Compile Data Set for Download or QSAR
Report error Found 51 Enz. Inhib. hit(s) with all data for entry = 9507
TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50396071BDBM50396071(CHEMBL2170582 | US10828301, Compound R921303)
Affinity DataIC50: 0.450nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 255515BDBM255515(US9499493, R950368 | US10828301, Compound R950368)
Affinity DataIC50: 10.7nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 255514BDBM255514(US9499493, R921304 | US10828301, Compound R921304)
Affinity DataIC50: 12.8nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 471742BDBM471742(US10828301, Compound R908712 | (+/−)-5-Fluor...)
Affinity DataIC50: 24nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 255508BDBM255508(US9499493, R935302 | US10828301, Compound R935302)
Affinity DataIC50: 26.5nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 255513BDBM255513(US9499493, R940338 | US10828301, Compound R940338)
Affinity DataIC50: 28nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 471768BDBM471768(US10828301, Compound R940347 | N4-[(2,2-Dimethyl-4...)
Affinity DataIC50: 34.5nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 471741BDBM471741(US10828301, Compound R908702 | N4-(1,4-Benzoxazine...)
Affinity DataIC50: 37.8nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 255509BDBM255509(US9499493, R935304 | US10828301, Compound R935304)
Affinity DataIC50: 42nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 255488BDBM255488(US9499493, R935191 | US10828301, Compound R935191)
Affinity DataIC50: 45nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 471755BDBM471755(US10828301, Compound R935237 | 5-Fluoro-N4-(3-hydr...)
Affinity DataIC50: 45.5nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 255487BDBM255487(US9499493, R935190 | US10828301, Compound R935190)
Affinity DataIC50: 46.5nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 255507BDBM255507(US9499493, R935293 | US10828301, Compound R935293)
Affinity DataIC50: 46.5nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 255505BDBM255505(US9499493, R926839 | US10828301, Compound R926839)
Affinity DataIC50: 55nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 255510BDBM255510(US9499493, R935307 | US10828301, Compound R935307)
Affinity DataIC50: 57nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 255485BDBM255485(US9499493, R926816 | US10828301, Compound R926816)
Affinity DataIC50: 61.5nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 471765BDBM471765(US10828301, Compound R940323 | N4-[(2,2-Dimethyl-4...)
Affinity DataIC50: 62nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 471772BDBM471772(US10828301, Compound R950373 | N4-(3-Methylcarbony...)
Affinity DataIC50: 66.5nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 255477BDBM255477(US9499493, R926505 | US10828301, Compound R926505)
Affinity DataIC50: 70.3nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 471724BDBM471724(US10828301, Compound R935193 | N4-(3,4-Ethylenedio...)
Affinity DataIC50: 75nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 255481BDBM255481(US9499493, R926745 | US10828301, Compound R926745)
Affinity DataIC50: 92.5nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 255511BDBM255511(US9499493, R935309 | US10828301, Compound R935309)
Affinity DataIC50: 98nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 471746BDBM471746(US10828301, Compound R926753 | 5-Fluoro-N4-(3-hydr...)
Affinity DataIC50: 108nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 255482BDBM255482(US9499493, R926782 | US10828301, Compound R926782)
Affinity DataIC50: 116nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 255502BDBM255502(US9499493, R909268 | US10828301, Compound R909268)
Affinity DataIC50: 125nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 255495BDBM255495(US9499493, R940276 | US10828301, Compound R940276)
Affinity DataIC50: 126nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 255478BDBM255478(US9499493, R926508 | US10828301, Compound R926508)
Affinity DataIC50: 132nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 471744BDBM471744(US10828301, Compound R920410 | N4-(3-Chloro-4-trif...)
Affinity DataIC50: 157nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 255490BDBM255490(US9499493, R935194 | US10828301, Compound R935194)
Affinity DataIC50: 169nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 471751BDBM471751(US10828301, Compound R926891 | N4-(3-Chloro-4-meth...)
Affinity DataIC50: 170nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 255497BDBM255497(US9499493, R940290 | US10828301, Compound R940290)
Affinity DataIC50: 187nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 255512BDBM255512(US9499493, R935310 | US10828301, Compound R935310)
Affinity DataIC50: 200nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 255483BDBM255483(US9499493, R926791 | US10828301, Compound R926791)
Affinity DataIC50: 207nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 255496BDBM255496(US9499493, R940277 | US10828301, Compound R940277)
Affinity DataIC50: 214nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 471721BDBM471721(US10828301, Compound R935138 | 5-Fluoro-N2-(3-hydr...)
Affinity DataIC50: 229nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 471752BDBM471752(US10828301, Compound R926931 | 5-Fluoro-N4-[(1H)-i...)
Affinity DataIC50: 255nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 471726BDBM471726(US10828301, Compound R935196 | N2-[3-(1-Bis(N-meth...)
Affinity DataIC50: 266nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50068649BDBM50068649(CHEMBL3402361 | US10828301, Compound R921302)
Affinity DataIC50: 268nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 255504BDBM255504(US9499493, R926834 | US10828301, Compound R926834)
Affinity DataIC50: 292nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 471738BDBM471738(US10828301, Compound R945144 | N4-(3,4-Ethylenedio...)
Affinity DataIC50: 383nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 255484BDBM255484(US9499493, R926813 | US10828301, Compound R926813)
Affinity DataIC50: 405nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50068779BDBM50068779(US9499493, R945071 | CHEMBL3402397 | US10828301, C...)
Affinity DataIC50: 430nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 471748BDBM471748(US10828301, Compound R926757 | 5-Fluoro-N4-(3-hydr...)
Affinity DataIC50: 510nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 255480BDBM255480(US9499493, R926715 | US10828301, Compound R926715)
Affinity DataIC50: 534nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 255498BDBM255498(US9499493, R945140 | US10828301, Compound R945140)
Affinity DataIC50: 611nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 255493BDBM255493(US9499493, R940269 | US10828301, Compound R940269)
Affinity DataIC50: 685nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 471730BDBM471730(US10828301, Compound R940275 | N2-(3-tert-Butylcar...)
Affinity DataIC50: 734nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 471727BDBM471727(US10828301, Compound R940255 | N4-(3,5-Dimethyl-4-...)
Affinity DataIC50: 770nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 255479BDBM255479(US9499493, R926594 | US10828301, Compound R926594)
Affinity DataIC50: 770nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 255499BDBM255499(US9499493, R945142 | US10828301, Compound R945142)
Affinity DataIC50: 2.01E+3nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

Displayed 1 to 50 (of 51 total ) | Next | Last >>
Jump to: