BDBM280914 (S)-3-(2-{4-amino- 2-[6-chloro-1- (2,3,6-trifluoro- benzyl)-1H-indazol- 3-yl]-5-methyl- 6-oxo-6,7-dihydro- 5H-pyrrolo[2,3-d] pyrimidin-5-yl}- 1,3-thiazol-4-yl)- 2,2-dimethyl- propanoic acid::US10030027, Example 190A::US10428076, Example 190A
SMILES CC(C)(Cc1csc(n1)[C@]1(C)C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2c(F)ccc(F)c2F)c2cc(Cl)ccc12)C(O)=O
InChI Key InChIKey=YIBOFMZPYHMORQ-LJAQVGFWSA-N
Data 2 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 280914
TargetGuanylate cyclase soluble subunit alpha-1/beta-1(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataKi: 0.0310nMAssay Description:The binding buffer was composed of 50 mM triethanolamine, pH 7.4, 3 mM MgCl2, 0.025% BSA, 2 mM dithiothreitol (DTT), 300 μM DETA/NO and 400 _...More data for this Ligand-Target Pair
Affinity DataKi: 0.0310nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair