Compile Data Set for Download or QSAR
Report error Found 15 Enz. Inhib. hit(s) with all data for entry = 893
LigandChemical structure of BindingDB Monomer ID 297409BDBM297409(US10117858, Example 16 | US20240058315, Example 17)
Affinity DataEC50:  8nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 297410BDBM297410(US10117858, Example 17)
Affinity DataEC50:  10nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 297396BDBM297396(US10117858, Example 2 | 3-Amino-6-bromo-5-trifluor...)
Affinity DataEC50:  15nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 297403BDBM297403(US10117858, Example 12 | 3-Amino-6-methoxy-5-trifl...)
Affinity DataEC50:  35nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 297401BDBM297401(US10117858, Example 11 | 3-Amino-6-(4-fluoro-pheny...)
Affinity DataEC50:  37nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 297406BDBM297406(US10117858, Example 7 | 3-Amino-6-(4-fluoro-phenyl...)
Affinity DataEC50:  40nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 297402BDBM297402(US10117858, Example 5 | US20240058315, Example 5)
Affinity DataEC50:  50nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 297407BDBM297407(US10117858, Example 15 | 5-Amino-6′-methyl-3...)
Affinity DataEC50:  51nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 297398BDBM297398(US10117858, Example 3 | 3-Amino-6-bromo-5-trifluor...)
Affinity DataEC50:  55nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 297408BDBM297408(US10117858, Example 8 | 3-Amino-6-(4-fluoro-phenyl...)
Affinity DataEC50:  60nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 297400BDBM297400(US10117858, Example 6 | US10117858, Example 4 | US...)
Affinity DataEC50:  76nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 297397BDBM297397(US10117858, Example 9 | US10117858, Example 10 | U...)
Affinity DataEC50:  90nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 297397BDBM297397(US10117858, Example 9 | US10117858, Example 10 | U...)
Affinity DataEC50:  112nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 297405BDBM297405(US10117858, Example 14 | 5-Amino-6′-methyl-3...)
Affinity DataEC50:  115nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 297400BDBM297400(US10117858, Example 6 | US10117858, Example 4 | US...)
Affinity DataEC50:  426nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent