Compile Data Set for Download or QSAR
Report error Found 43 Enz. Inhib. hit(s) with all data for entry = 8978
TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50121328(CHEMBL3622090 | US10562882, Example 35)
Affinity DataIC50: 290nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50121324(CHEMBL3622086 | US10562882, Example 3)
Affinity DataIC50: 320nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50121325(CHEMBL3622087 | US10562882, Example 15)
Affinity DataIC50: 330nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50121324(CHEMBL3622086 | US10562882, Example 3)
Affinity DataIC50: 330nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM433582(US10562882, Example 10 | 4-[3-(1-Ethyl-1H-indol-2-...)
Affinity DataIC50: 390nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM433661(5-[3-(5-Chloro-3-methylpyridin-2-yl)-3-fluoropiper...)
Affinity DataIC50: 400nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM433642(4-[3-(5-Chloro-3-methylpyridin-2-yl)-3-methoxypipe...)
Affinity DataIC50: 470nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM433637(4-{3-[5-Chloro-3-(trifluoromethyl)pyridin-2-yl]-3-...)
Affinity DataIC50: 480nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM433587(US10562882, Example 12 | 5-[3-(1-Ethyl-1H-indol-2-...)
Affinity DataIC50: 480nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM433641(4-{3-[5-Chloro-3-(trifluoromethyl)pyridin-2-yl]-3-...)
Affinity DataIC50: 510nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM433589(US10562882, Example 14 | N-Methyl-5-{3-[1-(propan-...)
Affinity DataIC50: 540nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM433588(US10562882, Example 13 | N,N-Dimethyl-5-{3-[1-(pro...)
Affinity DataIC50: 760nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50121327(CHEMBL3622089 | US10562882, Example 27)
Affinity DataIC50: 910nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM433646(5-[3-(5-Chloro-3-methylpyridin-2-yl)-3-methoxypipe...)
Affinity DataIC50: 920nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM433584(US10562882, Example 11 | 5-[3-(1-Ethyl-1H-indol-2-...)
Affinity DataIC50: 940nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM433636(5-[3-(5-Chloro-3-methylpyridin-2-yl)piperidine-1-c...)
Affinity DataIC50: 1.04E+3nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM433577(US10562882, Example 8 | N,N-Dimethyl-4-[3-(1-methy...)
Affinity DataIC50: 1.07E+3nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM433578(US10562882, Example 9 | N-Methyl-5-[3-(1-methyl-1H...)
Affinity DataIC50: 1.08E+3nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM433558(US10562882, Example 4 | N,N-Dimethyl-4-[3-(1-methy...)
Affinity DataIC50: 1.22E+3nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM433660(5-[3-(5-Chloro-3-methylpyridin-2-yl)-3-fluoropiper...)
Affinity DataIC50: 1.25E+3nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM433602(US10562882, Example 20 | 5-[3-(5-Chloro-1-ethyl-1H...)
Affinity DataIC50: 1.25E+3nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM433592(US10562882, Example 16 | 1-Methyl-4-{3-[1-(propan-...)
Affinity DataIC50: 1.44E+3nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM433645(5-[3-(5-Chloro-3-methylpyridin-2-yl)-3-methoxypipe...)
Affinity DataIC50: 1.49E+3nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM433639(5-{3-[5-Chloro-3-(trifluoromethyl)pyridin-2-yl]-3-...)
Affinity DataIC50: 1.62E+3nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM433607(5-[3-(5-Chloro-1-ethyl-1H-indol-2-yl)piperidine-1-...)
Affinity DataIC50: 1.73E+3nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM433560(US10562882, Example 6 | N-Methyl-5-{3-[1-(propan-2...)
Affinity DataIC50: 1.74E+3nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM433564(US10562882, Example 7 | 2-[1-(1-Ethyl-1H-pyrazole-...)
Affinity DataIC50: 1.82E+3nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM433640(5-Chloro-2-[1-(1-ethyl-1H-pyrazole-4-carbonyl)-3-m...)
Affinity DataIC50: 1.88E+3nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM433638(5-({3-[5-Chloro-3-(trifluoromethyl)pyridin-2-yl]-3...)
Affinity DataIC50: 2.08E+3nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM433600(US10562882, Example 18 | 5-[3-(1-Ethyl-3-methyl-1H...)
Affinity DataIC50: 2.17E+3nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM433663(5-Chloro-2-[1-(1-ethyl-1H-pyrazole-4-carbonyl)-3-f...)
Affinity DataIC50: 2.39E+3nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM433599(US10562882, Example 17 | 1-Ethyl-2-{1-[(1-ethyl-1H...)
Affinity DataIC50: 2.59E+3nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM433601(US10562882, Example 19 | 5-[3-(1-Ethyl-5-methyl-1H...)
Affinity DataIC50: 2.69E+3nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM433617(4-[3-(1-Ethyl-5-methyl-1H-indol-2-yl)piperidine-1-...)
Affinity DataIC50: 3.12E+3nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM433662(5-Chloro-2-[1-(1-ethyl-1H-pyrazole-4-carbonyl)-3-m...)
Affinity DataIC50: 3.41E+3nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM433665(4-[3-(5-Chloro-3-methylpyridin-2-yl)-3-fluoropiper...)
Affinity DataIC50: 5.00E+3nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM433606(US10562882, Example 21 | 5-[3-(1-Ethyl-5-methyl-1H...)
Affinity DataIC50: 5.34E+3nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM433609(N,N-Dimethyl-5-[3-(3-methyl-1H-indol-2-yl)piperidi...)
Affinity DataIC50: 7.41E+3nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50121326(CHEMBL3622088 | US10562882, Example 23)
Affinity DataIC50: 7.41E+3nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM433559(US10562882, Example 5 | 2-[1-(6-Chloropyridazine-4...)
Affinity DataIC50: 7.46E+3nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM433610(4-[3-(1-Ethyl-3-methyl-1H-indol-2-yl)piperidine-1-...)
Affinity DataIC50: 7.86E+3nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50121329(CHEMBL3622091 | US10562882, Example 42)
Affinity DataIC50: 9.00E+3nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM50121324(CHEMBL3622086 | US10562882, Example 3)
Affinity DataIC50: 9.06E+3nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent