Compile Data Set for Download or QSAR
Report error Found 30 Enz. Inhib. hit(s) with all data for entry = 8779
TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 419188BDBM419188(5-[Difluoro(phenyl)methyl]-7-(1,2,5-triazaspiro[2....)
Affinity DataKi:  0.800nMAssay Description:The affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
US Patent

TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 419190BDBM419190(5-tert-Butyl-3-[(2-chlorophenyl)methyl]-7-(1,2,5-t...)
Affinity DataKi:  3.30nMAssay Description:The affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
US Patent

TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 419260BDBM419260(5-tert-Butyl-7-(3,3-difluoropyrrolidin-1-yl)-3-({2...)
Affinity DataKi:  4.20nMAssay Description:The affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
US Patent

TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 419261BDBM419261(5-tert-Butyl-3-[(2-ethynylphenyl)methyl]-7-(1,2,5-...)
Affinity DataKi:  5.60nMAssay Description:The affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
US Patent

TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 419269BDBM419269(5-tert-Butyl-7-(3,3-difluoropyrrolidin-1-yl)-3-[[2...)
Affinity DataKi:  9nMAssay Description:The affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
US Patent

TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 419262BDBM419262(3-[(2-Chlorophenyl)methyl]-5-[difluoro(phenyl)meth...)
Affinity DataKi:  9.90nMAssay Description:The affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
US Patent

TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 419270BDBM419270((3S)-1-[5-tert-Butyl-3-[[2-ethynyl-6-[3-(trifluoro...)
Affinity DataKi:  12nMAssay Description:The affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
US Patent

TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 419185BDBM419185(5-tert-Butyl-3-[(4-methyl-1,2,5-oxadiazol-3-yl)met...)
Affinity DataKi:  16.1nMAssay Description:The affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
US Patent

TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 419267BDBM419267(5-[Difluoro(phenyl)methyl]-3-[(2-ethynylphenyl)met...)
Affinity DataKi:  19nMAssay Description:The affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
US Patent

TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 419268BDBM419268(5-[Difluoro(phenyl)methyl]-7-(3,3-difluoropyrrolid...)
Affinity DataKi:  31nMAssay Description:The affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
US Patent

TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 419263BDBM419263(5-[Difluoro(phenyl)methyl]-3-[(4-methyl-1,2,5-oxad...)
Affinity DataKi:  45.5nMAssay Description:The affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
US Patent

TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 419264BDBM419264(5-tert-Butyl-3-({2-chloro-4-[3-(trifluoromethyl)-3...)
Affinity DataKi:  55.6nMAssay Description:The affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
US Patent

TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 419271BDBM419271((3S)-1-[5-[Difluoro(phenyl)methyl]-3-[[2-ethynyl-6...)
Affinity DataKi:  58nMAssay Description:The affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
US Patent

TargetCannabinoid receptor 1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 419261BDBM419261(5-tert-Butyl-3-[(2-ethynylphenyl)methyl]-7-(1,2,5-...)
Affinity DataKi:  132nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
US Patent

TargetCannabinoid receptor 1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 419269BDBM419269(5-tert-Butyl-7-(3,3-difluoropyrrolidin-1-yl)-3-[[2...)
Affinity DataKi:  147nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
US Patent

TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 419266BDBM419266(4-({5-tert-Butyl-7-[(3S)-3-hydroxypyrrolidin-1-yl]...)
Affinity DataKi:  200nMAssay Description:The affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
US Patent

TargetCannabinoid receptor 1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 419190BDBM419190(5-tert-Butyl-3-[(2-chlorophenyl)methyl]-7-(1,2,5-t...)
Affinity DataKi:  321nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
US Patent

TargetCannabinoid receptor 1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 419267BDBM419267(5-[Difluoro(phenyl)methyl]-3-[(2-ethynylphenyl)met...)
Affinity DataKi:  465nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
US Patent

TargetCannabinoid receptor 1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 419260BDBM419260(5-tert-Butyl-7-(3,3-difluoropyrrolidin-1-yl)-3-({2...)
Affinity DataKi:  488nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
US Patent

TargetCannabinoid receptor 1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 419262BDBM419262(3-[(2-Chlorophenyl)methyl]-5-[difluoro(phenyl)meth...)
Affinity DataKi:  799nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
US Patent

TargetCannabinoid receptor 1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 419188BDBM419188(5-[Difluoro(phenyl)methyl]-7-(1,2,5-triazaspiro[2....)
Affinity DataKi:  993nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
US Patent

TargetCannabinoid receptor 2(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 419265BDBM419265(4-{[5-tert-Butyl-7-(3,3-difluoropyrrolidin-1-yl)-3...)
Affinity DataKi:  1.16E+3nMAssay Description:The affinity of the compounds of the invention for cannabinoid receptors was determined using recommended amounts of membrane preparations (PerkinElm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
US Patent

TargetCannabinoid receptor 1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 419185BDBM419185(5-tert-Butyl-3-[(4-methyl-1,2,5-oxadiazol-3-yl)met...)
Affinity DataKi:  2.96E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
US Patent

TargetCannabinoid receptor 1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 419268BDBM419268(5-[Difluoro(phenyl)methyl]-7-(3,3-difluoropyrrolid...)
Affinity DataKi:  3.39E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
US Patent

TargetCannabinoid receptor 1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 419263BDBM419263(5-[Difluoro(phenyl)methyl]-3-[(4-methyl-1,2,5-oxad...)
Affinity DataKi:  5.41E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
US Patent

TargetCannabinoid receptor 1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 419265BDBM419265(4-{[5-tert-Butyl-7-(3,3-difluoropyrrolidin-1-yl)-3...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
US Patent

TargetCannabinoid receptor 1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 419266BDBM419266(4-({5-tert-Butyl-7-[(3S)-3-hydroxypyrrolidin-1-yl]...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
US Patent

TargetCannabinoid receptor 1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 419271BDBM419271((3S)-1-[5-[Difluoro(phenyl)methyl]-3-[[2-ethynyl-6...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
US Patent

TargetCannabinoid receptor 1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 419264BDBM419264(5-tert-Butyl-3-({2-chloro-4-[3-(trifluoromethyl)-3...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
US Patent

TargetCannabinoid receptor 1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 419270BDBM419270((3S)-1-[5-tert-Butyl-3-[[2-ethynyl-6-[3-(trifluoro...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2020
Entry Details
US Patent