Compile Data Set for Download or QSAR
Report error Found 34 Enz. Inhib. hit(s) with all data for entry = 11481
TargetAutotaxin(Human)
Suzhou Ark Biopharmaceutical

US Patent
LigandPNGBDBM620091((R)-2-(ethyl(2-ethyl-5-(2-(3-hydroxypyrrolidin-1-y...)
Affinity DataIC50: 3.80nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetAutotaxin(Human)
Suzhou Ark Biopharmaceutical

US Patent
LigandPNGBDBM620072(2-((2-ethyl-6-(5-(3-hydroxyazetidin-1-carbonyl)pyr...)
Affinity DataIC50: 4.40nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetAutotaxin(Human)
Suzhou Ark Biopharmaceutical

US Patent
LigandPNGBDBM620090((S5)-2-(ethyl(2-ethyl-5-(2-(3-hydroxypyrrolidin-1-...)
Affinity DataIC50: 4.60nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetAutotaxin(Human)
Suzhou Ark Biopharmaceutical

US Patent
LigandPNGBDBM620067(2-((2-ethyl-6-(5-fluoro-6-(2-(3-hydroxyazetidin-1-...)
Affinity DataIC50: 5.20nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetAutotaxin(Human)
Suzhou Ark Biopharmaceutical

US Patent
LigandPNGBDBM620089(2-(ethyl(2-ethyl-5-(2-(4-hydroxypiperidin-1-yl)pyr...)
Affinity DataIC50: 5.5nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetAutotaxin(Human)
Suzhou Ark Biopharmaceutical

US Patent
LigandPNGBDBM620081(2-((5-(2-(1,1-dioxidoisothiazolidin-2-yl)pyrimidin...)
Affinity DataIC50: 7.40nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetAutotaxin(Human)
Suzhou Ark Biopharmaceutical

US Patent
LigandPNGBDBM620085(2-((5-(2-(1,1-dioxido-1,2-thiazinan-2-yl)pyrimidin...)
Affinity DataIC50: 11nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetAutotaxin(Human)
Suzhou Ark Biopharmaceutical

US Patent
LigandPNGBDBM620086(2-(ethyl(2-ethyl-5-(2-(3-hydroxyazetidin-1-yl)pyri...)
Affinity DataIC50: 11nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetAutotaxin(Human)
Suzhou Ark Biopharmaceutical

US Patent
LigandPNGBDBM620087(2-(ethyl(2-ethyl-5-(2-(3-(hydroxymethyl)azetidin-1...)
Affinity DataIC50: 11nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetAutotaxin(Human)
Suzhou Ark Biopharmaceutical

US Patent
LigandPNGBDBM620088(1-(5-(3-((5-cyano-4-(4-fluorophenyl)thiazol-2-yl)(...)
Affinity DataIC50: 12nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetAutotaxin(Human)
Suzhou Ark Biopharmaceutical

US Patent
LigandPNGBDBM620077((R)-2-((2-ethyl-6-(5-(2-(3-hydroxypyrrolidin-1-yl)...)
Affinity DataIC50: 13nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetAutotaxin(Human)
Suzhou Ark Biopharmaceutical

US Patent
LigandPNGBDBM620082(2-((5-(2-(1,1-dioxidoisothiazolidin-2-yl)pyrimidin...)
Affinity DataIC50: 15nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetAutotaxin(Human)
Suzhou Ark Biopharmaceutical

US Patent
LigandPNGBDBM620083(2-((6-(5-(1,1-dioxidoisothiazolidin-2-yl)pyrazin-2...)
Affinity DataIC50: 17nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetAutotaxin(Human)
Suzhou Ark Biopharmaceutical

US Patent
LigandPNGBDBM620074(2-((2-ethyl-6-(3-fluoro-5-(2-(3-hydroxyazetidin-1-...)
Affinity DataIC50: 18nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetAutotaxin(Human)
Suzhou Ark Biopharmaceutical

US Patent
LigandPNGBDBM620076(2-((2-ethyl-6-(5-(2-(3-(hydroxymethyl)azetidin-1-y...)
Affinity DataIC50: 19nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetAutotaxin(Human)
Suzhou Ark Biopharmaceutical

US Patent
LigandPNGBDBM620068(2-((2-ethyl-6-(5-(2-(3-hydroxyazetidin-1-yl)-2-oxo...)
Affinity DataIC50: 21nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetAutotaxin(Human)
Suzhou Ark Biopharmaceutical

US Patent
LigandPNGBDBM620092(2-(ethyl(2-ethyl-5-(2-morpholinopyrimidin-5-yl)-2H...)
Affinity DataIC50: 23nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetAutotaxin(Human)
Suzhou Ark Biopharmaceutical

US Patent
LigandPNGBDBM620075((S)-2-((2-ethyl-6-(5-(2-(3-hydroxypyrrolidin-1-yl)...)
Affinity DataIC50: 25nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetAutotaxin(Human)
Suzhou Ark Biopharmaceutical

US Patent
LigandPNGBDBM620071(2-((2-ethyl-6-(5-(2-(3-hydroxyazetidin-1-yl)-2-oxo...)
Affinity DataIC50: 25nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetAutotaxin(Human)
Suzhou Ark Biopharmaceutical

US Patent
LigandPNGBDBM620073(2-((2-ethyl-6-(5-(1-(3-hydroxyazetidin-1-yl)-2-met...)
Affinity DataIC50: 28nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetAutotaxin(Human)
Suzhou Ark Biopharmaceutical

US Patent
LigandPNGBDBM620066(2-((2-ethyl-6-(6-(2-(3-hydroxyazetidin-1-yl)-2-oxo...)
Affinity DataIC50: 29nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetAutotaxin(Human)
Suzhou Ark Biopharmaceutical

US Patent
LigandPNGBDBM620070(2-((2-ethyl-6-(6-(2-(3-hydroxyazetidin-1-yl)-2-oxo...)
Affinity DataIC50: 29nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetAutotaxin(Human)
Suzhou Ark Biopharmaceutical

US Patent
LigandPNGBDBM620065(2-((2-ethyl-6-(4-(2-(3-hydroxyazetidin-1-yl)-2-oxo...)
Affinity DataIC50: 30nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetAutotaxin(Human)
Suzhou Ark Biopharmaceutical

US Patent
LigandPNGBDBM620079(5-(3-((5-cyano-4-(4-fluorophenyl)thiazol-2-yl)(met...)
Affinity DataIC50: 40nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetAutotaxin(Human)
Suzhou Ark Biopharmaceutical

US Patent
LigandPNGBDBM620078(2-(5-(3-((5-cyano-4-(4-fluorophenyl)thiazol-2-yl)(...)
Affinity DataIC50: 42nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetAutotaxin(Human)
Suzhou Ark Biopharmaceutical

US Patent
LigandPNGBDBM620084(N-(5-(3-((5-cyano-4-(4-fluorophenyl)thiazol-2-yl)(...)
Affinity DataIC50: 45nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetAutotaxin(Human)
Suzhou Ark Biopharmaceutical

US Patent
LigandPNGBDBM620069(2-((2-ethyl-6-(6-(2-(3-hydroxyazetidin-1-yl)-2-oxo...)
Affinity DataIC50: 48nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetAutotaxin(Human)
Suzhou Ark Biopharmaceutical

US Patent
LigandPNGBDBM50187686(CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...)
Affinity DataIC50: 112nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Suzhou Ark Biopharmaceutical

US Patent
LigandPNGBDBM620090((S5)-2-(ethyl(2-ethyl-5-(2-(3-hydroxypyrrolidin-1-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Rapid activation of human delayed rectifier potassium current (IKr) is mainly mediated by hERG ion channel and participates in repolarization of huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Suzhou Ark Biopharmaceutical

US Patent
LigandPNGBDBM620092(2-(ethyl(2-ethyl-5-(2-morpholinopyrimidin-5-yl)-2H...)
Affinity DataIC50: 3.00E+4nMAssay Description:Rapid activation of human delayed rectifier potassium current (IKr) is mainly mediated by hERG ion channel and participates in repolarization of huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Suzhou Ark Biopharmaceutical

US Patent
LigandPNGBDBM50187686(CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...)
Affinity DataIC50: 3.00E+4nMAssay Description:Rapid activation of human delayed rectifier potassium current (IKr) is mainly mediated by hERG ion channel and participates in repolarization of huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Suzhou Ark Biopharmaceutical

US Patent
LigandPNGBDBM620081(2-((5-(2-(1,1-dioxidoisothiazolidin-2-yl)pyrimidin...)
Affinity DataIC50: 3.00E+4nMAssay Description:Rapid activation of human delayed rectifier potassium current (IKr) is mainly mediated by hERG ion channel and participates in repolarization of huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Suzhou Ark Biopharmaceutical

US Patent
LigandPNGBDBM620089(2-(ethyl(2-ethyl-5-(2-(4-hydroxypiperidin-1-yl)pyr...)
Affinity DataIC50: 3.00E+4nMAssay Description:Rapid activation of human delayed rectifier potassium current (IKr) is mainly mediated by hERG ion channel and participates in repolarization of huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetAutotaxin(Human)
Suzhou Ark Biopharmaceutical

US Patent
LigandPNGBDBM620080(2-((2-ethyl-6-(5-fluoro-6-(3-hydroxyazetidin-1-car...)
Affinity DataIC50: 0nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent