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Target
Metallo-beta-lactamase type 2
Ligand
BDBM574737
Substrate
n/a
Meas. Tech.
metallo-beta-lactamase inhibition assay
IC50
314±n/a nM
Citation
 Cooper, I; Orr, D; Wilkinson, A; Finlayson, J; Bunt, A; Appelqvist, P; Wallberg, H; Wångsell, F Antibacterial compounds US Patent  US11459296 Publication Date 10/4/2022 
Target
Name:
Metallo-beta-lactamase type 2
Synonyms:
B2 metallo-beta-lactamase | BLAN1_KLEPN | Beta-lactamase NDM-1 | Beta-lactamase type II | Metallo-beta-lactamase NDM-1 | Metallo-beta-lactamase type 2 | Metallo-beta-lactamase type II | NDM-1 | New Delhi metallo-beta-lactamase-1 | blaNDM-1
Type:
PROTEIN
Mol. Mass.:
28498.15
Organism:
Klebsiella pneumoniae
Description:
ChEMBL_103887
Residue:
270
Sequence:
MELPNIMHPVAKLSTALAAALMLSGCMPGEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR
  
Inhibitor
Name:
BDBM574737
Synonyms:
(Hydrochloride Salt): 3-(2-Amino-1,3-benzothiazol-4-yl)-1-sulfamoyl-pyrrole-2-carboxylic acid hydrochloride | US11459296, Example 53
Type:
Small organic molecule
Emp. Form.:
C12H11N4O4S2
Mol. Mass.:
339.37
SMILES:
NS(=O)(=O)n1ccc(c1C(O)=O)-c1cccc2sc([NH3+])nc12
Structure:
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