Compile Data Set for Download or QSAR
Report error Found 27 Enz. Inhib. hit(s) with all data for entry = 10533
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Hanmi Pharm.

US Patent
LigandChemical structure of BindingDB Monomer ID 476709BDBM476709(2-((5-chloro-4-(6-methyl-1H-indole-3-yl)pyrimidine...)
Affinity DataIC50: 0.400nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Hanmi Pharm.

US Patent
LigandChemical structure of BindingDB Monomer ID 546731BDBM546731((3-(5-chloro-2-((3-cyclopropyl-5-(((3R, 5S)-3,5-di...)
Affinity DataIC50: 0.400nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Hanmi Pharm.

US Patent
LigandChemical structure of BindingDB Monomer ID 546731BDBM546731((3-(5-chloro-2-((3-cyclopropyl-5-(((3R, 5S)-3,5-di...)
Affinity DataIC50: 0.5nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Hanmi Pharm.

US Patent
LigandChemical structure of BindingDB Monomer ID 476700BDBM476700(5-chloro-N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethyl...)
Affinity DataIC50: 1.10nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Hanmi Pharm.

US Patent
LigandChemical structure of BindingDB Monomer ID 476702BDBM476702(N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethylpiperazin...)
Affinity DataIC50: 1.20nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Hanmi Pharm.

US Patent
LigandChemical structure of BindingDB Monomer ID 476695BDBM476695(5-chloro-4-(6-chloro-1H-indole-3-yl)-N-(3-cyclopro...)
Affinity DataIC50: 1.5nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Hanmi Pharm.

US Patent
LigandChemical structure of BindingDB Monomer ID 476711BDBM476711(US10870639, Example 26 | ((2R,6R)-4-(3-((5-chloro...)
Affinity DataIC50: 1.5nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Hanmi Pharm.

US Patent
LigandChemical structure of BindingDB Monomer ID 476699BDBM476699((R)-5-chloro-N-(3-cyclopropyl-5-((3-methylpiperazi...)
Affinity DataIC50: 1.80nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Hanmi Pharm.

US Patent
LigandChemical structure of BindingDB Monomer ID 476700BDBM476700(5-chloro-N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethyl...)
Affinity DataIC50: 1.80nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Hanmi Pharm.

US Patent
LigandChemical structure of BindingDB Monomer ID 476695BDBM476695(5-chloro-4-(6-chloro-1H-indole-3-yl)-N-(3-cyclopro...)
Affinity DataIC50: 1.90nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Hanmi Pharm.

US Patent
LigandChemical structure of BindingDB Monomer ID 476710BDBM476710(US10870639, Example 25 | (R)-5-chloro-N-(3-cyclopr...)
Affinity DataIC50: 2.30nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Hanmi Pharm.

US Patent
LigandChemical structure of BindingDB Monomer ID 476711BDBM476711(US10870639, Example 26 | ((2R,6R)-4-(3-((5-chloro...)
Affinity DataIC50: 2.30nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Hanmi Pharm.

US Patent
LigandChemical structure of BindingDB Monomer ID 476708BDBM476708(3-(5-chloro-2-((3-cyclopropyl-5-(((3R,5S)-3,5-dime...)
Affinity DataIC50: 2.40nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Hanmi Pharm.

US Patent
LigandChemical structure of BindingDB Monomer ID 476702BDBM476702(N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethylpiperazin...)
Affinity DataIC50: 2.5nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Hanmi Pharm.

US Patent
LigandChemical structure of BindingDB Monomer ID 476697BDBM476697(2-((2R,6S)-4-(3-((5-chloro-4-(1H-indole-3-yl)pyrim...)
Affinity DataIC50: 3.60nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Hanmi Pharm.

US Patent
LigandChemical structure of BindingDB Monomer ID 476701BDBM476701(chloro-N-(3-cyclopropyl-5-((3,5-dimethyl piperazin...)
Affinity DataIC50: 3.60nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Hanmi Pharm.

US Patent
LigandChemical structure of BindingDB Monomer ID 476706BDBM476706(3-(5-chloro-2-((3-cyclopropyl-5-(((3R,5S)-3,5-dime...)
Affinity DataIC50: 3.70nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Hanmi Pharm.

US Patent
LigandChemical structure of BindingDB Monomer ID 476712BDBM476712(US10870639, Example 31 | (2R,6S)-4-(3-((5-chloro-4...)
Affinity DataIC50: 6.90nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Hanmi Pharm.

US Patent
LigandChemical structure of BindingDB Monomer ID 476698BDBM476698(2-((2R,6S)-4-(3-((5-chloro-4-(6-methyl-1H-indole-3...)
Affinity DataIC50: 7.20nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Hanmi Pharm.

US Patent
LigandChemical structure of BindingDB Monomer ID 476696BDBM476696(2-((2R,6S)-4-(3-((5-chloro-4-(6-fluoro-1H-indole-3...)
Affinity DataIC50: 8.10nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Hanmi Pharm.

US Patent
LigandChemical structure of BindingDB Monomer ID 476703BDBM476703(N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethylpiperazin...)
Affinity DataIC50: 8.70nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Hanmi Pharm.

US Patent
LigandChemical structure of BindingDB Monomer ID 476705BDBM476705(5-chloro-N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethyl...)
Affinity DataIC50: 9.5nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Hanmi Pharm.

US Patent
LigandChemical structure of BindingDB Monomer ID 476706BDBM476706(3-(5-chloro-2-((3-cyclopropyl-5-(((3R,5S)-3,5-dime...)
Affinity DataIC50: 13nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Hanmi Pharm.

US Patent
LigandChemical structure of BindingDB Monomer ID 476710BDBM476710(US10870639, Example 25 | (R)-5-chloro-N-(3-cyclopr...)
Affinity DataIC50: 20nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Hanmi Pharm.

US Patent
LigandChemical structure of BindingDB Monomer ID 476707BDBM476707(3-(5-chloro-2-((3-cyclopropyl-5-(((3R,5S)-3,5-dime...)
Affinity DataIC50: 50nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Hanmi Pharm.

US Patent
LigandChemical structure of BindingDB Monomer ID 476709BDBM476709(2-((5-chloro-4-(6-methyl-1H-indole-3-yl)pyrimidine...)
Affinity DataIC50: 50nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Hanmi Pharm.

US Patent
LigandChemical structure of BindingDB Monomer ID 476705BDBM476705(5-chloro-N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethyl...)
Affinity DataIC50: 50nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
US Patent