Target
A disintegrin and metalloproteinase with thrombospondin motifs 6
Ligand
BDBM471798
Substrate
n/a
Meas. Tech.
In Vitro Assay
IC50
12.5±n/a nM
Citation
 Labéguère, FGHeng, RDe Ceuninck, FAAlvey, LJAmantini, DBrebion, FLDeprez, PMGosmini, RLJary, HMPeixoto, CPop-Botez, IEVarin, ML 5-[3-[piperazin-1-yl]-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS 4 and 5 inhibitors for treating e.g. osteoarthritis US Patent  US10829478 Publication Date 11/10/2020 
Target
Name:
A disintegrin and metalloproteinase with thrombospondin motifs 6
Synonyms:
ADAM-TS 6 | ADAM-TS6 | ADAMTS-6 | ADAMTS6 | ATS6_HUMAN
Type:
Protein
Mol. Mass.:
125276.26
Organism:
Human
Description:
Q9UKP5
Residue:
1117
Sequence:
MEILWKTLTWILSLIMASSEFHSDHRLSYSSQEEFLTYLEHYQLTIPIRVDQNGAFLSFTVKNDKHSRRRRSMDPIDPQQAVSKLFFKLSAYGKHFHLNLTLNTDFVSKHFTVEYWGKDGPQWKHDFLDNCHYTGYLQDQRSTTKVALSNCVGLHGVIATEDEEYFIEPLKNTTEDSKHFSYENGHPHVIYKKSALQQRHLYDHSHCGVSDFTRSGKPWWLNDTSTVSYSLPINNTHIHHRQKRSVSIERFVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVARLIVLTEDQPNLEINHHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLITRYDICTYKNKPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKGHEAAKLMAAHITANTNPFSWSACSRDYITSFLDSGRGTCLDNEPPKRDFLYPAVAPGQVYDADEQCRFQYGATSRQCKYGEVCRELWCLSKSNRCVTNSIPAAEGTLCQTGNIEKGWCYQGDCVPFGTWPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFREKQCADFDNMPFRGKYYNWKPYTGGGVKPCALNCLAEGYNFYTERAPAVIDGTQCNADSLDICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEVREVAMSKNYIALKSEGDDYYINGAWTIDWPRKFDVAGTAFHYKRPTDEPESLEALGPTSENLIVMVLLQEQNLGIRYKFNVPITRTGSGDNEVGFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCESKCDSTPISNTEECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTCQGH
  
Inhibitor
Name:
BDBM471798
Synonyms:
5-[3-[(3S)-4-(3,4- difluoro-5- methoxy-phenyl)- 3-methyl- piperazin- 1-yl]-2-methyl-3- oxo-propyl]- 5-(2- pyridyl) imidazolidine- 2,4-dione | US10829478, Compound 49
Type:
Small organic molecule
Emp. Form.:
C24H27F2N5O4
Mol. Mass.:
487.4991
SMILES:
COc1cc(cc(F)c1F)N1CCN(C[C@@H]1C)C(=O)[C@@H](C)C[C@]1(NC(=O)NC1=O)c1ccccn1 |r|
Structure:
Search PDB for entries with ligand similarity: