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Found 31 Enz. Inhib. hit(s) with all data for entry = 165
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM199539((1r,5s,7s)-9-methyl-3-oxa-9-azabicyclo [3.3.1]nona...)
Affinity DataIC50:  0.462nMT: 2°CAssay Description:The 5-HT3 antagonist activity of the compounds of the invention was determined by measuring the ability of the compounds to inhibit the calcium flux ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM199092((1r,5s,7s)-3-oxa-9-azabicyclo[3.3.1]nonan- 7-yl 1-...)
Affinity DataIC50:  0.510nMT: 2°CAssay Description:The 5-HT3 antagonist activity of the compounds of the invention was determined by measuring the ability of the compounds to inhibit the calcium flux ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM199498(US10125145, Cpd. No. 11 | US9670229, 11 | n-((1r,5...)
Affinity DataIC50:  0.600nMT: 2°CAssay Description:The 5-HT3 antagonist activity of the compounds of the invention was determined by measuring the ability of the compounds to inhibit the calcium flux ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM199098(US9670229, 5 | n-((1r,5s,7s)-9-methyl-3-oxa-9-azab...)
Affinity DataIC50:  0.620nMT: 2°CAssay Description:The 5-HT3 antagonist activity of the compounds of the invention was determined by measuring the ability of the compounds to inhibit the calcium flux ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM199522((1r,5s,7s)-3-oxa-9-azabicyclo[3.3.1]nonan- 7-yl 1-...)
Affinity DataIC50:  0.650nMT: 2°CAssay Description:The 5-HT3 antagonist activity of the compounds of the invention was determined by measuring the ability of the compounds to inhibit the calcium flux ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM199485(US10125145, Cpd. No. 10 | US9670229, 10 | n-((1r,5...)
Affinity DataIC50:  0.650nMT: 2°CAssay Description:The 5-HT3 antagonist activity of the compounds of the invention was determined by measuring the ability of the compounds to inhibit the calcium flux ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM199504(5-fluoro-n-((1r,5s,7s)-9-methyl-3-oxa-9- azabicycl...)
Affinity DataIC50:  0.662nMT: 2°CAssay Description:The 5-HT3 antagonist activity of the compounds of the invention was determined by measuring the ability of the compounds to inhibit the calcium flux ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM199484((1r,5s,7s)-9-methyl-d3-3-oxa-9-azabicyclo [3.3.1]n...)
Affinity DataIC50:  0.680nMT: 2°CAssay Description:The 5-HT3 antagonist activity of the compounds of the invention was determined by measuring the ability of the compounds to inhibit the calcium flux ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM199096(US10125145, Cpd. No. 4 | US9670229, 4 | n-((1r,5s,...)
Affinity DataIC50:  0.690nMT: 2°CAssay Description:The 5-HT3 antagonist activity of the compounds of the invention was determined by measuring the ability of the compounds to inhibit the calcium flux ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM199501(5-fluoro-n-((1r,5s,7s)-9-methyl-3-oxa-9- azabicycl...)
Affinity DataIC50:  0.720nMT: 2°CAssay Description:The 5-HT3 antagonist activity of the compounds of the invention was determined by measuring the ability of the compounds to inhibit the calcium flux ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM199541((1r,5s,7s)-9-methyl-3-oxa-9-azabicyclo [3.3.1]nona...)
Affinity DataIC50:  0.745nMT: 2°CAssay Description:The 5-HT3 antagonist activity of the compounds of the invention was determined by measuring the ability of the compounds to inhibit the calcium flux ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM199513((1r,5s,7s)-3-oxa-9-azabicyclo[3.3.1] nonan-7-yl 1-...)
Affinity DataIC50:  0.75nMT: 2°CAssay Description:The 5-HT3 antagonist activity of the compounds of the invention was determined by measuring the ability of the compounds to inhibit the calcium flux ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM199482((1r,5s,7s)-9-methyl-d3-3-oxa-9-azabicyclo [3.3.1]n...)
Affinity DataIC50:  0.810nMT: 2°CAssay Description:The 5-HT3 antagonist activity of the compounds of the invention was determined by measuring the ability of the compounds to inhibit the calcium flux ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM199500(US10125145, Cpd. No. 12 | US9670229, 12 | n-((1r,5...)
Affinity DataIC50:  0.882nMT: 2°CAssay Description:The 5-HT3 antagonist activity of the compounds of the invention was determined by measuring the ability of the compounds to inhibit the calcium flux ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM199091((1r,5s,7s)-3-oxa-9-azabicyclo[3.3.1]nonan- 7-yl 1-...)
Affinity DataIC50:  0.950nMT: 2°CAssay Description:The 5-HT3 antagonist activity of the compounds of the invention was determined by measuring the ability of the compounds to inhibit the calcium flux ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM199094((1r,5s,7s)-3-oxa-9-azabicyclo[3.3.1]nonan- 7-yl 1-...)
Affinity DataIC50:  0.960nMT: 2°CAssay Description:The 5-HT3 antagonist activity of the compounds of the invention was determined by measuring the ability of the compounds to inhibit the calcium flux ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM199524((1r,5s,7s)-3-oxa-9-azabicyclo[3.3.1]nonan- 7-yl 1-...)
Affinity DataIC50:  1.01nMT: 2°CAssay Description:The 5-HT3 antagonist activity of the compounds of the invention was determined by measuring the ability of the compounds to inhibit the calcium flux ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM199092((1r,5s,7s)-3-oxa-9-azabicyclo[3.3.1]nonan- 7-yl 1-...)
Affinity DataIC50:  1.10nMT: 2°CAssay Description:The 5-HT3 antagonist activity of the compounds of the invention was determined by measuring the ability of the compounds to inhibit the calcium flux ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM199521((1r,5s,7s)-3-oxa-9-azabicyclo[3.3.1] nonan-7-yl 1-...)
Affinity DataIC50:  1.10nMT: 2°CAssay Description:The 5-HT3 antagonist activity of the compounds of the invention was determined by measuring the ability of the compounds to inhibit the calcium flux ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM199518((1r,5s,7s)-3-oxa-9-azabicyclo[3.3.1] nonan-7-yl 1-...)
Affinity DataIC50:  1.20nMT: 2°CAssay Description:The 5-HT3 antagonist activity of the compounds of the invention was determined by measuring the ability of the compounds to inhibit the calcium flux ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM199503(5-fluoro-n-((1r,5s,7s)-9-methyl-3-oxa-9- azabicycl...)
Affinity DataIC50:  1.34nMT: 2°CAssay Description:The 5-HT3 antagonist activity of the compounds of the invention was determined by measuring the ability of the compounds to inhibit the calcium flux ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM199544(3-(3-(((1r,5s,7s)-9-methyl- 3-oxa-9-azabicyclo[3.3...)
Affinity DataIC50:  1.36nMT: 2°CAssay Description:The 5-HT3 antagonist activity of the compounds of the invention was determined by measuring the ability of the compounds to inhibit the calcium flux ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM199527((1r,5s,7s)-3-oxa-9-azabicyclo[3.3.1]nonan- 7-yl 1-...)
Affinity DataIC50:  1.39nMT: 2°CAssay Description:The 5-HT3 antagonist activity of the compounds of the invention was determined by measuring the ability of the compounds to inhibit the calcium flux ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM199533((1r,5s,7s)-9-methyl-3-oxa-9- azabicyclo[3.3.1]nona...)
Affinity DataIC50:  1.44nMT: 2°CAssay Description:The 5-HT3 antagonist activity of the compounds of the invention was determined by measuring the ability of the compounds to inhibit the calcium flux ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM199520((1r,5s,7s)-3-oxa-9-azabicyclo[3.3.1] nonan-7-yl 1-...)
Affinity DataIC50:  1.5nMT: 2°CAssay Description:The 5-HT3 antagonist activity of the compounds of the invention was determined by measuring the ability of the compounds to inhibit the calcium flux ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM199518((1r,5s,7s)-3-oxa-9-azabicyclo[3.3.1] nonan-7-yl 1-...)
Affinity DataIC50:  2.01nMT: 2°CAssay Description:The 5-HT3 antagonist activity of the compounds of the invention was determined by measuring the ability of the compounds to inhibit the calcium flux ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM199538((1r,5s,7s)-9-methyl-3-oxa-9- azabicyclo[3.3.1]nona...)
Affinity DataIC50:  2.04nMT: 2°CAssay Description:The 5-HT3 antagonist activity of the compounds of the invention was determined by measuring the ability of the compounds to inhibit the calcium flux ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM199512((1r,5s,7s)-3-oxa-9-azabicyclo[3.3.1] nonan-7-yl 1-...)
Affinity DataIC50:  2.5nMT: 2°CAssay Description:The 5-HT3 antagonist activity of the compounds of the invention was determined by measuring the ability of the compounds to inhibit the calcium flux ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM199110((1r,5s,7s)-9-methyl-d3-3-oxa-9-azabicyclo [3.3.1]n...)
Affinity DataIC50:  2.86nMT: 2°CAssay Description:The 5-HT3 antagonist activity of the compounds of the invention was determined by measuring the ability of the compounds to inhibit the calcium flux ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM199519((1r,5s,7s)-3-oxa-9-azabicyclo[3.3.1] nonan-7-yl 1-...)
Affinity DataIC50:  3.68nMT: 2°CAssay Description:The 5-HT3 antagonist activity of the compounds of the invention was determined by measuring the ability of the compounds to inhibit the calcium flux ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM199542((1r,5s,7s)-9-methyl-3-oxa-9-azabicyclo [3.3.1]nona...)
Affinity DataIC50: >1.00E+3nMT: 2°CAssay Description:The 5-HT3 antagonist activity of the compounds of the invention was determined by measuring the ability of the compounds to inhibit the calcium flux ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent