polycyclic compounds as allosteric SHP2 inhibitors
REVOLUTION MEDICINES, INC.
07/16/23
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159
Pyridone amides as modulators of sodium channels
VERTEX PHARMACEUTICALS INCORPORATED
07/16/23
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7
Tetrahydro-1H-pyrido [3,4-b]indole anti-estrogenic drugs
Olema Pharmaceuticals, Inc.
07/16/23
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50
4-substitued cytisine analogues
TBA
07/09/23
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7
Antibody-drug conjugates comprising a cyclic dinucleotide
Takeda Pharmaceutical Company Limited
07/09/23
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37
Bicyclic heterocycles as FGFR4 inhibitors
Incyte Corporation; Incyte Holdings Corporation
07/09/23
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36
Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors
AstraZeneca AB
07/09/23
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378
Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators
Janssen Pharmaceutica NV
07/09/23
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56
FGFR4 inhibitor, preparation method therefor, and applications thereof
Jiangsu Hansoh Pharmaceutical Group Co., Ltd.; Shanghai Hansoh Biomedical Co., Ltd.
07/09/23
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11
Fused imidazo-piperidine JAK inhibitors
Theravance Biopharma R&D IP, LLC
07/09/23
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148
Granzyme B directed imaging and therapy
CytoSite Biopharma Inc.
07/09/23
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65
Inhibitors of RAF kinases
KINNATE BIOPHARMA INC.
07/09/23
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204
MCL1 inhibitors
Gilead Sciences, Inc.
07/09/23
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97
Methods of treating intraocular pressure with activators of Tie-2
EyePoint Pharmaceuticals, Inc.
07/09/23
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80
RIP1K inhibitors
Rigel Pharmaceuticals, Inc.
07/09/23
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206
Therapeutically active compounds and their methods of use
Servier Pharmaceuticals LLC
07/09/23
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86
Heterocyclic compounds as RET kinase inhibitors
Cancer Research Technology Limited
07/03/23
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496
Imidazole-containing inhibitors of ALK2 kinase
BioCryst Pharmaceuticals, Inc.
07/03/23
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18
Tetrazole derivatives as TRPA1 inhibitors
Boehringer Ingelheim International GmbH
07/03/23
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8
Thienopyrrole compounds
Gilead Sciences, Inc.
07/03/23
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26
Tricyclic urea compounds as JAK2 V617F inhibitors
Incyte Corporation
07/03/23
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54
Benzimidazole derivative compounds and uses thereof
Pfizer Inc.
07/02/23
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13
MASP-2 inhibitors and methods of use
OMEROS CORPORATION
07/02/23
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129
Substituted 2-azabicyclo[3.1.1]heptane and 2-azabicyclo[3.2.1]octane derivatives as orexin receptor antagonists
CHRONOS THERAPEUTICS LIMITED
07/02/23
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28
Treatment of Rett syndrome
Cold Spring Harbor Laboratory
07/02/23
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87
Tricyclic compounds as histone methyltransferase inhibitors
Global Blood Therapeutics, Inc.
07/02/23
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170
ALK2 inhibitors and methods for inhibiting BMP signaling
The Brigham and Women''s Hospital, Inc.; The United States of America, as Represented by the Secretary, Dept. of Health and Human Services
06/26/23
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4
Aminopyrimidinyl derivatives
Pfizer Inc.
06/26/23
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37
Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors
AstraZeneca AB
06/26/23
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32
Fused ring pyrimidine amino compound and preparation method, pharmaceutical composition, and use thereof
Shanghai Institute Of Material Medica, Chinese Academy of Sciences
06/26/23
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4
Glucagon-like peptide1 receptor agonists
Eli Lilly and Company
06/26/23
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23
Indolizine derivatives and their application in medicine
KIND PHARMACEUTICAL
06/26/23
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252
Pyrazole MAGL inhibitors
H. LUNDBECK A/S
06/26/23
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32
Pyridine and pyrazine derivatives as preferential cannabinoid 2 agonists
HOFFMANN-LA ROCHE INC.; EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
06/26/23
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6
Substituted piperazines as BTK inhibitors
HUTCHISON MEDIPHARMA LIMITED
06/26/23
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8
7-phenylethylamino-4H-pyrimido[4,5-d][1,3]oxazin-2-one compounds as mutant IDH1 and IDH2 inhibitors
Eli Lilly and Company
06/19/23
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98
Allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) for the treatment of disease
Petra Pharma Corporation
06/19/23
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8
Amide compounds for treatment of immune and inflammatory disorders
Achillion Pharmaceuticals, Inc.
06/19/23
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81
C-Abl tyrosine kinase inhibitory compound embodiments and methods of making and using the same
The United States of America, as represented by the Secretary, Department of Health and Human Services; Pontificia Universidad Catolica de Chile
06/19/23
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18
Compound as mTOR inhibitor and use thereof
MEDICINAL BIOCONVERGENCE RESEARCH CENTER; INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY
06/19/23
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18
Halo-allylamine SSAO/VAP-1 inhibitor and use thereof
NANJING TRANSTHERA BIOSCIENCES CO., LTD.
06/19/23
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663
Indazoles as hematopoietic progenitor kinase 1 (HPK1) inhibitors and methods using same
1ST Biotherapeutics, Inc.
06/19/23
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113
Oxadiazaspiro compounds for the treatment of drug abuse and addiction
ESTEVE PHARMACEUTICALS, S.A.
06/19/23
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2
Pan-tropic entry inhibitors
Emory University
06/19/23
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14
Pyrazolochlorophenyl compounds, compositions and methods of use thereof
Genentech, Inc.
06/19/23
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50
Selective androgen receptor degrader (SARD) ligands and methods of use
University of Tennessee Research Foundation
06/19/23
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111
Substituted 4-phenylpiperidines, their preparation and use
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
06/19/23
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228
Substituted imidazo[1,5-a]pyrazines for IRE1 inhibition
Optikira LLC; The Regents of the University of California
06/19/23
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814
Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors
Array Biopharma Inc.
06/19/23
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320
Substituted pyrido[2,3-d]pyrimidines as inhibitors of Ras pathway signaling
Kumquat Biosciences Inc.
06/19/23
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2
5-HT2A agonists for use in treatment of depression
LOPHORA APS
06/11/23
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156
BRD4-kinase inhibitors as cancer therapeutics
H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
06/11/23
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8
Compounds for degrading Tau protein aggregates and uses thereof
APRINOIA THERAPEUTICS LIMITED
06/11/23
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9
Derivatives of 4-aminoantipyrine as anti-Alzheimers butyrylcholinesterase inhibitors
TBA
06/11/23
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11
GLP-1 receptor agonist and use thereof
ILDONG PHARMACEUTICAL CO., LTD.
06/11/23
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443
MCL-1 inhibitors
Gilead Sciences, Inc.
06/11/23
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10
Polypeptide compound, pharmaceutical composition, preparation method and application thereof
CHENGDU SINTANOVO BIOTECHNOLOGY CO., LTD.
06/11/23
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31
Substituted 1′,2′-dihydro-3′H-spiro[cyclohexane-1,4′-pyrimido[5′,4′:4,5]pyrrolo[2,1-c][1,2,4]triazin]-3′-ones as cyclin-dependent kinase inhibitors
G1 Therapeutics, Inc.
06/11/23
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46
Substituted benzene compounds
Epizyme, Inc.
06/11/23
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144
Tetrahydrobenzofurodiazepinone compound and pharmaceutical use thereof
Japan Tobacco Inc.
06/11/23
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155
Amino acid compounds and methods of use
Pliant Therapeutics, Inc.
06/02/23
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192
Combination treatments comprising administration of 1H-pyrazolo[4,3-b]pyridines
H. Lundbeck A/S
06/02/23
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78
Compounds for the treatment of BRAF-associated diseases and disorders
Array BioPharma Inc.
06/02/23
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18
Diazaindole derivative and use thereof as CHK1 inhibitor
MEDSHINE DISCOVERY INC.
06/02/23
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12
Dimethyl amino azetidine amides as JAK inhibitors
THERAVANCE BIOPHARMA R&D IP, LLC
06/02/23
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48
Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents
TBA
06/02/23
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124
Pharmaceutical compounds
PFIZER INC.
06/02/23
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93
Pyrazoles
JANSSEN PHARMACEUTICALS, INC.
06/02/23
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22
Selective estrogen receptor degraders
Eli Lilly and Company
06/02/23
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53
Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors
Pfizer Inc.
06/02/23
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99
Substituted amino triazoles useful as chitinase inhibitors
Molecure S.A.
06/02/23
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14
Substituted pyrrolo[3,4-d]imidazoles as MDM2-p53 inhibitors
LUOXIN PHARMACEUTICAL (SHANGHAI) CO., LTD.; SHANDONG LUOXIN PHARMACEUTICAL GROUP STOCK CO., LTD.; MEDSHINE DISCOVERY INC.
06/02/23
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17
6-aryl-4-morpholin-1-ylpyridone compounds useful for the treatment of cancer and diabetes
Sprint Bioscience AB
06/01/23
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21
Compounds and methods useful for treating or preventing cancers
THE BROAD INSTITUTE, INC.; DANA-FARBER CANCER INSTITUTE, INC.
06/01/23
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253
Compounds which are inhibitors of Notum
UCL Business LTD
06/01/23
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9
Method for controlling hematophagous or sap-feeding arthropods
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
06/01/23
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313
Opioid receptor modulators
EPIODYNE, INC.
06/01/23
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90
Selective D3 dopamine receptor agonists and methods of their use
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; THE UNIVERSITY OF KANSAS; THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
06/01/23
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19
Substituted pyrazolo[1,5-a]pyrazines as negative allosteric modulators of group II metabotropic glutamate receptor
SUMITOMO PHARMA CO., LTD.
06/01/23
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260
Sulfonamide compound or salt thereof
Taiho Pharmaceutial Co., Ltd.
06/01/23
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14
7-phenylethylamino-4H-pyrimido[4,5-d][1,3]oxazin-2-one compounds as mutant IDH1 and IDH2 inhibitors
Eli Lilly and Company
05/27/23
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39
Lymphoid-specific tyrosine phosphatase (LYP) inhibitors
Purdue Research Foundation
05/27/23
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111
SHP2 phosphatase inhibitors and methods of use thereof
D. E. Shaw Research, LLC; Relay Therapeutics, Inc.
05/27/23
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46
Substituted [1,2,4]triazolo[4,3-a]pyrazines as modulators of sodium channel activity
PRAXIS PRECISION MEDICINES, INC.
05/27/23
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57
Substituted pyridine derivatives as SARM1 inhibitors
NURA BIO, INC.
05/27/23
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32
Tetrahydropyranooxazine derivatives having selective BACE1 inhibitory activity
SHIONOGI & CO., LTD.
05/27/23
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21
Triazolo-pyrimidine compounds and uses thereof
Dizal (Jiangsu) Pharmaceutical Co., Ltd.
05/27/23
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223
Indole carboxamide compounds
Bristol-Myers Squibb Company
05/22/23
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2
Method of treatment with histamine-3 receptor inverse agonist
SUVEN LIFE SCIENCES LIMITED
05/22/23
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4
Protein degraders and uses thereof
KYMERA THERAPEUTICS, INC.
05/22/23
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15
Spirocyclic compounds
C4 Therapeutics, Inc.
05/22/23
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19
Uracil compound as c-MET/AXL inhibitor
MEDSHINE DISCOVERY, INC.
05/22/23
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20
6-amino-2,4-dihydropyrano [2,3-c] pyrazoles and methods of use
Purdue Research Foundation
05/11/23
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1532
Aminopyrrolotriazines as kinase inhibitors
Bristol-Myers Squibb Company
05/11/23
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186
Benzoimidazoles as prolyl hydroxylase inhibitors
Janssen Pharmaceutica NV
05/11/23
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18
Compounds active towards nuclear receptors
NUEVOLUTION A/S
05/10/23
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19
Heterocyclic compounds as immunomodulators
Incyte Corporation
05/10/23
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36
Oxysterols and methods of use thereof
SAGE THERAPEUTICS, INC.
05/10/23
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83
Substituted pyridotriazine compounds and uses thereof
Gilead Sciences, Inc.
05/10/23
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24
3-triazolyl methyl-1,3,5-triazine-2,4-dione compounds and preparation method and application thereof
SHAANXI PANLONG PHARMACEUTICAL CO., LTD.
05/09/23
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302
8-aminoisoquinoline compounds and uses thereof
Genentech, Inc.
05/09/23
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116
Enzyme inhibitors
KalVista Pharmaceuticals Limited
05/09/23
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123
Glycosidase inhibitors
Asceneuron SA
05/09/23
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167
Inhibitors of RHO associated coiled-coil containing protein kinase
Kadmon Corporation, LLC
05/09/23
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10
Pharmaceutical formulations comprising CCR3 antagonists
Alkahest, Inc.
05/09/23
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62
Substituted condensed thiophenes as modulators of sting
CTXT PTY LIMITED
05/09/23
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22
Beta-amino acid derivative, kinase inhibitor and pharmaceutical composition containing the same, and method for performing an in vivo related application that benefits from the inhibition of a kinase
INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
05/05/23
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106
Bicyclic amide compounds and methods of use thereof
Genentech, Inc.
05/05/23
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9
Curcumin analogues as zinc chelators and their uses
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK; CHEM-MASTER INTERNATIONAL INC.
05/05/23
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42
FGFR4 inhibitor and preparation method and use thereof
Jiangsu Hansoh Pharmaceutical Group Co., Ltd.; Shanghai Hansoh Biomedical Co., Ltd.
05/05/23
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40
Heterocyclic compounds as immunomodulators
Incyte Corporation
05/05/23
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138
Imidazolonylquinolines and the use thereof as ATM kinase inhibitors
Merck Patent GmbH
05/05/23
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161
Methylamine derivatives as lysysl oxidase inhibitors for the treatment of cancer
THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL
05/05/23
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93
Octahydropyrido[1,2-alpha]pyrazines as MAGL inhibitors
Hoffmann-La Roche Inc.
05/05/23
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5
PDE9 inhibitors with imidazo triazinone backbone and imidazo pyrazinone backbone for treatment of peripheral diseases
H. Lundbeck A/S
05/05/23
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19
Compounds and therapeutic uses thereof
VioGen Biosciences, LLC
04/30/23
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64
MTORC1 modulators and uses thereof
Aeovian Pharmaceuticals, Inc.
04/30/23
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285
PCSK9 inhibitors and methods of use thereof
AstraZeneca AB
04/30/23
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34
Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors
Array BioPharma Inc.
04/30/23
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19
Compounds and compositions for the treatment of parasitic diseases
Novartis AG
04/23/23
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53
Cyclic dinucleotides as sting agonists
Janssen Biotech, Inc.
04/23/23
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10
Enhancing CD8+ T cells for adoptive T cell therapy by inhibiting PTPN1 (PTP1B) and PTPN2 (TC-PTP)
THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
04/23/23
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26
JAK1 pathway inhibitors for the treatment of gastrointestinal disease
Incyte Corporation
04/23/23
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427
Monoacylglycerol lipase modulators
Janssen Pharmaceutica NV
04/23/23
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20
PD-L1/STING conjugates and methods of use
Incyte Corporation
04/23/23
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4
Psilocin derivatives as serotonergic psychedelic agents for the treatment of CNS disorders
MINDSET PHARMA INC.
04/23/23
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3
SHP2 inhibitor compositions and methods for treating cancer
Revolution Medicines, Inc.
04/23/23
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719
Substituted indole Mcl-1 inhibitors
Vanderbilt University
04/23/23
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28
Benzamide compounds
Recurium IP Holdings, LLC
04/14/23
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26
Bicyclic heterocycles as FGFR inhibitors
Incyte Corporation
04/14/23
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13
Bipyrazole derivatives as JAK inhibitors
Incyte Corporation
04/14/23
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27
Certain chemical compositions and methods of use thereof
Algen Biotechnologies, Inc.
04/14/23
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164
Compounds, compositions, and methods
Denali Therapeutics Inc.
04/14/23
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46
Heterocyclic compound, application thereof and pharmaceutical composition comprising same
SUZHOU SINOVENT PHARMACEUTICALS CO., LTD.
04/14/23
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26
Highly active CSF1R inhibitor compound
XIAMEN BIOTIME BIOTECHNOLOGY CO., LTD.
04/14/23
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25
Indoleamine-2,3-dioxygenase inhibitor, preparation method therefor and use thereof
HINOVA PHARMACEUTICALS INC.
04/14/23
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40
Inhibitors of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) and methods of use thereof
STINGRAY THERAPEUTICS, INC.
04/14/23
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73
Inhibitors of protein arginine methyltransferase 5 (PRMT5), pharmaceutical products thereof, and methods thereof
Pharmablock Sciences (Nanjing), Inc.
04/14/23
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14
Oxazolidinone antibiotic compounds and process of preparation
BUGWORKS RESEARCH, INC.
04/14/23
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99
PARP1 inhibitors and uses thereof
XINTHERA, INC.
04/14/23
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3
Psilocin derivatives as serotonergic psychedelic agents for the treatment of CNS disorders
Mindset Pharma Inc.
04/14/23
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144
Pyrrolotriazine compounds as TAM inhibitors
Incyte Corporation
04/14/23
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51
Small molecule inducers of autophagy
Board of Regents, The University of Texas System
04/14/23
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514
Substituted pyrazolo[3,4-b]pyrazines as SHP2 phosphatase inhibitors
D. E. Shaw Research, LLC; Relay Therapeutics, Inc.
04/14/23
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4
Amino alcohol derivative, pharmaceutical composition and application thereof
BEIJING FORELAND PHARMA CO., LTD.
04/09/23
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15
Aromatic heterocyclic compound, intermediate thereof, preparation method therefor, and pharmaceutical composition and use thereof
SHANGHAI YINGLI PHARMACEUTICAL CO., LTD
04/09/23
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6
Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia
STEALTH BIOTHERAPEUTICS INC.
04/09/23
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13
Dash inhibitors, and uses related thereto
Trustees of Tufts College
04/09/23
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165
Dihydrothieno[3,2-b]pyridine compounds
IDEAYA BIOSCIENCES, INC.
04/09/23
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33
Heterocyclic compounds as BET inhibitors
NUVATION BIO INC.
04/09/23
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27
Inhibitors of EGFR and methods of use thereof
Dana-Farber Cancer Institute, Inc.
04/09/23
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479
MASP-2 inhibitors and methods of use
OMEROS CORPORATION
04/09/23
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22
Methods of treatment using 4-(3-cyanophenyl)-6-pyridinylpyrimidine mGlu5 modulators
Heptares Therapeutics Limited
04/09/23
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57
RIP1K inhibitors
Rigel Pharmaceuticals, Inc.
04/09/23
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2
Solid forms of a plasma kallikrein inhibitor and salts thereof
KalVista Pharmaceuticals Limited
04/09/23
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80
Spirocyclic compounds
C4 Therapeutics, Inc.
04/09/23
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225
Substituted pyridopyrimidinonyl compounds useful as T cell activators
TBA
04/09/23
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145
Substituted pyrrolo[1,2-a]pyrazines and pyrrolo[1,2-a][1,4]diazepines as TREX1 inhibitors
VENENUM BIODESIGN, LLC
04/09/23
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73
Triazolopyrimidine derivatives for use as ghrelin o-acyl transferase (GOAT) inhibitors
Boehringer Ingelheim International GmbH
04/09/23
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21
Compounds useful as immunomodulators
Bristol-Myers Squibb Company
03/31/23
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227
Condensed ring compounds having dopamine D3 receptor antagonistic effect
Shionogi & Co., Ltd.
03/31/23
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289
Fluoroalkyl-oxadiazoles and uses thereof
Tenaya Therapeutics, Inc.
03/31/23
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22
Heterocyclic RIP1 inhibitory compounds
Rigel Pharmaceuticals, Inc.
03/31/23
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3
Heterocyclic compounds for inhibiting TYK2 activities
Beijing Innocare Pharma Tech Co.
03/31/23
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20
Inhibiting mutant IDH-1
FORMA Therapeutics, Inc.
03/31/23
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282
Inhibitors of LRRK2 kinase
HALIA THERAPEUTICS, INC.
03/31/23
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72
Spiro-oxazolones
Hoffmann-La Roche Inc.
03/31/23
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64
Therapeutic agent for non-motor symptoms associated with Parkinson's disease
Sumitomo Pharma Co., Ltd.
03/31/23
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23
Thienopyrimidones
Boehringer Ingelheim International GmbH
03/31/23
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29
Alkynyl-substituted heterocyclic compound, preparation method therefor and medical use thereof
Beijing Innocare Pharma Tech Co., Ltd.
03/26/23
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44
Antibacterial agents: arylalkylcarboxamido phloroglucinols
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
03/26/23
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4
BRD4 inhibitor
HINOVA PHARMACEUTICALS INC.
03/26/23
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14
Cyanoaryl-aniline compounds for treatment of dermal disorders
NFLECTION THERAPEUTICS, INC.
03/26/23
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40
Heterocyclic compounds as immunomodulators
Incyte Corporation
03/26/23
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26
Inhibitor of indoleamine 2,3-dioxygenase-1 and methods of manufacture and use thereof
University Health Network
03/26/23
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171
Inhibitors of histone deacetylase
The General Hospital Corporation; The Broad Institute, Inc.; Massachusetts Institute of Technology
03/26/23
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452
N-cyano-7-azanorbornane derivatives and uses thereof
AMGEN INC.
03/26/23
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38
Pyrazine compounds and uses thereof
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.
03/26/23
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73
Pyrrolo[1,2-b]pyridazine derivatives
Gilead Sciences, Inc.
03/26/23
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69
Bicyclic heterocycles as FGFR inhibitors
Incyte Corporation
03/20/23
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4
Heterocyclic compounds as immunomodulators
Incyte Corporation
03/20/23
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2
Inhibiting mutant isocitrate dehydrogenase 1 (mIDH1)
FORMA Therapeutics, Inc.
03/20/23
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39
5-heteroaryl-1H-pyrazol-3-amine derivative
Sumitomo Pharma Co., Ltd.
03/19/23
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158
5-membered heteroaryl carboxamide compounds for treatment of HBV
Assembly Biosciences, Inc.
03/19/23
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145
Amino acid compounds and methods of use
Pliant Therapeutics, Inc.
03/19/23
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70
Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
Enanta Pharmaceuticals, Inc.
03/19/23
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17
Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (DLK) kinase for the treatment of disease
Board of Regents, The University of Texas System
03/19/23
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158
Cannabinoid receptor type 2 (CB2) modulators and uses thereof
Teon Therapeutics, Inc.
03/19/23
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50
Combination therapies using caspase-1 dependent anticancer agents and PGE2 antagonists
Trustees of Tufts College
03/19/23
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478
Compounds and uses thereof
Foghorn Therapeutics Inc.
03/19/23
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4
Compounds for use as inhibitors of alternative oxidase or cytochrome bc1 complex
AlternOx Scientific Limited
03/19/23
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62
Fused amino pyridine as HSP90 inhibitors
Guris, Inc.
03/19/23
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377
Indole compounds and analogues thereof
BioCryst Pharmaceuticals, Inc.
03/19/23
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373
Isoquinolines as inhibitors of HPK1
Genentech, Inc.
03/19/23
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17
Morpholinylpyridone compounds
Sprint Bioscience AB
03/19/23
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175
Proteasome activity enhancing compounds
Proteostasis Therapeutics, Inc.
03/19/23
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22
RIP1 inhibitory compounds and methods for making and using the same
Rigel Pharmaceuticals, Inc.
03/19/23
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718
Ras inhibitors
Revolution Medicines, Inc.
03/19/23
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149
Substituted 1,2-oxaborolan-2-ols as PDE4 inhibitors
Pfizer Inc.
03/19/23
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17
2-(substituted benzene matrix) aromatic formate FTO inhibitor, preparation method therefor, and applications thereof
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
03/12/23
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474
ACLY inhibitors and uses thereof
Nimbus Artemis, Inc.
03/12/23
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98
Amide compounds as kinase inhibitors, compositions and methods of treatment
Translational Drug Development LLC
03/12/23
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215
Bruton's tyrosine kinase inhibitors
SUZHOU BAIJIBUGONG PHARMACEUTICAL TECHNOLOGY CO., LTD.
03/12/23
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656
PD-1/PD-L1 inhibitors
Gilead Sciences, Inc.
03/12/23
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22
Phosphonate linkers and their use to facilitate cellular retention of compounds
Merck Sharp & Dohme LLC
03/12/23
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59
Potent and selective inhibitors of monoamine transporters; method of making; and use thereof
THE USA, AS REPRESENTED BY THE SECRETARY, DHHS
03/12/23
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46
Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use
Amgen Inc.
03/06/23
-
21
Fused bicyclic (hetero)aromatic compounds useful for the treatment of cancers
Jazz Pharmaceuticals Ireland Limited
03/06/23
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109
Heterocyclic compounds as RET kinase inhibitors
Cancer Research Technology Limited
03/06/23
-
137
Oxazino-quinazoline and oxazino-quinoline type compound, preparation method and uses thereof
BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED
03/06/23
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23
Substituted 1,4-methanopyrido[1′,2′:4,5]pyrazino[1,2-a]pyrimidines for treating viral infections
Gilead Sciences, Inc.
03/06/23
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581
Transglutaminase 2 (TG2) inhibitors
Sitari Pharma, Inc.
03/06/23
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80
Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same
LegoChem Biosciences, Inc.
03/05/23
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822
HPK1 antagonists and uses thereof
Nimbus Saturn, Inc.
03/05/23
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523
Heterocyclic compounds and uses thereof
MILLENNIUM PHARMACEUTICALS, INC.
03/05/23
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238
Isoquinolin-3-yl carboxamides and preparation and use thereof
BioSplice Therapeutics, Inc.
03/05/23
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45
Kinase inhibitor compounds and compositions and methods of use
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
03/05/23
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9
LSD1 inhibitors and medical uses thereof
Constellation Pharmaceuticals, Inc.
03/05/23
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59
Neprilysin inhibitors
THERAVANCE BIOPHARMA R&D IP, LLC
03/05/23
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13
Pharmacophores, compounds and methods having application in the treatment of cancer through inhibition of CYP17A1 and CYP19A1
MANGOSUTHU UNIVERSITY OF TECHNOLOGY
03/05/23
-
31
Therapeutic compounds and methods of use thereof
LIGATURE THERAPEUTICS PTE. LTD.
03/05/23
-
5
Amide compound having bet proteolysis-inducing action and medicinal application thereof
MITSUBISHI TANABE PHARMA CORPORATION
02/26/23
-
47
BTK inhibitor compounds
Eli Lilly and Company
02/26/23
-
10
Bi-heteroaryl substitute 1,4-benzodiazepines and uses thereof for the treatment of cancer
Janssen Pharmaceutica NV
02/26/23
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230
Compositions and methods for treating CNS disorders
Sage Therapeutics, Inc.
02/26/23
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6
Compounds and compositions for the treatment of neurodegenerative and inflammatory diseases
SARBONNE UNIVERSITE; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE; ASSISTANCE PUBLIQUE—HÔPITAUX DE PARIS; INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE; UNIVERSITÉ DE MONTPELLIER; ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER
02/26/23
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65
Compounds for the treatment of kinase-dependent disorders
Exelixis, Inc.
02/26/23
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25
Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, Rasopathies, and fibrotic disease
SHY Therapeutics LLC
02/26/23
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108
Heterocyclic compounds and uses thereof
Infinity Pharmaceuticals, Inc.
02/26/23
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6
IRAK degraders and uses thereof
DANA-FARBER CANCER INSTITUTE, INC.
02/26/23
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27
Methods and composition of 4-substituted benzoylpiperazine-1-substituted carbonyls as beta-catenin/B-cell lymphoma 9 inhibitors
UNIVERSISITY OF UTAH RESEARCH FOUNDATION
02/26/23
-
42
Phenothiazine derivatives and uses thereof
CAMP4 THERAPEUTICS CORPORATION
02/26/23
-
126
Pyrazolopyrimidine compounds and uses thereof
Incyte Corporation
02/26/23
-
5
Quinoline compounds as IRAK inhibitors and uses thereof
Merck Patent GmbH
02/26/23
-
17
STK19 inhibitors for treatment of cancer
TRUSTEES OF BOSTON UNIVERSITY; XIAMEN UNIVERSITY
02/26/23
-
46
Sting modulator compounds, and methods of making and using
Takeda Pharmaceutical Company Limited
02/26/23
-
51
Substituted Imidazo[1,2-a]-pyridines as IRAK 1/4 and FLT3 inhibitors
CHILDREN''S HOSPITAL MEDICAL CENTER; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES
02/26/23
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96
Substituted imidazolidin-2-one derivatives as PRMT5 inhibitors
AURIGENE DISCOVERY TECHNOLOGIES LIMITED
02/26/23
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71
Substituted piperazines as selective HDAC1,2 inhibitors
REGENACY PHARMACEUTICALS, LLC
02/26/23
-
1
Substituted piperidines as BTK inhibitors
HAISCO PHARMACEUTICALS PTE. LTD.
02/26/23
-
8
Synthesis of peptide borate ester compound and use thereof
JIANGSU CHIA TAI FENGHAI PHARMACEUTICAL CO., LTD.
02/26/23
-
5
Tetrahydroisoquinoline derivatives, preparation process and use thereof
Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.
02/26/23
-
94
Therapeutic compounds and methods of use thereof
Agency for Science, Technology and Research (A*STAR)
02/26/23
-
16
Analogs of dextromethorphan with balanced receptor activities
Center for Neurologic Study
02/20/23
-
11
Benzisoxazole derivative
Sumitomo Pharma Co., Ltd.
02/20/23
-
155
Dihydropyrrolopyridine inhibitors of ROR-gamma
Vitae Pharmaceuticals, LLC
02/20/23
-
15
Dioxoloisoquinolinone derivatives and use thereof
HANMI PHARMACEUTICAL CO., LTD.
02/20/23
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287
Heterobicyclic amides as inhibitors of CD38
Ribon Therapeutics, Inc.
02/20/23
-
21
Heterocyclic compounds as immunomodulators
Incyte Corporation
02/20/23
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26
Histone deacetylases (HDACs) inhibitors
AnnJi Pharmaceutical Co., Ltd.
02/20/23
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100
Isoindolines as HDAC inhibitors
Valo Health, Inc.
02/20/23
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198
MAP4K1 inhibitors
Blueprint Medicines Corporation
02/20/23
-
39
Methods for treating depressive symptoms
ALKERMES PHARMA IRELAND LIMITED
02/20/23
-
85
Pyrazolo[3,4-B]pyridines and imidazo[1,5-B]pyridazines as PDE1 inhibitors
H. Lundbeck A/S
02/20/23
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10
Pyrrolo[1,2-b] pyridazine derivatives
Gilead Sciences, Inc.
02/20/23
-
75
Quinazoline compounds, preparation method, use, and pharmaceutical composition thereof
INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES
02/20/23
-
54
Bicyclic heterocycles as FGFR inhibitors
Incyte Holdings Corporation; Incyte Corporation
02/17/23
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228
Compositions and methods for treating CNS disorders
Sage Therapeutics, Inc.
02/17/23
-
59
Cyano cyclobutyl compounds for CBL-B inhibition and uses thereof
NURIX THERAPEUTICS, INC.
02/17/23
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382
Cyclic polypeptides for PCSK9 inhibition
Merck Sharp & Dohme LLC; Ra Pharmaceuticals, Inc.
02/17/23
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3
Deuterated colony stimulating factor-1 receptor (CSF-1R) inhibitors
GENZYME CORPORATION
02/17/23
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17
Ligands to cereblon (CRBN)
DANA-FARBER CANCER INSTITUTE, INC.
02/17/23
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93
Naphthyridinone derivatives and their use in the treatment of arrhythmia
Novartis AG
02/17/23
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16
Small molecule inhibition of transcription factor SALL4 and uses thereof
DANA-FARBER CANCER INSTITUTE, INC.; THE BRIGHAM AND WOMEN''S HOSPITAL, INC.
02/17/23
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291
Substituted heteroaromatic pyrazolo-pyridines and their use as GLUN2B receptor modulators
JANSSEN PHARMACEUTICA NV
02/17/23
-
9
Use of known compounds as D-amino acid oxidase inhibitors
National Taiwan University; National Yang Ming Chiao Tung University; National Health Research Institutes
02/17/23
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431
2-(morpholin-4-yl)-1,7-naphthyridines
Bayer Pharma Aktiengesellschaft
02/16/23
-
30
Alpha-5 beta-1 inhibitors
The Regents of the University of California; Shanghai ChemPartner Co., Ltd.
02/16/23
-
45
Analogs for the treatment of disease
Insilico Medicine IP Limited
02/16/23
-
45
Analogs for the treatment of disease
Insilico Medicine IP Limited
02/16/23
-
63
Compositions and methods for treating infections
Vyera Pharmaceuticals, LLC
02/16/23
-
31
Compounds
INFLAZOME LIMITED
02/16/23
-
9
Imidazo[4,5-C]pyridine derived SSAO inhibitors
PROXIMAGEN, LLC
02/16/23
-
123
Kinase inhibitors
The University of Manchester
02/16/23
-
31
Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists
Bristol-Myers Squibb Company
02/16/23
-
17
Protacs targeting coronavirus 3CL protease and preparation method and application thereof
SHAANXI PANLONG PHARMACEUTICAL CO., LTD.
02/16/23
-
51
SHP2 phosphatase inhibitors and methods of use thereof
Relay Therapeutics, Inc.; D. E. Shaw Research, LLC
02/16/23
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61
Use of aminomethylenecyclohexane-1,3-dione compound
WIGEN BIOMEDICINE TECHNOLOGY (SHANGHAI) CO., LTD.
02/16/23
-
717
Heterocyclic compound as a protein kinase inhibitor
HK inno.N Corporation
02/13/23
-
14
JAK kinase inhibitor and preparation method and use thereof
SHANGHAI LONGWOOD BIOPHARMACEUTICALS CO., LTD.
02/13/23
-
31
Substituted pyrrolo[2,3-d]pyrimidines as inhibitors of protein arginine methyl transferase 5 (PRMT5)
Prelude Therapeutics, Incorporated
02/13/23
-
7
Alkyne substituted quinazoline compound and methods of use
Newgen Therapeutics, Inc.
02/12/23
-
10
Compounds for treating ILK-mediated diseases
The Cleveland Clinic Foundation
02/12/23
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1076
Indole and azaindole inhibitors of pad enzymes
Bristol-Myers Squibb Company
02/12/23
-
310
Inhibitors of cysteine proteases and methods of use thereof
Pardes Biosciences, Inc.
02/12/23
-
7
Metabolites of [3-(4-{2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1H-imidazol-4 yl}-phenoxy)-propyl]-diethyl-amine
VTV THERAPEUTICS LLC
02/12/23
-
15
Pyrazole compounds as LSD1 inhibitors and applications thereof
MEDSHINE DISCOVERY INC.
02/12/23
-
58
CDPK1 inhibitors, compositions, and methods related thereto
Vyera Pharmaceuticals, LLC; Washington University
02/05/23
-
11
Crystalline succinate salt of 6-(6-aminopyrazin-2-yl)-n-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine
Kronos Bio, Inc.
02/05/23
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50
Fused tricyclic ring derivatives as Src homology-2 phosphate inhibitors
NIKANG THERAPEUTICS, INC.
02/05/23
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8
Inhibitors of DNMT1 as anticancer therapeutic agents
Victoria Link Limited; Albert Einstein College of Medicine
02/05/23
-
15
MTOR inhibitor compounds
GALDERMA RESEARCH & DEVELOPMENT
02/05/23
-
2
Macrocycle and composition comprising thereof
Shenzhen TargetRx, Inc.
02/05/23
-
9
Protacs based on VHL ligand targeting coronavirus 3CL protease and preparation method and application thereof
SHAANXI PANLONG PHARMACEUTICAL CO., LTD.
02/05/23
-
10
Radiolabeled pharmaceuticals and methods of making and using same
YALE UNIVERSITY
02/05/23
-
370
Substituted heteroaryls as inhibitors of the BCL6 BTB domain protein-protein interaction
ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR)
02/05/23
-
59
Compounds useful in HIV therapy
GlaxoSmithKline Intellectual Property Development Limited; The University of North Carolina at Chapel Hill; ViiV Healthcare Company
01/31/23
-
50
Aminocyclobutanes as monoacylglycerol lipase modulators
Janssen Pharmaceutica NV
01/28/23
-
250
Anti-tumor effect potentiator using novel biphenyl compound
Taiho Pharmaceutical Co., Ltd.
01/28/23
-
16
BRK inhibitory compound
ONO PHARMACEUTICAL CO., LTD.
01/28/23
-
102
CRBN ligands and uses thereof
KYMERA THERAPEUTICS, INC.
01/28/23
-
139
Compounds and methods for the enhanced degradation of targeted proteins
Arvinas Operations, Inc.; Yale University
01/28/23
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1
Substituted diamino heterocyclic carboxamide compound and a composition containing the compound and use thereof
Shenzhen TargetRx, Inc.
01/28/23
-
107
Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases
Takeda Pharmaceutical Company Limited
01/28/23
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35
2,6-diamino-3,4-dihydropyrimidin-4-one derivatives and use thereof in therapy
THOMAS HELLEDAYS STIFTELSE FÖR MEDICINSK FORSKNING
01/21/23
-
3
Aryl-piperidine derivatives
Artax Biopharma Inc.
01/21/23
-
76
Azaspirocycles as monoacylglycerol lipase modulators
Janssen Pharmaceutica NV
01/21/23
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159
Compounds and methods for treating oxalate-related diseases
OxaluRx, Inc.
01/21/23
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138
Dihydroorotate dehydrogenase inhibitors
TBA
01/21/23
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19
HDAC8 inhibitors for treating cancer
CITY OF HOPE; TAIPEI MEDICAL UNIVERSITY; ACADEMIA SINICA
01/21/23
-
62
Inhibitors of fibroblast activation protein
PRAXIS BIOTECH LLC
01/21/23
-
81
SSAO inhibitor
TBA
01/21/23
-
3
Tetrahydroquinoline derivatives and a process of preparation thereof
KING ABDULAZIZ UNIVERSITY
01/21/23
-
30
Therapeutic compounds and methods of use thereof
LIGATURE THERAPEUTICS PTE. LTD.
01/21/23
-
196
1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
H. Lundbeck A/S
01/20/23
-
150
ACLY inhibitors and uses thereof
Nimbus Artemis, Inc.
01/20/23
-
45
Amide derivatives useful in the treatment of HBV infection or HBV-induced diseases
Janssen Sciences Ireland Unlimited Company
01/20/23
-
120
Benzisoxazole sulfonamide derivatives
Pfizer Inc.; CTXT PTY LTD
01/20/23
-
23
Cyclic dinucleotides as sting agonists
Janssen Biotech, Inc.
01/20/23
-
24
Cyclic peptide immunomodulators
Bristol-Myers Squibb Company
01/20/23
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54
Indazole compounds and uses thereof
Incyte Corporation
01/20/23
-
320
MTA-cooperative PRMT5 inhibitors
Mirati Therapeutics, Inc.
01/20/23
-
66
N-(substituted-phenyl)-sulfonamide derivatives as kinase inhibitors
Nerviano Medical Sciences S.R.L.
01/20/23
-
7
Peptides for treatment of medical disorders
Humanwell Pharmaceutical US
01/20/23
-
4
Therapeutic methods and combinations
TBA
01/20/23
-
2
Thieno[3,2-d]pyrimidine derivative compound having inhibitory activity for protein kinase
Hanmi Pharm. Co., Ltd.
01/20/23
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153
Tri-substituted aryl and heteroaryl derivatives as modulators of PI3-kinase and autophagy pathways
Neuropore Therapies, Inc.
01/20/23
-
26
Azaindolylpyridone and diazaindolylpyridone compounds
Sprint Bioscience AB
01/17/23
-
38
Dopamine D2 receptor ligands
The Broad Institute, Inc.; Massachusetts Institute of Technology
01/17/23
-
152
Pyrimidine-fused cyclic compound, preparation method therefor and application thereof
BLUERAY THERAPEUTICS (SHANGHAI) CO., LTD
01/17/23
-
275
Tricyclic heterocycles as BET protein inhibitors
Incyte Corporation; Incyte Holdings Corporation
01/17/23
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368
Amido spirocyclic amide and sulfonamide derivatives
Valo Health, Inc.; Genentech, Inc.
01/06/23
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137
Compounds and methods useful in the treatment of a PRMT5-mediated disorder
ARGONAUT THERAPEUTICS LIMITED
01/06/23
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140
Compounds for inhibiting TNIK and medical uses thereof
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY
01/06/23
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127
Compounds for treatment of PD-L1 diseases
ChemoCentryx, Inc.
01/06/23
-
2
Deuterated compounds as rock inhibitors
Fochon Pharmaceuticals, Ltd.
01/06/23
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82
Mu opioid receptor modulators
The Regents of the University of California; Friedrich-Alexander-Universität Erlangen-Nürnberg; The Board of Trustees of the Leland Stanford Junior University; The University of North Carolina at Chapel Hill
01/06/23
-
35
N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (ATX) modulators
Boehringer Ingelheim International GmbH
01/06/23
-
222
Substituted imidazo[1,2-c]pyrimidines as PRC2 inhibitors
MIRATI THERAPEUTICS, INC.
01/06/23
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121
Substituted pyrazolopyrimidines and substituted purines and their use as ubiquitin-specific-processing protease 1 (USP1) inhibitors
KSQ Therapeutics, Inc.
01/06/23
-
5
Synthesis of (+)-cannabinoids and their therapeutic effects
SYMRISE AG
01/06/23
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222
2-(3′-(hydroxymethyl)-1-methyl-5-((5-(2-methyl-4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-yl)amino)-6-oxo-1,6-dihydro-[3,4′-bipyridin]-2′-yl)-7,7-dimethyl-7,8-dihydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one as a BTK inhibitor
HUTCHISON MEDIPHARMA LIMITED
12/30/22
-
66
5-5 fused rings as C5a inhibitors
CHEMOCENTRYX, INC.
12/30/22
-
6
5-aminolevulinate synthase inhibitors and methods of use thereof
University of South Florida
12/30/22
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486
Diaryl substituted 6,5-fused ring compounds as C5aR inhibitors
CHEMOCENTRYX, INC.
12/30/22
-
38
EP4 antagonist
ONO PHARMACEUTICAL CO., LTD.
12/30/22
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49
Heterocyclic RIP1 kinase inhibitors
Rigel Pharmaceuticals, Inc.
12/30/22
-
71
Inhibitors of Rho associated coiled-coil containing protein kinase
Kadmon Corporation, LLC
12/30/22
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321
MTA-cooperative PRMT5 inhibitors
Mirati Therapeutics, Inc.
12/30/22
-
70
Macrocyclic chlorine substituted indole derivatives
Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc.
12/30/22
-
6
Method for treating inflammation
KING FAISAL UNIVERSITY
12/30/22
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225
OX2R compounds
TBA
12/30/22
-
14
Prostate-specific membrane antigen targeted high-affinity agents for endoradiotherapy of prostate cancer
The Johns Hopkins University
12/30/22
-
154
Small molecule modulators of the BTB domain of Keap1
MedImmune Limited
12/30/22
-
4
Substituted 1,2-dihydro-3H-pyrazolo[3,4-D]pyrimidin-3-ones as inhibitors of WEE-1 kinase
Newave Pharmaceutical Inc.
12/30/22
-
4
Substituted piperidine compounds and their use
Eisai R&D Management Co., Ltd.
12/30/22
-
5
Targeted drug rescue with novel compositions, combinations, and methods thereof
TBA
12/30/22
-
24
Tetrazolone-substituted dihydropyridinone MGAT2 inhibitors
Bristol-Myers Squibb Company
12/30/22
-
94
Urea-substituted aromatic ring-linked dioxinoquinoline compounds, preparation method and uses thereof
BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED
12/30/22
-
35
1,4-diphenyl-1H-imidazole and 2,4-diphenylthiazole derivatives and preparation method therefor and use thereof
SOUTHERN MEDICAL UNIVERSITY
12/24/22
-
27
1H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors
AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO—A.C.R.A.F. S.p.A.
12/24/22
-
52
Acyclic antivirals
JANSSEN PHARMACEUTICA NV
12/24/22
-
14
Cyclic dinucleotides as sting agonists
Janssen Biotech, Inc.
12/24/22
-
111
Imidazopyrazinones as PDE1 inhibitors
H. Lundbeck A/S
12/24/22
-
67
Inhibitors of blood coagulation factor XIII
Zedira GmbH
12/24/22
-
172
Inhibitors of cysteine proteases and methods of use thereof
Pardes Biosciences, Inc.
12/24/22
-
1
Mcl-1 inhibitors and methods of use thereof
AstraZeneca AB
12/24/22
-
37
Pyrazolo[1,5-a]pyrazin-4-yl derivatives
Pfizer Inc.
12/24/22
-
186
Pyrazolotriazolopyrimidine derivatives as A2A receptor antagonist
BEIGENE, LTD.
12/24/22
-
79
Substituted pyrazolyl[4,3-c]pyridine compounds as RET kinase inhibitors
Array BioPharma Inc.
12/24/22
-
95
Tricyclic compounds and their use as phosphodiesterase inhibitors
PFIZER, INC.
12/24/22
-
35
Benzoimidazoles as selective inhibitors of indoleamine 2,3-dioxygenases
BEIGENE, LTD.
12/23/22
-
11
Compounds for treatment of hypoproliferative disorders
LU LICENSE AB
12/23/22
-
27
Diacylglycerol acyl transferase 2 inhibitor
Pfizer Inc.
12/23/22
-
5
Docosahexaenoic acid endocannabinoid epoxide derivative compositions
The Board of Trustees of the University of Illinois
12/23/22
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279
Pyrazolyl pyrimidinylamine compounds as CDK2 inhibitors
Incyte Corporation
12/23/22
-
18
Quinazolinones that inhibit the formation of tau oligomers and their method of use
Oligomerix, Inc.
12/23/22
-
93
RIP1 inhibitory compounds and methods for making and using the same
Rigel Pharmaceuticals, Inc.
12/23/22
-
146
SSAO inhibitors and use thereof
Eccogene (Shanghai) Co., Ltd.
12/23/22
-
19
Sphingosine analogs and use thereof against bacterial lung infections
Yeda Research and Development Co. Ltd.; University of Duisburg-Essen
12/23/22
-
51
3-substituted piperidine compounds for Cbl-b inhibition, and use thereof
Nurix Therapeutics, Inc.
12/11/22
-
69
Compound functioning as bromodomain protein inhibitor, and composition
Betta Pharmaceuticals Co., Ltd.
12/11/22
-
48
Compound having ERK kinase inhibitory activity and use thereof
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
12/11/22
-
10
Cyclic di-nucleotide compounds as sting agonists
Merck Sharp & Dohme LLC
12/11/22
-
13
Heterocyclic compounds as immunomodulators
Incyte Corporation
12/11/22
-
94
Heterocyclic inhibitors of PTPN11
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
12/11/22
-
16
Modulators of the NMDA receptor
H. Lundbeck A/S
12/11/22
-
60
Nitrogenous heterocyclic aromatic compound, preparation method therefor, pharmaceutical composition thereof, and application thereof
SHANGHAI YINGLI PHARMACEUTICAL CO., LTD
12/11/22
-
142
Pharmaceutical compounds
OTSUKA PHARMACEUTICAL CO., LTD.; TAIHO PHARMACEUTICAL CO., LTD.
12/11/22
-
31
Pyridazines
Boehringer Ingelheim International GmbH
12/11/22
-
187
Substituted lactams showing serotonin 5-HT receptor activity
SUMITOMO PHARMA CO., LTD.
12/11/22
-
21
Substituted pyridines as apoptosis signal-regulating kinase 1 inhibitors
Enanta Pharmaceuticals, Inc.
12/11/22
-
27
Tricyclic compounds
JACOBIO PHARMACEUTICALS CO., LTD.
12/11/22
-
15
2-beta-naphthyl-acetic acid analogs as AKR1C3 inhibitors and methods of using same
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA; VANDERBILT UNIVERSITY
12/07/22
-
286
6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors
Novartis AG
12/07/22
-
20
Annulated glycosidase inhibitors
Asceneuron SA
12/07/22
-
30
Antibacterial compounds
INFEX Therapeutics Limited
12/07/22
-
140
Biaryl derivative, preparation method thereof and pharmaceutical application thereof
ABBISKO THERAPEUTICS CO., LTD.
12/07/22
-
72
Broad spectrum antiviral compositions and methods
Evrys Bio, LLC
12/07/22
-
74
Broad spectrum inhibitors of filoviruses
Microbiotix, Inc.; Albert Einstein College of Medicine; The Government of the United States as Represented by the Secretary of the Army
12/07/22
-
3
Combination of pure 5-HT6 receptor antagonists with acetylcholinesterase inhibitors
Suven Life Sciences Limited
12/07/22
-
3
Crystalline forms of a lysyl oxidase-like 2 inhibitor and methods of making
PHARMAKEA, INC.
12/07/22
-
108
Heterocyclic compounds for the inhibition of PASK
BioEnergenix LLC
12/07/22
-
71
Imidazopyridazine and imidazopyridine compounds and uses thereof
Incyte Corporation
12/07/22
-
48
Isothiazolo[5,4-D]pyrimidine compound as IRAK4 inhibitor
Chia Tai Tianqing Pharmaceutical Group Co., Inc.
12/07/22
-
227
Modulators of methyl modifying enzymes, compositions and uses thereof
Constellation Pharmaceuticals, Inc.
12/07/22
-
160
N/O-linked Degrons and Degronimers for protein degradation
C4 Therapeutics, Inc.
12/07/22
-
67
Pyrazine carbamates and their use as GluN2B receptor modulators
JANSSEN PHARMACEUTICA NV
12/07/22
-
5
Substituted pyrrolo[2,3-d]pyrimidines as JAK inhibitors
VIMALAN BIOSCIENCES, INC.
12/07/22
-
229
TEAD inhibitors and uses thereof
IKENA ONCOLOGY, INC.
12/07/22
-
36
Tri-substituted heteroaryl derivatives as Src homology-2 phosphatase inhibitors
NIKANG THERAPEUTICS, INC.
12/07/22
-
15
3-pyrrolidine-indole derivatives as serotonergic psychedelic agents for the treatment of CNS disorders
MINDSET PHARMA INC.
12/04/22
-
215
Cyclic di-nucleotide compounds as sting agonists
Merck Sharp & Dohme LLC
12/04/22
-
25
JAK inhibitors containing a 4-membered heterocyclic amide
THERAVANCE BIOPHARMA R&D IP, LLC
12/04/22
-
452
KRas G12D inhibitors
MIRATI THERAPEUTICS, INC.; ARRAY BIOPHARMA INC.
12/04/22
-
143
Receptor inhibitor, pharmaceutical composition comprising same, and use thereof
BEIJING TIDE PHARMACEUTICAL CO., LTD.
12/04/22
-
576
Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
12/04/22
-
16
Substituted [1,2,4]triazolo[4,3-a]pyrazines as phosphodiesterase inhibitors
ELI LILLY AND COMPANY
12/04/22
-
72
Substituted eneoxindoles and uses thereof
Gilead Sciences, Inc.
12/04/22
-
44
Substituted propanamides as inhibitors of nucleases
MASARYKOVA UNIVERZITA
12/04/22
-
1
Substituted pyrazolo[1,5-a]pyrimidines as tropomyosin receptor kinase inhibitors
SHENZHEN TARGETRX, INC.
12/04/22
-
29
Tricyclic compounds useful to treat orthomyxovirus infections
Novartis AG
12/04/22
-
4
(S)-3-(2-(4-(benzyl)-3-oxopiperazin-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid derivatives and related compounds as caspase inhibitors for treating cardiovascular diseases
Histogen, Inc.
11/20/22
-
66
Galactoside inhibitor of galectins
GALECTO BIOTECH AB
11/20/22
-
49
Macrocyclic chlorine substituted indole derivatives
Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc.
11/20/22
-
225
Pyrrolo[2,3-b]pyridine compounds and their use in the treatment of cancer
Cancer Research Technology Limited
11/20/22
-
12
Tricyclic amine compounds as CDK2 inhibitors
Incyte Corporation
11/20/22
-
360
Aminoimidazopyridazines as kinase inhibitors
Bristol-Myers Squibb Company
11/19/22
-
116
Anti-inflammatory compound, and preparation and use thereof
E-Nitiate Biopharmaceuticals (Hangzhou) Co., Ltd.
11/19/22
-
25
Aromatic heterocyclic substituted olefin compound, preparation method for same, pharmaceutical composition of same, and applications thereof
SHANGHAI YINGLI PHARMACEUTICAL CO., LTD
11/19/22
-
83
Compound exhibiting enteropeptidase inhibitory activity
LG CHEM, LTD.
11/19/22
-
90
Compounds, salts thereof and methods for treatment of diseases
ACADIA PHARMACEUTICALS INC.
11/19/22
-
64
Cyclic compound having dopamine D3 receptor antagonistic effect
SHIONOGI & CO., LTD.
11/19/22
-
10
Hetero ring-fused phenyl compounds for inhibiting TNIK and medical uses thereof
Korea Research Institute of Chemical Technology; Industry-Academic Cooperation Foundation, Yonsei University
11/19/22
-
32
Heterocyclylmethylidene derivatives and their use as modulators of mGluR5 receptors
Recordati Industria Chimica e Farmacentica S.p.A.
11/19/22
-
33
Indoleamine-2,3-dioxygenase inhibitor, the preparative method and the use thereof
HINOVA PHARMACEUTICALS INC.
11/19/22
-
95
Inhibitors of cyclin-dependent kinases
TBA
11/19/22
-
118
Pharmaceutical compounds for treatment of medical disorders
Achillion Pharmaceuticals, Inc.
11/19/22
-
46
Pyrimidine JAK inhibitors for the treatment of skin diseases
THERAVANCE BIOPHARMA R&D IP, LLC
11/19/22
-
98
Pyrimidine TBK/IKKe inhibitor compounds and uses thereof
Merck Patent GmbH
11/19/22
-
7
Quinoline analogs as phosphatidylinositol 3-kinase inhibitors
NANJING ZHENGXIANG PHARMACEUTICALS CO., LTD.
11/19/22
-
5
Selective A2A receptor antagonist
INXMED (NANJING) CO., LTD.
11/19/22
-
94
Spiroheptanyl hydantoins as rock inhibitors
Bristol-Myers Squibb Company
11/19/22
-
6
Substituted 1,2,3,4-tetrahydroquinolines as inhibitors of repair enzyme 8-oxoguanine deoxyribonucleic acid glycosylase activity
The Board of Trustees of the Leland Stanford Junior University
11/19/22
-
79
Substituted macrocyclic indole derivatives
TBA
11/19/22
-
30
Substituted pyrimidines, pharmaceutical compositions and therapeutic methods thereof
TBA
11/19/22
-
353
Tetrahydroquinoline derivatives as P2X7 receptor antagonists
RaQualia Pharma Inc.; Asahi Kasei Pharma Corporation
11/19/22
-
22
Triazolo-azepine derivatives
Hoffmann-La Roche Inc.
11/19/22
-
32
Tricyclic amine compounds as CDK2 inhibitors
Incyte Corporation
11/19/22
-
10
p38α mitogen-activated protein kinase inhibitors
GEN1E LIFESCIENCES INC.
11/19/22
-
12
ASK1 inhibitor compounds and uses thereof
SEAL ROCK THERAPEUTICS, INC.
11/13/22
-
56
ATR inhibitor and application thereof
Wuxi Biocity Biopharmaceutics Co., Ltd.
11/13/22
-
129
Heterocyclic inhibitors of ATR kinase
Board of Regents, The University of Texas System; ChemPartner Corporation
11/13/22
-
359
Heterocyclylamines as PI3K inhibitors
Incyte Corporation; Incyte Holdings Corporation
11/13/22
-
164
LSD1 inhibitor and preparation method and application thereof
MEDSHINE DISCOVERY INC.
11/13/22
-
70
PDE9 inhibitor and use thereof
Nanjing TransThera Biosciences Co. Ltd.
11/13/22
-
17
Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators
Genentech, Inc.
11/13/22
-
166
TYK2 inhibitors and uses thereof
Nimbus Lakshmi, Inc.
11/13/22
-
70
Aryl cyclopropyl-amino-isoquinolinyl amide compounds
Aerie Pharmaceuticals, Inc.
11/07/22
-
69
Bromodomain inhibitor compound and use thereof
Shanghai Institute of Materia Medica, Chinese Academy of Sciences; Suzhou Suplead Life Sciences Co., Ltd.
11/07/22
-
124
Composition and methods for inhibiting mammalian sterile 20-like kinase 1
THE SCRIPPS RESEARCH INSTITUTE; UNIVERSITÄT BREMEN
11/07/22
-
8
Cycloalkyl-diamines for the treatment of inflammation
MediSynergics, LLC
11/07/22
-
291
Dihydrooxadiazinones
Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc.; Dana-Farber Cancer Institute, Inc.
11/07/22
-
40
IRAK4 inhibiting agents
BIOGEN MA INC.
11/07/22
-
84
Imidazo-pyridine compounds as PAD inhibitors
JUBILANT EPIPAD LLC
11/07/22
-
465
Imidazolyl pyrimidinylamine compounds as CDK2 inhibitors
Incyte Corporation
11/07/22
-
312
Immunomodulator compounds
ChemoCentryx, Inc.
11/07/22
-
332
Indazoles and azaindazoles as LRRK2 inhibitors
ESCAPE Bio, Inc.
11/07/22
-
543
Inhibitors of KEAP1-Nrf2 protein-protein interaction
Janssen Pharmaceutica NV
11/07/22
-
22
JAK inhibitor and use thereof
ZHUHAI UNITED LABORATORIES CO., LTD.
11/07/22
-
13
Kinase inhibitors
Insilico Medicine IP Limited
11/07/22
-
24
Prolyl hydroxylase inhibitors and methods of use
Akebia Therapeutics, Inc.
11/07/22
-
4
Psilocin derivatives as serotonergic psychedelic agents for the treatment of CNS disorders
Mindset Pharma Inc.
11/07/22
-
84
Small molecule inhibitors of neutral sphingomyelinase 2 (nSMase2) for the treatment of neurodegenerative diseases
The Johns Hopkins University; Institute of Organic Chemistry & Biochemistry
11/07/22
-
228
Substituted pyrrolopyridine-derivatives
Bayer Pharma Aktiengesellschaft; Bayer Aktiengesellschaft; Deutsches Krebsforschungszentrum
11/07/22
-
1
Substituted quinolines useful as kinase inhibitors
Teligene Ltd.
11/07/22
-
22
4-carboxamido-isoindolinone derivatives as selective parp-1 inhibitors
NERVIANO MEDICAL SCIENCES S.R.L.
11/06/22
-
208
Amide substituted indole compounds useful as TLR inhibitors
Bristol-Myers Squibb Company
11/06/22
-
29
Arginase inhibitors and methods of use thereof
AstraZeneca AB
11/06/22
-
452
Aryl and heteroaryl substituted indole compounds
Bristol-Myers Squibb Company
11/06/22
-
589
Bcl-2 inhibitors
BEIGENE, LTD.
11/06/22
-
150
Bicyclic compounds
VIVACE THERAPEUTICS, INC.
11/06/22
-
18
Compounds as neuronal histamine receptor-3 antagonists and uses thereof
XWPHARMA LTD.
11/06/22
-
26
DACOS type NNRTIS amino acid ester derivative, preparation method thereof, pharmaceutical composition, and application thereof
Yunnan University; Kunming Institute of Zoology, Chinese Academy of Sciences
11/06/22
-
145
Dosage forms and regimens for amino acid compounds
Pliant Therapeutics, Inc.
11/06/22
-
67
Heterocyclic compounds as anti-viral agents
ENANTA PHARMACEUTICALS, INC.
11/06/22
-
16
Hypoxia inducible factor-2(alpha) inhibitors and their use in the treatment of diseases
NIKANG THERAPEUTICS, INC.
11/06/22
-
316
Piperidinyl-methyl-purineamines as NSD2 inhibitors and anti-cancer agents
NOVARTIS AG
11/06/22
-
39
Substituted imidazo[1,5-a]pyrazines as Bruton's tyrosine kinase inhibitors
TRANSTHERA SCIENCES (NANJING), INC.
11/06/22
-
67
Substituted pyrrolopyridines as JAK inhibitors
TBA
11/06/22
-
30
Treatment of tachycardia
OSLO UNIVERSITY HOSPITAL HF
11/06/22
-
53
AMPK activators
KALLYOPE, INC.
11/05/22
-
22
Tryptophan hydroxylase inhibitor and pharmaceutical composition including same
Gwangju Institute of Science and Technolgy; Korea Advanced Institute of Science and Technology; KyungPook National University Industry-Academic Cooperation Foundation; Curacle Co., LTD.
11/05/22
-
149
Compounds and uses thereof
Foghorn Therapeutics Inc.
10/30/22
-
78
Compounds for the treatment of BRAF-associated diseases and disorders
Array BioPharma Inc.
10/30/22
-
5
Compounds useful as immunomodulators
Bristol-Myers Squibb Company
10/30/22
-
97
Formulations of Tie-2 activators and methods of use thereof
EYEPOINT PHARMACEUTICALS, INC.
10/30/22
-
55
Heterocyclic compound as JAK inhibitor, and salts and therapeutic use thereof
Suzhou Longbiotech Pharmaceuticals Co., Ltd.
10/30/22
-
66
Heterocyclic compounds as immunomodulators
Incyte Corporation
10/30/22
-
136
Heterocyclic compounds as modulators of mGluR7
Pragma Therapeutics
10/30/22
-
212
Inhibitors of protein kinases
Alexion Pharmaceuticals, Inc.
10/30/22
-
19
Inhibitors of tryptophan dioxygenases (IDO1 and TDO) and their use in therapy
Auckland UniServices Limited
10/30/22
-
103
Oxoacridinyl acetic acid derivatives and methods of use
STINGTHERA, INC.
10/30/22
-
379
P300/CBP hat inhibitors
Constellation Pharmaceuticals, Inc.
10/30/22
-
1022
Substituted pyrazolo[1,5-a]pyrimidines as TYK2 inhibitors
Nimbus Lakshmi, Inc.
10/30/22
-
37
Sulfonamide-substituted cyanopyrrolidines with activity as DUB inhibitors
MISSION THERAPEUTICS LIMITED
10/30/22
-
6
Acetamide thienotriazolodiazepines and uses thereof
Dana-Farber Cancer Institute, Inc.
10/28/22
-
58
Antibacterial compounds
FORGE THERAPEUTICS, INC.
10/28/22
-
121
Aryl, heteroaryl, and heterocyclic compounds for treatment of immune and inflammatory disorders
Achillion Pharmaceuticals, Inc.
10/28/22
-
80
CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer
AMGEN INC.
10/28/22
-
3
Derivatives of an FGFR inhibitor
Incyte Corporation
10/28/22
-
36
Dioxinoquinoline compounds, preparation method and uses thereof
BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED
10/28/22
-
114
Heterocycle compounds as Tyro3, Axl and MerTK (TAM) family of receptor tyrosine kinase inhibitors
Development Center for Biotechnology
10/28/22
-
27
Heterocyclic compounds as immunomodulators
Incyte Corporation
10/28/22
-
85
Inhibitors of RAF kinases
KINNATE BIOPHARMA INC.
10/28/22
-
26
JAK1 pathway inhibitors for the treatment of chronic lung allograft dysfunction
Incyte Corporation
10/28/22
-
118
Mitogen-activated protein kinase inhibitors, methods of making, and methods of use thereof
Washington University
10/28/22
-
16
Pyrazolopyridine compounds and uses thereof
Incyte Corporation
10/28/22
-
208
RIP1 inhibitory compounds and methods for making and using the same
Rigel Pharmaceuticals, Inc.
10/28/22
-
13
Substituted piperidines as kinase inhibitors
Daewoong Pharmaceutical Co., Ltd.
10/28/22
-
13
Treatment of upper aerodigestive tract disorders and cough
TBA
10/28/22
-
79
Tropomyosin-related kinase (TRK) inhibitors
Genzyme Corporation
10/28/22
-
22
1-Pyridazin-/triazin-3-yl-piper(-azine)/idine/pyrolidine derivatives and compositions thereof for inhibiting the activity of SHP2
NOVARTIS AG
10/23/22
-
153
Alcoxyamino derivatives for treating pain and pain related conditions
ESTEVE PHARMACEUTICALS, S.A.
10/23/22
-
1
Biochemical binding of RET9 and VEGFR2 inhibitors
Kala Pharmaceuticals, Inc.
10/23/22
-
23
Cyclic dinucleotide compound and uses thereof
SHANGHAI JEMINCARE PHARMACEUTICALS CO., LTD.; JIANGXI JEMINCARE GROUP CO., LTD.
10/23/22
-
64
Dihydroquinolinones for medical treatment
C4 Therapeutics, Inc.
10/23/22
-
307
Heteroaryl inhibitors of PDE4
Tetra Discovery Partners, LLC
10/23/22
-
138
Heterocyclic compounds as LSD1 inhibitors
Incyte Corporation
10/23/22
-
11
Isoquinoline derivatives and use thereof
Purdue Pharma L.P.
10/23/22
-
62
Macrocyclic indole derivatives
The Broad Institute, Inc.; Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft
10/23/22
-
40
Pyrido[3,2-d]pyrimidine compounds as immunomodulators
Incyte Corporation
10/23/22
-
81
Pyrimidinones as PI3K inhibitors
Incyte Holdings Corporation; Incyte Corportion
10/23/22
-
41
Small molecule activators of Parkin enzyme function
Mayo Foundation for Medical Education and Research
10/23/22
-
8
[1,2,4]Triazolo derivatives as PDE1 inhibitors for the treatment of diabetes
ELI LILLY AND COMPANY
10/23/22
-
23
1,4-substituted isoquinoline inhibitors of KEAP1/NRF2 protein-protein interaction
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
10/17/22
-
34
Amine compound for inhibiting SSAO/VAP-1 and use thereof
SUNSHINE LAKE PHARMA CO., LTD.
10/17/22
-
15
Amino acid compounds with unbranched linkers and methods of use
Pliant Therapeutics, Inc.
10/17/22
-
21
Aryl-phosphorus-oxygen compound as EGFR kinase inhibitor
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.
10/17/22
-
479
Benzodiazepine derivatives as RSV inhibitors
Enanta Pharmaceuticals, Inc.
10/17/22
-
218
CDK2/4/6 inhibitors
Pfizer Inc.
10/17/22
-
45
Substituted heterocyclic derivatives as PI3K inhibitors
Incyte Corporation
10/17/22
-
601
TYK2 inhibitors and uses thereof
Nimbus Lakshmi, Inc.
10/17/22
-
2
Tricyclic compounds as Cyp1 inhibitors
The General Hospital Corporation
10/17/22
-
267
1-cyano-pyrrolidine compounds as USP30 inhibitors
Mission Therapeutics Limited
10/16/22
-
66
Arginase inhibitors as therapeutics
Mars, Incorporated
10/16/22
-
104
Compounds and methods for treating oxalate-related diseases
OxaluRx, Inc.
10/16/22
-
34
Compounds for targeting mutant huntingtin protein and uses thereof
CHDI Foundation, Inc.
10/16/22
-
159
Inhibitors of cyclin-dependent kinases
KINNATE BIOPHARMA INC.
10/16/22
-
7
Pentafluorosulfanyl-substituted amide derivatives, preparation methods thereof and medical uses thereof
Beijing Innocare Pharma Tech Co., Ltd.
10/16/22
-
215
Piperazine derivatives as MAGL inhibitors
Hoffmann-La Roche Inc.
10/16/22
-
47
Pyrazolopyridines and triazolopyridines as A2A / A2B inhibitors
Incyte Corporation
10/16/22
-
314
Rho-associated protein kinase inhibitor, pharmaceutical composition comprising same, and preparation method and use thereof
BEIJING TIDE PHARMACEUTICAL CO., LTD.
10/16/22
-
38
Aromatic vinyl or aromatic ethyl derivative, preparation method therefor, intermediate, pharmaceutical composition, and application
GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.
10/09/22
-
1
Diphenylaminopyrimidine compound for inhibiting kinase activity
Shenzhen TargetRx, Inc.
10/09/22
-
20
Heterocyclic compound as CSF-1R inhibitor and use thereof
MEDSHINE DISCOVERY INC.
10/09/22
-
45
Heterocyclic compounds useful as aurora a selective inhibitors
Jacobio Pharmaceuticals Co., Ltd.
10/09/22
-
120
Spiropyrrolidine derived antiviral agents
Enanta Pharmaceuticals, Inc.
10/09/22
-
7
Substituted azetidine dihydrothienopyridines and their use as phosphodiesterase inhibitors
UNION therapeutics A/S
10/09/22
-
19
Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors
Incyte Corporation
10/09/22
-
209
2-amino-n-heteroaryl-nicotinamides as Nav1.8 inhibitors
Merck Sharp & Dohme LLC
10/06/22
-
132
CD73 inhibitors
ORIC PHARMACEUTICALS, INC.
10/06/22
-
106
Galactoside inhibitor of galectins
Galecto Biotech AB
10/06/22
-
164
Heterocyclic prolinamide derivatives
ORION OPHTHALMOLOGY LLC
10/06/22
-
41
Acetyl-CoA carboxylase modulators
Monsanto Technology LLC
10/05/22
-
20
Inhibiting mutant IDH-1
FORMA Therapeutics, Inc.
10/05/22
-
56
Inhibitors of RAF kinases
KINNATE BIOPHARMA INC.
10/05/22
-
19
Inhibitors of histone deacetylase
The Broad Institute, Inc.; The General Hospital Corporation
10/05/22
-
34
Purine derivatives and the use thereof as medicament
Boehringer Ingelheim International GmbH
10/05/22
-
94
RIP1 inhibitory compounds and methods for making and using the same
Rigel Pharmaceuticals, Inc.
10/05/22
-
177
Serine/threonine kinase inhibitors
Genentech, Inc.
10/05/22
-
32
3-arylindazoles as selective MEK4 inhibitors
NORTHWESTERN UNIVERSITY
09/25/22
-
10
Antimalarial compounds, process for preparation and their use for drug resistant malaria
Council of Scientific and Industrial Research; International Centre for Genetic Engineering and Biotechnology (ICGEB)
09/25/22
-
229
Compounds
TMEM16A LIMITED
09/25/22
-
23
Compounds and methods for inhibiting CPY26 enzymes
Queen''s University at Kingston
09/25/22
-
54
Compounds that inhibit Mcl-1 protein
AMGEN INC.
09/25/22
-
549
Compounds useful as inhibitors of ATR kinase
VERTEX PHARMACEUTICALS INCORPORATED
09/25/22
-
92
Cyano-substituted heterocycles with activity as inhibitors of USP30
MISSION THERAPEUTICS LIMITED
09/25/22
-
79
FGFR inhibitor and application thereof
Betta Pharmaceuticals Co., Ltd.
09/25/22
-
598
GLS1 inhibitors for treating disease
Board of Regents, The University of Texas System
09/25/22
-
21
Heteroaryl plasma kallikrein inhibitors
Takeda Pharmaceutical Company Limited
09/25/22
-
60
Heterocyclic inhibitors of tyrosine kinase
Board of Regents, The University of Texas System
09/25/22
-
124
Imidazolidin-2-one compounds as PRMT5 modulators
AURIGENE DISCOVERY TECHNOLOGIES LIMITED
09/25/22
-
27
Lysophosphatidic acid receptor 1 (LPAR1) inhibitor compounds
Eli Lilly and Company
09/25/22
-
365
Melt-extruded solid dispersions containing an apoptosis-inducing agent
AbbVie Inc.; AbbVie Deutschland GMBH & Co KG
09/25/22
-
10
Optically active azabicyclo ring derivative
Sumitomo Dainippon Pharma Co., Ltd.
09/25/22
-
17
P-phenylenediamine derivative as potassium channel regulator and preparation method and medical application thereof
SHANGHAI ZHIMENG BIOPHARMA INC.
09/25/22
-
47
Pharmaceutical composition for preventing or treating acute myeloid leukemia or metastatic breast cancer
PELEMED CO., LTD.
09/25/22
-
5
Process for the synthesis of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-tetrahydropyran-4-yl-7H-imidazo[1,5-a]pyrazin-8-one
Imara Inc.
09/25/22
-
447
Pyridine compound substituted with azole
TAISHO PHARMACEUTICAL CO., LTD.
09/25/22
-
94
RIP1 inhibitory compounds and methods for making and using the same
Rigel Pharmaceuticals Inc.
09/25/22
-
14
Substituted benzimidazoles, their preparation and their use as pharmaceuticals
EPIGENETIX, INC.
09/25/22
-
528
Substituted benzofuran, benzopyrrole, benzothiophene, and structurally related complement inhibitors
BioCryst Pharmaceuticals, Inc.
09/25/22
-
185
Substituted cyclohexyl compounds as NOP inhibiiors
Dart NeuroScience, LLC
09/25/22
-
73
Substituted dihydrothienopyrimidines and their use as phosphodiesterase inhibitors
Union therapeutics A/S
09/25/22
-
62
Substituted pyrazoles as LRRK2 inhibitors
OSCOTEC INC.
09/25/22
-
7
Therapeutic compounds and uses thereof
Kala Pharmaceuticals, Inc.
09/25/22
-
31
CRBN ligands and uses thereof
KYMERA THERAPEUTICS, INC.
09/19/22
-
9
Compounds and methods for inhibiting CYP26 enzymes
Queen''s University at Kingston
09/19/22
-
29
Functionalized peptides as antiviral agents
Enanta Pharmaceuticals, Inc.
09/19/22
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102
Lysyl oxidase-like 2 inhibitors and uses thereof
PharmAkea, Inc.
09/19/22
-
12
Prodrugs of modulators of the NMDA receptor
H. Lundbeck A/S
09/19/22
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56
Compounds useful as RET inhibitors
Cancer Research Technology Limited
09/11/22
-
122
Spiropyrrolidine derived antiviral agents
Enanta Pharmaceuticals, Inc.
09/11/22
-
305
TGF-beta inhibitors
Rigel Pharmaceuticals, hic.; Bristol-Myers Squibb Company
09/11/22
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198
1-cyano-pyrrolidine derivatives as DUB inhibitors
MISSION THERAPEUTICS LIMITED
09/10/22
-
261
2,4-disubstituted pyrimidines useful as kinase inhibitors
Celgene CAR LLC
09/10/22
-
163
Cyclopropyl-amide compounds as dual LSD1/HDAC inhibitors
Jubilant Epicore LLC
09/10/22
-
347
HIV protease inhibitors
Gilead Sciences, Inc.
09/10/22
-
324
Inhibitors of plasma kallikrein and uses thereof
Takeda Pharmaceutical Company Limited
09/10/22
-
89
Nitrile-containing antiviral compounds
Pfizer Inc.
09/10/22
-
210
Phenoxymethyl derivatives
Hoffmann-La Roche Inc.
09/10/22
-
281
Pyridine and pyridimine compounds as PI3K-gamma inhibitors
Incyte Corporation
09/10/22
-
33
Substituted penta-fused hexa-heterocyclic compounds, preparation method therefor, drug combination and use thereof
Xiamen University
09/10/22
-
16
Substituted pyrimidines as CDK4/6 inhibitors
Beijing Xuanyi PharmaSciences Co., Ltd.
09/10/22
-
241
2-substituted pyrazole amino-4-substituted amino-5-pyrimidine formamide compound, composition, and application thereof
TBA
09/05/22
-
33
Apoptosis signal-regulating kinase 1 (ASK 1) inhibitor compounds
PHARMAKEA, INC.
09/05/22
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152
Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
Enanta Pharmaceuticals, Inc.
09/05/22
-
28
Autotaxin inhibitor compounds
Sabre Therapeutics LLC
09/05/22
-
42
Benzamide compounds
Recurium IP Holding, LLC
09/05/22
-
69
Benzopyrazole compound used as RHO kinase inhibitor
MEDSHINE DISCOVERY INC.
09/05/22
-
280
Inhibitors of fibroblast growth factor receptor kinases
KINNATE BIOPHARMA INC.
09/05/22
-
9
KRAS mutant protein inhibitors
JACOBIO PHARMACEUTICALS CO., LTD.
09/05/22
-
137
Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect
SHIONOGI & CO., LTD.
09/05/22
-
43
PGDH inhibitors and methods of making and using
MYOFORTE THERAPEUTICS, INC.
09/05/22
-
128
Phenyl and pyridinyl substituted imidazoles as modulators of RORγT
Janssen Pharmaceutica NV
09/05/22
-
20
Quaternary lactam compound and pharmaceutical use thereof
SHANGHAI MEIYUE BIOTECH DEVELOPMENT CO., LTD.
09/05/22
-
64
Substituted nicotinimide inhibitors of BTK and their preparation and use in the treatment of cancer, inflammation and autoimmune disease
Guangzhou Innocare Pharma Tech Co., Ltd.
09/05/22
-
2
Substituted pyrazolopyrimidines useful as kinases inhibitors
Teligene Ltd.
09/05/22
-
31
4H-pyrrolo[3,2-c]pyridin-4-one derivatives
Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; Dana-Farber Cancer Institute, Inc.; The Broad Institute, Inc.
08/29/22
-
75
Aliphatic acid amide derivative
SUMITOMO DAINIPPON PHARMA CO., LTD.
08/29/22
-
35
Glycoside derivatives and uses thereof
Novartis AG
08/29/22
-
52
Imidazole and triazole containing bicyclic compounds as JAK inhibitors
Theravance Biopharma R&D IP, LLC
08/29/22
-
55
Spiropyrrolidine derived antiviral agents
Enanta Pharmaceuticals, Inc.
08/29/22
-
33
Substituted piperidines as kinase inhibitors
Daewoong Pharmaceutical Co., Ltd.
08/29/22
-
207
Compounds and methods for kinase modulation, and indications therefor
Plexxikon Inc.
08/28/22
-
34
Dopamine D3 receptor selective antagonists/partial agonists and uses thereof
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
08/28/22
-
466
Heteroaryl Rheb inhibitors and uses thereof
NAVITOR PHARMACEUTICALS, INC.
08/28/22
-
266
Heterocyclic compounds as immunomodulators
Incyte Corporation
08/28/22
-
34
Identification of stabilizers of multimeric proteins
Leland Stanford Junior University
08/28/22
-
28
Substituted [1,2,4]triazolo[4,3-A]pyrazines as prolyl endopeptidase inhibitors
Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft
08/28/22
-
11
hTRPV1 chemical agents
University of Pittsburgh—Of the Commonwealth System of Higher Education
08/28/22
-
12
CD73 inhibitors and therapeutic uses thereof
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.
08/21/22
-
22
Imidazooxazole derivative having antitumor effect, and pharmaceutical composition including same
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
08/21/22
-
33
Inhibitors of lysine gingipain
CORTEXYME, INC.
08/21/22
-
42
MAGL inhibitors
H. LUNDBECK A/S
08/21/22
-
94
RIP1 inhibitory compounds and methods for making and using the same
Rigel Pharmaceuticals, Inc.
08/21/22
-
30
Substituted pyrazolo[3,4-d]pyrimidines as Wee1 inhibitors
NUVATION BIO INC.
08/21/22
-
19
Benzenesulfonamide compounds and their use as therapeutic agents
Xenon Pharmaceuticals Inc.
08/15/22
-
203
CD73 inhibitors
ORIC PHARMACEUTICALS, INC.
08/15/22
-
26
CaMKII inhibitors and uses thereof
The Johns Hopkins University
08/15/22
-
32
Chemical compounds
ASTRAZENECA AB
08/15/22
-
68
Imidopiperidine compounds as inhibitors of human polynucleotide kinase phosphatase
The Governors of the University of Alberta
08/15/22
-
18
Optically active crosslinked cyclic secondary amine derivative
Sumitomo Dainippon Pharma Co., Ltd.
08/15/22
-
134
Spiropyrrolidine derived antiviral agents
Enanta Pharmaceuticals, Inc.
08/15/22
-
22
Thienopyrazine carboxamides as ubiquitin-specific protease inhibitors
VALO HEALTH, INC.
08/15/22
-
26
Combination therapy for treatment of hematological diseases
Incyte Corporation
08/14/22
-
67
Ketone inhibitors of lysine gingipain
CORTEXYME, INC.
08/14/22
-
42
Benzamide compounds
Recurium IP Holdings, LLC
08/07/22
-
147
Cyanopyrrolidines as dub inhibitors for the treatment of cancer
MISSION THERAPEUTICS LIMITED
08/07/22
-
415
Inhibitors of Bruton's tyrosine kinase and methods of their use
Janssen Pharmaceutica NV
08/07/22
-
22
Modulators of the 5-hydroxytryptamine receptor 7 and their method of use
Temple University—Of The Commonwealth System of Higher Education; Praeventix, LLC
08/07/22
-
121
Pyridine quinoline compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
Vanderbilt University
08/07/22
-
708
Substituted carboxamides as inhibitors of WDR5 protein-protein binding
Propellon Therapeutics Inc.
08/07/22
-
18
Tricyclic fused derivatives of 1-(cyclo)alkyl pyrtdin-2-one useful for the treatment of cancer
JUBILANT BIOSYS LIMITED
08/07/22
-
173
9-substituted amino triazolo quinazoline derivatives as adenosine receptor antagonists, pharmaceutical compositions and their use
Merck Sharp & Dohme Corp.
08/06/22
-
61
9H-pyrrolo-dipyridine derivatives
TBA
08/06/22
-
410
Azabenzimidazoles and their use as AMPA receptor modulators
Janssen Pharmaceutica NV
08/06/22
-
17
Ghrelin O-acyltransferase inhibitors
Glaxosmithkline Intellectual Property Development Limited
08/06/22
-
46
Heteroaryl[4,3-C]pyrimidine-5-amine derivative, preparation method therefor, and medical uses thereof
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.
08/06/22
-
113
Hsp90 inhibitors and uses thereof
TRUSTEES OF BOSTON UNIVERSITY; The Governing Council of the University of Toronto
08/06/22
-
91
Imidazo[4,5-C]quinoline derivatives as LRRK2 inhibitors
Pfizer Inc.
08/06/22
-
20
Inhibiting mutant isocitrate dehydrogenase 1 (mIDH-1)
FORMA Therapeutics, Inc.
08/06/22
-
177
Inhibitors of cysteine proteases and methods of use thereof
Pardes Biosciences, Inc.
08/06/22
-
375
Macrocyclic flu endonuclease inhibitors
Janssen BioPharma, Inc.
08/06/22
-
19
Morpholine derivative
Hoffmann-La Roche Inc.
08/06/22
-
83
Oxo-tetrahydro-isoquinoline carboxylic acids as STING inhibitors
Merck Sharp & Dohme Corp.
08/06/22
-
6
Protease inhibitors
Medivir AB
08/06/22
-
182
Pyranopyrazole and pyrazolopyridine immunomodulators for treatment of autoimmune diseases
THE ROCKEFELLER UNIVERSITY
08/06/22
-
63
Pyrazole compound
SUMITOMO DAINIPPON PHARMA CO., LTD.
08/06/22
-
193
Substituted dihydroimidazopyridinediones as MKNK1 and MKNK2 inhibitors
Bayer Pharma Aktiengesellschaft; Bayer Aktiengesellschaft
08/06/22
-
37
Thienodiazepine derivatives and application thereof
CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD.
08/06/22
-
54
Treatment of GVHD
KADMON CORPORATION, LLC; REGENTS OF THE UNIVERSITY OF MINNESOTA
08/06/22
-
78
4,6 dihydropyrrolo [3,4-C] pyrazole-5 (1H)-carbonitrile derivates for treating cancer
MISSION THERAPEUTICS LIMITED
08/01/22
-
25
Cyano thienotriazolodiazepines and uses thereof
Dana-Farber Cancer Institute, Inc.
08/01/22
-
23
Inhibitors of KRAS G12C and methods of using the same
AMGEN INC.
08/01/22
-
47
Substituted pyrrolo[1,2-a]pyrazines and pyrrolo[1,2-a][1,4]diazepines as TREX1 inhibitors
Venenum Biodesign, LLC
08/01/22
-
85
3-(5-amino-pyrazin-2-yl)-benzenesulfonamide derivatives and related compounds as PI3K-gamma kinase inhibitors
Incyte Corporation
07/31/22
-
22
Benzofuran, benzothiophene, and indole analogs that inhibit the formation of tau oligomers and their method of use
Oligomerix, Inc.
07/31/22
-
29
Heterocyclic compounds as adenosine antagonists
Nuvation Bio Inc.
07/31/22
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176
Phenylacetamides as inhibitors of rock
Bristol-Myers Squibb Company
07/31/22
-
475
Piperidine CXCR7 receptor modulators
IDORSIA PHARMACEUTICALS LTD.
07/31/22
-
52
Substituted quinazolines for inhibiting kinase activity
NEUPHARMA, INC.
07/31/22
-
213
Tosylacetate based compounds and derivatives thereof as PHGDH inhibitors
Boehringer Ingelheim International GmbH
07/31/22
-
26
Treatment of hidradenitis suppurativa using JAK inhibitors
Incyte Corporation
07/31/22
-
156
2-arylsulfonamido-N-arylacetamide derivatized STAT3 inhibitors
University of Hawaii
07/28/22
-
83
Benzenesulfonamide compounds and their use as therapeutic agents
Xenon Pharmaceuticals Inc.
07/24/22
-
47
Benzimidazole and indole compounds and uses thereof
Incyte Corporation
07/24/22
-
10
Chemical compounds
GlaxoSmithKline Intellectual Property (No. 2) Limited
07/24/22
-
66
Five membered-aminoheterocycle and 5,6-or 6,6-membered bicyclic aminoheterocyclic inhibitors of rock for the treatment of heart failure
Bristol-Myers Squibb Company
07/24/22
-
108
Heterocyclic compounds and uses thereof
Nuvation Bio Inc.
07/24/22
-
27
JAK kinase inhibitor compounds for treatment of respiratory disease
Theravance Biopharma R&D IP, LLC
07/24/22
-
24
Substituted tetrahydropyran dihydrothienopyrimidines and their use as phosphodiesterase inhibitors
UNION therapeutics A/S
07/24/22
-
1
Combination therapy involving diaryl macrocyclic compounds
TURNING POINT THERAPEUTICS, INC.
07/21/22
-
3
Composition for inhibiting growth of SARS-CoV-2 and method of preparing the same
Medicare Pharmaceuticals Inc.; MEDICARE LC.
07/21/22
-
37
Diarylhydantoin compounds and methods of use thereof
Nuvation Bio Inc.
07/21/22
-
237
Heterocyclic inhibitors of MCT4
Vettore, LLC
07/21/22
-
18
Pyrimidine compounds and pharmaceutical compositions for preventing or treating cancers including the same
Hanmi Pharm. Co., Ltd.
07/21/22
-
184
Pyrimidine tricyclic enone derivatives for inhibition of ROR-gamma and other uses
REATA PHARMACEUTICALS, INC.
07/21/22
-
171
RAD51 inhibitors
Cyteir Therapeutics, Inc.
07/21/22
-
16
Substituted azetidine dihydrothienopyrimidines and their use as phosphodiesterase inhibitors
UNION THERAPEUTICS A/S
07/21/22
-
256
Substituted piperidine compound and use thereof
TAKEDA PHARMACEUTICAL COMPANY LIMITED
07/21/22
-
781
Tetrahydro-imidazo quinoline compositions as CBP/P300 inhibitors
FORMA Therapeutics, Inc.
07/21/22
-
82
Tricyclic CRBN ligands and uses thereof
KYMERA THERAPEUTICS, INC.
07/21/22
-
32
Aryl ethene derivative and pharmaceutical composition containing same as active ingredient
Daegu-Gyeongbuk Medical Innovation Foundation; KYUNGPOOK NATIONAL UNIVERSITY HOSPITAL; Kyungpook National University Industry-Academic Cooperation Foundation
07/16/22
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1775
EIF4E-inhibiting compounds and methods
eFFECTOR Therapeutics, Inc.
07/16/22
-
33
Macrocyclic fluorine substituted indole derivatives
The Broad Institute, Inc.; Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft
07/16/22
-
390
Piperidin-4-yl azetidine derivatives as JAK1 inhibitors
Incyte Corporation; Incyte Holdings Cororation
07/16/22
-
6
Pyrrolidine compounds
Eli Lilly and Company
07/16/22
-
369
Substituted piperazines as KRAS G12C inhibitors
AMGEN INC.
07/16/22
-
9
AMPK activators
KALLYOPE, INC.
07/10/22
-
51
Aromatic derivative, preparation method for same, and medical applications thereof
BIOARDIS LLC
07/10/22
-
19
Compound as selective JAK inhibitor, and salt and therapeutic use thereof
Suzhou Longbiotech Pharmaceuticals Co., Ltd.
07/10/22
-
435
Compounds and compositions for the inhibition of NAMPT
Valo Health, Inc.; Genentech, Inc.
07/10/22
-
9
Enantiomers of substituted thiazoles as antiviral compounds
Innovative Molecules GmbG
07/10/22
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229
Fused pyrimidine compounds as BRD4 and JAK2 dual inhibitors and methods for use thereof
APTOSE BIOSCIENCES INC.
07/10/22
-
41
Inhibitors of RET
BLUEPRINT MEDICINES CORPORATION
07/10/22
-
61
Macrocyclic compounds that inhibit MCL-1 protein
AMGEN INC.
07/10/22
-
63
Substituted bicyclic pyrimidine-based compounds and compositions and uses thereof
TBA
07/10/22
-
171
Alpha-hydroxy phenylacetic acid pharmacophore or bioisostere Mcl-1 protein antagonists
AMGEN INC.
07/05/22
-
291
Colony stimulating factor-1 receptor (CSF-1R) inhibitors
GENZYME CORPORATION
07/05/22
-
28
Tricyclic compounds for use in treatment of proliferative disorders
ARGONAUT THERAPEUTICS LIMITED
07/05/22
-
32
Cyclopentane compounds
Dizal (Jiangsu) Pharmaceutical Co., Ltd.
07/04/22
-
55
MAPK inhibitors
EverBrilliant Pharma Pty Ltd
07/04/22
-
16
Modulators of methyl modifying enzymes, compositions and uses thereof
Constellation Pharmaceuticals, Inc.
07/04/22
-
375
P300/CBP HAT inhibitors
Constellation Pharmaceuticals, Inc.
07/04/22
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34
Pharmaceutical composition for ANO1 antagonist with anticancer activity
INDUSTRY-ACADEMIC COOPERATION FOUNDATION YONSEI UNIVERSITY
07/04/22
-
1
Aminopyrimidine compound and composition comprising same and use thereof
Shenzhen TargetRx, Inc.
06/26/22
-
14
Benzamide derivatives as PPAR-gamma modulators
Medibiofarma, S.L.
06/26/22
-
48
Carbocyclic prolinamide derivatives
ORION OPHTHALMOLOGY LLC
06/26/22
-
19
Class of amino-substituted nitrogen-containing fused ring compounds, preparation method therefor, and use thereof
SHANGHAI RINGENE BIOPHARMA CO., LTD.
06/26/22
-
1
Indazole compound for use in inhibiting kinase activity, composition and application thereof
Shenzhen TargetRx, Inc.
06/26/22
-
224
Inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan 2,3-dioxygenase
IDORSIA PHARMACEUTICALS LTD
06/26/22
-
17
Maslinic and oleanolic acids derivatives for treating SARS-CoV-2 infection
KING ABDULAZIZ UNIVERSITY
06/26/22
-
105
Method of treatment using substituted pyrazolo[1,5-a] pyrimidine compounds
Array BioPharma Inc.
06/26/22
-
331
Small molecule inhibitors of galectin-3
Bristol-Myers Squibb Company
06/26/22
-
3
Substituted 1,2,3,3a,4,5,7,9,13,13a-decahydropyrido[1′,2′:4,5]pyrazino[1,2-a]pyrrolo[1,2-c]pyrimidines having HIV integrase inhibitory activity
SHIONOGI & CO., LTD.; VIIV HEALTHCARE COMPANY
06/26/22
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516
Triaryl compounds for treatment of PD-L1 diseases
ChemoCentryx, Inc.
06/26/22
-
14
Tricyclic fused pyridin-2-one derivatives and their use as BRD4 inhibitors
Jubilant Biosys Limited
06/26/22
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73
19-NOR neuroactive steroids and methods of use thereof
Sage Therapeutics, Inc.
06/24/22
-
15
Aromatic compound, pharmaceutical composition and use thereof
Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.
06/24/22
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587
Biaryl derivative as GPR120 agonist
LG CHEM. LTD.
06/24/22
-
53
Bicyclic heterocyclic derivatives
Merck Patent GmbH
06/24/22
-
48
Dihydropyrimidine compounds and uses thereof in medicine
SUNSHINE LAKE PHARMA CO., LTD.
06/24/22
-
205
Imidazotriaines and imidazopyrimidines as kinase inhibitors
INCYTE HOLDINGS CORPORATION; INCYTE CORPORATION
06/24/22
-
51
Sulfoximine glycosidase inhibitors
Asceneuron SA
06/24/22
-
126
TRPV4 antagonists
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED
06/24/22
-
41
[1,6]naphthyridine compounds and derivatives as CDK8/CDK19 inhibitors
Boehringer Ingelheim International GmbH
06/24/22
-
9
1,8-naphthyridinone compounds and uses thereof
NUVATION BIO INC.
06/19/22
-
637
Compounds and methods for modulating adenosine A2B receptor and adenosine A2A receptor
Corvus Pharmaceuticals, Inc.
06/19/22
-
11
Fused imidazo-piperidine JAK inhibitors
THERAVANCE BIOPHARMA R&D IP, LLC
06/19/22
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72
Pyrazole derivative compound and use thereof
HANMI PHARM. CO., LTD.
06/19/22
-
371
Pyrazolo[1,5-A]pyrazin-4-yl and related derivatives
Pfizer Inc.
06/19/22
-
49
Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
Prelude Therapeutics Incorporated
06/19/22
-
45
Substituted imidazo[1,2-A]pyridines as IRAK 1/4 and flt3 inhibitors
CHILDREN''S HOSPITAL MEDICAL CENTER; THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES
06/19/22
-
71
3-hydroxy-quinazoline-2,4-dione derivatives and their use as nuclease modulators
Ludwig Institute for Cancer Research Ltd
06/17/22
-
22
Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
TES PHARMA S.R.L.
06/17/22
-
43
N2,N4-diphenylpyrimidine-2,4-diamine derivative, method for preparing same, and pharmaceutical composition containing same as active ingredient for prevention or treatment of cancer
Korea Research Institute of Chemical Technology
06/17/22
-
409
Substituted bicyclic compounds as farnesoid X receptor modulators
Bristol-Myers Squibb Company
06/17/22
-
3
Triple combination of pure 5-HT6 receptor antagonists, acetylcholinesterase inhibitors and NMDA receptor antagonist
Suven Life Sciences Limited
06/17/22
-
508
Bicyclic fused pyridine compounds as inhibitors of TAM kinases
ARRAY BIOPHARMA INC
06/13/22
-
114
Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases
University of Washington through its Center for Commercialization
06/13/22
-
69
Compounds and methods for inhibiting JAK
Dizal (Jiangsu) Pharmaceutical Co., Ltd.
06/13/22
-
116
Cyclopropylamines as LSD1 inhibitors
Incyte Corporation
06/13/22
-
11
FXR (NR1H4) modulating compounds
Gilead Sciences, Inc.
06/13/22
-
63
Macrocyclic derivative of pyrazol[3,4-d]pyrimidin-3-one, pharmaceutical composition and use thereof
SHANGHAI DE NOVO PHARMATECH CO., LTD.
06/13/22
-
4
Metalloenzyme inhibitor compounds
Mycovia Pharmaceuticals, Inc.
06/13/22
-
288
PCSK9 inhibitors and methods of use thereof
AstraZeneca AB
06/13/22
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157
Phenyl indole allosteric inhibitors of P97 ATPase
University of Pittsburgh—Of the Commonwealth System of Higher Education; National Institutes of Health, A Component of the U.S. Department of Hearth and Human Services; The Regents of the University of California
06/13/22
-
3
Pyrimidine derivative having effect of inhibiting cancer cell growth and pharmaceutical composition containing same
ONCOBIX CO., LTD.
06/13/22
-
34
Quinazoline and indole compounds to treat medical disorders
Achillion Pharmaceuticals, Inc.
06/13/22
-
172
Therapeutic compounds and uses thereof
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.
06/13/22
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52
Tricyclic inhibitors of poly(ADP-ribose)polymerase
Rakovina Therapeutics Inc.
06/13/22
-
510
Small molecule inhibitors of lactate dehydrogenase and methods of use thereof
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA; THE UAB RESEARCH FOUNDATION; VANDERBILT UNIVERSITY; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
06/12/22
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86
(4-hydroxypyrrolidin-2-yl)-heterocyclic compounds and methods of use thereof
Genentech, Inc.
06/10/22
-
12
2-phenyl-3,4-dihydropyrrolo[2,1-Ff] [1,2,4]triazinone derivatives as phosphodiesterase inhibitors and uses thereof
TOPADUR PHARMA AG
06/10/22
-
134
Compounds useful for treating gastrointestinal tract disorders
ARDELYX, INC.
06/10/22
-
2
Ethynyl derivatives
Hoffmann-La Roche Inc.
06/10/22
-
56
Isoquinoline amine compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
Vanderbilt University
06/10/22
-
174
Proteasome activity enhancing compounds
Proteostasis Therapeutics, Inc.
06/10/22
-
76
Pyrazolopyridine compounds and uses thereof
Incyte Corporation
06/10/22
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90
Spirocyclic ROR-gamma modulators
ESCALIER BIOSCIENCES B.V.
06/10/22
-
61
Sulfonimidoylpurinone compounds and methods of treatment using the same
Hoffmann-La Roche Inc.
06/10/22
-
98
Tricyclic inhibitors of the BCL6 BTB domain protein-protein interaction and uses thereof
ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR)
06/10/22
-
6
Dipeptidyl ketoamide meta-methoxyphenyl derivatives and uses thereof
LANDSTEINER GENMED, S.L.
06/09/22
-
1
Formulations of an AXL/MER inhibitor
Incyte Corporation
06/09/22
-
21
Heteroaryl amide derivatives as selective inhibitors of histone deacetylases 1 and/or 2(HDAC1-2)
Medibiofarma, S.L.
06/09/22
-
95
Inhibitors of plasma kallikrein
Kalvista Pharmaceuticals Limited
06/09/22
-
4
Organosilicon carriers for use in treating infections and/or diseases caused by SARS viruses
TBA
06/09/22
-
3
Aminobenzimidazole derivatives, treatments, and methods of inhibiting histone deacetylase
Translational Drug Development, LLC
06/06/22
-
274
Combination of isoindolinone derivatives with SGI-110
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED
06/06/22
-
78
Fused pyrimidine compound or salt thereof
Taiho Pharmaceutical Co., Ltd.
06/06/22
-
99
Fused ring compounds
Genentech, Inc.
06/06/22
-
134
Isoxazole compounds as inhibitors of heat shock proteins
Cancer Research Technology Limited; The Institute of Cancer Research; Vernalis (R&D) Limited
06/06/22
-
197
KIF18A inhibitors
AMGEN INC.
06/06/22
-
8
Morpholine derivates as inhibitors of Vps34
Neuropore Therapies, Inc.
06/06/22
-
77
Protein kinase B inhibitors
ASTRAZENECA AB
06/06/22
-
116
Spiro-condensed pyrrolidine derivatives as deubiquitylating enzymes (DUB) inhibitors
MISSION THERAPEUTICS LIMITED
06/06/22
-
183
Substituted heterocyclic sulfonamide compounds useful as TRPA1 modulators
Genentech, Inc.
06/06/22
-
6
Substituted pyrrolopyridines as ATR inhibitors
BlueValley Pharmaceutical LLC
06/06/22
-
36
Substituted sulfoximine compounds
Cadila Healthcare Limited
06/06/22
-
11
2,3-dihydro-isoindole-1-one derivative as BTK kinase suppressant, and pharmaceutical composition including same
CrystalGenomics, Inc.
05/30/22
-
166
KDM1A inhibitors for the treatment of disease
Imago Biosciences, Inc.
05/30/22
-
99
Purine inhibitors of human phosphatidylinositol 3-kinase delta
Merck Sharp & Dohme Corp.
05/30/22
-
244
Human plasma kallikrein inhibitors
BioCryst Pharmaceuticals, Inc.
05/29/22
-
128
Myocyte enhancer factor 2 (MEF2) modulators
STANDARD LLC
05/29/22
-
32
Selective androgen receptor degrader (SARD) ligands and methods of use thereof
UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
05/29/22
-
38
Substituted tetrahydroquinolinone compounds as ROR gamma modulators
AURIGENE DISCOVERY TECHNOLOGIES LIMITED
05/29/22
-
108
Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors
Incyte Corporation; Incyte Holdings Corporation
05/29/22
-
15
Bicyclic inhibitors of histone deacetylase
Alkermes, Inc.
05/22/22
-
812
Compounds that inhibits MCL-1 protein
AMGEN INC.
05/22/22
-
18
Heterocycles useful as anti-cancer agents
Hangzhou Innogate Pharma Co., Ltd.
05/22/22
-
275
Inhibitors of phosphoglycerate dehydrogenase (PHGDH) and uses thereof
Whitehead Institute for Biomedical Research; Dana-Farber Cancer Institute, Inc.; The United States of America, as represented by the Secretary, Department of Health and Human Services
05/22/22
-
10
Substituted pyridines as inhibitors of histone deacetylase
Alkermes, Inc.
05/22/22
-
122
Tertiary alcohols as PI3K-γ inhibitors
Incyte Corporation
05/22/22
-
16
5-hydroxytryptamine receptor 7 modulators and their use as therapeutic agents
Temple University-Of the Commonwealth System of Higher Education
05/14/22
-
137
Cyclin dependent kinase inhibitors
Pfizer Inc.
05/14/22
-
333
Inhibitors of low molecular weight protein tyrosine phosphatase and uses thereof
LA JOLLA INSTITUTE OF ALLERGY & IMMUNOLOGY; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
05/14/22
-
23
Pyridylpyridone compounds
Sprint Bioscience AB
05/14/22
-
30
Pyrrole tricyclic compounds as A2A / A2B inhibitors
Incyte Corporation
05/14/22
-
71
Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
Prelude Therapeutics Incorporated
05/14/22
-
218
Substituted imidazo[1,2-c]pyrimidines as PRC2 inhibitors
MIRATI THERAPEUTICS, INC.
05/14/22
-
93
Substituted n-pyrimidin-4-yl-3-amino-pyrrolo[3,4-c]pyrazoles as protein kinase C inhibitors
PFIZER INC.
05/14/22
-
217
TYK2 inhibitors and uses thereof
Nimbus Lakshmi, Inc.
05/14/22
-
4
2,3-dihydrofuro[2,3-b]pyridine compounds
Eli Lilly and Company
05/08/22
-
42
Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors
Incyte Holdings Corporation; Incyte Corporation
05/08/22
-
17
Cannabinoid receptor modulators
Arena Pharmaceuticals, Inc.
05/08/22
-
88
Compositions for treating neurodegenerative diseases
Cognition Therapeutics, Inc.
05/08/22
-
341
Compound, compositions, and methods
DENALI THERAPEUTICS INC.
05/08/22
-
25
Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
SHY Therapeutics LLC
05/08/22
-
103
Histone demethylase inhibitors
CELGENE QUANTICEL RESEARCH, INC.
05/08/22
-
52
Indoleamine 2,3-dioxygenase inhibitor, method for preparation and use thereof
NANJING HUAWE MEDICINE TECHNOLOGY GROUP CO., LTD.
05/08/22
-
21
Linear glycosidase inhibitors
Asceneuron SA
05/08/22
-
42
MAGL inhibitors
H. LUNDBECK A/S
05/08/22
-
16
Phenylpyrazolylacetamide compounds and derivatives as CDK8/CDK19 inhibitors
Boehringer Ingelheim International GmbH
05/08/22
-
49
Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
Prelude Therapeutics, Incorporated
05/08/22
-
52
Substituted pyrazolo-pyrazines and their use as GluN2B receptor modulators
JANSSEN PHARMACEUTICA NV
05/08/22
-
7
Substituted pyridine derivatives useful as C-FMS kinase inhibitors
Janssen Pharmaceutica NV
05/08/22
-
32
Compositions and methods for treating parasitic diseases
The Regents of the University of California; Washington University
05/03/22
-
109
Compounds useful as inhibitors of ALCAT 1
PERENNA PHARMACEUTICALS, INC.
05/03/22
-
80
Ectonucleotidase inhibitors and methods of use thereof
CALITHERA BIOSCIENCES, INC.
05/03/22
-
5
Nitrogenous tricyclic compounds and uses thereof in medicine
SUNSHINE LAKE PHARMA CO., LTD.
05/03/22
-
31
Prognostic biomarkers for TTK inhibitor chemotherapy
NETHERLANDS TRANSLATIONAL RESEARCH CENTER B.V.
05/03/22
-
20
Pyridinamine-pyridone and pyrimidinamine- pyridone compounds
Sprint Bioscience AB
05/03/22
-
121
Pyridone derivatives having tetrahydropyranylmethyl groups
Daiichi Sankyo Company, Limited
05/03/22
-
41
Selective inhibitors of protein arginine methytransterase 5 (PRMT5)
Prelude Therapeutics Incorporated
05/03/22
-
53
Substituted bridged diazepane derivatives and use thereof as TASK-1 and TASK-3 inhibitors
Bayer Pharma Aktiengesellschaft; Bayer Aktiengesellschaft
05/03/22
-
376
Substituted indole Mcl-1 inhibitors
Vanderbilt University
05/03/22
-
20
1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase
Incyte Corporation; Incyte Holdings Corporation
05/02/22
-
119
3,4-disubstituted 3-cyclobutene-1,2-diones and use thereof
ALLERGAN, INC.
05/02/22
-
96
Certain chemical entities, compositions, and methods
NEUPHARMA, INC
05/02/22
-
27
HDAC6 inhibitors and imaging agents
The General Hospital Corporation
05/02/22
-
55
Indole derivatives and their use as protein kinase inhibitors
RESPIVERT LIMITED
05/02/22
-
204
Metallo-beta-lactamase inhibitors and methods of use thereof
Merck Sharp & Dohme Corp.
05/02/22
-
117
NLRP3 inflammasome inhibitors
Novartis AG
05/02/22
-
595
Substituted 1H-imidazo[4,5-b]pyridin-2(3H)-ones and their use as GLUN2B receptor modulators
JANSSEN PHARMACEUTICA NV
05/02/22
-
526
Substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine derivatives and uses thereof
Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft
05/02/22
-
1
Sulfinylpyridines and their use in the treatment of cancer
Oblique Therapeutics AB
05/02/22
-
243
Triazolopyrimidine compounds and uses thereof
Novartis AG
05/02/22
-
28
Anti-proliferative agents for treating PAH
Pfizer Inc.
04/29/22
-
13
Aza-indazole compounds for use in tendon and/or ligament injuries
NOVARTIS AG
04/29/22
-
247
Human plasma kallikrein inhibitors
BioCryst Pharmaceuticals, Inc.
04/29/22
-
37
Iridinesulfonamide compound and use method thereof
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.; Centaurus Biopharma Co., Ltd.
04/29/22
-
281
Kinase inhibitors and uses thereof
DENALI THERAPEUTICS INC.
04/29/22
-
14
Personal care compositions comprising fatty acid amide derivatives
Conopco, Inc.
04/29/22
-
302
Substituted 6-azabenzimidazole compounds
Gilead Sciences, Inc.
04/29/22
-
100
Sulfonamides as modulators of sodium channels
VERTEX PHARMACEUTICALS INCORPORATED
04/29/22
-
19
Tricyclic compounds as glycogen synthase kinase 3 (GSK3) inhibitors and uses thereof
The Broad Institute, Inc.; Biogen MA Inc.
04/29/22
-
56
Compounds targeting PRMT5
Aligos Therapeutics, Inc.
04/25/22
-
573
Fused ring derivative having MGAT-2 inhibitory activity
SHIONOGI & CO., LTD.
04/25/22
-
113
Aminopyrimidinyl compounds
Pfizer Inc.
04/24/22
-
16
Galactopyranosyl-cyclohexyl derivauves as E-selectin antagonists
GLYCOMIMETICS. INC.
04/24/22
-
115
Heteroaryl inhibitors of PAD4
Padlock Therapeutics, Inc.
04/24/22
-
92
N-((het)arylmethyl)-heteroaryl-carboxamides compounds as kallikrein inhibitors
KalVista Pharmaceuticals Limited
04/24/22
-
13
Rho kinase inhibitor BA-1049 (R) and active metabolites thereof
BioAxone BioSciences, Inc.
04/24/22
-
30
5-hydroxytryptamine receptor 7 activity modulators and their method of use
Temple University-Of The Commonwealth System of Higher Education
04/17/22
-
111
Alkyl substituted triazole compounds as agonists of the APJ Receptor
AMGEN INC.
04/17/22
-
377
Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators
Janssen Pharmaceutica NV
04/17/22
-
8
Glutaminase inhibitor discovery and nanoparticle-enhanced delivery for cancer therapy
THE JOHNS HOPKINS UNIVERSITY
04/17/22
-
44
Heterocyclic compounds for the inhibition of PASK
BioEnergenix LLC
04/17/22
-
246
Human plasma kallikrein inhibitors
BioCryst Pharmaceuticals, Inc.
04/17/22
-
36
N-aryl oxamic acids
Purdue Research Foundation