BDBM280846 4-(2-{4-amino-2-[6- chloro-1-(2-fluorobenzyl)- 1H-indazol-3-yl]-5- methyl-6-oxo-6,7- dihydro-5H-pyrrolo[2,3- d]pyrimidin-5-yl}-1,3- oxazol-4-yl)-2,2- difluorobutanoic acid::US10030027, Example 127A::US10428076, Example 127A
SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2cc(Cl)ccc12)c1nc(CCC(F)(F)C(O)=O)co1
InChI Key InChIKey=NWYURJJJXZUILA-UHFFFAOYSA-N
Data 2 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 280846
TargetGuanylate cyclase soluble subunit alpha-1/beta-1(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataKi: 0.0570nMAssay Description:The binding buffer was composed of 50 mM triethanolamine, pH 7.4, 3 mM MgCl2, 0.025% BSA, 2 mM dithiothreitol (DTT), 300 μM DETA/NO and 400 _...More data for this Ligand-Target Pair
Affinity DataKi: 0.0570nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair