Compile Data Set for Download or QSAR
Report error Found 35 Enz. Inhib. hit(s) with all data for entry = 10962
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581306BDBM581306(US11504368, Example 24 | (2S)-2-[(5-{[(2,4-diamino...)
Affinity DataIC50: 3nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581300BDBM581300(US11504368, Example 18 | (2S)-2-[(6-cyclopropoxy-5...)
Affinity DataIC50: 3nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581317BDBM581317(US11504368, Example 35 | (2S)-2-[(5-{[(2,4-diamino...)
Affinity DataIC50: 5nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581313BDBM581313(US11504368, Example 31 | (2S)-2-[(5-{[(2,4-diamino...)
Affinity DataIC50: 8nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581288BDBM581288(US11504368, Example 6 | (2S)-2-[(5-{[(2,4-diamino-...)
Affinity DataIC50: 10nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581298BDBM581298(US11504368, Example 16 | (2S)-4- [(benzenesulfonyl...)
Affinity DataIC50: 11nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581286BDBM581286(US11504368, Example 4 | (2S)-2-[(5-{[(2,4-diamino-...)
Affinity DataIC50: 12nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581314BDBM581314(US11504368, Example 32 | (2S)-2-({5-[2-(2,4-diamin...)
Affinity DataIC50: 13nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581308BDBM581308(US11504368, Example 26 | (2S)-2-({5-[2-(2,4-diamin...)
Affinity DataIC50: 14nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581287BDBM581287(US11504368, Example 5 | (2S)-2-[(3-chloro-5-{[(2,4...)
Affinity DataIC50: 15nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581294BDBM581294(US11504368, Example 12 | (2S)-2-cyclohexyl-2-[(5-{...)
Affinity DataIC50: 17nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581285BDBM581285(US11504368, Example 3 | (2S)-2-[(5-{[(2,4-diamino-...)
Affinity DataIC50: 19nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581297BDBM581297(US11504368, Example 15 | (2S)-2-[(5-{[(2,4-diamino...)
Affinity DataIC50: 23nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581283BDBM581283(US11504368, Example 1 | (2S)-2-[(5-{[(2,4-diamino-...)
Affinity DataIC50: 24nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581307BDBM581307(US11504368, Example 25 | (2R)-2-[(4S)-4-carboxy-4-...)
Affinity DataIC50: 30nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581299BDBM581299(US11504368, Example 17 | (2S)-2-[(5-{[(2,4-diamino...)
Affinity DataIC50: 32nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581296BDBM581296(US11504368, Example 14 | (2S)-2-[(5-{[(2,4-diamino...)
Affinity DataIC50: 36nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581305BDBM581305(US11504368, Example 23 | (2S)-2-[(4S)-4-carboxy-4-...)
Affinity DataIC50: 43nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581311BDBM581311(US11504368, Example 29 | (2S)-2-({5-[2-(2,4-diamin...)
Affinity DataIC50: 44nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581293BDBM581293(US11504368, Example 11 | (2S)-3-cyclopentyl-2-[(5-...)
Affinity DataIC50: 46nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581292BDBM581292(US11504368, Example 10 | (2S)-2-({5-[2-(2,4-diamin...)
Affinity DataIC50: 49nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581291BDBM581291(US11504368, Example 9 | (2S)-2-({5-[2-(2,4-diamino...)
Affinity DataIC50: 53nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581316BDBM581316(US11504368, Example 34 | (2S)-2-({5-[2-(2,4-diamin...)
Affinity DataIC50: 60nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581309BDBM581309(US11504368, Example 27 | (2S)-2-({5-[2-(2,4-diamin...)
Affinity DataIC50: 65nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581284BDBM581284(US11504368, Example 2 | (2S)-2-[(5-{[(2,4-diamino-...)
Affinity DataIC50: 68nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581301BDBM581301(US11504368, Example 19 | (2S)-2-({3-chloro-5-[2-(2...)
Affinity DataIC50: 72nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581310BDBM581310(US11504368, Example 28 | (2S)-2-[(4S)-4-carboxy-4-...)
Affinity DataIC50: 92nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581315BDBM581315(US11504368, Example 33 | (2S)-2-({5-[2-(2,4-diamin...)
Affinity DataIC50: 92nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581295BDBM581295(US11504368, Example 13 | (2S)-2-({5-[2-(2,4-diamin...)
Affinity DataIC50: 103nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581289BDBM581289(US11504368, Example 7 | (2S)-2-({5-[2-(2,4-diamino...)
Affinity DataIC50: 154nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581304BDBM581304(US11504368, Example 22 | (2S)-2-[(5-{[(2,4-diamino...)
Affinity DataIC50: 195nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581303BDBM581303(US11504368, Example 21 | (2S)-2-({5-[2-(2,4-diamin...)
Affinity DataIC50: 298nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581290BDBM581290(US11504368, Example 8 | (2S)-2-({5-[2-(2,4-diamino...)
Affinity DataIC50: 312nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581302BDBM581302(US11504368, Example 20 | (2S)-2-({5-[2-(2,4-diamin...)
Affinity DataIC50: 913nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581312BDBM581312(US11504368, Example 30 | (2S)-2-({5-[2-(2,4-diamin...)
Affinity DataIC50: 1.10E+3nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent