Compile Data Set for Download or QSAR
Report error Found 607 Enz. Inhib. hit(s) with all data for entry = 11412
TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613466BDBM613466(US11731943, Example 207 | 1-[4-(cyanomethyl)-3-flu...)
Affinity DataKi:  0.110nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613454BDBM613454(methyl N-[4-carbamoyl-1-[4- (cyanomethyl)-3-fluoro...)
Affinity DataKi:  0.110nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613466BDBM613466(US11731943, Example 207 | 1-[4-(cyanomethyl)-3-flu...)
Affinity DataKi:  0.130nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613454BDBM613454(methyl N-[4-carbamoyl-1-[4- (cyanomethyl)-3-fluoro...)
Affinity DataKi:  0.150nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613483BDBM613483(US11731943, Example 224 | methyl N-[4-carbamoyl-1-...)
Affinity DataKi:  0.150nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613515BDBM613515(US11731943, Example 256 | methyl N-[4-carbamoyl-1-...)
Affinity DataKi:  0.150nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613483BDBM613483(US11731943, Example 224 | methyl N-[4-carbamoyl-1-...)
Affinity DataKi:  0.160nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613467BDBM613467(US11731943, Example 208 | methyl N-[4-carbamoyl-1-...)
Affinity DataKi:  0.170nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613465BDBM613465(US11731943, Example 206 | methyl N-[4-carbamoyl-1-...)
Affinity DataKi:  0.180nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613480BDBM613480(US11731943, Example 221 | 3-[(2- cyanocyclopropane...)
Affinity DataKi:  0.180nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613544BDBM613544(US11731943, Example 285 | methyl N-[4-carbamoyl-1-...)
Affinity DataKi:  0.190nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613499BDBM613499(US11731943, Example 240 | 3-[(2- cyanocyclopropane...)
Affinity DataKi:  0.190nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613503BDBM613503(US11731943, Example 244 | methyl N-[4-carbamoyl-1-...)
Affinity DataKi:  0.200nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613450BDBM613450(1-[4-(cyanomethyl)-1-[(2-fluoro- 5-hydroxy-4-pheny...)
Affinity DataKi:  0.200nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 611819BDBM611819(US11731943, Example 14)
Affinity DataKi:  0.200nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613494BDBM613494(US11731943, Example 235 | methyl N-[4-carbamoyl-1-...)
Affinity DataKi:  0.210nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613467BDBM613467(US11731943, Example 208 | methyl N-[4-carbamoyl-1-...)
Affinity DataKi:  0.210nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613496BDBM613496(US11731943, Example 237 | methyl N-[4-carbamoyl-1-...)
Affinity DataKi:  0.220nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613471BDBM613471(US11731943, Example 212 | 1-[4-(cyanomethyl)-1-[[4...)
Affinity DataKi:  0.220nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613462BDBM613462(US11731943, Example 203 | methyl N-[4-carbamoyl-1-...)
Affinity DataKi:  0.220nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613504BDBM613504(US11731943, Example 245 | 1-[1-(cyanomethyl)-4-(4-...)
Affinity DataKi:  0.230nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613544BDBM613544(US11731943, Example 285 | methyl N-[4-carbamoyl-1-...)
Affinity DataKi:  0.230nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613460BDBM613460(US11731943, Example 201 | 1-[4-(cyanomethyl)-3-flu...)
Affinity DataKi:  0.230nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613474BDBM613474(US11731943, Example 215 | 1-[4-(cyanomethyl)-3-flu...)
Affinity DataKi:  0.240nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613460BDBM613460(US11731943, Example 201 | 1-[4-(cyanomethyl)-3-flu...)
Affinity DataKi:  0.240nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613522BDBM613522(US11731943, Example 263 | methyl N-[4-carbamoyl-1-...)
Affinity DataKi:  0.240nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613445BDBM613445((General Procedure O) | US11731943, Example 186)
Affinity DataKi:  0.240nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613519BDBM613519(US11731943, Example 260 | 1-[4-(cyanomethyl)-1-[(4...)
Affinity DataKi:  0.25nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613535BDBM613535(US11731943, Example 276 | 1-[1-(cyanomethyl)-4-[4-...)
Affinity DataKi:  0.25nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613507BDBM613507(US11731943, Example 248 | (General Procedure R))
Affinity DataKi:  0.25nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613474BDBM613474(US11731943, Example 215 | 1-[4-(cyanomethyl)-3-flu...)
Affinity DataKi:  0.25nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613462BDBM613462(US11731943, Example 203 | methyl N-[4-carbamoyl-1-...)
Affinity DataKi:  0.25nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613455BDBM613455(methyl N-[4-carbamoyl-1-[4- (cyanomethyl)-3-fluoro...)
Affinity DataKi:  0.260nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613548BDBM613548(US11731943, Example 289 | methyl N-[4-carbamoyl-1-...)
Affinity DataKi:  0.260nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613452BDBM613452(1-[4-(cyanomethyl)-3-fluoro-1- [(6-phenyl-3-pyridy...)
Affinity DataKi:  0.260nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613455BDBM613455(methyl N-[4-carbamoyl-1-[4- (cyanomethyl)-3-fluoro...)
Affinity DataKi:  0.270nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613479BDBM613479(US11731943, Example 220 | methyl N-[4-carbamoyl-1-...)
Affinity DataKi:  0.270nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613492BDBM613492(US11731943, Example 233 | 1-[4-(cyanomethyl)-3-flu...)
Affinity DataKi:  0.270nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613472BDBM613472(US11731943, Example 213 | 1-[4-(cyanomethyl)-3-flu...)
Affinity DataKi:  0.280nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613507BDBM613507(US11731943, Example 248 | (General Procedure R))
Affinity DataKi:  0.280nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613547BDBM613547(US11731943, Example 288 | 1-[1-(cyanomethyl)-4-[4-...)
Affinity DataKi:  0.280nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613497BDBM613497(US11731943, Example 238 | methyl N-[4-carbamoyl-1-...)
Affinity DataKi:  0.290nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613499BDBM613499(US11731943, Example 240 | 3-[(2- cyanocyclopropane...)
Affinity DataKi:  0.290nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613517BDBM613517(US11731943, Example 258 | methyl N-[4-carbamoyl-1-...)
Affinity DataKi:  0.290nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613480BDBM613480(US11731943, Example 221 | 3-[(2- cyanocyclopropane...)
Affinity DataKi:  0.300nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613552BDBM613552(US11731943, Example 293 | methyl N-[4-carbamoyl-1-...)
Affinity DataKi:  0.300nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613471BDBM613471(US11731943, Example 212 | 1-[4-(cyanomethyl)-1-[[4...)
Affinity DataKi:  0.300nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613511BDBM613511(US11731943, Example 252 | methyl N-[4-carbamoyl-1-...)
Affinity DataKi:  0.300nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613543BDBM613543(US11731943, Example 284 | methyl N-[4-carbamoyl-1-...)
Affinity DataKi:  0.300nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 613510BDBM613510(US11731943, Example 251 | methyl N-[4-carbamoyl-1-...)
Affinity DataKi:  0.300nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
US Patent

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