Compile Data Set for Download or QSAR
Report error Found 248 Enz. Inhib. hit(s) with all data for entry = 596
TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280795BDBM280795((S)-3-(2-{4-amino-2-[6- fluoro-1-(2-fluorobenzyl)-...)
Affinity DataKi:  0.0220nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280822BDBM280822((S)-2-(3-(4-{4-amino-2- [1-(2-fluorobenzyl)-1H- py...)
Affinity DataKi:  0.0260nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280911BDBM280911(3-(2-{4-amino-2- [6-chloro-1-(2- fluoro-3-methyl- ...)
Affinity DataKi:  0.0290nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280876BDBM280876(3-(2-{4-amino- 2-[1-(cyclohexyl- methyl)-1H- pyraz...)
Affinity DataKi:  0.0310nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280914BDBM280914((S)-3-(2-{4-amino- 2-[6-chloro-1- (2,3,6-trifluoro...)
Affinity DataKi:  0.0310nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280904BDBM280904(3-(2-{4-amino-2- [6-chloro-1-(2,3- difluorobenzyl)...)
Affinity DataKi:  0.0310nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280821BDBM280821((S)-(3-(4-{4-Amino-2-[1-(2-fluorobenzyl)-1H-pyrazo...)
Affinity DataKi:  0.0390nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280918BDBM280918((S)-3-(2-{4-amino- 2-[6-fluoro-1-(3- fluorobenzyl)...)
Affinity DataKi:  0.0410nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280824BDBM280824((5S,2S)-2-(3-(4-{4- amino-2-[1-(2- fluorobenzyl)-1...)
Affinity DataKi:  0.0420nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280823BDBM280823((5S)-(3-(4-{4-amino-2-[1- (2-fluorobenzyl)-1H- pyr...)
Affinity DataKi:  0.0450nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280740BDBM280740(3-(2-{4-Amino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,...)
Affinity DataKi:  0.0470nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280973BDBM280973(4-Amino-2-[1-(2-fluorobenzyl)-1H-indazol-3-yl]-5-m...)
Affinity DataKi:  0.0480nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280913BDBM280913(3-(2-{4-amino-2- [6-chloro-1-(2,3,6- trifluorobenz...)
Affinity DataKi:  0.0490nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280945BDBM280945(3-(2-{4-amino-2- [1-(3-fluoro- benzyl)-1H- indazol...)
Affinity DataKi:  0.0500nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280924BDBM280924(3-(2-{4-amino-2- [1-(2,3-difluoro- benzyl)-6-fluor...)
Affinity DataKi:  0.0520nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280917BDBM280917(4-(2-{4-amino-2- [6-fluoro-1-(2- fluorobenzyl)-1H-...)
Affinity DataKi:  0.0520nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280826BDBM280826((S)—N-((2H-Tetrazol-5-yl)methyl)-3-(4-{4-amin...)
Affinity DataKi:  0.0560nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280940BDBM280940((2E)-3-(4-{4- amino-2-[6- chloro-1-(2- fluorobenzy...)
Affinity DataKi:  0.0570nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280846BDBM280846(4-(2-{4-amino-2-[6- chloro-1-(2-fluorobenzyl)- 1H-...)
Affinity DataKi:  0.0570nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280862BDBM280862(3-(2-{4-amino-2-[6- chloro-1-(2-fluorobenzyl)- 1H-...)
Affinity DataKi:  0.0580nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280825BDBM280825((5S)-(3-(4-{4-amino-2-[1- (2-fluorobenzyl)-1H- pyr...)
Affinity DataKi:  0.0580nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280985BDBM280985((4-{4-Amino-2-[6-chloro-1-(2-fluorobenzyl)-1H-inda...)
Affinity DataKi:  0.0580nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280817BDBM280817((S)-3-(2-{4-amino-2-[6- chloro-1-(2- fluorobenzyl)...)
Affinity DataKi:  0.0600nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280884BDBM280884((S)-3-(4-{4-amino- 2-[6-chloro-1- (cyclopentylmeth...)
Affinity DataKi:  0.0620nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280870BDBM280870(4-(2-{4-amino-2- [1-(2-fluorobenzyl)- 1H-pyrazolo[...)
Affinity DataKi:  0.0620nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280968BDBM280968(5-[4-(2H-tetrazol- 5-yl)pyridin-2- yl]-4-amino-2- ...)
Affinity DataKi:  0.0620nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280813BDBM280813((S)-3-(2-{4-amino-2-[1- (2-fluorobenzyl)-1H- pyraz...)
Affinity DataKi:  0.0630nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280969BDBM280969(5-{4-[(2H-tetrazol- 5-yl)methyl] phenyl}-4-amino- ...)
Affinity DataKi:  0.0630nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280760BDBM280760((S)-3-(4-{4-amino-2-[1-(2- fluorobenzyl)-1H- pyraz...)
Affinity DataKi:  0.0640nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280830BDBM280830((S)-4-Amino-2-[6-chloro-1-(2-fluorobenzyl)-1H-inda...)
Affinity DataKi:  0.0660nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280794BDBM280794(3-(3-{4-amino-2-[6-fluoro-1- (2-fluorobenzyl)-1H-i...)
Affinity DataKi:  0.0660nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280939BDBM280939((2E)-3-(4-{4- amino-2-[1-(2- fluorobenzyl)-1H- pyr...)
Affinity DataKi:  0.0670nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280946BDBM280946((S)-3-(2-{4-amino- 5-methyl-6- oxo-2-[1-(2,3,6- tr...)
Affinity DataKi:  0.0670nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280742BDBM280742(3-(2-{4-amino- 2-[6-chloro-1- (2-fluorobenzyl)- 1H...)
Affinity DataKi:  0.0670nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280974BDBM280974(4-Amino-2-[6-fluoro-1-(2-fluorobenzyl)-1H-indazol-...)
Affinity DataKi:  0.0680nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280964BDBM280964(4-amino-2-[6- chloro-1-(2- fluorobenzyl)-1H- indaz...)
Affinity DataKi:  0.0680nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280923BDBM280923((S)-3-(2-{4-amino- 2-[1-(2,3- difluorobenzyl)-6- f...)
Affinity DataKi:  0.0700nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280891BDBM280891(4-(2-{4-amino-2- [6-chloro-1-(2- fluorobenzyl)-1H-...)
Affinity DataKi:  0.0700nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280934BDBM280934(3-(2-{4-amino-2- [6-fluoro-1-(2- fluoro-3-methyl- ...)
Affinity DataKi:  0.0720nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280980BDBM280980(6-{4-Amino-2-[6-chloro-1-(2-fluorobenzyl)-1H-indaz...)
Affinity DataKi:  0.0730nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280986BDBM280986(3-[1-{4-Amino-2-[6-chloro-1-(2-fluorobenzyl)-1H-in...)
Affinity DataKi:  0.0740nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280851BDBM280851(US10030027, Example 132AB | 3-{2-[4-amino-2-{6- ch...)
Affinity DataKi:  0.0740nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280981BDBM280981((S)-4-Amino-2-[6-chloro-1-(2-fluorobenzyl)-1H-inda...)
Affinity DataKi:  0.0740nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280965BDBM280965((S)-4-amino-2- [1-(2-fluoro- benzyl)-1H- pyrazolo[...)
Affinity DataKi:  0.0750nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280871BDBM280871(4-(2-{4-amino-2- [1-(2-fluorobenzyl)- 1H-pyrazolo[...)
Affinity DataKi:  0.0750nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280796BDBM280796((S)-3-(4-{4-amino-2-[6- chloro-1-(2,6- difluoroben...)
Affinity DataKi:  0.0750nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280907BDBM280907((S)-3-(2-{4-amino- 2-[6-chloro-1-(2,6- difluoroben...)
Affinity DataKi:  0.0760nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280844BDBM280844(US10030027, Example 126AB | 3-{2-[4-amino-5-methyl...)
Affinity DataKi:  0.0770nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280761BDBM280761(3-(3-{4-amino-2-[1-(2- fluorobenzyl)-1H- pyrazolo[...)
Affinity DataKi:  0.0780nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 280950BDBM280950(3-(2-{4-amino-2- [1-(cyclohexyl- methyl)-1H- indaz...)
Affinity DataKi:  0.0790nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

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