Compile Data Set for Download or QSAR
Report error Found 35 Enz. Inhib. hit(s) with all data for entry = 8922
TargetMitogen-activated protein kinase 14(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandChemical structure of BindingDB Monomer ID 429424BDBM429424(5-(5- (cyclopropylcarbamoyl)- 3-fluoro-2-methylphe...)
Affinity DataIC50: 100nMAssay Description:Experimental Method: 40 nM p38a was added into a reaction buffer, which include 20 mM HEPES (4-hydroxyethylpiperazine ethanesulfonic acid), 5 mM MgCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandChemical structure of BindingDB Monomer ID 429433BDBM429433(N3-cyclopropyl-3',5- difluoro-N4'- isobutyl-N4',6-...)
Affinity DataIC50: 100nMAssay Description:Experimental Method: 40 nM p38a was added into a reaction buffer, which include 20 mM HEPES (4-hydroxyethylpiperazine ethanesulfonic acid), 5 mM MgCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandChemical structure of BindingDB Monomer ID 429432BDBM429432(N3-cyclopropyl-3',5- difluoro-N4'- isobutyl-6-meth...)
Affinity DataIC50: 100nMAssay Description:Experimental Method: 40 nM p38a was added into a reaction buffer, which include 20 mM HEPES (4-hydroxyethylpiperazine ethanesulfonic acid), 5 mM MgCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandChemical structure of BindingDB Monomer ID 429419BDBM429419(N-cyclohexyl-6-(5- (cyclopropylcarbamoyl)- 3-fluor...)
Affinity DataIC50: 100nMAssay Description:Experimental Method: 40 nM p38a was added into a reaction buffer, which include 20 mM HEPES (4-hydroxyethylpiperazine ethanesulfonic acid), 5 mM MgCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandChemical structure of BindingDB Monomer ID 429416BDBM429416(N-cyclopentyl-6-(5- (cyclopropylcarbamoyl)- 3-fluo...)
Affinity DataIC50: 100nMAssay Description:Experimental Method: 40 nM p38a was added into a reaction buffer, which include 20 mM HEPES (4-hydroxyethylpiperazine ethanesulfonic acid), 5 mM MgCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandChemical structure of BindingDB Monomer ID 429423BDBM429423(5-(5- (cyclopropylcarbamoyl)- 3-fluoro-2-methylphe...)
Affinity DataIC50: 100nMAssay Description:Experimental Method: 40 nM p38a was added into a reaction buffer, which include 20 mM HEPES (4-hydroxyethylpiperazine ethanesulfonic acid), 5 mM MgCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandChemical structure of BindingDB Monomer ID 428937BDBM428937(US10550073, Example 3 | 6-(5- cyclopropylcarbamoyl...)
Affinity DataIC50: 100nMAssay Description:Experimental Method: 40 nM p38a was added into a reaction buffer, which include 20 mM HEPES (4-hydroxyethylpiperazine ethanesulfonic acid), 5 mM MgCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandChemical structure of BindingDB Monomer ID 429452BDBM429452(6-(5-(allylcarbamoyl)- 3-fluoro-2- methylphenyl)-N...)
Affinity DataIC50: 100nMAssay Description:Experimental Method: 40 nM p38a was added into a reaction buffer, which include 20 mM HEPES (4-hydroxyethylpiperazine ethanesulfonic acid), 5 mM MgCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandChemical structure of BindingDB Monomer ID 429451BDBM429451(6-(5-(allylcarbamoyl)- 3-fluoro-2- methylphenyl)-N...)
Affinity DataIC50: 100nMAssay Description:Experimental Method: 40 nM p38a was added into a reaction buffer, which include 20 mM HEPES (4-hydroxyethylpiperazine ethanesulfonic acid), 5 mM MgCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandChemical structure of BindingDB Monomer ID 429448BDBM429448(6-(5- (cyclopropylcarbamoyl)- 3-fluoro-2- methylph...)
Affinity DataIC50: 100nMAssay Description:Experimental Method: 40 nM p38a was added into a reaction buffer, which include 20 mM HEPES (4-hydroxyethylpiperazine ethanesulfonic acid), 5 mM MgCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandChemical structure of BindingDB Monomer ID 429447BDBM429447(6-(5- (cyclopropylcarbamoyl)- 3-fluoro-2- methylph...)
Affinity DataIC50: 100nMAssay Description:Experimental Method: 40 nM p38a was added into a reaction buffer, which include 20 mM HEPES (4-hydroxyethylpiperazine ethanesulfonic acid), 5 mM MgCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandChemical structure of BindingDB Monomer ID 429450BDBM429450(6-(5- (cyclopropylcarbamoyl)- 3-fluoro-2- methylph...)
Affinity DataIC50: 100nMAssay Description:Experimental Method: 40 nM p38a was added into a reaction buffer, which include 20 mM HEPES (4-hydroxyethylpiperazine ethanesulfonic acid), 5 mM MgCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandChemical structure of BindingDB Monomer ID 429449BDBM429449(6-(5- (cyclopropylcarbamoyl)- 3-fluoro-2- methylph...)
Affinity DataIC50: 100nMAssay Description:Experimental Method: 40 nM p38a was added into a reaction buffer, which include 20 mM HEPES (4-hydroxyethylpiperazine ethanesulfonic acid), 5 mM MgCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandChemical structure of BindingDB Monomer ID 429446BDBM429446(6-(5- (cyclopropylcarbamoyl)- 3-fluoro-2- methylph...)
Affinity DataIC50: 100nMAssay Description:Experimental Method: 40 nM p38a was added into a reaction buffer, which include 20 mM HEPES (4-hydroxyethylpiperazine ethanesulfonic acid), 5 mM MgCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandChemical structure of BindingDB Monomer ID 429441BDBM429441(6-(5- (cyclopropylcarbamoyl)- 3-fluoro-2- methylph...)
Affinity DataIC50: 100nMAssay Description:Experimental Method: 40 nM p38a was added into a reaction buffer, which include 20 mM HEPES (4-hydroxyethylpiperazine ethanesulfonic acid), 5 mM MgCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandChemical structure of BindingDB Monomer ID 429434BDBM429434(N4'-cyclopentyl-N3- cyclopropyl-3',5- difluoro-6-m...)
Affinity DataIC50: 100nMAssay Description:Experimental Method: 40 nM p38a was added into a reaction buffer, which include 20 mM HEPES (4-hydroxyethylpiperazine ethanesulfonic acid), 5 mM MgCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandChemical structure of BindingDB Monomer ID 429431BDBM429431(N4'-cyclohexyl-N3- cyclopropyl-5-fluoro- N4',6-dim...)
Affinity DataIC50: 550nMAssay Description:Experimental Method: 40 nM p38a was added into a reaction buffer, which include 20 mM HEPES (4-hydroxyethylpiperazine ethanesulfonic acid), 5 mM MgCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandChemical structure of BindingDB Monomer ID 429422BDBM429422(6-(5- (cyclopropylcarbamoyl)- 3-fluoro-2- methylph...)
Affinity DataIC50: 550nMAssay Description:Experimental Method: 40 nM p38a was added into a reaction buffer, which include 20 mM HEPES (4-hydroxyethylpiperazine ethanesulfonic acid), 5 mM MgCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandChemical structure of BindingDB Monomer ID 429440BDBM429440(N-cyclopropyl-3-fluoro- 4-methyl-5-(5-(4- methylpi...)
Affinity DataIC50: 550nMAssay Description:Experimental Method: 40 nM p38a was added into a reaction buffer, which include 20 mM HEPES (4-hydroxyethylpiperazine ethanesulfonic acid), 5 mM MgCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandChemical structure of BindingDB Monomer ID 429439BDBM429439(N-cyclopropyl-3-fluoro-4- methyl-5-(5-(piperidin-1...)
Affinity DataIC50: 550nMAssay Description:Experimental Method: 40 nM p38a was added into a reaction buffer, which include 20 mM HEPES (4-hydroxyethylpiperazine ethanesulfonic acid), 5 mM MgCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandChemical structure of BindingDB Monomer ID 429435BDBM429435(N3-cyclopropyl-5- fluoro-N4'-isobutyl-3',6- dimeth...)
Affinity DataIC50: 550nMAssay Description:Experimental Method: 40 nM p38a was added into a reaction buffer, which include 20 mM HEPES (4-hydroxyethylpiperazine ethanesulfonic acid), 5 mM MgCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandChemical structure of BindingDB Monomer ID 429437BDBM429437(3-(2-(butylamino)benzo [d]thiazol-6-yl)- N-cyclopr...)
Affinity DataIC50: 550nMAssay Description:Experimental Method: 40 nM p38a was added into a reaction buffer, which include 20 mM HEPES (4-hydroxyethylpiperazine ethanesulfonic acid), 5 mM MgCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandChemical structure of BindingDB Monomer ID 429436BDBM429436(N-cyclopropyl-3-fluoro- 5-(2-(isobutylamino) benzo...)
Affinity DataIC50: 550nMAssay Description:Experimental Method: 40 nM p38a was added into a reaction buffer, which include 20 mM HEPES (4-hydroxyethylpiperazine ethanesulfonic acid), 5 mM MgCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandChemical structure of BindingDB Monomer ID 50418610BDBM50418610(GW-856553 | GW856553X | LOSMAPIMOD | US10550073, C...)
Affinity DataIC50: 5.50E+3nMAssay Description:Experimental Method: 40 nM p38a was added into a reaction buffer, which include 20 mM HEPES (4-hydroxyethylpiperazine ethanesulfonic acid), 5 mM MgCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandChemical structure of BindingDB Monomer ID 50418610BDBM50418610(GW-856553 | GW856553X | LOSMAPIMOD | US10550073, C...)
Affinity DataIC50: 2.00E+4nMAssay Description:Experimental Method: 4-hydroxydiclofenac (the substrate for CYP450 and 2C9 enzymes) and different doses of compounds were added into human liver micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandChemical structure of BindingDB Monomer ID 428937BDBM428937(US10550073, Example 3 | 6-(5- cyclopropylcarbamoyl...)
Affinity DataIC50: 5.00E+4nMAssay Description:Experimental Method: 4-hydroxydiclofenac (the substrate for CYP450 and 2C9 enzymes) and different doses of compounds were added into human liver micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandChemical structure of BindingDB Monomer ID 429449BDBM429449(6-(5- (cyclopropylcarbamoyl)- 3-fluoro-2- methylph...)
Affinity DataIC50: 5.00E+4nMAssay Description:Experimental Method: 4-hydroxydiclofenac (the substrate for CYP450 and 2C9 enzymes) and different doses of compounds were added into human liver micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandChemical structure of BindingDB Monomer ID 429447BDBM429447(6-(5- (cyclopropylcarbamoyl)- 3-fluoro-2- methylph...)
Affinity DataIC50: 5.00E+4nMAssay Description:Experimental Method: 4-hydroxydiclofenac (the substrate for CYP450 and 2C9 enzymes) and different doses of compounds were added into human liver micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandChemical structure of BindingDB Monomer ID 429435BDBM429435(N3-cyclopropyl-5- fluoro-N4'-isobutyl-3',6- dimeth...)
Affinity DataIC50: 5.00E+4nMAssay Description:Experimental Method: 4-hydroxydiclofenac (the substrate for CYP450 and 2C9 enzymes) and different doses of compounds were added into human liver micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandChemical structure of BindingDB Monomer ID 429446BDBM429446(6-(5- (cyclopropylcarbamoyl)- 3-fluoro-2- methylph...)
Affinity DataIC50: 5.00E+4nMAssay Description:Experimental Method: 4-hydroxydiclofenac (the substrate for CYP450 and 2C9 enzymes) and different doses of compounds were added into human liver micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandChemical structure of BindingDB Monomer ID 429441BDBM429441(6-(5- (cyclopropylcarbamoyl)- 3-fluoro-2- methylph...)
Affinity DataIC50: 5.00E+4nMAssay Description:Experimental Method: 4-hydroxydiclofenac (the substrate for CYP450 and 2C9 enzymes) and different doses of compounds were added into human liver micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandChemical structure of BindingDB Monomer ID 429419BDBM429419(N-cyclohexyl-6-(5- (cyclopropylcarbamoyl)- 3-fluor...)
Affinity DataIC50: 5.00E+4nMAssay Description:Experimental Method: 4-hydroxydiclofenac (the substrate for CYP450 and 2C9 enzymes) and different doses of compounds were added into human liver micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandChemical structure of BindingDB Monomer ID 429416BDBM429416(N-cyclopentyl-6-(5- (cyclopropylcarbamoyl)- 3-fluo...)
Affinity DataIC50: 5.00E+4nMAssay Description:Experimental Method: 4-hydroxydiclofenac (the substrate for CYP450 and 2C9 enzymes) and different doses of compounds were added into human liver micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandChemical structure of BindingDB Monomer ID 429454BDBM429454(3'-amino-N3-cyclopropyl- 5-fluoro-6-methyl-N4'-neo...)
Affinity DataIC50: 5.00E+4nMAssay Description:Experimental Method: 4-hydroxydiclofenac (the substrate for CYP450 and 2C9 enzymes) and different doses of compounds were added into human liver micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandChemical structure of BindingDB Monomer ID 429424BDBM429424(5-(5- (cyclopropylcarbamoyl)- 3-fluoro-2-methylphe...)
Affinity DataIC50: 5.00E+4nMAssay Description:Experimental Method: 4-hydroxydiclofenac (the substrate for CYP450 and 2C9 enzymes) and different doses of compounds were added into human liver micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent