Compile Data Set for Download or QSAR
Report error Found 115 Enz. Inhib. hit(s) with all data for entry = 9966
TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504229BDBM504229(N-[2-[(2R)-2-Fluoro-3-hydroxy- 3-methyl-butyl]-6-i...)
Affinity DataKi:  0.170nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504219BDBM504219((R)-N-(6-(2,2-Difluoroethoxy)- 2-(2-fluoro-3-hydro...)
Affinity DataKi:  0.260nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504215BDBM504215(N-[6-(3-Fluorocyclobutoxy)-2- [(2R)-2-fluoro-3-hyd...)
Affinity DataKi:  0.280nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504233BDBM504233((R)-N-(6-Ethoxy-2-(2-fluoro-3- hydroxy-3-methylbut...)
Affinity DataKi:  0.370nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504232BDBM504232((R)-N-(2-(2-Fluoro-3-hydroxy- 3-methylbutyl)-6-iso...)
Affinity DataKi:  0.420nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504234BDBM504234(US11034698, Example 83 | US11034698, Example 84)
Affinity DataKi:  0.490nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504239BDBM504239((R)-N-(6-(Difluoromethoxy)-2- (2-fluoro-3-hydroxy-...)
Affinity DataKi:  0.5nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504218BDBM504218(N-[6-(3-Chlorocyclobutoxy)-2- [(2R)-2-fluoro-3-hyd...)
Affinity DataKi:  0.510nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504238BDBM504238((R)-N-(2-(2-Fluoro-3-hydroxy- 3-methylbutyl)-6-(ox...)
Affinity DataKi:  0.590nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504241BDBM504241((R)-N-(6-(tert-Butoxy)-2-(2- fluoro-3-hydroxy-3- m...)
Affinity DataKi:  0.610nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504267BDBM504267((R)-N-(2-(2-Fluoro-3-hydroxy- 3-methylbutyl)-1-oxo...)
Affinity DataKi:  0.630nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504228BDBM504228((R)-N-(6-Cyclopropoxy-2-(2- fluoro-3-hydroxy-3- me...)
Affinity DataKi:  0.630nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504220BDBM504220(US11034698, Example 66 | US11034698, Example 67)
Affinity DataKi:  0.670nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504224BDBM504224((R)-N-(2-(2-Fluoro-3-hydroxy- 3-methylbutyl)-1-oxo...)
Affinity DataKi:  0.700nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504234BDBM504234(US11034698, Example 83 | US11034698, Example 84)
Affinity DataKi:  0.710nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504202BDBM504202((R)-N-(6-Methoxy-2,2-dimethyl- 2,3-dihydrobenzofur...)
Affinity DataKi:  0.870nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504230BDBM504230((R)-N-(2-(2-Fluoro-3-hydroxy- 3-methylbutyl)-6-(ox...)
Affinity DataKi:  0.970nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504231BDBM504231((R)-N-(6-(Cyclopentyloxy)-2-(2- fluoro-3-hydroxy-3...)
Affinity DataKi:  0.970nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504225BDBM504225(US11034698, Example 71 | US11034698, Example 72)
Affinity DataKi:  1nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504220BDBM504220(US11034698, Example 66 | US11034698, Example 67)
Affinity DataKi:  1.10nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504214BDBM504214((R)-N-(2-(2-Fluoro-3-hydroxy- 3-methylbutyl)-6-((1...)
Affinity DataKi:  1.10nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504237BDBM504237((R)-N-(2-(2-Fluoro-3-hydroxy- 3-methylbutyl)-6-met...)
Affinity DataKi:  1.30nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504240BDBM504240((R)-N-(2-(2-Fluoro-3-hydroxy- 3-methylbutyl)-6-((1...)
Affinity DataKi:  1.30nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504258BDBM504258(N-(2-((R)-2-Fluoro-3-hydroxy- 3-methylbutyl)-6-((7...)
Affinity DataKi:  1.30nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504247BDBM504247((R)-N-(6-(4-(2,2- Difluoroethyl)piperidin-1-yl)-2-...)
Affinity DataKi:  1.5nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504250BDBM504250(N-(2-((R)-2-Fluoro-3-hydroxy- 3-methylbutyl)-6-((R...)
Affinity DataKi:  1.80nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504236BDBM504236((R)-N-(2-(2-Fluoro-3-hydroxy- 3-methylbutyl)-1-oxo...)
Affinity DataKi:  1.80nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504222BDBM504222(US11034698, Example 68 | US11034698, Example 69)
Affinity DataKi:  1.80nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504246BDBM504246(N-[6-(Dimethylamino)-2- isopropyl-1-oxo-isoindolin...)
Affinity DataKi:  1.90nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504256BDBM504256((R)-N-(6-(4-(2-(1H-Imidazol-1- yl)ethyl)piperazin-...)
Affinity DataKi:  2.10nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504173BDBM504173(N-(6-(4-((4-Chloro-1H- imidazol-5-yl)methyl)pipera...)
Affinity DataKi:  2.30nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504222BDBM504222(US11034698, Example 68 | US11034698, Example 69)
Affinity DataKi:  2.5nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504259BDBM504259((R)-N-(2-(2-Fluoro-3-hydroxy- 3-methylbutyl)-1-oxo...)
Affinity DataKi:  2.60nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504262BDBM504262((R)-N-(2-(2-Fluoro-3-hydroxy- 3-methylbutyl)-6-(4-...)
Affinity DataKi:  2.60nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504205BDBM504205(5-((2-Aminoethyl)amino)-N-(6- methoxy-2,2-dimethyl...)
Affinity DataKi:  3.20nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504225BDBM504225(US11034698, Example 71 | US11034698, Example 72)
Affinity DataKi:  3.20nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 50511348BDBM50511348(CHEMBL4566431 | US11034698, Example 105)
Affinity DataKi:  3.40nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 50511357BDBM50511357(CHEMBL4452765 | US11034698, Example 92)
Affinity DataKi:  3.70nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504227BDBM504227(N-[6-(Azetidin-3-yloxy)-2- [(2R)-2-fluoro-3-hydrox...)
Affinity DataKi:  3.70nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504166BDBM504166(N-(6-(4-(2-Acetamidoethyl)piperazin-1-yl)-2,2-dime...)
Affinity DataKi:  3.70nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504171BDBM504171(N-[2,2-dimethyl-6-[4-[(4- methyl-1H-imidazol-5- yl...)
Affinity DataKi:  3.80nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504172BDBM504172(N-[6-[4-[(4-ethyl-1H-imidazol- 5-yl)methyl]piperaz...)
Affinity DataKi:  3.90nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504201BDBM504201((R)-5-(3-Aminopiperidin-1-yl)- N-(6-methoxy-2,2-di...)
Affinity DataKi:  4.10nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504203BDBM504203(5-amino-N-(6-Methoxy-2,2- dimethyl-2,3- dihydroben...)
Affinity DataKi:  4.60nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504174BDBM504174(N-(2,2-Dimethyl-6-(4-((4- methylthiazol-5- yl)meth...)
Affinity DataKi:  4.60nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504245BDBM504245(N-[6-Morpholino-2-(2- oxaspiro[3,3]heptan-6-yl)-1-...)
Affinity DataKi:  4.90nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504254BDBM504254((R)-N-(6-(4-((3-Ethylisoxazol-4- yl)methyl)piperaz...)
Affinity DataKi:  5nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504165BDBM504165(N-(2,2-Dimethyl-6-(4-(2- (methylsulfonamido)ethyl)...)
Affinity DataKi:  5.10nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504175BDBM504175(N-(2,2-Dimethyl-6-(4-((5- methylisoxazol-4- yl)met...)
Affinity DataKi:  5.20nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 504177BDBM504177(N-(2,2-Dimethyl-6-(4-((3- methylisoxazol-4- yl)met...)
Affinity DataKi:  5.20nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

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