Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with all data for entry = 11383
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM611019(US10626107, Example A crystal form of compound WX_...)
Affinity DataIC50: 0.350nMAssay Description:The standard Lance Ultra method was performed by a 10 μL enzyme reaction system containing 0.5 nM CDK2/cyclin A protein, 100 nM ULight-MBP polyp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2023
Entry Details
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM611019(US10626107, Example A crystal form of compound WX_...)
Affinity DataIC50: 0.800nMAssay Description:The standard Lance Ultra method was performed by a 10 μL enzyme reaction system containing 0.3 nM CDK4/cyclin D1 protein, 50 nM ULight-4E-BP1 po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2023
Entry Details
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM6309(8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1...)
Affinity DataIC50: 0.980nMAssay Description:The standard Lance Ultra method was performed by a 10 μL enzyme reaction system containing 0.3 nM CDK4/cyclin D1 protein, 50 nM ULight-4E-BP1 po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 1.02nMAssay Description:The standard Lance Ultra method was performed by a 10 μL enzyme reaction system containing 0.5 nM CDK2/cyclin A protein, 100 nM ULight-MBP polyp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2023
Entry Details
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 1.22nMAssay Description:The standard Lance Ultra method was performed by a 10 μL enzyme reaction system containing 0.3 nM CDK4/cyclin D1 protein, 50 nM ULight-4E-BP1 po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2023
Entry Details
US Patent

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM611019(US10626107, Example A crystal form of compound WX_...)
Affinity DataIC50: 2.43nMAssay Description:The standard Lance Ultra method was performed by a 10 μL enzyme reaction system containing 0.8 nM CDK6/cyclin D1 protein, 50 nM ULight-4E-BP1 po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2023
Entry Details
US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM6309(8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1...)
Affinity DataIC50: 5.23nMAssay Description:The standard Lance Ultra method was performed by a 10 μL enzyme reaction system containing 0.5 nM CDK2/cyclin A protein, 100 nM ULight-MBP polyp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2023
Entry Details
US Patent

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 14.7nMAssay Description:The standard Lance Ultra method was performed by a 10 μL enzyme reaction system containing 0.8 nM CDK6/cyclin D1 protein, 50 nM ULight-4E-BP1 po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2023
Entry Details
US Patent

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM6309(8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1...)
Affinity DataIC50: 1.31E+3nMAssay Description:The standard Lance Ultra method was performed by a 10 μL enzyme reaction system containing 0.8 nM CDK6/cyclin D1 protein, 50 nM ULight-4E-BP1 po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2023
Entry Details
US Patent