BDBM643730 (4S)-7-bromo-8-chloro-6-(2,6-difluorophenyl)-1,4-dimethyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine::US20240002393, Example 80

SMILES C[C@@H]1N=C(c2c(F)cccc2F)c2c(Br)c(Cl)ccc2-n2c(C)nnc12

InChI Key InChIKey=QVZZNRSGVFBFOO-QMMMGPOBSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 643730   

TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM643730((4S)-7-bromo-8-chloro-6-(2,6-difluorophenyl)-1,4-d...)
Affinity DataKi:  3nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM643730((4S)-7-bromo-8-chloro-6-(2,6-difluorophenyl)-1,4-d...)
Affinity DataKi:  23.6nMAssay Description:Table 2: Electrophysiological experiments were performed using the Roboocyte instrument (MultiChannelSystems, Reutlingen, Germany) on days 3 to 5 aft...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM643730((4S)-7-bromo-8-chloro-6-(2,6-difluorophenyl)-1,4-d...)
Affinity DataKi:  42.6nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM643730((4S)-7-bromo-8-chloro-6-(2,6-difluorophenyl)-1,4-d...)
Affinity DataKi:  1.07E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent