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Found 96 Enz. Inhib. hit(s) with all data for entry = 10841
LigandPNGBDBM573147(US11453673, Example 9)
Affinity DataIC50:  0.958nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM573138(US11453673, Example 4)
Affinity DataIC50:  1.06nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM573155(US11453673, Example 16)
Affinity DataIC50:  1.20nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM573136(US11453673, Example 3)
Affinity DataIC50:  1.26nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM573154(US11453673, Example 15)
Affinity DataIC50:  1.40nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM573144(US11453673, Example 6)
Affinity DataIC50:  1.88nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
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LigandPNGBDBM573148(US11453673, Example 10)
Affinity DataIC50:  2nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM573139(US11453673, Example 5)
Affinity DataIC50:  2.70nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM573135(US11453673, Example 2)
Affinity DataIC50:  2.81nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
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LigandPNGBDBM573154(US11453673, Example 15)
Affinity DataIC50:  3.10nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
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LigandPNGBDBM573138(US11453673, Example 4)
Affinity DataIC50:  3.65nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM573138(US11453673, Example 4)
Affinity DataIC50:  3.71nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM573135(US11453673, Example 2)
Affinity DataIC50:  3.73nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
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LigandPNGBDBM573147(US11453673, Example 9)
Affinity DataIC50:  3.73nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
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LigandPNGBDBM573135(US11453673, Example 2)
Affinity DataIC50:  4.11nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
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LigandPNGBDBM573149(US11453673, Example 11)
Affinity DataIC50:  4.77nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
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LigandPNGBDBM573154(US11453673, Example 15)
Affinity DataIC50:  4.90nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
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LigandPNGBDBM573147(US11453673, Example 9)
Affinity DataIC50:  4.94nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
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LigandPNGBDBM573144(US11453673, Example 6)
Affinity DataIC50:  5.98nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM573152(US11453673, Example 13)
Affinity DataIC50:  6.35nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM573155(US11453673, Example 16)
Affinity DataIC50:  6.54nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
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LigandPNGBDBM573148(US11453673, Example 10)
Affinity DataIC50:  6.72nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
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LigandPNGBDBM573144(US11453673, Example 6)
Affinity DataIC50:  7.03nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
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LigandPNGBDBM573145(US11453673, Example 7)
Affinity DataIC50:  7.76nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
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LigandPNGBDBM573155(US11453673, Example 16)
Affinity DataIC50:  8.67nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
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LigandPNGBDBM573136(US11453673, Example 3)
Affinity DataIC50:  9.36nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
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LigandPNGBDBM573146(US11453673, Example 8)
Affinity DataIC50:  10.1nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
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LigandPNGBDBM573148(US11453673, Example 10)
Affinity DataIC50:  10.6nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
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LigandPNGBDBM573136(US11453673, Example 3)
Affinity DataIC50:  11nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
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LigandPNGBDBM573139(US11453673, Example 5)
Affinity DataIC50:  11.1nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
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LigandPNGBDBM573139(US11453673, Example 5)
Affinity DataIC50:  11.5nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
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LigandPNGBDBM573134(US11453673, Example 1)
Affinity DataIC50:  12nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
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LigandPNGBDBM573149(US11453673, Example 11)
Affinity DataIC50:  13.2nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
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LigandPNGBDBM573150(US11453673, Example 12)
Affinity DataIC50:  13.2nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM573149(US11453673, Example 11)
Affinity DataIC50:  17.6nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM573134(US11453673, Example 1)
Affinity DataIC50:  20.3nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM573152(US11453673, Example 13)
Affinity DataIC50:  21.8nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM573152(US11453673, Example 13)
Affinity DataIC50:  21.8nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
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LigandPNGBDBM573153(US11453673, Example 14)
Affinity DataIC50:  22.3nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
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LigandPNGBDBM573146(US11453673, Example 8)
Affinity DataIC50:  25.4nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
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LigandPNGBDBM573145(US11453673, Example 7)
Affinity DataIC50:  28.5nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM573134(US11453673, Example 1)
Affinity DataIC50:  29.4nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM573145(US11453673, Example 7)
Affinity DataIC50:  32.7nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
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LigandPNGBDBM573150(US11453673, Example 12)
Affinity DataIC50:  33.9nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM573146(US11453673, Example 8)
Affinity DataIC50:  36.9nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
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LigandPNGBDBM573150(US11453673, Example 12)
Affinity DataIC50:  44.6nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
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LigandPNGBDBM573153(US11453673, Example 14)
Affinity DataIC50:  48nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
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LigandPNGBDBM573153(US11453673, Example 14)
Affinity DataIC50:  52.4nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
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TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha/beta(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM573146(US11453673, Example 8)
Affinity DataIC50:  2.66E+3nMAssay Description:Table 7: The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of h...More data for this Ligand-Target Pair
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TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM573134(US11453673, Example 1)
Affinity DataIC50:  5.59E+3nMAssay Description:Table 6: The following PDE activities are measured using [3H]cAMP as reaction substrate: human PDE3A (catalytic domain) and human PDE4D. Both enzymes...More data for this Ligand-Target Pair
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