Compile Data Set for Download or QSAR
Report error Found 698 Enz. Inhib. hit(s) with all data for entry = 9511
LigandChemical structure of BindingDB Monomer ID 471740BDBM471740((R)-5-[3-[4-(3,4- difluoro-5- methoxy- phenyl) pip...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471743BDBM471743(5-cyclopropyl-5- [3-[(3S)-4-(3,4- difluoro-5- meth...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471736BDBM471736(5-cyclopropyl-5- [3-[4-(3,4- difluoro-5- methoxy- ...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471788BDBM471788((5S)-5- cyclopropyl- 5-[3-[(3S)-4-(3,4- difluoro-5...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471771BDBM471771(5-[3-[(3S)-4-(4- chloro-3,5- dimethoxy- phenyl)- 3...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471775BDBM471775(5-[3-[4-(4-chloro- 3,5-dimethoxy- phenyl) piperazi...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471769BDBM471769(5-cyclopropyl-5- [(2S)-3-[(3S)-4- (3,4-difluoro-5-...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471764BDBM471764((5S)-5- cyclopropyl- 5-[(2S)-3-[4-(3- fluoro-5-met...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471766BDBM471766((5R)-5-[(2S)-3-[4- (3-fluoro-5- methoxy- phenyl) p...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471761BDBM471761(5-[3-[(3S)-4-(4- chloro-3-methoxy- phenyl)-3-methy...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471757BDBM471757(5-[3-[(3S)-4-(3,4- difluoro-5- methoxy-phenyl)- 3-...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471801BDBM471801(5-[3-[4-(3,4- difluoro-5- methoxy- phenyl) piperaz...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471827BDBM471827(5-[3-[(3S)-4-(3- chloro-4-fluoro-5- methoxy-phenyl...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471799BDBM471799(5-[3-[4-(3-chloro- 4-fluoro-5- methoxy- phenyl) pi...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471800BDBM471800(5-[3-[4-(3,4- difluoro-5- methoxy- phenyl) piperaz...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471797BDBM471797(5-[3-[4-(3,4- dichloro-5- methoxy- phenyl) piperaz...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471798BDBM471798(5-[3-[(3S)-4-(3,4- difluoro-5- methoxy-phenyl)- 3-...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471795BDBM471795(5-[3-[(3S)-4-(3,4- difluoro-5- methoxy-phenyl)- 3-...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471796BDBM471796(5-[3-[(3S)-4-(4- chloro-3-methoxy- phenyl)-3-methy...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471933BDBM471933(5-[3-[(3S)-4-(4- chloro-3,5- dimethoxy- phenyl)- 3...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471793BDBM471793(5-[3-[(3S)-4-(3,4- difluoro-5- methoxy-phenyl)- 3-...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471794BDBM471794(5-[3-[4-(3,4- difluoro-5- methoxy- phenyl) piperaz...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471791BDBM471791(5-[3-[4-(4-chloro- 3,5-dimethoxy- phenyl) piperazi...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471792BDBM471792(5-[3-[4-(4-chloro- 3-methoxy- phenyl)-3-methyl- pi...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471789BDBM471789(5-[3-[4-(4-chloro- 3-fluoro-5- methoxy- phenyl) pi...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471790BDBM471790(5-[3-[(3S)-4-(4- chloro-3-fluoro-5- methoxy-phenyl...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471841BDBM471841((5S)-5-[3-[(3S)- 4-(4-chloro- 3-fluoro- 5-methoxy-...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471838BDBM471838((5S)-5-[3-[(3S)-4- (3-chloro- 4-fluoro- 5-methoxy-...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471839BDBM471839((5R)-5-[3-[(3S)-4- (3-chloro- 4-fluoro- 5-methoxy-...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471837BDBM471837(5-[3-[(3S)-4-(3,4- difluoro-5- methoxy-phenyl)- 3-...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471834BDBM471834((5S)-5-[(2S)-3-[4- (3,4-difluoro-5- methoxy- pheny...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471830BDBM471830((5R)-5-[(2R)-3-[4- (3,4-difluoro-5- methoxy- pheny...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471831BDBM471831((5R)-5-[(2S)-3- [4-(3,4-difluoro- 5-methoxy- pheny...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471828BDBM471828((5S)-5-[(2S)-3-[4- (3,4-difluoro-5- methoxy- pheny...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471829BDBM471829((5R)-5-[3-[(3S)-4- (4-chloro-3- methoxy-phenyl)- 3...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetADAMTS5(Rat)
Galapagos

US Patent
LigandChemical structure of BindingDB Monomer ID 471764BDBM471764((5S)-5- cyclopropyl- 5-[(2S)-3-[4-(3- fluoro-5-met...)
Affinity DataIC50: 12.5nMAssay Description:TABLE VII: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID NO: 2) by rnADAMTS-5 (1-564-6H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 379980BDBM379980(US9926281, Compound 468 | US10829478, Compound 85)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471849BDBM471849((5R)-5-[3-[(3S)-4- (4-chloro- 3-ethoxy- 5-methoxy-...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetADAMTS5(Rat)
Galapagos

US Patent
LigandChemical structure of BindingDB Monomer ID 471743BDBM471743(5-cyclopropyl-5- [3-[(3S)-4-(3,4- difluoro-5- meth...)
Affinity DataIC50: 12.5nMAssay Description:TABLE VII: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID NO: 2) by rnADAMTS-5 (1-564-6H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471847BDBM471847((5R)-5-[3-[4-(4- chloro-3-ethoxy- 5-methoxy- pheny...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471845BDBM471845((5R)-5-[3-[4-(4- fluoro-3,5- dimethoxy- phenyl) pi...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471846BDBM471846((5R)-5-[3-[(3S)-4- (4-chloro-3-ethyl- phenyl)- 3-m...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471974BDBM471974(US10829478, Compound 100 | 5-[3-[(3S)-4-(4- chloro...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471975BDBM471975(US10829478, Compound 101 | 5-[3-[(3S)-4-[4- chloro...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetADAMTS5(Rat)
Galapagos

US Patent
LigandChemical structure of BindingDB Monomer ID 471793BDBM471793(5-[3-[(3S)-4-(3,4- difluoro-5- methoxy-phenyl)- 3-...)
Affinity DataIC50: 12.5nMAssay Description:TABLE VII: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID NO: 2) by rnADAMTS-5 (1-564-6H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 379986BDBM379986(US9926281, Compound 471 | US10829478, Compound 98)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetADAMTS5(Rat)
Galapagos

US Patent
LigandChemical structure of BindingDB Monomer ID 471794BDBM471794(5-[3-[4-(3,4- difluoro-5- methoxy- phenyl) piperaz...)
Affinity DataIC50: 12.5nMAssay Description:TABLE VII: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID NO: 2) by rnADAMTS-5 (1-564-6H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471869BDBM471869((5R)-5-[3-[(3S)- 4-[4-chloro-3- (dimethylamino)- 5...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 471855BDBM471855((5R)-5-[3-[(3S)- 4-(3-chloro-5- methoxy-phenyl)- 3...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetADAMTS5(Rat)
Galapagos

US Patent
LigandChemical structure of BindingDB Monomer ID 471792BDBM471792(5-[3-[4-(4-chloro- 3-methoxy- phenyl)-3-methyl- pi...)
Affinity DataIC50: 12.5nMAssay Description:TABLE VII: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID NO: 2) by rnADAMTS-5 (1-564-6H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

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