Compile Data Set for Download or QSAR
Report error Found 8 Enz. Inhib. hit(s) with all data for entry = 102
TargetFatty-acid amide hydrolase 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174013(4-(2,2-difluoro-benzo[1,3]dioxol-5-ylmethyl)-piper...)
Affinity DataIC50: 75nMpH: 9.0Assay Description:T84 frozen cell pellets or transfected SK-N-MC cells (contents of 1×15 cm culture dishes) were homogenized in 50 mL of FAAH assay buffer (125 mM Tris...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetFatty-acid amide hydrolase 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174013(4-(2,2-difluoro-benzo[1,3]dioxol-5-ylmethyl)-piper...)
Affinity DataIC50: 320nMpH: 9.0Assay Description:Transfected SK-N-MC cells (contents of 1×15 cm culture dishes) were homogenized in 50 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0.2% Glycerol,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetFatty-acid amide hydrolase 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM188461(US9688664, Comparator Compound | US9169224, 150)
Affinity DataIC50: 340nMpH: 9.0Assay Description:T84 frozen cell pellets or transfected SK-N-MC cells (contents of 1×15 cm culture dishes) were homogenized in 50 mL of FAAH assay buffer (125 mM Tris...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetFatty-acid amide hydrolase 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM188461(US9688664, Comparator Compound | US9169224, 150)
Affinity DataIC50: 450nMpH: 9.0Assay Description:Transfected SK-N-MC cells (contents of 1×15 cm culture dishes) were homogenized in 50 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0.2% Glycerol,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetCytochrome P450 2D6(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM188461(US9688664, Comparator Compound | US9169224, 150)
Affinity DataIC50: 2.00E+3nMpH: 7.4Assay Description:The assay was set up and executed using a Biomek FXp robotic liquid handling workstation (Beckman Coulter Corp., Fullerton, Calif.), integrated with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetCytochrome P450 2D6(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM188461(US9688664, Comparator Compound | US9169224, 150)
Affinity DataIC50: 3.20E+3nMpH: 7.4Assay Description:The assay was set up and executed using a Biomek FXp robotic liquid handling workstation (Beckman Coulter Corp., Fullerton, Calif.), integrated with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetCytochrome P450 2D6(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174013(4-(2,2-difluoro-benzo[1,3]dioxol-5-ylmethyl)-piper...)
Affinity DataIC50: 1.10E+4nMpH: 7.4Assay Description:The assay was set up and executed using a Biomek FXp robotic liquid handling workstation (Beckman Coulter Corp., Fullerton, Calif.), integrated with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetCytochrome P450 2D6(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174013(4-(2,2-difluoro-benzo[1,3]dioxol-5-ylmethyl)-piper...)
Affinity DataIC50: 2.40E+4nMpH: 7.4Assay Description:The assay was set up and executed using a Biomek FXp robotic liquid handling workstation (Beckman Coulter Corp., Fullerton, Calif.), integrated with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent