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Found 30 Enz. Inhib. hit(s) with all data for entry = 10853
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Infex Therapeutics

US Patent
LigandPNGBDBM574730((hydrochloride salt): 3-[4-(Piperidin-4-yl)phenyl]...)
Affinity DataIC50:  151nMAssay Description:Inhibition of metallo-β-lactamase enzyme function was performed at 37° C. in buffer at pH 7.5 (50 mM HEPES, 150 mM NaCl, 0.1 mM ZnSO4, 20 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Infex Therapeutics

US Patent
LigandPNGBDBM574735((Hydrochloride Salt): 3-[4-(3-Aminopropylcarbamoyl...)
Affinity DataIC50:  263nMAssay Description:Inhibition of metallo-β-lactamase enzyme function was performed at 37° C. in buffer at pH 7.5 (50 mM HEPES, 150 mM NaCl, 0.1 mM ZnSO4, 20 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Infex Therapeutics

US Patent
LigandPNGBDBM574732(US11459296, Example 40)
Affinity DataIC50:  264nMAssay Description:Inhibition of metallo-β-lactamase enzyme function was performed at 37° C. in buffer at pH 7.5 (50 mM HEPES, 150 mM NaCl, 0.1 mM ZnSO4, 20 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Infex Therapeutics

US Patent
LigandPNGBDBM574737((Hydrochloride Salt): 3-(2-Amino-1,3-benzothiazol-...)
Affinity DataIC50:  314nMAssay Description:Inhibition of metallo-β-lactamase enzyme function was performed at 37° C. in buffer at pH 7.5 (50 mM HEPES, 150 mM NaCl, 0.1 mM ZnSO4, 20 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Infex Therapeutics

US Patent
LigandPNGBDBM574714(3-(4-Methanesulfonylphenyl)- 1-sulfamoyl-1H-pyrrol...)
Affinity DataIC50:  444nMAssay Description:Inhibition of metallo-β-lactamase enzyme function was performed at 37° C. in buffer at pH 7.5 (50 mM HEPES, 150 mM NaCl, 0.1 mM ZnSO4, 20 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Infex Therapeutics

US Patent
LigandPNGBDBM574716(3-(Pyridin-3-yl)-1-sulfamoyl- 1H-pyrrole-2-carboxy...)
Affinity DataIC50:  448nMAssay Description:Inhibition of metallo-β-lactamase enzyme function was performed at 37° C. in buffer at pH 7.5 (50 mM HEPES, 150 mM NaCl, 0.1 mM ZnSO4, 20 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Infex Therapeutics

US Patent
LigandPNGBDBM574713(3-(p-tolyl)-1-sulfamoyl-1H- pyrrole-2-carboxylic a...)
Affinity DataIC50:  479nMAssay Description:Inhibition of metallo-β-lactamase enzyme function was performed at 37° C. in buffer at pH 7.5 (50 mM HEPES, 150 mM NaCl, 0.1 mM ZnSO4, 20 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Infex Therapeutics

US Patent
LigandPNGBDBM574744(3-(6-Aminopyridin-3-yl)-2- (1H-tetrazol-5-yl)-1H- ...)
Affinity DataIC50:  506nMAssay Description:Inhibition of metallo-β-lactamase enzyme function was performed at 37° C. in buffer at pH 7.5 (50 mM HEPES, 150 mM NaCl, 0.1 mM ZnSO4, 20 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Infex Therapeutics

US Patent
LigandPNGBDBM574729(US11459296, Example 26)
Affinity DataIC50:  512nMAssay Description:Inhibition of metallo-β-lactamase enzyme function was performed at 37° C. in buffer at pH 7.5 (50 mM HEPES, 150 mM NaCl, 0.1 mM ZnSO4, 20 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Infex Therapeutics

US Patent
LigandPNGBDBM574726(3-[4- (Cyclopropylsulfonylamino) phenyl]-1-sulfamo...)
Affinity DataIC50:  548nMAssay Description:Inhibition of metallo-β-lactamase enzyme function was performed at 37° C. in buffer at pH 7.5 (50 mM HEPES, 150 mM NaCl, 0.1 mM ZnSO4, 20 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Infex Therapeutics

US Patent
LigandPNGBDBM574727(3-(6-Acetamido-3-pyridyl)-1- sulfamoyl-pyrrole-2- ...)
Affinity DataIC50:  608nMAssay Description:Inhibition of metallo-β-lactamase enzyme function was performed at 37° C. in buffer at pH 7.5 (50 mM HEPES, 150 mM NaCl, 0.1 mM ZnSO4, 20 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Infex Therapeutics

US Patent
LigandPNGBDBM574734(US11459296, Example 47)
Affinity DataIC50:  656nMAssay Description:Inhibition of metallo-β-lactamase enzyme function was performed at 37° C. in buffer at pH 7.5 (50 mM HEPES, 150 mM NaCl, 0.1 mM ZnSO4, 20 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Infex Therapeutics

US Patent
LigandPNGBDBM574721(US11459296, Example 18)
Affinity DataIC50:  725nMAssay Description:Inhibition of metallo-β-lactamase enzyme function was performed at 37° C. in buffer at pH 7.5 (50 mM HEPES, 150 mM NaCl, 0.1 mM ZnSO4, 20 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Infex Therapeutics

US Patent
LigandPNGBDBM574712((Free Acid): 3-(6-Aminopyridin-3-yl)-1-sulfamoyl-1...)
Affinity DataIC50:  826nMAssay Description:Inhibition of metallo-β-lactamase enzyme function was performed at 37° C. in buffer at pH 7.5 (50 mM HEPES, 150 mM NaCl, 0.1 mM ZnSO4, 20 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Infex Therapeutics

US Patent
LigandPNGBDBM574740(3-[1-(3-Aminopropanoyl)-4- piperidyl]-1-sulfamoyl-...)
Affinity DataIC50:  834nMAssay Description:Inhibition of metallo-β-lactamase enzyme function was performed at 37° C. in buffer at pH 7.5 (50 mM HEPES, 150 mM NaCl, 0.1 mM ZnSO4, 20 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Infex Therapeutics

US Patent
LigandPNGBDBM574731(US11459296, Example 36)
Affinity DataIC50:  1.01E+3nMAssay Description:Inhibition of metallo-β-lactamase enzyme function was performed at 37° C. in buffer at pH 7.5 (50 mM HEPES, 150 mM NaCl, 0.1 mM ZnSO4, 20 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Infex Therapeutics

US Patent
LigandPNGBDBM574743((free tetrazole): 3-(1-Methyl-1H-pyrazol-4-yl)-2-(...)
Affinity DataIC50:  1.18E+3nMAssay Description:Inhibition of metallo-β-lactamase enzyme function was performed at 37° C. in buffer at pH 7.5 (50 mM HEPES, 150 mM NaCl, 0.1 mM ZnSO4, 20 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Infex Therapeutics

US Patent
LigandPNGBDBM574739((free acid): 3-[1-(2-Aminoacetyl)-4-piperidyl]-1-s...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of metallo-β-lactamase enzyme function was performed at 37° C. in buffer at pH 7.5 (50 mM HEPES, 150 mM NaCl, 0.1 mM ZnSO4, 20 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Infex Therapeutics

US Patent
LigandPNGBDBM574738((free acid): 3-(1-Acetylpiperidin-4-yl)-1-sulfamoy...)
Affinity DataIC50:  1.31E+3nMAssay Description:Inhibition of metallo-β-lactamase enzyme function was performed at 37° C. in buffer at pH 7.5 (50 mM HEPES, 150 mM NaCl, 0.1 mM ZnSO4, 20 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Infex Therapeutics

US Patent
LigandPNGBDBM574717(3-(Pyridin-4-yl)-1-sulfamoyl- 1H-pyrrole-2-carboxy...)
Affinity DataIC50:  1.35E+3nMAssay Description:Inhibition of metallo-β-lactamase enzyme function was performed at 37° C. in buffer at pH 7.5 (50 mM HEPES, 150 mM NaCl, 0.1 mM ZnSO4, 20 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Infex Therapeutics

US Patent
LigandPNGBDBM574728(US11459296, Example 25)
Affinity DataIC50:  1.36E+3nMAssay Description:Inhibition of metallo-β-lactamase enzyme function was performed at 37° C. in buffer at pH 7.5 (50 mM HEPES, 150 mM NaCl, 0.1 mM ZnSO4, 20 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Infex Therapeutics

US Patent
LigandPNGBDBM574722(3-(3-Fluorophenyl)-1- sulfamoyl-pyrrole-2- carboxy...)
Affinity DataIC50:  1.53E+3nMAssay Description:Inhibition of metallo-β-lactamase enzyme function was performed at 37° C. in buffer at pH 7.5 (50 mM HEPES, 150 mM NaCl, 0.1 mM ZnSO4, 20 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Infex Therapeutics

US Patent
LigandPNGBDBM574724(US11459296, Example 22)
Affinity DataIC50:  2.09E+3nMAssay Description:Inhibition of metallo-β-lactamase enzyme function was performed at 37° C. in buffer at pH 7.5 (50 mM HEPES, 150 mM NaCl, 0.1 mM ZnSO4, 20 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Infex Therapeutics

US Patent
LigandPNGBDBM574742((sodium salt): 3-Pyrrol-1-yl-1-sulfamoyl-pyrrole-2...)
Affinity DataIC50:  2.57E+3nMAssay Description:Inhibition of metallo-β-lactamase enzyme function was performed at 37° C. in buffer at pH 7.5 (50 mM HEPES, 150 mM NaCl, 0.1 mM ZnSO4, 20 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Infex Therapeutics

US Patent
LigandPNGBDBM574736((Sodium Salt): 3-(6-Oxo-1,6-dihydropyridin-3-yl)-1...)
Affinity DataIC50:  2.69E+3nMAssay Description:Inhibition of metallo-β-lactamase enzyme function was performed at 37° C. in buffer at pH 7.5 (50 mM HEPES, 150 mM NaCl, 0.1 mM ZnSO4, 20 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Infex Therapeutics

US Patent
LigandPNGBDBM574733(US11459296, Example 46)
Affinity DataIC50:  2.79E+3nMAssay Description:Inhibition of metallo-β-lactamase enzyme function was performed at 37° C. in buffer at pH 7.5 (50 mM HEPES, 150 mM NaCl, 0.1 mM ZnSO4, 20 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Infex Therapeutics

US Patent
LigandPNGBDBM574715(3-(1-Methyl-1H-pyrazol-4-yl)- 1-sulfamoyl-1H-pyrro...)
Affinity DataIC50:  2.86E+3nMAssay Description:Inhibition of metallo-β-lactamase enzyme function was performed at 37° C. in buffer at pH 7.5 (50 mM HEPES, 150 mM NaCl, 0.1 mM ZnSO4, 20 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Infex Therapeutics

US Patent
LigandPNGBDBM574723(3-(6-Amino-5-fluoro-3- pyridyl)-1-sulfamoyl-pyrrol...)
Affinity DataIC50:  3.36E+3nMAssay Description:Inhibition of metallo-β-lactamase enzyme function was performed at 37° C. in buffer at pH 7.5 (50 mM HEPES, 150 mM NaCl, 0.1 mM ZnSO4, 20 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Infex Therapeutics

US Patent
LigandPNGBDBM574741((Sodium Salt): 3-(Cyclopropylmethoxy)-1-sulfamoyl-...)
Affinity DataIC50:  3.89E+3nMAssay Description:Inhibition of metallo-β-lactamase enzyme function was performed at 37° C. in buffer at pH 7.5 (50 mM HEPES, 150 mM NaCl, 0.1 mM ZnSO4, 20 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Infex Therapeutics

US Patent
LigandPNGBDBM574718(US11459296, Example 11)
Affinity DataIC50:  4.12E+3nMAssay Description:Inhibition of metallo-β-lactamase enzyme function was performed at 37° C. in buffer at pH 7.5 (50 mM HEPES, 150 mM NaCl, 0.1 mM ZnSO4, 20 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent