Compile Data Set for Download or QSAR
Report error Found 169 Enz. Inhib. hit(s) with all data for entry = 11561
TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626988BDBM626988((2s,4R*)-2-((2S*,4R*)-4-(4-(tert-Butyl)phenyl)-2-m...)
Affinity DataIC50: 0.200nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626965BDBM626965(US11787798, Example 141 | US11787798, Example 144 ...)
Affinity DataIC50: 0.200nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626948BDBM626948((2s,4s)-2-(4-(4-(tert-Butyl)phenyl)piperidine-1-ca...)
Affinity DataIC50: 0.200nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626990BDBM626990((2s,4S*)-2-((2R*,4S*)-4-(4-(tert-Butyl)phenyl)-2-m...)
Affinity DataIC50: 0.300nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626910BDBM626910((2s,4s)-2-(4-(4-(Trimethylsilyl)phenyl)piperidine-...)
Affinity DataIC50: 0.300nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626969BDBM626969((racemic)-(2s,4s)-2-(4-(4-(tert-Butyl)phenyl)-2-me...)
Affinity DataIC50: 0.300nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626967BDBM626967((2s,4R*)-2-((3S*,4S*)-4-(4-(tert-Butyl)phenyl)-3-m...)
Affinity DataIC50: 0.300nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626920BDBM626920((2s,4s)-2-(4-(4-(tert-Butyl)-3-methoxyphenyl)piper...)
Affinity DataIC50: 0.400nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626965BDBM626965(US11787798, Example 141 | US11787798, Example 144 ...)
Affinity DataIC50: 0.400nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626902BDBM626902((2s,4s)-2-(4-(4-Isobutylphenyl)piperidine-1-carbon...)
Affinity DataIC50: 0.5nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626820BDBM626820((2s,4s)-2-(4-(4-(1-Methylcyclopropyl)phenyl)piperi...)
Affinity DataIC50: 0.5nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626888BDBM626888((2s,4s)-2-(4-(3-(tert-Butyl)-4-chlorophenyl)piperi...)
Affinity DataIC50: 0.600nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626917BDBM626917((2s,4s)-2-(4-(3-(Trimethylsilyl)phenyl)piperidine-...)
Affinity DataIC50: 0.700nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626870BDBM626870(US11787798, Example 48 | US11787798, Example 51 | ...)
Affinity DataIC50: 0.700nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626951BDBM626951((2r,4s)-2-(4-(4-(tert-Butyl)phenyl)piperidine-1-ca...)
Affinity DataIC50: 0.900nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626836BDBM626836((2r,4s)-2-(4-(4-(1-Methylcyclopropyl)phenyl)piperi...)
Affinity DataIC50: 1.10nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626922BDBM626922((racemic)-(2s,4s)-2-(4-(4-(sec-Butyl)phenyl)piperi...)
Affinity DataIC50: 1.10nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626890BDBM626890((2s,4s)-2-(4-(3-(tert-Butyl)-4-fluorophenyl)piperi...)
Affinity DataIC50: 1.10nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626803BDBM626803((2s,4s)-2-(4-(4-Isopropylphenyl)piperidine-1-carbo...)
Affinity DataIC50: 1.10nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626979BDBM626979(US11787798, Example 154 | US11787798, Example 155 ...)
Affinity DataIC50: 1.20nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626986BDBM626986((2s,4R*)-2-((3S*,4S*)-4-([1,1'-Biphenyl]-3-yl)-3-m...)
Affinity DataIC50: 1.5nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626800BDBM626800((2s,4s)-2-(4-(3-Methyl-4-(trifluoromethoxy)phenyl)...)
Affinity DataIC50: 1.60nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626806BDBM626806((2s,4s)-2-(4-(3-(tert-Butyl)phenyl)piperidine-1-ca...)
Affinity DataIC50: 1.60nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626818BDBM626818((2s,4s)-2-(4-(4-Cyclobutylphenyl)piperidine-1-carb...)
Affinity DataIC50: 1.60nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626918BDBM626918((2r,4s)-2-(4-(4-(Trimethylsilyl)phenyl)piperidine-...)
Affinity DataIC50: 2.10nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626884BDBM626884((2s,4s)-2-(4-(2-Chloro-3-(trifluoromethoxy)phenyl)...)
Affinity DataIC50: 2.30nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626957BDBM626957((2R*,4s,8S*)-2-(4-(4-(tert-Butyl)phenyl)piperidine...)
Affinity DataIC50: 2.40nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626977BDBM626977((racemic)-(2s,4S)-2-((3R,4R)-3-Methyl-4-(4-methyl-...)
Affinity DataIC50: 2.5nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626987BDBM626987((racemic)-(2s,4R)-2-((2S,4S)-4-(3-(tert-Butyl)phen...)
Affinity DataIC50: 2.5nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626906BDBM626906((2s,4s)-2-(4-(3-Isobutylphenyl)piperidine-1-carbon...)
Affinity DataIC50: 2.5nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626965BDBM626965(US11787798, Example 141 | US11787798, Example 144 ...)
Affinity DataIC50: 2.5nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626805BDBM626805((2s,4s)-2-(4-(4-Methyl-3-(trifluoromethyl)phenyl)p...)
Affinity DataIC50: 2.90nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626843BDBM626843((2s,4s)-2-(4-(3-(1-Methylcyclopropyl)phenyl)piperi...)
Affinity DataIC50: 3.20nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626923BDBM626923((racemic)-(2r,4s)-2-(4-(4-(sec-Butyl)phenyl)piperi...)
Affinity DataIC50: 3.5nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626900BDBM626900((2s,4s)-2-(4-(4-(Pentafluoro-lambda6-sulfaneyl)phe...)
Affinity DataIC50: 3.70nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626978BDBM626978((racemic)-(2s,4S)-2-((3R,4R)-3-Methyl-4-(3-methyl-...)
Affinity DataIC50: 3.70nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626895BDBM626895((2r, 4s)-2-(4-(3-(tert-Butyl)-4-chlorophenyl)piper...)
Affinity DataIC50: 3.80nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626933BDBM626933((2s,4s)-2-(4-(5-Chlorobenzofuran-2-yl)piperidine-1...)
Affinity DataIC50: 3.90nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626993BDBM626993((2s,4S*)-2-((2R*,4S*)-4-(3-(tert-Butyl)phenyl)-2-m...)
Affinity DataIC50: 4.20nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626870BDBM626870(US11787798, Example 48 | US11787798, Example 51 | ...)
Affinity DataIC50: 4.20nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626885BDBM626885((2s,4s)-2-(4-(2-Methyl-3-(trifluoromethoxy)phenyl)...)
Affinity DataIC50: 4.30nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626801BDBM626801((2s,4s)-2-(4-(4-Cyclopropylphenyl)piperidine-1-car...)
Affinity DataIC50: 4.30nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626802BDBM626802((2s,4s)-2-(4-(3-Methyl-4-(trifluoromethyl)phenyl)p...)
Affinity DataIC50: 4.30nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626955BDBM626955((racemic)-(2s,4s)-2-(4-(4-(tert-Butyl)phenyl)piper...)
Affinity DataIC50: 4.5nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626916BDBM626916((2R*,4s,8S*)-8-Methyl-2-(4-(4-(1-methylcyclopropyl...)
Affinity DataIC50: 4.5nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626971BDBM626971((racemic)-(2s,4S)-2-((3R,4R)-3-Methyl-4-(3-methyl-...)
Affinity DataIC50: 4.70nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626907BDBM626907((2s,4s)-2-(4-(4-(2-Hydroxypropan-2-yl)phenyl)piper...)
Affinity DataIC50: 4.70nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626963BDBM626963((2s, 4s)-2-(4-(4-Methyl-3-(trifluoromethoxy)phenyl...)
Affinity DataIC50: 4.70nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626867BDBM626867((2s,4s)-2-(4-(6-(tert-Butyl)pyridin-3-yl)piperidin...)
Affinity DataIC50: 5nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 626875BDBM626875((2s,4s)-2-(4-(3-Phenoxyphenyl)piperidine-1-carbony...)
Affinity DataIC50: 5.20nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

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