Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) with all data for entry = 8619
TargetIndoleamine 2,3-dioxygenase 1(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM408630(US10358451, Compound 16 | 4-(2-(6-fluoro-5H-imidaz...)
Affinity DataIC50: 100nMAssay Description:In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM408631(US10358451, Compound 17 | (1R,2s,3S,5s,7s)-5-(2-(6...)
Affinity DataIC50: 100nMAssay Description:In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM408633(US10358451, Compound 18k-2)
Affinity DataIC50: 100nMAssay Description:In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM408626(US10358451, Compound 15d-3)
Affinity DataIC50: 100nMAssay Description:In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM408629(US10358451, Compound 15e | 1-((3r,5r,7r)-adamantan...)
Affinity DataIC50: 100nMAssay Description:In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM408616(US10358451, Compound 14f | 1s,3r,5R,7S)-3-(1-hydro...)
Affinity DataIC50: 100nMAssay Description:In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM408617(US10358451, Compound 15d | (1s,3r,5R,7S)-3-(2-(6-f...)
Affinity DataIC50: 100nMAssay Description:In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetTryptophan 2,3-dioxygenase(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM408630(US10358451, Compound 16 | 4-(2-(6-fluoro-5H-imidaz...)
Affinity DataIC50: 200nMAssay Description:In vitro TDO enzymatic activity was determined in a mixture of 50 mM potassium phosphate buffer, pH 6.5; 200 nM human TDO enzyme, 300 μM L-Trypt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetTryptophan 2,3-dioxygenase(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM408631(US10358451, Compound 17 | (1R,2s,3S,5s,7s)-5-(2-(6...)
Affinity DataIC50: 200nMAssay Description:In vitro TDO enzymatic activity was determined in a mixture of 50 mM potassium phosphate buffer, pH 6.5; 200 nM human TDO enzyme, 300 μM L-Trypt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetTryptophan 2,3-dioxygenase(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM408614(US10358451, Compound 9 | 2-(5H-imidazo[5,1-a]isoin...)
Affinity DataIC50: 200nMAssay Description:In vitro TDO enzymatic activity was determined in a mixture of 50 mM potassium phosphate buffer, pH 6.5; 200 nM human TDO enzyme, 300 μM L-Trypt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetTryptophan 2,3-dioxygenase(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM408616(US10358451, Compound 14f | 1s,3r,5R,7S)-3-(1-hydro...)
Affinity DataIC50: 200nMAssay Description:In vitro TDO enzymatic activity was determined in a mixture of 50 mM potassium phosphate buffer, pH 6.5; 200 nM human TDO enzyme, 300 μM L-Trypt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetTryptophan 2,3-dioxygenase(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM408617(US10358451, Compound 15d | (1s,3r,5R,7S)-3-(2-(6-f...)
Affinity DataIC50: 200nMAssay Description:In vitro TDO enzymatic activity was determined in a mixture of 50 mM potassium phosphate buffer, pH 6.5; 200 nM human TDO enzyme, 300 μM L-Trypt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM408632(US10358451, Compound 18k-1)
Affinity DataIC50: 500nMAssay Description:In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM408622(US10358451, Compound 15d-2)
Affinity DataIC50: 500nMAssay Description:In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM408628(US10358451, Compound 15d-4)
Affinity DataIC50: 500nMAssay Description:In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM347015(US10202388, Compound 13 | US10358451, Compound 10)
Affinity DataIC50: 500nMAssay Description:In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM408618(US10358451, Compound 15d-1)
Affinity DataIC50: 500nMAssay Description:In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM408614(US10358451, Compound 9 | 2-(5H-imidazo[5,1-a]isoin...)
Affinity DataIC50: 500nMAssay Description:In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetTryptophan 2,3-dioxygenase(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM408629(US10358451, Compound 15e | 1-((3r,5r,7r)-adamantan...)
Affinity DataIC50: 500nMAssay Description:In vitro TDO enzymatic activity was determined in a mixture of 50 mM potassium phosphate buffer, pH 6.5; 200 nM human TDO enzyme, 300 μM L-Trypt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent