Patent: (prefix with "US" like US6078908)
  1. Patent
    Data
    Cmpds
    UniProt
    HGNC*
    Patent Title
    Organization
    Deposition
    Downloads
  2. 165
    2,4,6-TRISUBSTITUTED 1,3,5-TRIAZINES AS MODULATORS OF CX3CR1
    ASTRAZENECA AB
    09/24/24
  3. 158
    4-AMINOPYRROLO[2,1-F][1,2,4]TRIAZINES AND PREPARATION AND USES THEREOF
    Biosplice Therapeutics, Inc.
    09/24/24
  4. 29
    APPLICATIONS OF BIASED LIGANDS OF THE SEROTONIN 5-HT7 RECEPTOR FOR THE TREATMENT OF PAIN, MULTIPLE SCLEROSIS AND THE CONTROL OF THERMOREGULATION
    Centre National de la Recherche Scientifique; Université d''Orléans
    09/24/24
  5. 5
    BICYCLIC COMPOUNDS AS ALLOSTERIC SHP2 INHIBITORS
    Revolution Medicines, Inc.
    09/24/24
  6. 8
    BICYCLIC HETEROCYCLIC FGFR4 INHIBITOR, PHARMACEUTICAL COMPOSITION AND PREPARATION COMPRISING SAME, AND APPLICATION THEREOF
    Hangzhou Apeloa Medicine Research Institute Co., Ltd.; Apeloa Pharmaceutical Co., Ltd.
    09/24/24
  7. 3
    DEUTERATED DHODH INHIBITORS
    IMMUNIC AG
    09/24/24
  8. 16

    Fused Ring Derivatives Useful as KRAS G12D Inhibitors
    JACOBIO PHARMACEUTICALS CO., LTD.
    09/24/24
  9. 6

    GLYCOSYLTRANSFERASE INHIBITORS
    CALIFORNIA INSTITUTE OF TECHNOLOGY; UNIVERSITY OF TENNESSEE FRESEARCH FOUNDATION
    09/24/24
  10. 29
    IMIDAZO[1,2-B]PYRIDAZINE BASED TRICYCLIC COMPOUNDS AS INHIBITORS OF HASPIN AND THERAPEUTIC USES THEREOF
    FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS
    09/24/24
  11. 17
    INHIBITORS OF DYRK AND PIM
    COLD SPRING HARBOR LABORATORY; VICHEM CHEMIE RESEARCH, LTD.; THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
    09/24/24
  12. 4
    METHODS AND COMPOSITIONS COMPRISING A BRAF INHIBITOR AND A PD-1 BINDING ANTAGONIST
    Hoffmann-La Roche Inc.
    09/24/24
  13. 5
    NOVEL CYCLOPENTA[C]PYRROL NEGATIVE ALLOSTERIC MODULATORS OF NR2B
    Novartis AG; Cadent Therapeutics, Inc.
    09/24/24
  14. 45
    NOVEL N-ACYL-[3-SUBSTITUTED]-[8-SUBSTITUTED]-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR-MEDIATED DISORDERS
    Ogeda SA
    09/24/24
  15. 10
    SHP2-Targeting Small Molecules For Use As Anti-Cancer Agents
    West Virginia University Board of Governors on behalf of West Virginia University
    09/24/24
  16. 302
    SMALL MOLECULAR INHIBITORS OF NF-kB INDUCING KINASE
    Janssen Pharmaceutica NV
    09/24/24
  17. 2
    TETRAHYDROTHIENO PYRIDINE DERIVATIVES AS DDRS INHIBITORS
    CHIESI FARMACEUTICI S.P.A.
    09/24/24
  18. 88
    THIOPHENE COMPOUND AND APPLICATION THEREOF
    MEDSHINE DISCOVERY INC.
    09/24/24
  19. 17
    Alpha-synuclein ligands
    Washington University
    09/19/24
  20. 23
    Mofezolac derivatives as multi-functions selective COX-1 inhibitors
    ITEL Telecomunicazioni S.r.l.
    09/19/24
  21. 1074
    N-substituted indole derivatives as PGE2 receptor modulators
    IDORSIA PHARMACEUTICALS LTD
    09/19/24
  22. 277
    Small molecule DCN1 inhibitors and therapeutic methods using the same
    REGENTS OF THE UNIVERSITY OF MICHIGAN
    09/19/24
  23. 1
    A Crystal Form of a Fluorine-substituted Pyridopyrazole Compound and a Preparation Method Thereof
    JUMBO DRUG BANK CO., LTD
    09/18/24
  24. 27
    COMPOUNDS AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS
    UNIVERSITAT DE BARCELONA
    09/18/24
  25. 13
    FUSED CYCLIC COMPOUND AS WEE-1 INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF
    WIGEN BIOMEDICINE TECHNOLOGY (SHANGHAI) CO., LTD.
    09/18/24
  26. 52
    INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE, COMPOSITIONS, AND METHODS OF USE
    BRISTOL-MYERS SQUIBB COMPANY
    09/18/24
  27. 64

    MACROCYCLE COMPLEMENT FACTOR B INHIBITORS
    Alexion Pharmaceuticals, Inc.
    09/18/24
  28. 42
    MACROCYCLES AND THEIR USE
    BLOSSOMHILL THERAPEUTICS, INC.
    09/18/24
  29. 176
    NOVEL SUBSTITUTED PYRAZINE-CARBOXAMIDE DERIVATIVES
    Boehringer Ingelheim International GmbH
    09/18/24
  30. 53
    Pyrazole-containing macrophage migration inhibitory factor inhibitors
    YALE UNIVERSITY
    09/09/24
  31. 549
    Substituted aminoquinolones as DGKalpha inhibitors for immune activation
    BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; DEUTSCHES KREBSFORSCHUNGSZENTRUM
    09/09/24
  32. 141
    Vesicular monoamine transporter-2 ligands and their use in the treatment of psychostimulant abuse
    University of Kentucky Research Foundation
    09/09/24
  33. 20
    1,2,5-Oxadiazoles As Inhibitors Of Indoleamine 2,3- Dioxygenase
    Incyte Corporation; Incyte Holdings Corporation
    09/05/24
  34. 182
    2,8-DIAZASPIRO[4.5]DECANE COMPOUNDS
    Genentech, Inc.
    09/05/24
  35. 19
    8-(PICOLINAMIDE) SUBSTITUTED COUMARIN COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF
    LONGIVITRON (SUZHOU) BIOTECHNOLOGY CO., LTD
    09/05/24
  36. 240
    ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER
    BOEHRINGER INGELHEIM INTERNATIONAL GMBH; VANDERBILT UNIVERSITY
    09/05/24
  37. 1
    CRYSTALLINE FORMS OF (4S)-24-CHLORO-4-ETHYL-73-FLUORO-35-METHOXY-32,5-DIOXO-14-(TRIFLUORO-METHYL)-32H-6-AZA-3(4,1)-PYRIDINA-1(1)-[1,2,3]TRIAZOLA-2(1,2),7(1)-DIBENZENAHEPTAPHANE-74-CARBOXAMIDE
    Bayer Aktiengesellschaft
    09/05/24
  38. 17

    CULLIN-RING E3 UBIQUITIN LIGASE 4 INHIBITOR COMPOUNDS AND METHODS OF THEIR USE
    ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
    09/05/24
  39. 170
    HETEROAROYL AMIDES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF
    Merck Sharp & Dohme LLC
    09/05/24
  40. 4
    HIGH PURITY COPPER RADIOPHARMACEUTICAL COMPOSITIONS AND DIAGNOSTIC AND THERAPEUTIC USES THEREOF
    Nuclidium AG; University of Basel
    09/05/24
  41. 205
    KINASE MODULATORS AND METHODS OF USE THEREOF
    NEURON23, INC.
    09/05/24
  42. 5
    METHYLQUINAZOLINONE DERIVATIVES
    Hoffmann-La Roche Inc.
    09/05/24
  43. 10
    Methods and Compositions for Treating Cancer
    Ohio Northern University
    09/05/24
  44. 108
    NITROGEN-CONTAINING POLYCYCLIC FUSED RING COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF, PREPARATION METHOD THEREFOR, AND USE THEREOF
    APPLIED PHARMACEUTICAL SCIENCE, INC.
    09/05/24
  45. 15
    NOVEL DIOXANE DERIVATIVES
    Boehringer Ingelheim International GmbH
    09/05/24
  46. 10
    PYRIMIDINE AROMATIC RING COMPOUNDS
    Medshine Discovery Inc.
    09/05/24
  47. 486
    SMALL MOLECULE INHIBITORS OF SALT INDUCIBLE KINASES
    Janssen Biotech, Inc.; The Broad Institute, Inc.; The General Hospital Corporation
    09/05/24
  48. 87

    Compounds and probes for imaging huntingtin protein
    CHDI Foundation, Inc.
    08/29/24
  49. 29
    Fused tri-cyclic compound as PDE3/PDE4 dual inhibitor
    CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.
    08/29/24
  50. 28
    Preparation for 6-amino-1H-pyrazolo[3,4-d]pyrimidine-based JAK kinase inhibitor and application thereof
    INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES & PEKING UNION MEDICAL COLLEGE; CHINA PARMACEUTICAL UNIVERSITY
    08/29/24
  51. 4
    Saturated spirocyclics as antiviral agents
    Enanta Pharmaceuticals, Inc.
    08/29/24
  52. 22
    Use of 2-substituted indazoles for the treatment and prophylaxis of autoimmune diseases
    Bayer Pharma Aktiengesellschaft
    08/29/24
  53. 26
    Use of JAK1 inhibitors for the treatment of cutaneous lupus erythematosus and Lichen planus (LP)
    Incyte Corporation
    08/29/24
  54. 2
    COVALENT EGFR INHIBITORS AND METHODS OF USE THEREOF
    Dana-Farber Cancer Institute, Inc.
    08/27/24
  55. 2
    NUCLEOSIDE ANALOG AND USE THEREOF
    SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    08/27/24
  56. 60
    1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES AS BCL-2 INHIBITORS FOR THE TREATMENT OF NEOPLASTIC AND AUTOIMMUNE DISEASES
    Newave Pharmaceutical Inc.
    08/26/24
  57. 172
    AMINOHETEROARYL KINASE INHIBITORS
    Anrui Biomedical Technology (Guangzhou) Co.,Ltd.
    08/26/24
  58. 137
    COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THE SAME
    Arizona Board of Regents on Behalf of the University of Arizona; The Board of Trustees of the University of Illinois
    08/26/24
  59. 24
    FLUORINATED QUINOLINE, QUINOXALINE AND BENZO[B][1,4]OXAZINE DERIVATIVES AS DIHYDROOROTATE DEHYDROGENASE (DHODH) INHIBITORS FOR THE TREATMENT OF CANCER, AUTOIMMUNE AND INFLAMMATORY DISEASES
    Janssen Biotech, Inc.
    08/26/24
  60. 16
    GALACTOPYRANOSYL-CYCLOHEXYL DERIVATIVES AS E-SELECTIN ANTAGONISTS
    GLYCOMIMETICS, INC.
    08/26/24
  61. 10
    HETEROCYCLIC DERIVATIVES AS JANUS KINASE INHIBITORS
    CHIESI FARMACEUTICI S.P.A.
    08/26/24
  62. 136
    IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AND THEIR USE IN THERAPY
    Imperial College Innovations Limited; MyricX Pharma Limited
    08/26/24
  63. 44
    INHIBITORS OF MYELOPEROXIDASE
    ASTRAZENECA AB
    08/26/24
  64. 126
    KRAS G12C INHIBITORS
    BeiGene Switzerland GmbH
    08/26/24
  65. 98
    PHENALKYLAMINES AND METHODS OF MAKING AND USING THE SAME
    GILGAMESH PHARMACEUTICALS, INC.
    08/26/24
  66. 17
    POTENT AND SELECTIVE COMPOUNDS AS SEROTONIN 1B RECEPTOR MODULATORS
    LEUKOS BIOTECH, S.L.; FUNDACIÓ INSTITUT DE RECERCA CONTRA LA LEUCÈMIA JOSEP CARRERAS
    08/26/24
  67. 13
    PYRIDOPYRIMIDINONE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF
    Wuhan Humanwell Innovative Drug Research and Development Center Limited Company
    08/26/24
  68. 27
    SELECTIVE LIGANDS FOR TAU AGGREGATES
    KARIN & STEN MORTSTEDT CBD SOLUTIONS AB
    08/26/24
  69. 6
    Dual-functional compounds and methods of use
    Biofront Therapeutics (Beijing) Co.
    08/22/24
  70. 592
    Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of heart failure and disorders related thereto
    Arena Pharmaceuticals
    08/22/24
  71. 75
    BET SUBFAMILY INHIBITORS AND METHODS USING SAME
    Baylor College of Medicine
    08/19/24
  72. 200
    BI-ARYL DIHYDROOROTATE DEHYDROGENASE INHIBITORS
    Janssen Biotech
    08/19/24
  73. 4
    FUSED POLYCYCLIC SUBSTITUTED 5-CARBOXYLIC ACID THIENOPYRIMIDINE DIONE COMPOUND AND USE THEREOF
    Soter Biopharma
    08/19/24
  74. 94
    NEK7 INHIBITORS
    Halia Therapeutics
    08/19/24
  75. 25
    NOVEL BENZOFURAN, BENZOTHIOPHENE, AND INDOLE ANALOGS THAT INHIBIT THE FORMATION OF TAU OLIGOMERS AND THEIR METHOD OF USE
    Oligomerix
    08/19/24
  76. 18
    NOVEL QUINAZOLINONES THAT INHIBIT THE FORMATION OF TAU OLIGOMERS AND THEIR METHOD OF USE
    Oligomerix
    08/19/24
  77. 162
    Nitrogen-Containing Heterocyclic Compound, Pharmaceutical Compositions thereof and Use thereof
    280 Bio
    08/19/24
  78. 9
    PIPERAZINE DERIVATIVE AND USE THEREOF IN MEDICINE
    Chengdu Baiyu Pharmaceutical Co.
    08/19/24
  79. 85
    POLYPEPTIDE COMPOUND AND APPLICATION THEREOF
    Chengdu Sintanovo Biotechnology Co.
    08/19/24
  80. 157
    PYRIMIDINE COMPOUND AS WEE-1 INHIBITOR
    Wigen Biomedicine Technology (Shanghai) Co.
    08/19/24
  81. 85
    Pyrrolidine Main Protease Inhibitors as Antiviral Agents
    Abbvie
    08/19/24
  82. 69
    RIBONUCLEOTIDE REDUCTASE (RNR) INHIBITORS AND USES THEREOF
    Boundless Bio
    08/19/24
  83. 10
    TRICYCLIC COMPOUND AS HIF2-ALPHA INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
    Shanghai Jemincare Pharmaceuticals Co.
    08/19/24
  84. 3

    β-lactamase inhibitors
    Oxford University Innovation
    08/13/24
  85. 11
    1,7-naphthyridine derivative and preparation method and use therefor
    Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co.
    08/13/24
  86. 12
    Bicyclic pyrazolyl amines as CDK2 inhibitors
    Incyte
    08/13/24
  87. 1
    Fluoro-pyridinone phosphates and boronates useful as antibacterial agents
    Pfizer
    08/13/24
  88. 3
    N-(2-(substituted-naphth-1-yl)ethyl) substituted amide compound, preparation and uses thereof
    Beijing Greatway Pharmaceutical Technology Co.
    08/13/24
  89. 20
    Substituted cyclopenta[c]pyrroles as ABHD6 antagonists
    Ono Pharmaceutical Co.
    08/13/24
  90. 48
    Substituted thienopyrroles as PAD4 inhibitors
    Bristol-Myers Squibb
    08/13/24
  91. 21

    4-AMINOQUINAZOLINE COMPOUND
    Astellas Pharma
    08/09/24
  92. 39
    BICYCLIC PYRIDINE DERIVATIVE
    Sumitomo Pharma Co.
    08/09/24
  93. 31
    CYCLIN-DEPENDENT KINASE INHIBITING COMPOUNDS FOR THE TREATMENT OF MEDICAL DISORDERS
    G1 Therapeutics
    08/09/24
  94. 20
    FUSED RING DERIVATIVES CONTAINING 1,4-OXAZEPANE
    Medshine Discovery
    08/09/24
  95. 123
    HSD17B13 INHIBITORS AND/OR DEGRADERS
    Pfizer
    08/09/24
  96. 2
    INHIBITING CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN (CREB) BINDING PROTEIN (CBP)
    Formatherapeutics
    08/09/24
  97. 36
    INHIBITORS OF CYSTEINE PROTEASES
    Texas A&M University
    08/09/24
  98. 36

    N-(BENZOYL)-PHENYLALANINE COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF
    Hangzhou Apeloa Medicine Research Institute Co.
    08/09/24
  99. 67
    NITROGEN-CONTAINING SPIRO CYCLIC COMPOUNDS AND PHARMACEUTICAL USE THEREOF
    Japan Tobacco
    08/09/24
  100. 15
    NOVEL COMPOUNDS COMPRISING A NEW CLASS OF TRANSTHYRETIN LIGANDS FOR TREATMENT OF COMMON AGE-RELATED COMORBIDITIES
    Columbia University
    08/09/24
  101. 3
    OXA-IBOGAINE ANALOGUES FOR TREATMENT OF SUBSTANCE USE DISORDERS
    Columbia University
    08/09/24
  102. 26
    PURINES AND METHODS OF THEIR USE
    Kineta
    08/09/24
  103. 371
    PYRAZOLYLSULFONAMIDE COMPOUNDS AND THEIR USE IN THERAPY
    Hotspot Therapeutics
    08/09/24
  104. 22
    S-CONFIGURATION-CONTAINING AMINO BENZAMIDE PYRIDAZINONE COMPOUND, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF
    Shanghai Institute Of Materia Medica
    08/09/24
  105. 878
    SPIROCYCLOHEXANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS ANTI-APOPTOTIC INHIBITORS
    Les Laboratoires Servier
    08/09/24
  106. 1791

    PHARMACEUTICAL USE OF CYCLIC PEPTIDE COMPOUND
    Chugai Seiyaku Kabushiki Kaisha
    08/08/24
  107. 13
    Adenosine receptor activity of methyl/ethyl 3-(substituted benzoyl)-6,8-dimethylindolizine-2-substituted-1-carboxylates
    King Faisal University
    08/04/24
  108. 71
    Isoindolin-1-on derivative, method for preparing same, and pharmaceutical composition comprising same as effective component for preventing or treating cancer
    Korea Research Institute Of Chemical Technology
    08/04/24
  109. 121
    Monoacylglycerol lipase modulators for use in autism spectrum disorders
    Janssen Pharmaceutica
    08/04/24
  110. 29
    HETEROCYCLIC INHIBITORS OF CD73 FOR TREATMENT OF DISEASE
    Teon Therapeutics
    08/02/24
  111. 13
    INHIBITION OF KDM5A FOR PROMOTING ANTIGEN PRESENTATION, INCREASING CD8+ T CELL INFILTRATION AND BOOSTING ANTI-TUMOR IMMUNE RESPONSE
    The Wistar Institute Of Anatomy And Biology
    08/02/24
  112. 16
    5,6-DIHYDROTHIENO[3,4-H]QUINAZOLINE COMPOUND
    Medshine Discovery
    07/25/24
  113. 8
    ANTIVIRAL APPLICATION OF NUCLEOSIDE ANALOG OR COMBINATION FORMULATION CONTAINING NUCLEOSIDE ANALOG
    Shanghai Institute of Materia Medica, Chinese Academyof Sciences
    07/25/24
  114. 8
    HETEROCYCLIC INHIBITORS OF CD73 FOR TREATMENT OF DISEASE
    Teon Therapeutics
    07/25/24
  115. 15
    INHIBITORS AND DEGRADERS OF JANUS KINASE 2
    H. Lee Moffitt Cancer Center and Research Institute
    07/25/24
  116. 1
    INHIBITORS OF MENIN-MLL INTERACTION
    Biomea Fusion
    07/25/24
  117. 10
    METHACRYLAMIDES PROTEIN BINDERS AND USES THEREOF
    Yeda Research and Development Co.
    07/25/24
  118. 14
    N6-ADENOSINE-METHYLTRANSFERASE INHIBITORS IN CANCER TREATMENT
    University of Zurich
    07/25/24
  119. 63
    OXOINDOLINE COMPOUND FOR THE TREATMENT OF INFLAMMATORY DISEASES OR CANCER
    Hoffmann-La Roche
    07/25/24
  120. 120
    PREPARATION OF TETRAHYDROINDAZOLE DERIVATIVES AS NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS
    Merck Sharp & Dohme
    07/25/24
  121. 272
    TRICYCLIC COMPOUNDS AND USES THEREOF
    Hutchmed
    07/25/24
  122. 35
    Compounds and their use
    Astrazeneca
    07/22/24
  123. 326
    Substituted benzodiazoles and use thereof in therapy
    Thomas Helledays Stiftelse FÖR Medicinsk Forskning
    07/22/24
  124. 55
    AROMATIC HETEROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION, AND USE THEREOF
    Gt Apeiron Therapeutics
    07/16/24
  125. 91
    BORON CONTAINING PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM, METHODS AND USES THEREOF
    Boehringer Ingelheim Animal Health Usa
    07/16/24
  126. 40
    Benzimidazole Derivatives and Their Use As Inhibitors of ITK For The Treatment of Skin Disease
    Pfizer
    07/16/24
  127. 7
    COMPOSITIONS AND METHODS OF TREATING CONDITIONS
    The Uab Research Foundation
    07/16/24
  128. 1
    INDOLINE COMPOUND
    Medshine Discovery
    07/16/24
  129. 217

    INHIBITORS OF MYCOBACTERIUM TUBERCULOSIS LIPOAMIDE DEHYDROGENASE
    Cornell University
    07/16/24
  130. 4
    MACROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION, AND USE THEREOF
    Goharmony Therapeutics (Shenzhen) Co.
    07/16/24
  131. 35
    NRF2-ACTIVATING COMPOUND
    Senju Pharmaceutical Co.
    07/16/24
  132. 2
    PHENOL DERIVATIVE AND APPLICATION THEREOF IN MEDICAMENTS
    Hinye Pharmaceutical Co.
    07/16/24
  133. 3
    PYRIDINE DERIVATIVES AS MODULATORS OF SORTILIN ACTIVITY
    Insusense
    07/16/24
  134. 1
    SALT FORM AND CRYSTAL FORM OF PYRAZOLE SUBSTITUTED IMIDAZO[1,2- A]QUINOXALINE DERIVATIVE
    Ocumension Therapeutics (Suzhou) Co.
    07/16/24
  135. 5
    SUBSTITUTED N-(2-(2,6-DIOXOPIPERIDIN-3-YL)-1,3-DIOXOISOINDOLIN-5-YL)ARYLSULFONAMIDE ANALOGS AS MODULATORS OF CEREBLON PROTEIN
    St. Jude Children'S Research Hospital
    07/16/24
  136. 40
    SULFOXIMIDE SUBSTITUTED INDAZOLE IRAK4 KINASE INHIBITOR, PREPARATION METHOD THEREOF AND USE THEREOF
    Shanghai Xunhe Pharmaceutical Technology Co.
    07/16/24
  137. 6
    TETRAHYDRO-1H-PYRIDO[3,4-b]INDOLE ANTI-ESTROGENIC DRUGS
    Olema Pharmaceuticals
    07/16/24
  138. 50
    1,3,4,7-tetrahydro-2H-pyrrolo[3′,2′:5,6]pyrido[2,3-b][1,4]oxazepine bcl-2 inhibitors
    Abbvie
    07/13/24
  139. 49
    Modulators of STING (stimulator of interferon genes)
    Pfizer
    07/13/24
  140. 315
    Substituted bicyclic compounds useful as T cell activators
    Bristol-Myers Squibb
    07/13/24
  141. 178
    Arylamide derivative having antitumor activity
    Chugai Seiyaku Kabushiki Kaisha
    07/12/24
  142. 8
    Compounds for treating or inhibiting recurrence of acute myeloid leukemia
    Flash Therapeutics
    07/12/24
  143. 12
    Inhibitors for coronavirus
    Southwest Research Institute
    07/12/24
  144. 382
    Substituted aminothiazoles as DGKzeta inhibitors for immune activation
    Bayer Aktiengesellschaft
    07/12/24
  145. 115
    Substituted phenyloxazolidinones for antimicrobial therapy
    The Global Alliance For Tb Drug Development
    07/12/24
  146. 17
    ATF6 INHIBITORS AND USES THEREOF
    Altos Labs
    07/09/24
  147. 32
    AZA-ERGOLINE DERIVATIVE AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
    Shanghaitech University
    07/09/24
  148. 19
    BRANCHED MACROCYCLIC 4-(PYRAZOL-5-YL)-INDOLE DERIVATIVES AS INHIBITORS OF MCL-1
    Janssen Pharmaceutica
    07/09/24
  149. 16

    COMPOSITIONS AND METHODS FOR THE TREATMENT OF OCULAR DISORDERS
    Case Western Reserve University
    07/09/24
  150. 115
    HYDROXYHETEROCYCLOALKANE-CARBAMOYL DERIVATIVES
    Idorsia Pharmaceuticals
    07/09/24
  151. 3

    Methods for the Treatment of Fibrotic Disease
    Shy Therapeutics
    07/09/24
  152. 43
    Novel SIK Inhibitors
    Pfizer
    07/09/24
  153. 28
    PIM KINASE INHIBITOR
    Hangzhou Biosun Pharmaceutical Co.
    07/09/24
  154. 39
    PYRIMIDINE CARBOXAMIDE COMPOUND AND USE THEREOF
    Shanghai Meiyue Biotech Development Co.
    07/09/24
  155. 119
    Pyrido[2,3-D]Imidazole Derivatives and Their Use As Inhibitors of ITK for the Treatment of Skin Disease
    Pfizer
    07/09/24
  156. 54

    SPIROCYCLIC-SUBSTITUTED 6,7-DIHYDRO-PYRANO[2,3-d]PYRIMIDINE INHIBITORS OF KRAS G12C MUTANT
    Merck Sharp & Dohme
    07/09/24
  157. 9
    THERAPY BASED ON SYNTHETIC LETHALITY IN SWI/SNF COMPLEX-DYSFUNCTION CANCER
    National Cancer Center
    07/09/24
  158. 82
    TRICYCLIC COMPOUND AND USE THEREOF
    Nanjing Zaiming Pharmaceutical Co.
    07/09/24
  159. 236
    Benzodioxane modulators of leukotriene A4 hydrolase (LTA4H) for prevention and treatment of aging-associated diseases
    Alkahest
    07/03/24
  160. 27
    Inhibitors of bacterial glutaminyl cyclases for use in the treatment of periodontal and related diseases
    Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung
    07/03/24
  161. 26
    JAK1 pathway inhibitors for the treatment of vitiligo
    Incyte
    07/03/24
  162. 22
    Leucine-rich repeat kinase 2 (LRRK2) inhibitors
    H. Lundbeck
    07/03/24
  163. 568
    Modulators of HSD17B13 and methods of use thereof
    Regeneron Pharmaceuticals
    07/03/24
  164. 44
    Pyrazole compounds, pharmaceutical compositions thereof and use thereof
    Artivila (Shenzhen) Innovation Center
    07/03/24
  165. 8

    Urea compounds and compositions as SMARCA2/BRM ATPase inhibitors
    Novartis
    07/03/24
  166. 64
    BENZOTHIAZOLE AND QUINOLINE DERIVATIVES AND THEIR USE
    Shanghai Yao Yuan Biotechnology Co., Ltd.
    06/29/24
  167. 74

    COMPOUNDS AND METHODS FOR MODULATING FXR
    Terns Pharmaceuticals, Inc.
    06/29/24
  168. 8
    Compounds for Disease Treatment
    Duke University
    06/29/24
  169. 53

    HETEROAROMATIC COMPOUNDS
    AstraZeneca AB
    06/29/24
  170. 264
    HETEROCYCLIC AMIDE AND UREA COMPOUNDS AS JAK2 INHIBITORS
    Ajax Therapeutics, Inc.
    06/29/24
  171. 288
    Heterocycles as WIP1 Inhibitors
    PMV Pharmaceuticals, Inc.
    06/29/24
  172. 215
    IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AS IRAK4 INHIBITORS AND THEIR USE IN THE TREATMENT OF DISEASE
    BIOGEN MA INC.
    06/29/24
  173. 102
    INHIBITION OF nSMase FOR THE TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS INFECTION
    The Johns Hopkins University
    06/29/24
  174. 224
    KIT KINASE INHIBITORS AND METHODS OF USE THEREOF
    Deciphera Pharmaceuticals, LLC
    06/29/24
  175. 3
    METHODS OF TREATING CANCER USING HETEROARYL-BIPHENYL AMIDE DERIVATIVES
    CHEMOCENTRYX, INC.
    06/29/24
  176. 20
    NOVEL COMPOUNDS USEFUL AS STING AGONISTS AND USES THEREOF
    Jacobio Pharmaceuticals Co., Ltd.
    06/29/24
  177. 10
    NOVEL GLUTAMINYL CYCLASE INHIBITORS AND THE USE THEREOF IN TREATMENT OF VARIOUS DISEASES
    LTD "VALENTA-INTELLEKT"
    06/29/24
  178. 58
    PYRIDO OXAZINE DERIVATIVES AS ALK5 INHIBITORS
    CHIESI FARMACEUTICI S.P.A.
    06/29/24
  179. 49
    PYRIDO OXAZINE DERIVATIVES AS ALK5 INHIBITORS
    CHIESI FARMACEUTICI S.P.A.
    06/29/24
  180. 8
    QUINOLINE MERCAPTOACETATE SULFONAMIDE DERIVATIVE, INTERMEDIATE, PHARMACEUTICAL DERIVATIVE OR FORMULATION, AND PREPARATION METHOD AND USE THEREFOR
    JIANGSU CHIATAI QINGJIANG PHARMACEUTICAL CO., LTD.
    06/29/24
  181. 1044
    SARS-COV2 MAIN PROTEASE INHIBITORS
    Gilead Sciences, Inc.
    06/29/24
  182. 25
    SMALL MOLECULE REGULATORS OF ALVEOLAR TYPE 2 CELL PROLIFERATION FOR THE TREATMENT OF PULMONARY DISEASES
    THE SCRIPPS RESEARCH INSTITUTE
    06/29/24
  183. 3
    SUBSTITUTED TRICYCLIC COMPOUND AS PRMT5 INHIBITOR AND USE THEREOF
    NANJING SANHOME PHARMACEUTICAL CO., LTD.
    06/29/24
  184. 7

    TARGET FOR SCREENING ANTI-TUMOR DRUG, USE THEREOF AND SCREENING METHOD THEREFOR
    SHENYANG FUYANG PHARMACEUTICAL TECHNOLOGY CO., LTD.
    06/29/24
  185. 27
    Quinolines and azaquinolines as inhibitors of CD38
    Boehringer Ingelheim International GmbH
    06/27/24
  186. 3
    TRK inhibitors useful as anticancer drugs
    TYLIGAND BIOSCIENCE (SHANGHAI) LIMITED
    06/27/24
  187. 448
    ALPHA PROTEIN KINASE 1 INHIBITORS AND METHODS OF USE
    Shanghai Yao Yuan Biotechnology Co.
    06/20/24
  188. 523
    AZABICYCLIC SHP2 INHIBITORS
    IRBM
    06/20/24
  189. 10
    BENZIMIDAZOLE COMPOUND AND APPLICATION THEREOF
    Medshine Discovery
    06/20/24
  190. 6
    BRIDGED HETEROCYCLYL-SUBSTITUTED PYRIMIDINE COMPOUNDS, PREPARATION METHOD AND MEDICAL USE THEREOF
    The National Institutes Of Pharmaceutical R&D Co.
    06/20/24
  191. 30
    COMBINATION OF A T CELL THERAPY AND A DGK INHIBITOR
    Juno Therapeutics
    06/20/24
  192. 363
    INDAZOLE COMPOUNDS AS KINASE INHIBITORS
    Tyra Biosciences
    06/20/24
  193. 69
    LYSINE ACETYLTRANSFERASE 6A (KAT6A) INHIBITORS AND USES THEREOF
    Insilico Medicine Ip
    06/20/24
  194. 56
    NEW SPIRO[3H-INDOLE-3,2'-PYRROLIDIN]-2(1H)-ONE COMPOUNDS AND DERIVATIVES AS MDM2-P53 INHIBITORS
    Boehringer Ingelheim International
    06/20/24
  195. 101
    NOVEL ACC INHIBITORS
    Pfizer
    06/20/24
  196. 22
    PREPARATION AND APPLICATION METHOD OF HETEROCYCLIC COMPOUNDS AS KRAS INHIBITOR
    Shanghai Kechow Pharma
    06/20/24
  197. 485
    PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS
    Actelion Pharmaceuticals
    06/20/24
  198. 19
    PYRIMIDINES FOR DEGRADING BRUTON'S TYROSINE KINASE
    Abbvie
    06/20/24
  199. 4
    SERIES OF PIPERIDINE-SUBSTITUTED BENZOIC ACID COMPOUNDS, AND USE THEREOF
    Medshine Discovery
    06/20/24
  200. 84
    SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE DERIVATIVES, COMPOSITIONS AND PHARMACEUTICAL USES THEREOF
    Shanghai Haiyan Pharmaceutical Technology Co.
    06/20/24
  201. 245
    TRIAZOLYL-METHYL SUBSTITUTED ALPHA-D-GALACTOPYRANOSIDE DERIVATIVES
    Idorsia Pharmaceuticals
    06/20/24
  202. 135
    TRICYCLIC PYRIMIDINES AS CYCLIN-DEPENDENT KINASE 7 (CDK7) INHIBITORS
    Janssen Pharmaceutica
    06/20/24
  203. 10
    Dizocilpine derivatives as peripheral NMDA receptor antagonists
    Institut National De La Sante Et De La Recherche Medicale (Inserm
    06/17/24
  204. 65
    IRE1 small molecule inhibitors
    Cornell University
    06/17/24
  205. 33
    Imidazo[4,5-c]pyridine compounds as LSD-1 inhibitors
    Regents Of The University Of Michigan
    06/17/24
  206. 40
    INHIBITORS OF METTL3
    Strom Therapeutics
    06/12/24
  207. 95
    CARBONYL HETEROCYCLIC COMPOUND AND APPLICATION THEREOF
    Shanghai Pharmaceuticals Holding Co.
    06/11/24
  208. 217
    COMPOUNDS FOR TREATING CERTAIN LEUKEMIAS
    Terns Pharmaceuticals
    06/11/24
  209. 1
    CRYSTAL FORM AND SALT FORM OF BROMINE DOMAIN PROTEIN INHIBITOR AND PREPARATION METHOD THEREFOR
    Chia Tai Tianqing Pharmaceutical Group Co.
    06/11/24
  210. 506
    DIHYDROOXADIAZINONE COMPOUND AND PHARMACEUTICAL USE THEREOF
    Japan Tobacco
    06/11/24
  211. 60
    ERAP INHIBITORS
    Universite De Lille
    06/11/24
  212. 20
    HYDROXAMATE COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
    Shenzhen Chipscreen Biosciences Co.
    06/11/24
  213. 133
    INHIBITORS OF QPCTL AND QPCT
    TBA
    06/11/24
  214. 9
    NOVEL TETRAZOLES
    Boehringer Ingelheim International
    06/11/24
  215. 10
    PROTEIN-PROTEIN INTERACTION MODULATORS OF AURORA KINASE A AND THEIR USE IN THE PREVENTION AND/OR TREATMENT OF CANCER
    Eberhard Karls Universitat Tubingen
    06/11/24
  216. 419
    PYRIDINAMINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS
    Xenon Pharmaceuticals
    06/11/24
  217. 11
    TRICYCLIC KINASE INHIBITORS AND USES THEREOF
    Dana-Farber Cancer Institute
    06/11/24
  218. 9
    TRICYCLIC UBIQUITIN SPECIFIC PROTEASE 1 INHIBITOR AND USE THEREOF
    Shandong Xuanzhu Pharma Co.
    06/11/24
  219. 3
    Methods and compositions relating to steroid hormone receptor-dependent proliferative disorders
    Wayne State University
    06/07/24
  220. 15

    BRIDGED COMPOUNDS AS KRAS G12D INHIBITOR AND DEGRADER AND THE USE THEREOF
    Beigene Switzerland
    06/04/24
  221. 575
    CONDENSED HETEROCYCLIC COMPOUND
    Nissan Chemical
    06/04/24
  222. 92

    DIHYDRO-CYCLOPENTA-ISOQUINOLINE SULFONAMIDES DERIVATIVES
    Ucb Biopharma
    06/04/24
  223. 86
    HETEROAROMATIC COMPOUNDS AND USES THEREOF
    Hutchison Medipharma
    06/04/24
  224. 131

    Heterocycle RMB39 Modulators
    Recursion Pharmaceuticals
    06/04/24
  225. 175
    Heterocyclic Carboxylate Compounds as Glycolate Oxidase Inhibitors
    Lilac Therapeutics
    06/04/24
  226. 392
    IMIDAZOLO INDAZOLE COMPOUNDS AS JAK INHIBITORS
    Theravance Biopharma R&D Ip
    06/04/24
  227. 169
    MNK INHIBITORS
    Hepagene Therapeutics (Hk
    06/04/24
  228. 77
    MU-OPIOID RECEPTOR AGONISTS AND USES THEREFOR
    Kures
    06/04/24
  229. 29
    NOVEL LIGANDS FOR ASIALOGLYCOPROTEIN RECEPTOR
    Sanofi
    06/04/24
  230. 40
    Non-Covalent Inhibitors of the Main Protease of SARS-CoV-2 and Methods of Use
    Yale University
    06/04/24
  231. 5
    PYRIDINE COMPOUNDS AS ALLOSTERIC SHP2 INHIBITORS
    Revolution Medicines
    06/04/24
  232. 122
    QUINAZOLINE COMPOUNDS AND METHODS OF USE
    Iambic Therapeutics
    06/04/24
  233. 4

    USE OF 5-[[4-[2-[5-ACETYLPYRIDIN-2-YL]ETHOXY]BENZYL]-1,3-THIAZOLIDINE-2,4-DIONE AND ITS SALTS
    Minoryx Therapeutics
    06/04/24
  234. 34
    Anti-cancer/anti-fibrosis compounds
    The Regents Of The University Of California
    06/01/24
  235. 426
    2-Methyl-Quinazolines
    Bayer Pharma Aktiengesellschaft
    05/30/24
  236. 13
    ANTAGONISTS OF THE ADENOSINE A2A RECEPTOR
    Adorx Therapeutics
    05/30/24
  237. 14
    BORATE DERIVATIVE AND USES THEREOF
    Reistone Biopharma Company
    05/30/24
  238. 37
    COMPOSITIONS AND METHODS FOR INHIBITING M PRO PROTEASE ACTIVITY AND FOR PREVENTING AND TREATING SARS-COV-2 INFECTION
    Arizona Board Of Regents On Behalf Of The University Of Arizona
    05/30/24
  239. 126
    CYCLIC AMINE DERIVATIVES HAVING SEROTONIN RECEPTOR BINDING ACTIVITY
    Shionogi & Co.
    05/30/24
  240. 208
    GCN2 MODULATING COMPOUNDS AND USES THEREOF
    Hibercell
    05/30/24
  241. 31
    MACROCYCLIC BRANCHED 3-FLUORO-BUT-3-ENAMIDES AS INHIBITORS OF MCL-1
    Janssen Pharmaceutica
    05/30/24
  242. 22
    Nitrogen Containing 2,3-Dihydroquinazolinone Compounds as Nav1.8 Inhibitors
    Glaxosmithkline Intellectual Property Development
    05/30/24
  243. 24
    OXALAMIDE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY
    Ifm Due
    05/30/24
  244. 228
    PYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS BTK INHIBITORS
    Biogen Ma
    05/30/24
  245. 9
    PYRIMIDINE CARBOXAMIDE COMPOUND AND APPLICATION THEREOF
    Shanghai Meiyue Biotech Development Co.
    05/30/24
  246. 19
    Polycyclic Kinase Inhibitor
    Shandong Xuanzhu Pharma Co.
    05/30/24
  247. 55
    SMALL MOLECULE INHIBITOR FOR CATHEPSIN C AND MEDICINAL USE THEREOF
    Reistone Biopharma Company
    05/30/24
  248. 135
    TETRAHYDROTHIENOPYRIMIDINESULFONAMIDE COMPOUNDS
    Modulus Discovery
    05/30/24
  249. 161
    1,2,4-triazole derivatives as tankyrase inhibitors
    Oslo Universitetssykehus
    05/23/24
  250. 46
    Aminopyrazine diol compounds as PI3K-γ inhibitors
    Incyte
    05/23/24
  251. 155
    Diacylglyercol kinase modulating compounds
    Gilead Sciences
    05/23/24
  252. 41
    ADENOSINE A2A AND A2B RECEPTOR DUAL ANTAGONISTS FOR IMMUNO-ONCOLOGY
    Merck Sharp & Dohme
    05/22/24
  253. 26
    Combination therapy comprising JAK pathway inhibitor and rock inhibitor
    Incyte
    05/17/24
  254. 55
    Fused ring compound having urea structure
    Sanford Burnham Prebys Medical Discovery Institute
    05/17/24
  255. 256
    Inhibitors of the menin-MLL interaction
    Syndax Pharmaceuticals
    05/17/24
  256. 106
    P2X3 andor P2X2/3 receptor antagonist, pharmaceutical composition comprising same, and use thereof
    Beijing Tide Pharmaceutical Co.
    05/17/24
  257. 103
    Substituted pyrrolidones and piperidones as small molecule inhibitors of EZH2 and EED protein binding
    Northwestern University
    05/17/24
  258. 107
    Substituted tetrahydrofurans as modulators of sodium channels
    Vertex Pharmaceuticals
    05/17/24
  259. 14
    Sulfonylamide compounds as CDK2 inhibitors
    Incyte
    05/17/24
  260. 34
    [1,2,4]triazolo[1,5-a]pyridine compound as JAK inhibitor and use thereof
    Zhuhai United Laboratories Co.
    05/17/24
  261. 186
    ASGPR-BINDING COMPOUNDS FOR THE DEGRADATION OF EXTRACELLULAR PROTEINS
    Avilar Therapeutics
    05/10/24
  262. 67
    HETEROCYCLIC COMPOUND AS DIACYLGLYCEROL KINASE INHIBITOR AND USE THEREOF
    Lg Chem
    05/10/24
  263. 9
    KETOHEXOKINASE INHIBITOR AND USE THEREOF
    Sichuan Haisco Pharmaceutical Co.
    05/10/24
  264. 36
    MACROCYCLIC SPIROCYCLE DERIVATIVES AS MCL-1 INHIBITORS
    Janssen Pharmaceutica
    05/10/24
  265. 191
    MODIFIED PROTEINS AND PROTEIN DEGRADERS
    Cullgen (Shanghai)
    05/10/24
  266. 44
    NAPHTHYRIDINE AND PYRIDO[3,4-c]PYRIDAZINE DERIVATIVES AS GABAA ALPHA 5 RECEPTOR MODULATORS
    Richter Gedeon
    05/10/24
  267. 145
    PYRAZOLE DERIVATIVES USEFUL AS NAMPT MODULATORS
    Cytokinetics
    05/10/24
  268. 43
    SMALL-MOLECULE MODULATORS OF THE ORPHAN NUCLEAR RECEPTOR TLX
    Baylor College Of Medicine
    05/10/24
  269. 47
    19-nor neuroactive steroids and methods of use thereof
    Sage Therpeutics
    05/03/24
  270. 400
    6-azaindole compounds
    Bristol-Myers Squibb
    05/03/24
  271. 4
    Compound, preparation method and use thereof
    Guangxi Jiufu Biotechnology Co.
    05/03/24
  272. 126
    Compounds
    CTXT PTY
    05/03/24
  273. 639
    Compounds for modulating S1P1 activity and methods of using the same
    Trevena
    05/03/24
  274. 2
    Crystalline and salt forms of PPAR agonist compounds
    Mitobridge
    05/03/24
  275. 175
    GCN2 and perk kinase inhibitors and methods of use thereof
    Deciphera Pharmaceuticals
    05/03/24
  276. 155
    Isoindolinone compounds
    Monte Rosa Therapeutics
    05/03/24
  277. 331
    LPA receptor antagonists and uses thereof
    Gilead Sciences
    05/03/24
  278. 10
    LRRK2 inhibiting compounds and use thereof for treating neurodegenerative diseases
    Consejo Superior De Investigaciones Cientificas
    05/03/24
  279. 16
    Multi-targeted tyrosine kinase inhibitors and their pharmaceutical uses
    Shanghai AB Pharmatech
    05/03/24
  280. 3
    S6K1 protein kinase inhibitors as cancer therapeutics
    Xavier University Of Louisiana
    05/03/24
  281. 48
    Spiropyrrolidine derived antiviral agents
    Enanta Pharmaceuticals
    05/03/24
  282. 30
    COMPOUND CONTAINING 1,3-BENZODIOXOL STRUCTURE AND PREPARATION METHOD AND USE THEREOF
    Xi'An Xintong Pharmaceutical Research
    04/24/24
  283. 9
    Cereblon Ligands and Uses Thereof
    Regents Of The University Of Michigan
    04/24/24
  284. 15
    Cereblon Ligands and Uses Thereof
    Regents Of The University Of Michigan
    04/24/24
  285. 3
    DENDRIMER COMPOSITIONS AND METHODS FOR DRUG DELIVERY TO THE EYE
    Ashvattha Therapeutics
    04/24/24
  286. 384
    ENZYME INHIBITORS
    Kalvista Pharmaceuticals
    04/24/24
  287. 69
    HETEROCYCLIC G-PROTEIN-COUPLED RECEPTOR 52 (GPR52) AGONISTS
    Board Of Regents, The University Of Texas System
    04/24/24
  288. 513
    HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE
    Amgen
    04/24/24
  289. 103
    NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS
    Merck Sharp & Dohme
    04/24/24
  290. 6
    NOVEL GALACTOSIDE INHIBITOR OF GALECTINS
    Galecto Biotech
    04/24/24
  291. 36
    PIPERIDINYLPYRIDINYLCARBONITRILE DERIVATIVES AS INHIBITORS OF GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE AND GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE LIKE PROTEIN
    Boehringer Ingelheim International
    04/24/24
  292. 13
    Pyridine and Pyrazine derivative for the Treatment of CF, COPD, and Bronchiectasis
    Novartis
    04/24/24
  293. 80
    Substituted phenyl ethynyl pyridine carboxamides as potent inhibitors of SARS virus
    Southern Research Institute
    04/24/24
  294. 26
    THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS
    Terns Pharmaceuticals
    04/24/24
  295. 38
    THYROID HORMONE RECEPTOR b SELECTIVE AGONIST COMPOUND, PHARMACEUTICAL COMPOSITION AND USE THEREOF
    Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences
    04/24/24
  296. 26
    TREATMENT OF URTICARIA USING JAK INHIBITORS
    Incyte
    04/24/24
  297. 36
    2-aminoaryl-5-aryloxazole analogs for the treatment of neurodegenerative diseases
    Southern Research Institute
    04/23/24
  298. 4
    3-CYCLIC AMINE-INDOLE DERIVATIVES AS SEROTONERGIC AGENTS FOR THE TREATMENT OF CNS DISORDERS
    Mindset Pharma
    04/23/24
  299. 2
    4-AMINO-3-(4-PHENOXYPHENYL)-1,3-DIHYDRO-2H-IMIDAZO[4,5-C]PYRIDIN-2-ONE DERIVATIVES AND SALTS THEREOF
    Genzyme
    04/23/24
  300. 13
    Anti-malarial agents
    The Board Of Regents Of The University Of Texas System
    04/23/24
  301. 2
    BENZOPYRAZOLE INHIBITORS OF SARM1
    Disarm Therapeutics
    04/23/24
  302. 4
    CARBORANE HYDROXAMIC ACID MATRIX METALLOPROTEINASE INHIBITORS AND AGENTS FOR BORON NEUTRON CAPTURE THERAPY
    Loyola University Of Chicago
    04/23/24
  303. 120
    Chemical modulators of store-operated calcium channels and their therapeutic applications
    The Texas A&M University System
    04/23/24
  304. 30
    DIACYLGLYCEROL KINASE (DGK) ALPHA INHIBITORS AND USES THEREOF
    Insilico Medicine Ip
    04/23/24
  305. 126
    HMOX1 INDUCERS
    Mitobridge
    04/23/24
  306. 66
    ISOINDOLINONE COMPOUNDS
    Monte Rosa Therapeutics
    04/23/24
  307. 5
    Inhibitors for the B-catenin/B-cell lymphoma 9 (BCL9) protein-protein interaction
    H. Lee Moffitt Cancer Center and Research Institute
    04/23/24
  308. 4
    Inhibitors of SARM1 NADase activity and uses thereof
    Washington University
    04/23/24
  309. 61
    METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE
    Design Therapeutics
    04/23/24
  310. 32
    PEPTIDE MACROCYCLES AGAINST ACINETOBACTER BAUMANNII
    Hoffmann-La Roche
    04/23/24
  311. 51
    PYRROLO[3,2-B]PYRIDINE DERIVATIVES USEFUL IN TREATING CONDITIONS ASSOCIATED WITH CGAS
    Novartis
    04/23/24
  312. 11
    Phenoxyacetic acid derivatives, preparation method thereof and use thereof as medicament
    China Pharmaceutical University
    04/23/24
  313. 72
    Receptor inhibitors, pharmaceutical compositions comprising the same and use thereof
    Beijing Tide Pharmaceutical
    04/23/24
  314. 87
    SOS1 INHIBITORS AND USES THEREOF
    Qilu Regor Therapeutics
    04/23/24
  315. 6
    TREATMENTS FOR OBSESSIVE COMPULSIVE DISORDER
    Sirgartan Holdings
    04/23/24
  316. 12
    2-phenyl-3,4-dihydropyrrolo[2,1 -f] [1,2,4]triazinone derivatives as phosphodiesterase inhibitors and uses thereof
    Topadur Pharma
    04/18/24
  317. 20
    Isoxazolidines as RIPK1 inhibitors and use thereof
    Genzyme
    04/18/24
  318. 35
    Pyridine macrocycle compounds as ASK1 inhibiting agents
    Biogen Ma
    04/18/24
  319. 83
    Tricyclic heterocycles as FGFR inhibitors
    Incyte
    04/18/24
  320. 130
    6-phenyl-4,5-dihydropyridazin-3(2H)-one derivatives as PDE3A and PDE3B inhibitors for treating cancer
    Bayer Aktiengesellschaft
    04/17/24
  321. 98
    ErbB/BTK inhibitors
    Dizal (Jiangsu) Pharmaceutical
    04/17/24
  322. 183
    Heterocyclic GLP-1 agonists
    Gasherbrum Bio
    04/17/24
  323. 2
    Indazole amine derivative, preparation method therefor and medical use thereof
    Zhejiang Hisun Pharmaceutical
    04/17/24
  324. 3
    1,3-DIHYDRO-2H-PYRROLO[3,4-C]PYRIDINE DERIVATIVES AS GABAA A5 RECEPTOR MODULATORS
    Richter Gedeon
    04/12/24
  325. 16
    ANTI-HER2 IMMUNOCONJUGATES, AND USES THEREOF
    Bolt Biotherapeutics
    04/12/24
  326. 372
    APOPTOSIS INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES
    Abbvie
    04/12/24
  327. 658
    CD73 COMPOUNDS
    Gilead Sciences
    04/12/24
  328. 125
    COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY
    Case Western Reserve University
    04/12/24
  329. 70
    COMPOUNDS AND COMPOSITIONS AS MODULATORS OF TLR SIGNALING
    Neuropore Therapies
    04/12/24
  330. 159
    COMPOUNDS AS C5AR INHIBITORS
    Kira Pharmaceuticals (Suzhou)
    04/12/24
  331. 25
    COMPOUNDS FOR THE TREATMENT OF SARS
    Purdue Research Foundation
    04/12/24
  332. 120
    HETEROARYL CARBOXAMIDE COMPOUND
    Astellas Pharma
    04/12/24
  333. 160
    MACROCYCLIC COMPOUNDS AS PROTEASOME INHIBITORS
    Cornell University
    04/12/24
  334. 22
    NOVEL BIPHENYL DERIVATIVE AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF
    Xi'An Xinton Pharmaceutcal Research
    04/12/24
  335. 21
    POTENT AND SELECTIVE IRREVERSIBLE INHIBITORS OF IRAK1
    Dana-Farber Cancer Institute
    04/12/24
  336. 50
    SELECTIVE ESTROGEN RECEPTOR DEGRADERS AND USES THEREOF
    Inventisbio
    04/12/24
  337. 93
    Small Molecule Inhibitors of KRAS G12C Mutant
    Merck Sharp & Dohme
    04/12/24
  338. 29
    TRIAZOLONE COMPOUNDS AND USES THEREOF
    Tempest Therapeutics
    04/12/24
  339. 18
    HDAC6 inhibitors and imaging agents
    The General Hospital
    04/08/24
  340. 23
    Indole compounds and their use
    Ariagen
    04/08/24
  341. 108
    Monoacylglycerol lipase modulators
    Janssen Pharmaceutica
    04/08/24
  342. 76
    Pyrazolopyridine compounds and uses thereof
    Incyte
    04/08/24
  343. 18
    Quinolines that modulate SERCA and their use for treating disease
    Neurodon
    04/08/24
  344. 10
    Small molecule modulators of pantothenate kinases
    St. Jude Children'S Research Hospital
    04/08/24
  345. 3
    Sulfonamide or sulfinamide compound having effect of inducing BRD4 protein degradation and pharmaceutical use thereof
    Mitsubishi Tanabe Pharma
    04/08/24
  346. 24
    Tetrazole derivatives as TRPA1 inhibitors
    Boehringer Ingelheim International
    04/08/24
  347. 60
    ANTI-PD-L1 IMMUNOCONJUGATES, AND USES THEREOF
    Bolt Biotherapeutics
    04/04/24
  348. 99
    AZA-QUINAZOLINE COMPOUNDS AND METHODS OF USE
    Iambic Therapeutics
    04/04/24
  349. 4
    CDK INHIBITORS
    Qilu Regor Therapeutics
    04/04/24
  350. 194
    HETEROCYCLIC COMPOUND, INTERMEDIATE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
    Wuhan Ll Science and Technology Development
    04/04/24
  351. 293
    HSD17B13 INHIBITORS AND USES THEREOF
    Fl2022-001
    04/04/24
  352. 103
    Heterocyclic Derivatives as P2X7 Receptor Antagonists
    Breye Therapeutics
    04/04/24
  353. 35
    IMIDAZOLE COMPOUNDS AS INHIBITORS OF ENPP1
    Stingray Therapeutics
    04/04/24
  354. 8
    INHIBITORS OF POSITIVE STRAND RNA VIRUSES
    National Health Research Institutes
    04/04/24
  355. 82
    NOVEL POTASSIUM CHANNEL INHIBITORS
    Saniona
    04/04/24
  356. 47
    PYRAZOLO DERIVATIVES AS HUMAN DIHYDROOROTATE DEHYDROGENASE (HDHODH) INHIBITORS FOR USE AS ANTIVIRALS
    Drug Discovery and Clinic
    04/04/24
  357. 137
    TRICYCLIC COMPOUNDS AS EGFR INHIBITORS
    Qilu Pharmaceutical
    04/04/24
  358. 45
    IRAK degraders and uses thereof
    Kymera Therapeutics
    04/03/24
  359. 86
    Compounds and their uses as MIF inhibitors
    Nanjing Immunophage Biotech Co.
    03/25/24
  360. 51
    Purinone compounds and their use in treating cancer
    Astrazeneca
    03/21/24
  361. 2
    Substituted oxopyridine derivative
    Bayer Pharma Aktiengesellschaft
    03/21/24
  362. 258
    AZA-TETRACYCLIC OXAZEPINE COMPOUNDS AND USES THEREOF
    Genentech
    03/19/24
  363. 29
    COMPOUND USED AS KINASE INHIBITOR AND USE THEREOF
    Tyk Medicines
    03/19/24
  364. 503
    COMPOUNDS AS GCN2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
    Dong-A St Co.
    03/19/24
  365. 3
    Compositions and Methods for Managing Weight
    Unigen
    03/19/24
  366. 289
    PYRIMIDIN-2-YL SULFONAMIDE DERIVATIVES
    Hoffmann-La Roche
    03/19/24
  367. 248
    PYRIMIDINE-AND NITROGEN-CONTAINING BICYCLIC COMPOUND
    Asahi Kasei Pharma
    03/19/24
  368. 108
    RIPK1 INHIBITORS AND METHODS OF USE
    Merck Sharp & Dohme
    03/19/24
  369. 66
    SALT INDUCIBLE KINASE INHIBITORS
    The General Hospital
    03/19/24
  370. 9
    TETRACYCLIC COMPOUNDS AS DGK INHIBITORS
    Incyte
    03/19/24
  371. 187
    TETRAHYDROPYRIDO[3,4-d]PYRIMIDINES AS HPK1 INHIBITORS
    Merck Patent
    03/19/24
  372. 11
    TRIHETEROCYCLIC DERIVATIVE, AND PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF
    Shanghai De Novo Pharmatech Co.
    03/19/24
  373. 148
    Bicyclic compounds and their uses
    Novartis
    03/14/24
  374. 320
    Inhibitors of peptidylarginine deiminases
    Gilead Sciences
    03/14/24
  375. 35
    BENZENESULFONAMIDE DERIVATIVES AND USES THEREOF
    2692372 Ontario
    03/13/24
  376. 5
    BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE
    Prelude Therapeutics
    03/13/24
  377. 26
    COMPOSITIONS AND METHODS FOR THE TREATMENT AND PREVENTION OF NEUROLOGICAL DISORDERS
    Kineta
    03/13/24
  378. 46
    COMPOUND HAVING INHIBITORY ACTIVITY AGAINST O-GLUSACASE AND USE THEREOF
    Medifron Dbt
    03/13/24
  379. 210
    CYCLIC COMPOUNDS AND METHODS OF USING SAME
    SchröDinger
    03/13/24
  380. 83
    MODIFIED IMIDAZOPYRIDINES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS
    Merck Sharp & Dohme
    03/13/24
  381. 24
    MODULATORS OF FPR1 AND METHODS OF USING THE SAME
    Biofront
    03/13/24
  382. 18
    NOVEL INHIBITORS OF PIKFYVE AND METHODS USING SAME
    Tme Therapeutics
    03/13/24
  383. 188
    PYRIDAZINYL AMINO DERIVATIVES AS ALK5 INHIBITORS
    Chiesi Farmaceutici
    03/13/24
  384. 24
    PYRIDO[4,3-b]INDOLE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS
    Ventus Therapeutics U.S.
    03/13/24
  385. 1
    SALT OF COMPOUND FOR DEGRADING BTK, CRYSTAL FORM THEREOF, AND USE THEREOF IN MEDICINE
    Haisco Pharmaceuticals
    03/13/24
  386. 4
    BROMODOMAIN INHIBITORS FOR ANDROGEN RECEPTOR-DRIVEN CANCERS
    Forma Therapeutics
    03/12/24
  387. 11
    COMPOUNDS AND METHODS FOR TREATING VIRAL INFECTIONS
    Beth Israel Deaconess Medical Center
    03/12/24
  388. 34
    Fused pyrimidine derivatives as A2A/A2B inhibitors
    Incyte
    03/07/24
  389. 49
    Indanes as PD-L1 inhibitors
    Chemocentryx
    03/07/24
  390. 178
    Pyridazinone compounds and uses thereof
    Edgewise Therapeutics
    03/07/24
  391. 42
    Trans-indoline cyclopropylamine chemical compound, and method for preparation, pharmaceutical composition, and use thereof
    Shanghai Institute of Materia Medica
    03/07/24
  392. 20
    ABHD6 ANTAGONIST
    Ono Pharmaceutical Co.
    03/04/24
  393. 89
    MASP INHIBITORY COMPOUNDS AND USES THEREOF
    Bayer Aktiengesellschaft
    03/04/24
  394. 18
    MODULATORS OF PROGRAMMED DEATH-LIGAND-1
    Southern Research Institute
    03/04/24
  395. 32
    PYRIMIDINYL SULFONAMIDES AS INHIBITORS OF ACK1/TNK2 TYROSINE KINASE
    H. Lee Moffitt Cancer Center and Research Institute
    03/04/24
  396. 51
    TETRAZOLE DERIVATIVES
    Merck Patent
    03/04/24
  397. 16
    TRIAZINE DIONE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF IN MEDICINE
    Jiangsu Hengrui Pharmaceuticals Co.
    03/04/24
  398. 181
    Benzo[c][2,6]naphthyridine derivatives, compositions and therapeutic uses thereof
    Cambridge Enterprise
    03/02/24
  399. 83
    Heteroaryl-biphenyl amines for the treatment of PD-L1 diseases
    Chemocentryx
    03/02/24
  400. 210
    Modulators of Cystic Fibrosis Transmembrane Conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulators
    Vertex Pharmaceuticals
    03/02/24
  401. 288
    Naphthyridinone compounds useful as T cell activators
    Bristol-Myers Squibb
    03/02/24
  402. 136
    Streptococcus mutans glucosyl transferase inhibitors for dental caries therapy
    Uab Research Foundation
    03/02/24
  403. 107
    Substituted indazoles as IRAK4 inhibitors
    Astrazeneca
    03/02/24
  404. 421
    4-ALKOXYPYRROLO[2,1-F][1,2,4]TRIAZINES AND PREPARATION AND USES THEREOF
    Biosplice Therapeutics
    02/28/24
  405. 11
    ANTICHOLINERGIC AGENTS
    Rezubio Pharmaceuticals Co.
    02/28/24
  406. 126
    COMBINATION OF AN ALPHA2-ADRENOCEPTOR SUBTYPE C (ALPHA-2C) ANTAGONIST WITH A TASK1/3 CHANNEL BLOCKER FOR THE TREATMENT OF SLEEP APNEA
    Bayer Aktiengesellschaft
    02/28/24
  407. 12
    COMPOUNDS AND USE THEREOF IN METHODS OF TREATMENT
    University of Queensland
    02/28/24
  408. 1
    DEUTERIUM-MODIFIED THIENOPYRIDONE COMPOUND
    Chia Tai Tianqing Pharmaceutical Group Co.
    02/28/24
  409. 1
    METHOD FOR PREPARING BTK DEGRADING AGENT
    Haisco Pharmaceuticals
    02/28/24
  410. 3
    PYRIDAZINE AND 1,2,4-TRIAZINE DERIVATIVES AS FGFR KINASE INHIBITORS
    Beta Pharma
    02/28/24
  411. 78
    PYRIMIDINONE COMPOUNDS AND USES THEREOF
    Hutchison Medipharma
    02/28/24
  412. 5
    PYRROLOPYRIDINE COMPOUND AND APPLICATION THEREOF
    Medshine Discovery
    02/28/24
  413. 26
    REV-ERB AGONISTS
    Saint Louis University
    02/28/24
  414. 1
    SALT OF PYRROLOPYRIMIDINE COMPOUND, CRYSTALLINE FORM THEREOF, AND APPLICATION THEREOF
    Guangzhou Joyo Pharmatech Co.
    02/28/24
  415. 44
    SUBSTITUTED BENZO[f][l ,2,4JTRIAZOL0[4,3-a][l ,4JDIAZEPINES AS GABA A GAMMA! POSITIVE ALLOSTERIC MODULATORS
    Hoffmann-La Roche
    02/28/24
  416. 93
    THERAPEUTIC COMPOUNDS AND METHODS
    University of Minnesota
    02/28/24
  417. 5
    4-[[(7-aminopyrazolo[1,5-a]pyrimidin-5-yl)amino]methyl]piperidin-3-ol compounds as CDK inhibitors
    Carrick Therapeutics
    02/22/24
  418. 21
    Alkyne-containing antiviral agents
    Enanta Pharmaceuticals
    02/22/24
  419. 48
    Cathepsin L inhibitors
    Biofront Therapeutics (Beijing) Co.
    02/22/24
  420. 46
    Glycyrrhetinic acid derivatives for use in treating hyperkalemia
    Ardelyx
    02/22/24
  421. 144
    Inhibiting agents for bruton's tyrosine kinase
    Biogen Ma
    02/22/24
  422. 15
    Peptidomimetics for the treatment of Norovirus infection
    Emory University
    02/22/24
  423. 11
    Pharmaceutical compositions comprising substituted nucleotides and nucleosides for treating viral infections
    Emory University
    02/22/24
  424. 24
    ADENOSINE ANALOGS FOR THE TREATMENT OF DISEASE
    Biointervene
    02/19/24
  425. 37
    AMIDE COMPOUND, PHARMACEUTICAL COMPOSITION AND USE THEREOF
    Artivila (Shenzhen) Innovation Center
    02/19/24
  426. 3
    BENZODIAZEPINE COMPOUNDS, AND PREPARATION METHOD THEREFOR AND USE THEREOF
    China Pharmaceutical University
    02/19/24
  427. 35
    DIHYDROISOQUINOLINONE AND ISOINDOLINONE DERIVATIVES AND USES THEREOF
    Hefei Institutes of Physical Science, Chinese Academy of Sciences
    02/19/24
  428. 51
    HETEROARYLQUINAZOLINE COMPOUNDS AS PROTEIN KINASE INHIBITORS
    Chengdu Cynogen Bio-Pharmaceutical Technology
    02/19/24
  429. 88
    PYRIMIDINONE-CONTAINING 17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 13 INHIBITORS
    Enanta Pharmaceuticals
    02/19/24
  430. 8
    INHIBITION OF THE HIV-1 REPLICATION BY COMPOUNDS DIRECTED AGAINST A NEW TARGET OF THE VIRAL CYCLE
    Centre National De La Recherche Scientifique
    02/18/24
  431. 7
    PSMA INHIBITOR, COMPOUND AND APPLICATION
    Peking University First Hospital
    02/18/24
  432. 14
    SARM1 ENZYME ACTIVITY INHIBITOR AND USE THEREOF IN NEURODEGENERATIVE DISEASES
    Artivila Biopharma
    02/18/24
  433. 3
    USE OF PRIDOPIDINE AND ANALOGS FOR TREATING RETT SYNDROME
    Prilenia Neurotherapeutics
    02/18/24
  434. 137
    Bicyclic amines as CDK2 inhibitors
    Incyte
    02/15/24
  435. 13
    Fused bicyclic pyrimidine derivatives and uses thereof
    The Regents of The University of Colorado, A Body Corporate
    02/15/24
  436. 114
    Substituted pyrazolo[1,5-A]pyrazine compounds as ret kinase inhibitors
    Array Biopharma
    02/15/24
  437. 118
    Arginase inhibitors
    Rijksuniversiteit Groningen
    02/12/24
  438. 22
    COMBINATIONS OF DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITORS AND ACETYL-COA CARBOXYLASE INHIBITOR
    Pfizer
    02/12/24
  439. 48
    N-(2-(3-CYANO-2-AZABICYCLO[3.1.0]HEXAN-2-YL)-2-OXOETHYL)QUINOLINE-4-CARBOXAMIDES
    Astrazeneca
    02/12/24
  440. 2
    SUBSTITUTED PYRROLO [2, 3-b] PYRIDINE AND PYRAZOLO [3, 4-b] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS
    Fochon Biosciences
    02/12/24
  441. 118
    1,3-substituted cyclobutyl derivatives and uses thereof
    Novartis
    02/08/24
  442. 818
    Diacylglycerol kinase modulating compounds
    Gilead Sciences
    02/08/24
  443. 10
    Glutaminyl cyclase inhibitors and the use thereof in treatment of various diseases
    Ltd “Valenta-Intellekt”
    02/08/24
  444. 8
    Opioid compounds and uses thereof
    Rhodes Technologies
    02/08/24
  445. 1
    Oral compositions of MK2 pathway inhibitor for treatment of immune conditions
    Aclaris Therapeutics
    02/08/24
  446. 140
    USP30 inhibitors and uses thereof
    Vincere Biosciences
    02/08/24
  447. 7
    ANTIBODIES FOR OPIOID TREATMENTS
    The Scripps Research Institute
    02/03/24
  448. 413
    Acylsulfamide Compound and Pharmaceutical Use Therefor
    Japan Tobacco
    02/03/24
  449. 20
    CD73 INHIBITOR AND USE THEREOF
    Wuhan Humanwell Innovative Drug Research and Development Center
    02/03/24
  450. 99
    HIGH ACTIVITY HPK1 KINASE INHIBITOR
    Adlai Nortye Biopharma Co.
    02/03/24
  451. 27
    IMIDAZO[1,2-a]PYRAZINE OR PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVE AND USE THEREOF
    TENCENT TECHNOLOGY (SHENZHEN) COMPANY LIMITED
    02/03/24
  452. 7
    RNA VIRUS INHIBITOR COMPOUNDS WITH IMPROVED METABOLIC STABILITY AND USES THEREOF
    The Governors of The University of Alberta
    02/03/24
  453. 136
    TRICYCLIC TRIAZOLO COMPOUNDS AS DGK INHIBITORS
    Incyte
    02/03/24
  454. 25
    Alkynyl(hetero)aromatic compound for inhibiting protein kinase activity
    Shenzhen Targetrx
    02/02/24
  455. 15
    CDK8/19 inhibitors
    Joint Stock Company “Biocad”
    02/02/24
  456. 4
    IRE1α inhibitors and uses thereof
    The Regents of The University of California
    02/02/24
  457. 4
    Imidazopyridazine compounds and uses thereof
    Incyte
    02/02/24
  458. 6
    Pyridinone-based epigenetic modifiers and uses thereof
    The Board of Trustees of The University of Illinois
    02/02/24
  459. 1
    Radiolabelled MGL pet ligands
    Janssen Pharmaceutica
    02/02/24
  460. 62
    Substituted nicotinimide inhibitors of BTK for treating cancer
    Guangzhou Innocare Pharma Tech Co.
    02/02/24
  461. 456
    Pyrimidine derivatives as PGE2 receptor modulators
    Idorsia Pharmaceuticals
    02/01/24
  462. 25
    3-TETRAZOLYLMETHYL-1,3,5-TRIAZIN-2,4-DIONE COMPOUND INHIBITING CORONAVIRUS 3CL PROTEASE ACTIVITY AND PREPARATION METHOD AND USE THEREOF
    Shaanxi Panlong Pharmaceutical Co.
    01/28/24
  463. 120
    BICYCLIC INHIBITORS OF IRAK
    Rigel Pharmaceuticals
    01/28/24
  464. 12
    BIPHENYL PYRROLIDINE AND BIPHENYL DIHYDROIMIDAZOLE DERIVATIVES FOR INHIBITING ACTIVITY OF 5-HT7 SEROTONIN RECEPTOR, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT
    Korea Institute of Science and Technology
    01/28/24
  465. 27
    IMIDAZOPYRIDINE DERIVATIVES AND AZA-IMIDAZOPYRIDINE DERIVATIVES AS JANUS KINASE 2 INHIBITORS AND USES THEREOF
    Dana-Farber Cancer Institute
    01/28/24
  466. 331
    INHALED FORMULATIONS OF PGDH INHIBITORS AND METHODS OF USE THEREOF
    Epirium Bio
    01/28/24
  467. 123
    INHIBITORS OF THE INTERACTION BETWEEN TRIP8B AND HCN CHANNELS AND USES THEREOF FOR TREATING NEUROLOGICAL DISEASES AND DISORDERS
    Northwestern University
    01/28/24
  468. 65
    MALT1 MODULATORS AND USES THEREOF
    Rheos Medicines
    01/28/24
  469. 49
    METTL3 INHIBITORY COMPOUNDS
    Storm Therapeutics
    01/28/24
  470. 39
    MODIFIED BENZOFURAN-CARBOXAMIDES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS
    Merck Sharp & Dohme
    01/28/24
  471. 12
    MODULATORS OF PD-L1/PD-1 INTERACTION AND USES THEREOF
    Ramot at Tel-Aviv University
    01/28/24
  472. 22
    SUBSTITUTED DIARYLAMINE COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF, PREPARATION METHOD THEREFOR, AND USE THEREOF
    Suzhou Yabao Pharmaceutical R&D Co.
    01/28/24
  473. 17
    SUBSTITUTED S-ALANINATE DERIVATIVES
    Bayer Aktiengesellschaft
    01/28/24
  474. 3
    USE OF PRIDOPIDINE AND ANALOGS FOR THE TREATMENT OF ANXIETY AND DEPRESSION
    Prilenia Neurotherapeutics
    01/28/24
  475. 322
    cGAS INHIBITORS
    Eli Lilly
    01/28/24
  476. 304
    Substituted indazoles as hematopoietic progenitor kinase 1 (HPK1) inhibitors
    1St Biotherapeutics
    01/24/24
  477. 15
    1-methyl-4-[(4-phenylphenyl)sulfonylmethyl]cyclohexyanol and 1-methyl-4-[[4-(2-pyridyl)phenyl]sulfonylmethyl]cyclohexanol compounds and their therapeutic use
    Modern Biosciences
    01/23/24
  478. 16
    Anti-cancer nuclear hormone receptor-targeting compounds
    Nuvation Bio
    01/23/24
  479. 101
    Beta-lactam derivatives for the treatment of diseases
    Insilico Medicine Ip
    01/23/24
  480. 119
    Compounds useful as inhibitors of isoprenylcysteine carboxyl methyltransferase
    Agency For Science, Technology and Research
    01/23/24
  481. 23
    Heterocyclic compounds as pad inhibitors
    Jubilant Epipad
    01/23/24
  482. 1
    SSTR4 agonist salts
    Eli Lilly
    01/23/24
  483. 23
    Substituted amino six-membered nitric heterocyclic ring compound and preparation and use thereof
    Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    01/23/24
  484. 483
    Substituted pyrimido[5,4-d]pyrimidines as HER2 inhibitors
    Array Biopharma
    01/23/24
  485. 152
    COMPOUNDS FOR INHIBITING KIF18A
    Volastra Therapeutics
    01/19/24
  486. 2
    CSF1R KINASE INHIBITOR AND USE THEREOF
    Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    01/19/24
  487. 55
    FUSED TETRACYCLIC QUINAZOLINE DERIVATIVES AS INHIBITORS OF ERBB2
    Enliven Therapeutics
    01/19/24
  488. 30
    GCN2 AND PERK KINASE INHIBITORS AND METHODS OF USE THEREOF
    Deciphera Pharmaceuticals
    01/19/24
  489. 316
    HDAC6 INHIBITORS FOR TREATMENT OF METABOLIC DISEASE AND HFPEF
    Tenaya Therapeutics
    01/19/24
  490. 6
    HETEROARYL HETEROCYCLIC COMPOUNDS AND USES THEREOF
    Hutchison Medipharma
    01/19/24
  491. 45
    MEK INHIBITORS AND USES THEREOF
    Ikena Oncology
    01/19/24
  492. 31
    N-AROMATIC AMIDE COMPOUNDS, PREPARATION METHODS AND USES THEREOF
    Shenzhen Edk Pharmaceutical Technology
    01/19/24
  493. 4
    OXA- IBOGAINE INSPIRED ANALOGUES FOR TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS
    The Trustees of Columbia University In The City of New York
    01/19/24
  494. 78
    PYRAZOLEAMIDE DERIVATIVES
    Hoffmann-La Roche
    01/19/24
  495. 7
    Phenyl-3,4-dihydroisoquinolin-2(1h)-yl-ethan-1-one derivatives as dopamine d1receptor positive allosteric modulators
    Eli Lilly
    01/19/24
  496. 390
    SUBSTITUTED 4-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)THIOPHENE-2-CARBOXAMIDE DERIVATIVES AND USE THEREOF
    The Johns Hopkins University
    01/19/24
  497. 16
    Anti-cancer nuclear hormone receptor-targeting compounds
    Nuvation Bio
    01/17/24
  498. 6
    Conduritol aziridine derivatives and uses thereof
    University of Saskatchewan
    01/17/24
  499. 43
    Pyrazine derivative and application thereof in inhibiting SHP2
    Suzhou Genhouse Pharmaceutical
    01/17/24
  500. 39
    MACROCYCLIC PEPTIDE BORONATE IMMUNOMODULATORS
    Bristol-Myers Squibb
    01/16/24
  501. 212
    5-SUBSTITUTED INDOLE 3-AMIDE DERIVATIVES, PREPARATION METHOD AND USE THEREOF
    Origiant Pharmaceutical
    01/12/24
  502. 13
    BIPHENYL COMPOUND AS IMMUNOMODULATOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
    Shenzhen Chipscreen Biosciences
    01/12/24
  503. 49
    FUSED TRICYCLIC PYRIMIDINE-THIENO-PYRIDINE SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28
    Dana-Farber Cancer Institute
    01/12/24
  504. 84
    HETEROCYCLIC PERICONDENSED CDC7 KINASE INHIBITORS FOR THE TREATMENT OF CANCER
    SchrÖDinger
    01/12/24
  505. 64
    INHIBITOR OF ENHANCER OF ZESTE HOMOLOGUE 2, AND USE THEREOF
    Haisco Pharmaceuticals
    01/12/24
  506. 23
    N-ACYL AMINO ACID COMPOUNDS AND METHODS OF USE
    Pliant Therapeutics
    01/12/24
  507. 135
    PLK1 POLO BOX DOMAIN INHIBITORS AND METHOD OF TREATING CANCER
    The United States of America,As Represented By The Secretary,Department of Health and Human Services
    01/12/24
  508. 38
    SUBSTITUTED PYRROLO-PYRIDINONE DERIVATIVES AND THERAPEUTIC USES THEREOF
    The Broad Institute
    01/12/24
  509. 20
    TETRAHYDROISOQUINOLINE DERIVATIVE AND USE THEREOF
    Medshine Discovery
    01/12/24
  510. 79
    BACTERIAL DNA GYRASE INHIBITORS AND METHODS OF USE THEREOF
    The Florida International University Board of Trustees
    01/11/24
  511. 154
    COMPOUND AS BRAIN-PERMEABLE BTK OR HER2 INHIBITOR, PREPARATION METHOD THEREFOR, AND USE THEREOF
    Chengdu Hyperway Pharmaceuticals
    01/11/24
  512. 271
    POLO LIKE KINASE 4 INHIBITORS
    Oric Pharmaceuticals
    01/11/24
  513. 88
    QUINAZOLINE-2,4-DIAMINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING SAME AS ACTIVE INGREDIENT
    The Asean Foundation
    01/11/24
  514. 47
    TRUXILLIC ACID MONOESTER-DERIVATIVES AS SELECTIVE FABP5 INHIBITORS AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
    The Research Foundation For The State University of New York
    01/11/24
  515. 22
    Fused pyrrolines which act as ubiquitin-specific protease 30 (USP30) inhibitors
    Forma Therapeutics
    01/08/24
  516. 784
    Inhibitors of glycogen synthase 1 (GYS1) and methods of use thereof
    Maze Therapeutics
    01/08/24
  517. 92
    Inhibtors of Raf kinases
    Kinnate Biopharma
    01/08/24
  518. 54
    Macrocyclic compounds for the treatment of medical disorders
    Achillion Pharmaceuticals
    01/08/24
  519. 8
    Substituted pyrrolo[2,3-d]pyrimidines and pyrazolo[3,4-d]pyrimidines as inhibitors for multi-resistant cancers
    Ferris State University
    01/08/24
  520. 6
    1H-PYRROLO[2,3-C]PYRIDINE COMPOUNDS AND APPLICATION THEREOF
    Medshine Discovery
    01/04/24
  521. 192
    AGONISTS OF STIMULATOR OF INTERFERON GENES STING
    The Scripps Research Institute
    01/04/24
  522. 64
    MACROCYCLIC COMPOUND
    Asahi Kasei Pharma
    01/04/24
  523. 169
    NEW MACROCYCLIC LRRK2 KINASE INHIBITORS
    Les Laboratoires Servier
    01/04/24
  524. 10
    PREPARATION OF BIARYL RING-LINKED AROMATIC HETEROCYCLIC DERIVATIVE AS IMMUNOMODULATOR AND USE THEREOF
    Shanghai Longwood Biopharmaceuticals
    01/04/24
  525. 69
    PYRIDO[2,3-D]PYRIMIDIN-4-AMINES AS SOS1 INHIBITORS
    Bayer Aktiengesellschaft
    01/04/24
  526. 11
    PYRROLOPYRIMIDINE COMPOUND AS BTK INHIBITOR AND USE THEREOF
    Medshine Discovery
    01/04/24
  527. 42
    SMALL MOLECULE INHIBITORS OF BACTERIAL TOXINS
    Artizan Biosciences
    01/04/24
  528. 334
    4-hydroxypiperidine derivatives and their use as inhibitors of ubiquitin specific protease 19 (USP19)
    Almac Discovery
    12/29/23
  529. 57
    Fused tetracyclic quinazoline derivatives as inhibitors of ErbB2
    Enliven Therapeutics
    12/29/23
  530. 12
    Nitrile derivative that acts as inhibitor of dipeptidyl peptidase 1 and use thereof
    Haisco Pharmaceuticals
    12/29/23
  531. 31
    Prevention and/or treatment of CNS disorders
    Ildong Pharmaceutical
    12/29/23
  532. 1
    Site specific homogeneous with KSP inhibitors
    Bayer Pharma Aktiengesellschaft
    12/29/23
  533. 13
    Substituted pyrimidinones as agonists of the APJ receptor
    Amgen
    12/29/23
  534. 44
    Sulfonamide derivatives for protein degradation
    Dana-Farber Cancer Institute
    12/29/23
  535. 100
    INHIBITORS OF TYROSINE KINASE 2 MEDIATED SIGNALING
    Abbvie
    12/25/23
  536. 127
    NOVEL PHTHALAZINE DERIVATIVE HAVING ECTONUCLOEOTIDE PYROPHOSPHATASE/PHOSPHODIESTE RASE INHIBITORY ACTIVITY, AND USE THEREOF
    Txinno Bioscience
    12/25/23
  537. 8
    Toll-like receptor ligands
    Inimmune
    12/24/23
  538. 46
    2-AMINOPYRIMIDINE COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF AND APPLICATION THEREOF
    Guangzhou Salustier Biosciences
    12/20/23
  539. 53
    5-HT2A RECEPTOR INHIBITOR OR INVERSE AGONIST, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
    Geneora Pharma (Shijiazhuang) Co.
    12/20/23
  540. 37
    A COMPOUND HAVING INHIBITORY ACTIVITY AGAINST KRAS G12D MUTATION
    Taiho Pharmaceutical
    12/20/23
  541. 16
    BIOPROBES FOR LYSYL OXIDASES AND USES THEREOF
    Pharmaxis
    12/20/23
  542. 33
    BISPECIFIC ANTAGONISTS OF RETINOL-BINDING PROTEIN 4 THAT STABILIZE TRANSTHYRETIN TETRAMERS, THEIR PREPARATION, AND USE IN THE TREATMENT OF COMMON AGE-RELATED COMORBIDITIES
    The Trustees of Columbia University In The City of New York
    12/20/23
  543. 32
    Benzimidazole derivatives
    Hoffmann-La Roche
    12/20/23
  544. 319
    CARBOXYLIC ACID-CONTAINING COMPOUNDS AS MODULATORS OF BIS-PHOSPHOGLYCERATE MUTASE FOR THE TREATMENT OF SICKLE CELL DISEASE
    Genzyme
    12/20/23
  545. 176
    GALECTIN-3 INHIBITING 2-HYDROXYCYCLOALKANE-1-CARBAMOYL DERIVATIVES
    Idorsia Pharmaceuticals
    12/20/23
  546. 29
    HALOGENATED-HETEROARYL AND OTHER HETEROCYCLIC KINASE INHIBITORS, AND USES THEREOF
    Iomx Therapeutics
    12/20/23
  547. 262
    HETEROCYCLIC COMPOUNDS AND METHODS OF USE
    SchröDinger
    12/20/23
  548. 23
    Heteroaryl Derivative, Preparation Method Therefor, And Use Thereof
    Zhejiang Hisun Pharmaceutical
    12/20/23
  549. 27
    IMIDAZO[4,5-C]QUINOLINE COMPOUNDS AND THEIR USE AS ATM KINASE INHIBITORS
    Deutsches Krebsforschungszentrum
    12/20/23
  550. 623
    OXOPYRROLIDINE FPR2 AGONISTS
    Bristol-Myers Squibb
    12/20/23
  551. 3
    PYRROLIDINE COMPOUND AND USE THEREOF
    Simcere Pharmaceutical
    12/20/23
  552. 163
    QUINAZOLINONES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND METHODS OF USING THE SAME
    Repare Therapeutics
    12/20/23
  553. 30
    SUBSTITUTED PYRIDINES AS PARP1 INHIBITORS
    Xinthera
    12/20/23
  554. 7
    SULFONYLUREA DERIVATIVE AND MEDICAL USES THEREOF
    Shanghai Senhui Medicine
    12/20/23
  555. 24
    2-amino-N-(arylsulfinyl)-acetamide compounds as inhibitors of bacterial aminoacyl-tRNA synthetase
    Oxford Drug Design
    12/13/23
  556. 105
    2-oxoimidazolidine-4-carboxamides as NAv1.8 inhibitors
    Merck Sharp & Dohme
    12/13/23
  557. 64
    Azetidine and pyrrolidine PARP1 inhibitors and uses thereof
    Xinthera
    12/13/23
  558. 21
    Compounds for the modulation of cyclophilins function
    The University Court of The University of Edinburgh
    12/13/23
  559. 481
    Cyclobutyl amide monoacylglycerol lipase modulators
    Janssen Pharmaceutica
    12/13/23
  560. 76
    Glutarimides for medical treatment
    C4 Therapeutics
    12/13/23
  561. 188
    Heterocyclic compounds as monoacylglycerol lipase inhibitors
    Hoffmann-La Roche
    12/13/23
  562. 131
    AMINO ALCOHOL COMPOUNDS AND USES THEREOF
    Kineta
    12/10/23
  563. 264
    BIOMARKERS FOR CANCER THERAPY USING MDM2 ANTAGONISTS
    Otsuka Pharmaceutical
    12/10/23
  564. 153
    CASEIN KINASE 1 DELTA MODULATORS
    Janssen Pharmaceutica
    12/10/23
  565. 29
    COMPOUNDS FOR PREVENTION OR TREATMENT OF NEURODEGENERATIVE DISORDERS
    1St Biotherapeutics
    12/10/23
  566. 9
    HPK1 INHIBITORS AND USES THEREOF
    Qilu Regor Therapeutics
    12/10/23
  567. 4
    INDAZOLE DERIVATIVES AS CANNABINOID RECEPTOR PARTIAL AGONISTS
    Research Triangle Institute
    12/10/23
  568. 197
    KRAS G12D MODULATING COMPOUNDS
    Gilead Sciences
    12/10/23
  569. 187
    MACROCYCLIC HETEROCYCLES AND USES THEREOF
    Kumquat Biosciences
    12/10/23
  570. 59
    MODULATORS OF ALPHA-1 ANTITRYPSIN
    Vertex Pharmaceuticals
    12/10/23
  571. 19
    NOVEL PHARMACOLOGICAL CHAPERONE COMPOUNDS OF HUMAN ACID ALPHA-GLUCOSIDASE AND THE THERAPEUTIC USE THEREOF
    UniversitÉ
    12/10/23
  572. 60
    SHP2 INHIBITOR AND COMPOSITION AND APPLICATION THEREOF
    Betta Pharmaceuticals
    12/10/23
  573. 555
    STEROIDAL COMPOSITIONS AND METHODS OF TREATING LIPOGENIC CANCERS
    Asteroid Therapeutics
    12/10/23
  574. 54
    SUBSTITUTED 1H-PYRROLO[3,2-B]PYRIDINE COMPOUNDS AND METHODS OF USE THEREOF
    Bayer Aktiengesellschaft
    12/10/23
  575. 128
    URACIL DERIVATIVES AS MER-AXL INHIBITORS
    Bristol-Myers Squibb
    12/10/23
  576. 37
    Compounds and pharmaceutical uses thereof
    SyneuRx International (Taiwan)
    12/05/23
  577. 9
    Compounds for the treatment of SARS
    Purdue Research Foundation
    12/05/23
  578. 97
    MAP4K4 inhibitors
    Imperial College Innovations
    12/05/23
  579. 122
    Pyrrolotriazinones and imidazotriazinones as ubiquitin-specific protease 7 inhibitors
    Valo Health
    12/05/23
  580. 30
    Substituted pyridines as PARP1 inhibitors
    Xinthera
    12/05/23
  581. 51
    Tetrahydro-benzoazepine glycosidase inhibitors
    Asceneuron
    12/05/23
  582. 3
    Uses of a lysyl oxidase-like 2 inhibitor
    Pharmakea
    12/05/23
  583. 78
    AROMATIC ETHYLENE COMPOUND AND PREPARATION METHOD THEREFOR, AND INTERMEDIATE, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF
    Guangzhou Maxinovel Pharmaceuticals
    12/01/23
  584. 1
    INDOLO HEPTAMYL OXIME ANALOG CRYSTAL AS PARP INHIBITOR AND METHOD FOR PREPARING SAME
    Chia Tai Tianqing Pharmaceutical Group
    12/01/23
  585. 73
    INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY
    University of Virginia Patent Foundation
    12/01/23
  586. 1
    N-((1-BENZYLPIPERIDIN-3-YL)METHYL)-N-(2-METHOXYETHYL)NAPHTHALENE-2-SULFONAMIDE FOR THE TREATMENT OF CANINE COGNITIVE DYSFUNCTION AND OTHER FORMS OF DEMENTIA IN DOGS
    Univerza V Ljubljani
    12/01/23
  587. 7
    NOVEL SPIROPYRROLIDINE DERIVED ANTIVIRAL AGENTS
    Enanta Pharmaceuticals
    12/01/23
  588. 15
    Pyrazolopyridine Compounds and Methods of Inhibiting IRE1 Using Same
    Optikira
    12/01/23
  589. 18
    5-[[4-[[morpholin-2-yl]methylamino]-5-(trifluoromethyl)-2 Pyridyl]Amino]Pyrazine-2-carbonitrile and therapeutic uses thereof
    Cancer Research Technology
    11/29/23
  590. 165
    Aryl piperidines as monoacylglycerol lipase modulators
    Janssen Pharmaceutica
    11/29/23
  591. 79
    Compound having PD-L1 inhibitory activity, preparation method therefor and use thereof
    Shanghai Ennovabio Pharmaceuticals
    11/29/23
  592. 142
    Diacylglyceride O-acyltransferase 2 inhibitors
    Merck Sharp & Dohme
    11/29/23
  593. 157
    Dihydrobenzimidazolones for medical treatment
    C4 Therapeutics
    11/29/23
  594. 7
    Inhibiting ataxia telangiectasia and RAD3-related protein (ATR)
    Celator Pharmaceuticals
    11/29/23
  595. 94
    Inhibitors of VAP-1
    Acucela
    11/29/23
  596. 2
    Isoquinolinyl triazolone complexes
    Takeda Pharmaceutical
    11/29/23
  597. 8
    Methods of inhibiting cyclooxygenase
    King Faisal University
    11/29/23
  598. 150
    Plasma Kallikrein inhibitors and uses thereof
    Takeda Pharmaceutical
    11/29/23
  599. 46
    Pyrazolopyrimidine compounds as adenosine receptor antagonists
    Exscientia
    11/29/23
  600. 255
    Quaternary indazole glucocorticoid receptor antagonists
    Corcept Therapeutics
    11/29/23
  601. 2
    Solid forms of an HPK1 inhibitor
    Incyte
    11/29/23
  602. 34
    Substituted pyrazolo[4,3-d]pyrimidines and imidazo[5,1 -f][1,2,4]triazines as androgen receptor and phosphodiesterase dual inhibitors
    Ildong Pharmaceutical
    11/29/23
  603. 46
    Therapeutic compounds and methods of use
    Genentech
    11/29/23
  604. 27
    ARYL PHOSPHOROUS OXIDE COMPOUNDS AND USE THEREOF
    Chengdu Di''Ao Jiuhong Pharmaceutical Factory
    11/22/23
  605. 137
    ARYL SUBSTITUTED PYRROLO-PYRIDINONES AND THERAPEUTIC USES THEREOF
    Bayer Aktiengesellschaft
    11/22/23
  606. 85
    BROAD SPECTRUM ANTI-CANCER COMPOUNDS
    The Regents of The University of California
    11/22/23
  607. 14
    CDK9 INHIBITORS
    Biolexis Therapeutics
    11/22/23
  608. 3
    COMBINATION THERAPY
    Pfizer
    11/22/23
  609. 5
    FUSED IMIDAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF
    Jiangsu Hengrui Medicine
    11/22/23
  610. 37
    FUSED TRICYCLIC DERIVATIVE AND PHARMACEUTICAL APPLICATION THEREOF
    Chia Tai Tianqing Pharmaceutical Group
    11/22/23
  611. 32
    HETEROAROMATIC RING COMPOUND AS RET KINASE INHIBITOR, AND PREPARATION AND USE THEREOF
    Jiangsu Chia Tai Fenghai Pharmaceutical
    11/22/23
  612. 29
    IMIDAZOTRIAZINE AND PYRROLOPYRIMIDINE DERIVATIVES AS KRAS G12C INHIBITORS
    Beigene
    11/22/23
  613. 326
    NEUROACTIVE STEROIDS AND THEIR METHODS OF USE
    Sage Therapeutics
    11/22/23
  614. 32
    NOVEL BIARYL DERIVATIVE USEFUL AS DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITOR, AND USE THEREOF
    Lg Chem
    11/22/23
  615. 178
    OXADIAZOLE HDAC6 INHIBITORS AND USES THEREOF
    Eikonizo Therapeutics
    11/22/23
  616. 174
    PYRAZOLOPYRIDAZINONE COMPOUND, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF
    Broadenbio
    11/22/23
  617. 16
    TRIAZOLE DERIVATIVES AND THEIR USE AS TANKYRASE INHIBITORS
    Oslo Universitetssykehus
    11/22/23
  618. 9
    UNIT DOSAGE COMPOSITION OF AKT INHIBITOR
    Nanjing Chia Tai Tianqing Pharmaceutical
    11/22/23
  619. 1441
    FGFR inhibitors and methods of use thereof
    Relay Therapeutics
    11/17/23
  620. 253
    Imino sulfanone inhibitors of ENPP1
    Volastra Therapeutics
    11/17/23
  621. 56
    LRRK2 inhibitors
    H. Lundbeck
    11/17/23
  622. 281
    Methods for treating Crohn's disease using 3-((1R,3s,5S)-3-((7-((5-methyl-1H-pyrazol-3-yl)amino)-1,6-naphthyridin-5-yl)amino)-8-azabicyclo[3.2.1]octan-8-yl)propanenitrile
    Theravance Biopharma R&D Ip
    11/17/23
  623. 57
    Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors
    Orsobio
    11/17/23
  624. 15
    Prolyl hydroxylase domain-containing protein (PHD) inhibitors and uses thereof
    Insilico Medicine Ip
    11/17/23
  625. 20
    Pyridinamine-pyridone and pyrimidinamine-pyridone compounds
    Sprint Bioscience
    11/17/23
  626. 46
    Substituted 3-phenoxyazetidin-1-yl-pyrazines
    Boehringer Ingelheim International
    11/17/23
  627. 93
    Substituted N-pyrimidin-4-yl-3-aminopyrrolo[3,4-C]pyrazoles as protein kinase C inhibitors
    Pfizer
    11/17/23
  628. 34
    TYK2 pseudokinase ligands
    Ventyx Biosciences
    11/17/23
  629. 9
    1-(5-(2-CYANOPYRIDIN-4-YL)OXAZOLE-2-CARBONYL)-4-METHYLHEXAHYDROPYRROLO[3,4-B]PYR ROLE-5(1H)-CARBONITRILE AS USP30 INHIBITOR FOR USE IN THE TREATMENT OF MITOCHONDRIAL DYSFUNCTION, CANCER AND FIBROSIS
    Mission Therapeutics
    11/13/23
  630. 21
    1H-IMIDAZO [4,5-H] QUINAZOLINE COMPOUND AS NOVEL SELECTIVE FLT3 INHIBITORS
    Shengke Pharmaceuticals (Jiangsu)
    11/13/23
  631. 176
    2-OXO-IMIDAZOLIDINE-4-CARBOXAMIDES AS NAV1.8 INHIBITORS
    Merck Sharp & Dohme
    11/13/23
  632. 118
    4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-3,6-DIHYDROPYRIDINE-1-(2H)-CARBOXAMIDE DERIVATIVES AS LIMK AND/OR ROCK KINASES INHIBITORS FOR USE IN THE TREATMENT OF CANCER
    Centre National De La Recherche Scientifique
    11/13/23
  633. 87
    ARYLAMIDE COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND PREPARATION METHOD THEREFOR AND USE THEREOF
    Sichuan Kelun-Biotech Biopharmaceutical
    11/13/23
  634. 27
    COMPOUNDS WITH SEMIOCHEMICAL PROPERTIES AND BIOSENSORS
    Rothamsted Research
    11/13/23
  635. 51
    CYP46A1 INHIBITORS AND METHODS OF USE THEREOF
    Sage Therapeutics
    11/13/23
  636. 67
    HYDROXYPYRROLIDINE DERIVATIVE AND MEDICINAL APPLICATION THEREOF
    Mitsubishi Tanabe Pharma
    11/13/23
  637. 229
    N-(2-(4-CYANOTHIAZOLIDIN-3-YL)-2-OXOETHYL)-QUINOLINE-4-CARBOXAMIDES
    Astrazeneca
    11/13/23
  638. 46
    PTERIDINONE COMPOUNDS AND USES THEREOF
    Vertex Pharmaceuticals
    11/13/23
  639. 13
    PYRIMIDINE SMALL-MOLECULE COMPOUND AND APPLICATION THEREOF
    Wenzhou Medical University
    11/13/23
  640. 236
    PYRROLO[2,1-F][1,2,4]TRIAZINES AND PREPARATION AND USES THEREOF
    Biosplice Therapeutics
    11/13/23
  641. 1
    QUINOLINE COMPOUNDS
    Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd. Baiyunshan Pharmaceutical General Factory
    11/13/23
  642. 12
    RING-MODIFIED PROLINE SHORT PEPTIDE COMPOUND AND USE THEREOF
    Fujian Akeylink Biotechnology
    11/13/23
  643. 2
    Salts Of Nitrogen-Containing Heterocyclic Compound, And Solid Forms Of Salts, Pharmaceutical Composition And Use Thereof
    Wuhan Humanwell Innovative Drug Research and Development Center
    11/13/23
  644. 39
    THIAZOLO[5,4-B]PYRIDINE MALT-1 INHIBITORS
    Abbvie
    11/13/23
  645. 396
    Furin inhibitors
    Glaxosmithkline Intellectual Property Development
    11/07/23
  646. 84
    Methods and compounds for treating disorders
    Foghorn Therapeutics
    11/07/23
  647. 8
    Substituted pyridines as DNMT1 inhibitors
    Glaxosmithkline Intellectual Property Development
    11/07/23
  648. 258
    2-AMINOQUINAZOLINES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF
    Merck Sharp & Dohme
    11/06/23
  649. 59
    4,5,6,7-TETRAHYDROTHIENO[2,3-C]PYRIDINE SUMO INHIBITORS AND USES THEREOF
    Suvalent Therapeutics
    11/06/23
  650. 39
    BENZYLAMINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF
    Academy of Military Medical Sciences
    11/06/23
  651. 9
    BENZYLAMINE OR BENZYL ALCOHOL DERIVATIVE AND USES THEREOF
    Chengdu Hyperway Pharmaceuticals
    11/06/23
  652. 53
    CDK6/DYRK2 DUAL-TARGET INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF
    Jiangsu Tasly Diyi Pharmaceutical
    11/06/23
  653. 5
    COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA
    Stealth Biotherapeutics
    11/06/23
  654. 1
    CRYSTALLINE FORM OF TLR8 AGONIST
    Chia Tai Tianqing Pharmaceutical Group
    11/06/23
  655. 91
    MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF
    Children'S Hospital Medical Center
    11/06/23
  656. 12
    N-CYANOPYRROLIDINES WITH ACTIVITY AS USP30 INHIBITORS
    Mission Therapeutics
    11/06/23
  657. 2
    ORALLY BIOAVAILABLE, BRAIN-PENETRANT COMPOUND WITH SELECTIVITY FOR THE CANNABINOID TYPE 2 RECEPTOR WITH POTENTIAL USE TOWARDS VISCERAL PAIN MANAGEMENT AND NEURODEGENERATIVE DISORDERS
    University of Mississippi
    11/06/23
  658. 73
    OXOPYRROLIDINE UREA FPR2 AGONISTS
    Bristol-Myers Squibb
    11/06/23
  659. 13
    PIPERAZINE SUBSTITUTED INDAZOLE COMPOUNDS AS INHIBITORS OF PARG
    Ideaya Biosciences
    11/06/23
  660. 11
    PYRAZOLE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF
    Sichuan Kelun-Biotech Biopharmaceutical
    11/06/23
  661. 13
    PYRIMIDINE RING COMPOUND
    Medshine Discovery
    11/06/23
  662. 13
    Advantageous benzofuran compositions for mental disorders or enhancement
    Tactogen
    11/02/23
  663. 43
    Glucose-sensitive albumin-binding derivatives
    Novo Nordisk
    11/02/23
  664. 18
    Nicotinamide RIPK1 inhibitors
    Abbvie
    11/02/23
  665. 44
    Tricyclic pyridone compounds as JAK2 V617F inhibitors
    Incyte
    11/02/23
  666. 357
    3-(1H-IMIDAZOL-2-YL)-2,3,8,8A-TETRAHYDROINDOLIZIN-5(1H)-ONE DERIVATIVES USEFUL AS FACTOR XIA INHIBITORS
    Janssen Pharmaceutica
    10/30/23
  667. 258
    ANTAGONIST COMPOUNDS
    Adorx Therapeutics
    10/30/23
  668. 47
    ATR INHIBITORS AND USES THEREOF
    Antengene Discovery
    10/30/23
  669. 29
    ATX INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF
    Suzhou Ark Biopharmaceutical
    10/30/23
  670. 32
    CD73 INHIBITORS AND PHARMACEUTICAL USES THEREOF
    Risen (Suzhou) Pharma Tech
    10/30/23
  671. 170
    COMPOUND USEFUL AS CDK7 KINASE INHIBITOR AND USE THEREOF
    Tyk Medicines
    10/30/23
  672. 128
    FUSED HETEROAROMATIC PYRROLIDINONES
    Calithera Biosciences
    10/30/23
  673. 6
    INHIBITOR OF APOPTOSIS (IAP) PROTEIN ANTAGONISTS
    Sanford Burnham Prebys Medical Discovery Institute
    10/30/23
  674. 94
    INHIBITORS OF VAP-1
    Acucela
    10/30/23
  675. 137
    INTEGRIN INHIBITORS AND USES THEREOF IN COMBINATION WITH OTHER AGENTS
    Pliant Therapeutics
    10/30/23
  676. 36
    NOVEL COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
    Chong Kun Dang Pharmaceutical
    10/30/23
  677. 67
    PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE
    Akebia Therapeutics
    10/30/23
  678. 115
    SPIRO DERIVATIVES OF ALPHA-D-GALACTOPYRANOSIDES
    Idorsia Pharmaceuticals
    10/30/23
  679. 329
    SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATORY DISEASES
    Gossamer Bio Services
    10/30/23
  680. 44
    Carboxylic acid, acyl sulfonamide and acyl sulfamide-derivatized bicyclic aza-heteroaromatics as selective Mcl-1 inhibitors and as dual Mcl-1/Bcl-2 inhibitors
    University of Maryland, Baltimore
    10/29/23
  681. 75
    Methods and compositions for targeting PD-L1
    Aligos Therapeutics
    10/29/23
  682. 9
    Steroids and protein-conjugates thereof
    Regeneron Pharmaceuticals
    10/29/23
  683. 11
    TKI permeability enhancers
    City of Hope
    10/29/23
  684. 59
    1-ALKYL-5-ARYLIDENE-2-SELENOXOIMIDAZOLIDINE-4-ON AND DERIVATIVE THEREOF, PREPARATION METHOD THEREFOR, AND COMPOSITION COMPRISING SAME FOR PREVENTING, ALLEVIATING OR TREATING NEURODEGENERATIVE DISEASES
    Duksung Women''S University Industry-Academic Cooperation Foundation
    10/23/23
  685. 96
    ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE
    Petra Pharma
    10/23/23
  686. 120
    BCL6 INHIBITORS
    Cancer Research Technology
    10/23/23
  687. 56
    HALOALKYLPYRIDYL TRIAZOLE MLL1-WDR5 PROTEIN-PROTEIN INTERACTION INHIBITOR
    Huyabio International
    10/23/23
  688. 139
    IL-17A MODULATORS
    Sanofi
    10/23/23
  689. 13
    INDAZOLE DERIVATIVES AS INHIBITORS OF SARM1
    Disarm Therapeutics
    10/23/23
  690. 238
    ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF
    Biosplice Therapeutics
    10/23/23
  691. 47
    KCNT1 INHIBITORS AND METHODS OF USE
    Praxis Precision Medicines
    10/23/23
  692. 10
    METHOD FOR TREATING GRAFT VERSUS HOST DISEASE CAUSED BY HEMATOPOIETIC STEM CELL TRANSPLANTATION
    Beijing Tide Pharmaceutical
    10/23/23
  693. 58
    NEPRILYSIN INHIBITORS
    Theravance Biopharma R&D Ip
    10/23/23
  694. 417
    NOVEL OXADIAZOLE-BASED SELECTIVE HDAC6 INHIBITORS
    Italfarmaco
    10/23/23
  695. 33
    PHENYL TRIAZOLE MLL1-WDR5 PROTEIN-PROTEIN INTERACTION INHIBITOR
    Huyabio International
    10/23/23
  696. 185
    PLASMA KALLIKREIN INHIBITORS
    Merck Sharp & Dohme
    10/23/23
  697. 32
    QUINAZOLINONE HSD17B13 INHIBITORS AND USES THEREOF
    Inipharm
    10/23/23
  698. 3
    SALT OF DIHYDROPYRIDO[2,3-D]PYRIMIDINONE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF
    Nanjing Chia Tai Tianqing Pharmaceutical
    10/23/23
  699. 30
    Disulfiram derivatives as ALDH1A1 and MAGL inhibitors
    Batterjee Medical College
    10/20/23
  700. 295
    EIF4E inhibitors and uses thereof
    Pic Therapeutics
    10/20/23
  701. 34
    Muscarinic acetylcholine M1 receptor antagonists
    Pipeline Therapeutics
    10/20/23
  702. 55
    Protease inhibitors as antivirals
    Acea Therapeutics
    10/20/23
  703. 137
    Treating primary or idiopathic hyperoxaluria with small molecule inhibitors of lactate dehydrogenase
    Vanderbilt University
    10/20/23
  704. 57
    Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders
    Rugen Holdings (Cayman)
    10/20/23
  705. 187
    DICHLOROPHENOL HSD17B13 INHIBITORS AND USES THEREOF
    Inipharm
    10/18/23
  706. 54
    Benzimidazole Derivative Compounds and Uses Thereof
    Pfizer
    10/17/23
  707. 1030
    CARM1 INHIBITORS AND USES THEREOF
    Epizyme
    10/17/23
  708. 37
    CERTAIN (2S)-N-[(1S)-1-CYANO-2-PHENYLETHYL]-1,4-OXAZEPANE-2-CARBOXAMIDES AS DIPEPTIDYL PEPTIDASE 1 INHIBITORS
    Astrazeneca
    10/17/23
  709. 207
    COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
    Plexxikon
    10/17/23
  710. 143
    Compound containing structure of a five-membered heteroaromatic ring, pharmaceutical compositions thereof and applications thereof
    280 Bio
    10/17/23
  711. 5
    DIARYL AND ARYLHETEROARYL UREA DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO
    Arena Pharmaceuticals
    10/17/23
  712. 34
    ENPP1 Inhibitors and Their Use for the Treatment of Cancer
    The Board of Trustees of The Leland Stanford Junior University
    10/17/23
  713. 4
    IMIDAZO[1,2-A]PYRIDINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE
    Hoffmann-La Roche
    10/17/23
  714. 90
    INDOLE DERIVATIVES AND USES THEREOF FOR TREATING A CANCER
    Universite Claude Bernard Lyon 1
    10/17/23
  715. 461
    KRAS G12D INHIBITORS
    Mirati Therapeutics
    10/17/23
  716. 160
    N/O-Linked Degrons and Degronimers for Protein Degradation
    C4 Therapeutics
    10/17/23
  717. 7
    NOVEL TRICYCLIC AROMATIC HETEROCYCLIC COMPOUND AND PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF
    Shanghai Longwood Biopharmaceuticals
    10/17/23
  718. 26
    PTGR2 INHIBITORS AND THEIR USE
    National Health Research Institutes
    10/17/23
  719. 20
    ROR-GAMMA MODULATORS
    Escalier Biosciences
    10/17/23
  720. 29
    TRIAZINE COMPOUND AND COMPOSITION AND USE THEREOF
    Beijing Findcure Biosciences
    10/17/23
  721. 188
    YKL-40 INHIBITORS AND THEIR THERAPEUTIC APPLICATIONS
    Molecure
    10/17/23
  722. 98
    5-AMINO-8-(4-PYRIDYL)-[1,2,4]TRIAZOLO[4,3-C]PYRIMIDIN-3-ONE COMPOUNDS FOR USE AGAINST CANCER
    Astrazeneca
    10/16/23
  723. 100
    AMIDE DERIVATIVES
    Merck Patent
    10/16/23
  724. 144
    AMINO ACID COMPOUNDS AND METHODS OF USE
    Pliant Therapeutics
    10/16/23
  725. 44
    COMPOUND HAVING KDM5 INHIBITORY ACTIVITY AND PHARMACEUTICAL USE THEREOF
    Ono Pharmaceutical
    10/16/23
  726. 549
    COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE
    Vertex Pharmaceuticals
    10/16/23
  727. 250
    COMPOUNDS USEFUL AS T CELL ACTIVATORS
    Gossamer Bio Services
    10/16/23
  728. 20
    CONDENSED PYRAZOLE DERIVATIVES AS INHIBITORS OF SARM1
    Disarm Therapeutics
    10/16/23
  729. 5
    PRPK INHIBITORS
    Dana-Farber Cancer Institute
    10/16/23
  730. 24
    PYRAZOLOPYRIMIDINE COMPOUND USED AS ATR KINASE INHIBITOR
    Beijing Tide Pharmaceutical
    10/16/23
  731. 3
    SALT AND CRYSTAL FORM OF DIHYDROPYRIDO[2,3-d]PYRIMIDINE DERIVATE
    Nanjing Chia Tai Tianqing Pharmaceutical
    10/16/23
  732. 42
    4-ETHYNYLPYRIDINE DERIVATIVES USEFUL AS GCN2 INHIBITORS
    Ip2Ipo Innovations
    10/15/23
  733. 210
    BENZODIAZEPINE DERIVATIVES USEFUL IN TREATING A RESPIRATORY SYNCYTIAL VIRUS INFECTION
    Reviral
    10/15/23
  734. 164
    CARBOXYLIC ACID AROMATIC AMIDES AS ANTAGONISTS OF BRADYKININ B1 RECEPTOR
    Bayer Pharma Aktiengesellschaft
    10/15/23
  735. 176
    COMPOSITION CONTAINING ARYLAMIDE DERIVATIVE
    Chugai Seiyaku Kabushiki Kaisha
    10/15/23
  736. 124
    COMPOUNDS ACTIVE TOWARDS NUCLEAR RECEPTORS
    Nuevolution
    10/15/23
  737. 76
    COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY
    Ifm Due
    10/15/23
  738. 412
    GLP-1R MODULATING COMPOUNDS
    Ascletis Bioscience
    10/15/23
  739. 129
    INHIBITORS OF APOL1 AND METHODS OF USING SAME
    Vertex Pharmaceuticals
    10/15/23
  740. 135
    SUBSTITUTED PYRROLIZINE COMPOUNDS AND USES THEREOF
    Gilead Sciences
    10/15/23
  741. 162
    2-amino-3-carbonyl imidazopyridine and pyrazolopyridine compounds
    1St Biotherapeutics
    10/06/23
  742. 56
    ALK-5 inhibitors and uses thereof
    Sumitomo Pharma Oncology
    10/06/23
  743. 16
    Alkynyl (hetero) aromatic ring compounds used for inhibiting protein kinase activity
    Shenzhen Targetrx
    10/06/23
  744. 43
    Labelled cannabinergic ligands and related analogs
    Individual
    10/06/23
  745. 10
    Method of increasing platelet counts of a subject
    Korea Basic Science Institute
    10/06/23
  746. 31
    Acetamido-phenyltetrazole derivatives and methods of using the same
    Athenex
    10/01/23
  747. 125
    Methods of inhibiting kinases
    Insilico Medicine Ip
    10/01/23
  748. 22
    Small molecule inhibitors of ubiquitin specific protease 1 (USP1) and uses thereof
    Insilico Medicine Ip
    10/01/23
  749. 10
    Substituted pyrazlo[3,4-c]pyridines as selective BTK kinase inhibitors
    Jumbo Drug Bank
    10/01/23
  750. 5
    Substituted pyrazolopyrazines, imidazopyrazines and [1,2,4]triazolopyrazines as allosteric SHP2 inhibitors
    Revolution Medicines
    10/01/23
  751. 105
    Carboxamide compounds and uses thereof
    Incyte
    09/26/23
  752. 36
    Histone demethylase inhibitors
    Celgene Quanticel Research
    09/26/23
  753. 47
    N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists
    Ogeda
    09/26/23
  754. 93
    SARS-CoV-2 inhibitors for treating coronavirus infections
    Insilico Medicine Ip
    09/26/23
  755. 58
    Spiro compounds as glycosidase inhibitors
    Asceneuron
    09/26/23
  756. 106
    Substituted 1,2,4-triazoles as intermediates in the synthesis of TYK2 inhibitors
    Alumis
    09/26/23
  757. 31
    Substituted pyrazolo[3,4-d]pyrimidines as mTOR inhibitors
    Galderma Research & Development
    09/26/23
  758. 41
    HDAC inhibitor compounds and methods of treatment
    University of Florida Research Foundation
    09/25/23
  759. 298
    Therapeutic compounds, compositions and methods of use thereof
    Genentech
    09/25/23
  760. 20
    (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles
    Centrexion Therapeutics
    09/23/23
  761. 253
    Bicyclic compound and use thereof
    Sk Biopharmaceuticals
    09/23/23
  762. 3
    Bicyclic urea kinase inhibitors and uses thereof
    The General Hospital
    09/23/23
  763. 43
    Compositions and methods for inhibiting kinases
    Inhibikase Therapeutics
    09/23/23
  764. 151
    Polyheterocyclic compounds as METTL3 inhibitors
    Storm Therapeutics
    09/23/23
  765. 415
    Apoptosis inhibitors
    National Institute of Biological Sciences, Beijing
    09/21/23
  766. 176
    Compounds and compositions for treating conditions associated with NLRP activity
    Novartis
    09/21/23
  767. 80
    MCT4 inhibitors for treating disease
    Vettore
    09/21/23
  768. 49
    Methods of improving cell-based therapy
    The Regents of The University of California
    09/21/23
  769. 52
    Quinazoline derivatives as antitumor agents
    Suzhou Zanrong Pharma
    09/21/23
  770. 222
    Heterocyclic adenosine receptor antagonists
    Exelixis
    09/17/23
  771. 63
    Isoxazolyl-carbonyloxy azabicyclo[3.2.1]octanyl compounds as FXR activators
    Ardelyx
    09/17/23
  772. 27
    JAK kinase inhibitor compounds for treatment of respiratory disease
    Theravance Biopharma R&D Ip
    09/17/23
  773. 19
    N-(phenylsulfonyl)benzamides and related compounds as Bcl-2 inhibitors
    The Regents of The University of Michigan
    09/17/23
  774. 106
    Substituted pyrido[2,1-a]isoquinolines as VMAT2 inhibitors
    Neurocrine Biosciences
    09/17/23
  775. 1
    Benzenesulfonylbenazamide compound for inhibiting BCL-2 protein and composition and use thereof
    Shenzhen Targetrx
    09/15/23
  776. 570
    CDK2 inhibitors
    Pfizer
    09/15/23
  777. 164
    Compositions and methods of modulating short-chain dehydrogenase
    Case Western Reserve University
    09/15/23
  778. 25
    Heparanase inhibitors and use thereof
    Beta Therapeutics
    09/15/23
  779. 13
    Heterocyclic compounds as immunomodulators
    Incyte
    09/15/23
  780. 70
    Inhibitors of receptor interacting protein kinase I for the treatment of disease
    Board of Regents, The University of Texas System
    09/15/23
  781. 3
    Treatment of spondyloarthritis
    Pharmacyl
    09/15/23
  782. 107
    Azole derivatives as apelin receptor agonist
    Sanford Burnham Prebys Medical Discovery Institute
    09/08/23
  783. 5
    Bismuth(III) compounds and methods thereof
    The University of Hong Kong
    09/08/23
  784. 3
    Crystal form, salt type of substituted 2-hydro-pyrazole derivative and preparation method therefor
    Chia Tai Tianqing Pharmaceutical Group
    09/08/23
  785. 187
    Cyanotriazole compounds
    Otsuka Pharmaceutical
    09/08/23
  786. 9
    Heterocyclic indoles for use in influenza virus infection
    Janssen Sciences Ireland Uc
    09/08/23
  787. 420
    Heterocyclic sulfonamide derivative and medicine comprising same
    Ea Pharma
    09/08/23
  788. 117
    Inhibitor of lysine specific demethylase-1
    Celgene Quanticel Research
    09/08/23
  789. 332
    Inhibitors of low molecular weight protein tyrosine phosphatase and uses thereof
    Sanford Burnham Prebys Medical Discovery Institute
    09/08/23
  790. 42
    Peptide derivatives and uses thereof
    Nosopharm
    09/08/23
  791. 14
    Phosphodiesterase inhibitors and uses thereof
    The Trustees of Columbia University In The City of New York
    09/08/23
  792. 216
    2,4,5-trisubstituted 1,2,4-triazolones useful as inhibitors of DHODH
    Bayer Aktiengesellschaft
    09/04/23
  793. 12
    5 to 7 membered heterocyclic amides as JAK inhibitors
    Theravance Biopharma R&D Ip
    09/04/23
  794. 143
    5-heteroaryl substituted indazole-3-carboxamides and preparation and use thereof
    Biosplice Therapeutics
    09/04/23
  795. 39
    5-substituted difluoropiperidine compounds with blood-brain barrier penetrable capability
    Wayshine Biopharm Holding
    09/04/23
  796. 44
    GSK-3 inhibitors
    Bristol-Myers Squibb
    09/04/23
  797. 26
    Heteroaryl heterocyclyl compounds for the treatment of autoimmune disease
    Hoffmann-La Roche
    09/04/23
  798. 102
    Heteroaryl-biphenyl amides for the treatment of PD-L1 diseases
    Chemocentryx
    09/04/23
  799. 44
    Inhibitors of NEK7 kinase
    Halia Therapeutics
    09/04/23
  800. 218
    Fused 1,4-dihydrodioxin derivatives as inhibitors of heat shock transcription factor 1
    Cancer Research Technology
    08/31/23
  801. 44
    Hydroxyalkyl-piperazine derivatives as CXCR3 receptor modulators
    Idorsia Pharmaceuticals
    08/31/23
  802. 267
    Protein kinase modulators
    Cylene Pharmaceuticals
    08/31/23
  803. 563
    Aryl, heteroaryl, and heterocyclic pharmaceutical compounds for treatment of medical disorders
    Achillion Pharmaceuticals
    08/27/23
  804. 92
    Azaindole derivatives and their use as ERK kinase inhibitors
    Agv Discovery
    08/27/23
  805. 30
    Compounds for the treatment of kinase-dependent disorders
    Exelixis
    08/27/23
  806. 34
    ENPP1 inhibitors and their use for the treatment of cancer
    The Board of Trustees of The Leland Stanford Junior University
    08/27/23
  807. 89
    FAP-targeted radiopharmaceuticals and imaging agents, and uses related thereto
    Trustees of Tufts College
    08/27/23
  808. 34
    Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof
    Novartis
    08/27/23
  809. 250
    Human plasma kallikrein inhibitors
    Biocryst Pharmaceuticals
    08/27/23
  810. 410
    Immunomodulator compounds
    Chemocentryx
    08/27/23
  811. 122
    Monoacylglycerol lipase modulators
    Janssen Pharmaceutica
    08/27/23
  812. 536
    Substituted benzofuran, benzopyrrole, benzothiophene, and structurally related complement inhibitors
    Biocryst Pharmaceuticals
    08/27/23
  813. 98
    1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins
    Incyte
    08/18/23
  814. 364
    Bicyclic-fused heteroaryl or aryl compounds
    Pfizer
    08/18/23
  815. 8
    Composition for inducing differentiation and protection of neural stem cells and method for inducing neuro-regeneration using the same composition
    Genuv
    08/18/23
  816. 36
    Compounds and methods of use
    Medivation Technologies
    08/18/23
  817. 2
    Crystalline hydrate of a JAK inhibitor compound
    Theravance Biopharma R&D Ip
    08/18/23
  818. 34
    ENPP1 inhibitors and their use for the treatment of cancer
    The Board of Trustees of The Leland Stanford Junior University
    08/18/23
  819. 42
    Pyrazolo[3,4-b]pyrazine derivatives as SHP2 phosphatase inhibitors
    D. E. Shaw Research
    08/18/23
  820. 94
    Pyrazolyl derivatives useful as anti-cancer agents
    Novartis
    08/18/23
  821. 34
    Pyridine, pyrazine, and triazine compounds as allosteric SHP2 inhibitors
    Revolution Medicines
    08/18/23
  822. 143
    Pyrimidinone derivatives as SHP2 antagonists
    Merck Patent
    08/18/23
  823. 365
    SOS1 inhibitors
    Mirati Therapeutics
    08/18/23
  824. 9
    Substituted bicyclic compounds
    Bristol-Myers Squibb
    08/18/23
  825. 303
    Thiadiazole IRAK4 inhibitors
    Gilead Sciences
    08/18/23
  826. 79
    Agent enhancing antitumor effect using pyrazolo[3,4-d]pyrimidine compound
    Taiho Pharmaceutical
    08/11/23
  827. 100
    Carboxamide-pyrimidine derivatives as SHP2 antagonists
    Merck Patent
    08/11/23
  828. 42
    Compounds having tetrahydroindolizine-1-carboxamide as BCL-2 inhibitors
    Eil Therapeutics
    08/11/23
  829. 264
    Fused pyrimidine pyridinone compounds as JAK inhibitors
    Theravance Biopharma R&D Ip
    08/11/23
  830. 318
    Substituted benzamides
    Hoffmann-La Roche
    08/11/23
  831. 15
    2-[thiophen-2-yl)formamido]-N-(phenyl)-2-methylpropanamide derivatives and the use thereof as medicament
    Boehringer Ingelheim International
    08/06/23
  832. 234
    6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors
    Ajax Therapeutics
    08/06/23
  833. 44
    Compound having KDM5 inhibitory activity and pharmaceutical use thereof
    Ono Pharmaceutical
    08/06/23
  834. 82
    Cyclic ether derivatives of pyrazolo[1,5-A]pyrimidine-3-carboxyamide
    Boehringer Ingelheim International
    08/06/23
  835. 80
    Heterocyclic compounds, preparation methods therefor, and methods of uses thereof
    Inventisbio
    08/06/23
  836. 101
    Inhibitors of receptor interacting protein kinase I for the treatment of disease
    Board of Regents, The University of Texas System
    08/06/23
  837. 93
    Isoindoline compositions and methods for treating neurodegenerative disease
    Cognition Therapeutics
    08/06/23
  838. 21
    Isoquinoline-steroid conjugates and uses thereof
    Aerie Pharmaceuticals
    08/06/23
  839. 25
    MAGL inhibitors
    H. Lundbeck
    08/06/23
  840. 25
    Macrocyclic immunomodulators
    Chemocentryx
    08/06/23
  841. 51
    Macrocyclic indoles as Mcl-1 inhibitors
    Ascentage Pharma (Suzhou)
    08/06/23
  842. 1
    Method for preparing pyrrolidinyl urea derivative
    Zhangzhou Pien Tze Huang Pharmaceutical
    08/06/23
  843. 24
    Naphthyridinone compounds as JAK2 V617F inhibitors
    Incyte
    08/06/23
  844. 96
    Pyridazinones as PARP7 inhibtors
    Ribon Therapeutics
    08/06/23
  845. 217
    Therapeutic compounds and compositions
    Exithera Pharmaceuticals
    08/06/23
  846. 121
    ATM kinase inhibitors and compositions and methods of use thereof
    Chdi Foundation
    07/31/23
  847. 106
    Azalactam compounds as HPK1 inhibitors
    Pfizer
    07/31/23
  848. 82
    C5a receptor modulators
    Idorsia Pharmaceuticals
    07/31/23
  849. 123
    CDK inhibitors and their use as pharmaceuticals
    Prelude Therapeutics
    07/31/23
  850. 14
    Fluorinated tetrahydronaphthyridinyl nonanoic acid derivatives and uses thereof
    Ocuterra Therapeutics
    07/31/23
  851. 245
    Human plasma kallikrein inhibitors
    Biocryst Pharmaceuticals
    07/31/23
  852. 491
    MYST family histone acetyltransferase inhibitors
    Epizyme
    07/31/23
  853. 24
    Pyridinone MK2 inhibitors and uses thereof
    Xinthera
    07/31/23
  854. 385
    Substituted benzoxazole and benzofuran compounds as PDE7 inhibitors
    Dart Neuroscience
    07/31/23
  855. 138
    Bicycloheptane pyrrolidine orexin receptor agonists
    Merck Sharp & Dohme
    07/25/23
  856. 37
    Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors
    Astrazeneca
    07/25/23
  857. 22
    Compounds and compositions as protein kinase inhibitors
    Array Biopharma
    07/25/23
  858. 55
    Compounds useful as RET inhibitors
    Cancer Research Technology
    07/25/23
  859. 82
    MK2 inhibitors and uses thereof
    Xinthera
    07/25/23
  860. 2
    Methods of treating disorders using CSF1R inhibitors
    Deciphera Pharmaceuticals
    07/25/23
  861. 16
    Substituted aminobenzyl heteroaryl compounds as EGFR and/or PI3K inhibitors
    Mekanistic Therapeutics
    07/19/23
  862. 155
    5-membered and bicyclic heterocyclic amides as inhibitors of ROCK
    Bristol-Myers Squibb
    07/16/23
  863. 40
    Amino pyrimidine derivatives
    Novartis
    07/16/23
  864. 17
    Bicyclic compounds as ATX inhibitors
    Hoffmann-La Roche
    07/16/23
  865. 88
    CDK inhibitors and their use as pharmaceuticals
    Prelude Therapeutics
    07/16/23
  866. 35
    Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors
    Astrazeneca
    07/16/23
  867. 11
    Compounds for the treatment of kinase-dependent disorders
    Exelixis
    07/16/23
  868. 51
    Heterocyclic compounds as immunomodulators
    Incyte
    07/16/23
  869. 13
    Histone deacetylase inhibitors for immunomodulation in tumor microenvironment
    Great Novel Therapeutics Biotech & Medicals
    07/16/23
  870. 96
    Imidazopyrimidines and triazolopyrimidines as A2A / A2B inhibitors
    Incyte
    07/16/23
  871. 303
    Isoquinolin-3-yl carboxamides and preparation and use thereof
    Biosplice Therapeutics
    07/16/23
  872. 12
    Matrix metalloproteinase (MMP) inhibitors and methods of use thereof
    Foresee Pharmaceuticals
    07/16/23
  873. 21
    Pharmaceutical compounds
    Sareum
    07/16/23
  874. 82
    Polycyclic compounds as allosteric SHP2 inhibitors
    Revolution Medicines
    07/16/23
  875. 159
    Pyridone amides as modulators of sodium channels
    Vertex Pharmaceuticals
    07/16/23
  876. 7
    Tetrahydro-1H-pyrido [3,4-b]indole anti-estrogenic drugs
    Olema Pharmaceuticals
    07/16/23
  877. 50
    4-substitued cytisine analogues
    University of Bristol
    07/09/23
  878. 7
    Antibody-drug conjugates comprising a cyclic dinucleotide
    Takeda Pharmaceutical
    07/09/23
  879. 37
    Bicyclic heterocycles as FGFR4 inhibitors
    Incyte
    07/09/23
  880. 36
    Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors
    Astrazeneca
    07/09/23
  881. 378
    Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators
    Janssen Pharmaceutica
    07/09/23
  882. 56
    FGFR4 inhibitor, preparation method therefor, and applications thereof
    Jiangsu Hansoh Pharmaceutical Group
    07/09/23
  883. 11
    Fused imidazo-piperidine JAK inhibitors
    Theravance Biopharma R&D Ip
    07/09/23
  884. 148
    Granzyme B directed imaging and therapy
    Cytosite Biopharma
    07/09/23
  885. 65
    Inhibitors of RAF kinases
    Kinnate Biopharma
    07/09/23
  886. 204
    MCL1 inhibitors
    Gilead Sciences
    07/09/23
  887. 97
    Methods of treating intraocular pressure with activators of Tie-2
    Eyepoint Pharmaceuticals
    07/09/23
  888. 80
    RIP1K inhibitors
    Rigel Pharmaceuticals
    07/09/23
  889. 206
    Therapeutically active compounds and their methods of use
    Servier Pharmaceuticals
    07/09/23
  890. 86
    Heterocyclic compounds as RET kinase inhibitors
    Cancer Research Technology
    07/03/23
  891. 496
    Imidazole-containing inhibitors of ALK2 kinase
    Biocryst Pharmaceuticals
    07/03/23
  892. 18
    Tetrazole derivatives as TRPA1 inhibitors
    Boehringer Ingelheim International
    07/03/23
  893. 8
    Thienopyrrole compounds
    Gilead Sciences
    07/03/23
  894. 26
    Tricyclic urea compounds as JAK2 V617F inhibitors
    Incyte
    07/03/23
  895. 54
    Benzimidazole derivative compounds and uses thereof
    Pfizer
    07/02/23
  896. 13
    MASP-2 inhibitors and methods of use
    Omeros
    07/02/23
  897. 129
    Substituted 2-azabicyclo[3.1.1]heptane and 2-azabicyclo[3.2.1]octane derivatives as orexin receptor antagonists
    Chronos Therapeutics
    07/02/23
  898. 28
    Treatment of Rett syndrome
    Cold Spring Harbor Laboratory
    07/02/23
  899. 87
    Tricyclic compounds as histone methyltransferase inhibitors
    Global Blood Therapeutics
    07/02/23
  900. 170
    ALK2 inhibitors and methods for inhibiting BMP signaling
    The Brigham and Women'S Hospital
    06/26/23
  901. 4
    Aminopyrimidinyl derivatives
    Pfizer
    06/26/23
  902. 37
    Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors
    Astrazeneca
    06/26/23
  903. 32
    Fused ring pyrimidine amino compound and preparation method, pharmaceutical composition, and use thereof
    Shanghai Institute of Material Medica, Chinese Academy of Sciences
    06/26/23
  904. 4
    Glucagon-like peptide1 receptor agonists
    Eli Lilly
    06/26/23
  905. 23
    Indolizine derivatives and their application in medicine
    Kind Pharmaceutical
    06/26/23
  906. 252
    Pyrazole MAGL inhibitors
    H. Lundbeck
    06/26/23
  907. 32
    Pyridine and pyrazine derivatives as preferential cannabinoid 2 agonists
    Hoffmann-La Roche
    06/26/23
  908. 6
    Substituted piperazines as BTK inhibitors
    Hutchison Medipharma
    06/26/23
  909. 8
    7-phenylethylamino-4H-pyrimido[4,5-d][1,3]oxazin-2-one compounds as mutant IDH1 and IDH2 inhibitors
    Eli Lilly
    06/19/23
  910. 98
    Allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) for the treatment of disease
    Petra Pharma
    06/19/23
  911. 8
    Amide compounds for treatment of immune and inflammatory disorders
    Achillion Pharmaceuticals
    06/19/23
  912. 81
    C-Abl tyrosine kinase inhibitory compound embodiments and methods of making and using the same
    The United States of America, As Represented By The Secretary, Department of Health and Human Services
    06/19/23
  913. 18
    Compound as mTOR inhibitor and use thereof
    Medicinal Bioconvergence Research Center
    06/19/23
  914. 18
    Halo-allylamine SSAO/VAP-1 inhibitor and use thereof
    Nanjing Transthera Biosciences
    06/19/23
  915. 663
    Indazoles as hematopoietic progenitor kinase 1 (HPK1) inhibitors and methods using same
    1St Biotherapeutics
    06/19/23
  916. 113
    Oxadiazaspiro compounds for the treatment of drug abuse and addiction
    Esteve Pharmaceuticals
    06/19/23
  917. 2
    Pan-tropic entry inhibitors
    Emory University
    06/19/23
  918. 14
    Pyrazolochlorophenyl compounds, compositions and methods of use thereof
    Genentech
    06/19/23
  919. 50
    Selective androgen receptor degrader (SARD) ligands and methods of use
    University of Tennessee Research Foundation
    06/19/23
  920. 111
    Substituted 4-phenylpiperidines, their preparation and use
    The Trustees of Columbia University In The City of New York
    06/19/23
  921. 228
    Substituted imidazo[1,5-a]pyrazines for IRE1 inhibition
    Optikira
    06/19/23
  922. 814
    Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors
    Array Biopharma
    06/19/23
  923. 320
    Substituted pyrido[2,3-d]pyrimidines as inhibitors of Ras pathway signaling
    Kumquat Biosciences
    06/19/23
  924. 2
    5-HT2A agonists for use in treatment of depression
    Lophora
    06/11/23
  925. 156
    BRD4-kinase inhibitors as cancer therapeutics
    H. Lee Moffitt Cancer Center and Research Institute
    06/11/23
  926. 8
    Compounds for degrading Tau protein aggregates and uses thereof
    Aprinoia Therapeutics
    06/11/23
  927. 9
    Derivatives of 4-aminoantipyrine as anti-Alzheimers butyrylcholinesterase inhibitors
    Individual
    06/11/23
  928. 11
    GLP-1 receptor agonist and use thereof
    Ildong Pharmaceutical
    06/11/23
  929. 443
    MCL-1 inhibitors
    Gilead Sciences
    06/11/23
  930. 10