BDBM280796 (S)-3-(4-{4-amino-2-[6- chloro-1-(2,6- difluorobenzyl)-1H-indazol- 3-yl]-5-methyl-6-oxo-6,7- dihydro-5H-pyrrolo[2,3- d]pyrimidin-5- yl}phenyl)propanoic acid::US10030027, Example 64B::US10428076, Example 64B
SMILES C[C@]1(C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2c(F)cccc2F)c2cc(Cl)ccc12)c1ccc(CCC(O)=O)cc1
InChI Key InChIKey=ZMVUMPOAEYHCLB-PMERELPUSA-N
Data 2 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 280796
TargetGuanylate cyclase soluble subunit alpha-1/beta-1(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataKi: 0.0750nMAssay Description:The binding buffer was composed of 50 mM triethanolamine, pH 7.4, 3 mM MgCl2, 0.025% BSA, 2 mM dithiothreitol (DTT), 300 μM DETA/NO and 400 _...More data for this Ligand-Target Pair
Affinity DataKi: 0.0750nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair