Compile Data Set for Download or QSAR
Report error Found 85 Enz. Inhib. hit(s) with all data for entry = 7329
TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189451BDBM189451(US9174974, Example 39)
Affinity DataKi:  0.0200nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189454BDBM189454(US9174974, Example 38)
Affinity DataKi:  0.0500nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189450BDBM189450(US9174974, Example 36)
Affinity DataKi:  0.120nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189449BDBM189449(US9174974, Example 35)
Affinity DataKi:  0.140nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189448BDBM189448(US9174974, Example 34)
Affinity DataKi:  0.140nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189453BDBM189453(US9174974, Example 37)
Affinity DataKi:  0.140nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189447BDBM189447(US9174974, Example 33)
Affinity DataKi:  0.140nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189446BDBM189446(US9174974, Example 32)
Affinity DataKi:  0.150nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189445BDBM189445(US9174974, Example 31)
Affinity DataKi:  0.170nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189444BDBM189444(US9174974, Example 30)
Affinity DataKi:  0.170nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189443BDBM189443(US9174974, Example 29)
Affinity DataKi:  0.170nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189452BDBM189452(US9174974, Example 28)
Affinity DataKi:  0.200nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189442BDBM189442(US9174974, Example 27)
Affinity DataKi:  0.230nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189441BDBM189441(US9174974, Example 26)
Affinity DataKi:  0.230nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189440BDBM189440(US9174974, Example 25)
Affinity DataKi:  0.25nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189439BDBM189439(US9174974, Example 24)
Affinity DataKi:  0.280nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189438BDBM189438(US9174974, Example 23)
Affinity DataKi:  0.300nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189437BDBM189437(US9174974, Example 22)
Affinity DataKi:  0.310nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189436BDBM189436(US9174974, Example 21)
Affinity DataKi:  0.340nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189435BDBM189435(US9174974, Example 20)
Affinity DataKi:  0.360nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189434BDBM189434(US9174974, Example 19)
Affinity DataKi:  0.430nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189433BDBM189433(US9174974, Example 18)
Affinity DataKi:  0.440nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189432BDBM189432(US9174974, Example 17)
Affinity DataKi:  0.460nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189431BDBM189431(US9174974, Example 16)
Affinity DataKi:  0.5nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189430BDBM189430(US9174974, Example 15)
Affinity DataKi:  0.550nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189429BDBM189429(US9174974, Example 14)
Affinity DataKi:  0.570nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189428BDBM189428(US9174974, Example 13)
Affinity DataKi:  0.610nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189427BDBM189427(US9174974, Example 12)
Affinity DataKi:  0.620nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189426BDBM189426(US9174974, Example 11)
Affinity DataKi:  0.660nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189425BDBM189425(US9174974, Example 10)
Affinity DataKi:  0.900nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189424BDBM189424(US9174974, Example 9)
Affinity DataKi:  1nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189414BDBM189414(US9174974, Comparator 3)
Affinity DataKi:  1.10nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189422BDBM189422(US9174974, Example 7)
Affinity DataKi:  1.20nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189423BDBM189423(US9174974, Example 8)
Affinity DataKi:  1.20nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189421BDBM189421(US9174974, Example 6)
Affinity DataKi:  1.80nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189420BDBM189420(US9174974, Example 5)
Affinity DataKi:  2nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189419BDBM189419(US9174974, Example 4)
Affinity DataKi:  2.20nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189418BDBM189418(US9174974, Example 3)
Affinity DataKi:  2.30nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189417BDBM189417(US9174974, Example 2)
Affinity DataKi:  2.30nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189416BDBM189416(US9174974, Example 1)
Affinity DataKi:  2.5nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189413BDBM189413(US9174974, Comparator 2)
Affinity DataKi:  11nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189412BDBM189412(US9174974, Comparator 1)
Affinity DataKi:  38nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189446BDBM189446(US9174974, Example 32)
Affinity DataKi:  41nMpH: 7.4Assay Description:Tissue kallikrein-1 (37° C) activity was determined in reactions containing 0.05 nM enzyme and 90 μM substrate (H-D-Val-Leu-Arg-AFC) in buffer (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189447BDBM189447(US9174974, Example 33)
Affinity DataKi:  50nMpH: 7.4Assay Description:Tissue kallikrein-1 (37° C) activity was determined in reactions containing 0.05 nM enzyme and 90 μM substrate (H-D-Val-Leu-Arg-AFC) in buffer (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189444BDBM189444(US9174974, Example 30)
Affinity DataKi:  70nMpH: 7.4Assay Description:Tissue kallikrein-1 (37° C) activity was determined in reactions containing 0.05 nM enzyme and 90 μM substrate (H-D-Val-Leu-Arg-AFC) in buffer (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189414BDBM189414(US9174974, Comparator 3)
Affinity DataKi:  70nMpH: 7.4Assay Description:Tissue kallikrein-1 (37° C) activity was determined in reactions containing 0.05 nM enzyme and 90 μM substrate (H-D-Val-Leu-Arg-AFC) in buffer (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189426BDBM189426(US9174974, Example 11)
Affinity DataKi:  96nMpH: 7.4Assay Description:Tissue kallikrein-1 (37° C) activity was determined in reactions containing 0.05 nM enzyme and 90 μM substrate (H-D-Val-Leu-Arg-AFC) in buffer (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189424BDBM189424(US9174974, Example 9)
Affinity DataKi:  100nMpH: 7.4Assay Description:Tissue kallikrein-1 (37° C) activity was determined in reactions containing 0.05 nM enzyme and 90 μM substrate (H-D-Val-Leu-Arg-AFC) in buffer (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189451BDBM189451(US9174974, Example 39)
Affinity DataKi:  100nMpH: 7.4Assay Description:Tissue kallikrein-1 (37° C) activity was determined in reactions containing 0.05 nM enzyme and 90 μM substrate (H-D-Val-Leu-Arg-AFC) in buffer (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 189413BDBM189413(US9174974, Comparator 2)
Affinity DataKi:  110nMpH: 7.4Assay Description:Tissue kallikrein-1 (37° C) activity was determined in reactions containing 0.05 nM enzyme and 90 μM substrate (H-D-Val-Leu-Arg-AFC) in buffer (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

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