BDBM476699 (R)-5-chloro-N-(3-cyclopropyl-5-((3-methylpiperazine-1-yl)methyl)phenyl)-4-(1H-indole-3-yl)pyrimidine-2-amine::US10870639, Example 6::US11292786, Example 6

SMILES C[C@@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4ccccc34)cc(c2)C2CC2)CCN1

InChI Key InChIKey=YDYYOPDHIZNTIW-QGZVFWFLSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 476699   

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476699((R)-5-chloro-N-(3-cyclopropyl-5-((3-methylpiperazi...)
Affinity DataIC50:  1.80nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM476699((R)-5-chloro-N-(3-cyclopropyl-5-((3-methylpiperazi...)
Affinity DataIC50:  1.80nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent