BDBM573146 US11453673, Example 8

SMILES Cc1c(C)n2c(nnc2c(=O)n1CC1CCCCO1)C1(C)CC1

InChI Key InChIKey=HAKBILSEBDWPBF-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 573146   

LigandPNGBDBM573146(US11453673, Example 8)
Affinity DataIC50:  25.4nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM573146(US11453673, Example 8)
Affinity DataIC50:  36.9nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha/beta(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM573146(US11453673, Example 8)
Affinity DataIC50:  2.66E+3nMAssay Description:Table 7: The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM573146(US11453673, Example 8)
Affinity DataIC50: >1.00E+5nMAssay Description:Table 6: The following PDE activities are measured using [3H]cAMP as reaction substrate: human PDE3A (catalytic domain) and human PDE4D. Both enzymes...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM573146(US11453673, Example 8)
Affinity DataIC50:  5.77E+4nMAssay Description:Table 6: The following PDE activities are measured using [3H]cAMP as reaction substrate: human PDE3A (catalytic domain) and human PDE4D. Both enzymes...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM573146(US11453673, Example 8)
Affinity DataIC50:  10.1nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent