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Report error Found 171 Enz. Inhib. hit(s) with all data for entry = 11743
LigandPNGBDBM643722((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-...)
Affinity DataKi:  0.5nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643732((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-1,4-dimet...)
Affinity DataKi:  0.600nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643720((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-...)
Affinity DataKi:  0.800nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643750((4S)-7-chloro-6-(2,6-difluorophenyl)-8-iodo-1,4-di...)
Affinity DataKi:  0.800nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643728((4S)-8-bromo-7-chloro-6-(2,6-difluorophenyl)-1,4-d...)
Affinity DataKi:  0.800nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643717((4S)-8-bromo-7-chloro-6-(2,6-difluorophenyl)-4-met...)
Affinity DataKi:  0.800nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643749(US20240002393, Example 101 | [(4R)-8-bromo-7-chlor...)
Affinity DataKi:  1nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643719((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-...)
Affinity DataKi:  1.10nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643718((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-...)
Affinity DataKi:  1.10nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643715((4S)-8-bromo-7-chloro-6-(2-fluorophenyl)-4-methyl-...)
Affinity DataKi:  1.30nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643736((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-...)
Affinity DataKi:  1.40nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643743((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-...)
Affinity DataKi:  1.5nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643740((4S)-7-chloro-6-(2,6-difluorophenyl)-1,4-dimethyl-...)
Affinity DataKi:  1.80nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643742((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-...)
Affinity DataKi:  2nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643755((4S)-7-chloro-6-(2,6-difluorophenyl)-1-ethyl-4-met...)
Affinity DataKi:  2nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643726((4S)-7-bromo-8-chloro-6-(2,6-difluorophenyl)-4-met...)
Affinity DataKi:  2nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643737(5-[(4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-meth...)
Affinity DataKi:  2.10nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643745((4S)-7-chloro-6-(2,6-difluorophenyl)-1,4,8-trimeth...)
Affinity DataKi:  2.5nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643713((4S)-8-bromo-7-chloro-6-(2-fluorophenyl)-4-methyl-...)
Affinity DataKi:  2.60nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643727((4S)-7-bromo-8-chloro-6-(2,6-difluorophenyl)-4-met...)
Affinity DataKi:  2.60nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643733((4S)-8-bromo-7-chloro-1-cyclopropyl-6-(3-fluoro-2-...)
Affinity DataKi:  2.70nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643714(8-bromo-7-chloro-6-(2,6-difluorophenyl)-4H-[1,2,4]...)
Affinity DataKi:  2.80nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643730((4S)-7-bromo-8-chloro-6-(2,6-difluorophenyl)-1,4-d...)
Affinity DataKi:  3nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643719((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-...)
Affinity DataKi:  3nMAssay Description:Table 2: Electrophysiological experiments were performed using the Roboocyte instrument (MultiChannelSystems, Reutlingen, Germany) on days 3 to 5 aft...More data for this Ligand-Target Pair
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LigandPNGBDBM643754((4S)-7-chloro-6-(2,6-difluorophenyl)-4-methyl-8-(t...)
Affinity DataKi:  3nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643744((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-1-(2,6-di...)
Affinity DataKi:  3nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643741((4S)-7-chloro-8-(1,1-difluoroethyl)-6-(2,6-difluor...)
Affinity DataKi:  3.10nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643724((4S)-7,8-dichloro-6-(3-fluoro-2-pyridyl)-4-methyl-...)
Affinity DataKi:  3.20nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643747((4S)-7-chloro-8-(difluoromethyl)-6-(2,6-difluoroph...)
Affinity DataKi:  3.20nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643735((4S)-8-bromo-7-chloro-6-(3-fluoro-2-pyridyl)-1,4-d...)
Affinity DataKi:  3.30nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643748((4R)-8-bromo-7-chloro-6-(2,6-difluorophenyl)-4-(me...)
Affinity DataKi:  3.40nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643738((4S)-7-bromo-8-chloro-6-(2,6-difluorophenyl)-4-met...)
Affinity DataKi:  3.60nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643729((4S)-7-bromo-8-chloro-6-(2,6-difluorophenyl)-4-met...)
Affinity DataKi:  3.60nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643756((4S)-7-chloro-6-(2,6-difluorophenyl)-8-ethyl-1,4-d...)
Affinity DataKi:  3.70nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643720((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-...)
Affinity DataKi:  3.80nMMore data for this Ligand-Target Pair
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LigandPNGBDBM643739((4S)-7-bromo-8-chloro-6-(2,6-difluorophenyl)-4-met...)
Affinity DataKi:  4.30nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643731((4S)-7-bromo-8-chloro-6-(2,6-difluorophenyl)-4-met...)
Affinity DataKi:  4.30nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643753(US20240002393, Example 106 | [(4R)-7-chloro-6-(2,6...)
Affinity DataKi:  4.30nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643736((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-...)
Affinity DataKi:  4.40nMAssay Description:Table 2: Electrophysiological experiments were performed using the Roboocyte instrument (MultiChannelSystems, Reutlingen, Germany) on days 3 to 5 aft...More data for this Ligand-Target Pair
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LigandPNGBDBM643746((4S)-8-bromo-7-chloro-6-(2,6-difluorophenyl)-4-eth...)
Affinity DataKi:  4.40nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643720((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-...)
Affinity DataKi:  4.60nMAssay Description:Table 2: Electrophysiological experiments were performed using the Roboocyte instrument (MultiChannelSystems, Reutlingen, Germany) on days 3 to 5 aft...More data for this Ligand-Target Pair
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LigandPNGBDBM643717((4S)-8-bromo-7-chloro-6-(2,6-difluorophenyl)-4-met...)
Affinity DataKi:  4.90nMAssay Description:Table 2: Electrophysiological experiments were performed using the Roboocyte instrument (MultiChannelSystems, Reutlingen, Germany) on days 3 to 5 aft...More data for this Ligand-Target Pair
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LigandPNGBDBM643728((4S)-8-bromo-7-chloro-6-(2,6-difluorophenyl)-1,4-d...)
Affinity DataKi:  5.30nMAssay Description:Table 2: Electrophysiological experiments were performed using the Roboocyte instrument (MultiChannelSystems, Reutlingen, Germany) on days 3 to 5 aft...More data for this Ligand-Target Pair
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LigandPNGBDBM643751(US20240002393, Example 103 | [(4S)-7-chloro-6-(2,6...)
Affinity DataKi:  5.40nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643721((4S)-7,8-dichloro-6-(3-fluoro-2-pyridyl)-4-methyl-...)
Affinity DataKi:  5.60nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643718((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-...)
Affinity DataKi:  5.70nMAssay Description:Table 2: Electrophysiological experiments were performed using the Roboocyte instrument (MultiChannelSystems, Reutlingen, Germany) on days 3 to 5 aft...More data for this Ligand-Target Pair
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LigandPNGBDBM643736((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-...)
Affinity DataKi:  5.90nMMore data for this Ligand-Target Pair
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LigandPNGBDBM643734((4S)-8-bromo-7-chloro-6-(3-fluoro-2-pyridyl)-4-met...)
Affinity DataKi:  6.5nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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LigandPNGBDBM643750((4S)-7-chloro-6-(2,6-difluorophenyl)-8-iodo-1,4-di...)
Affinity DataKi:  6.60nMMore data for this Ligand-Target Pair
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LigandPNGBDBM643725((4S)-7,8-dichloro-1-cyclopropyl-6-(3-fluoro-2-pyri...)
Affinity DataKi:  7nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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