Compile Data Set for Download or QSAR
maximum 50k data
Found 38 Enz. Inhib. hit(s) with all data for entry = 10261
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523870(5-(4-Cyclopropyl-1H-imidazol-1-yl)-N-(6-(5,5-dimet...)
Affinity DataIC50:  1nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523874((R)-5-(4-(tert-Butyl)-1H-imidazol-1-yl)-2-fluoro-4...)
Affinity DataIC50:  1.40nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523868((R)-5-(4-Cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-...)
Affinity DataIC50:  1.80nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523886((S)-5-(4-Cyclopropyl-1H-imidazol-1-yl)-N-(6-(5-eth...)
Affinity DataIC50:  1.90nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523892((R)-5-(4-Cyclopropyl-1H-imidazol-1-yl)-N-(6-(5-eth...)
Affinity DataIC50:  1.90nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523896(5-(4-Cyclopropyl-1H-imidazol-1-yl)-N-(6-(6′,...)
Affinity DataIC50:  1.90nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523884((S)-5-(4-Cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-...)
Affinity DataIC50:  1.90nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523872((R)-2-Fluoro-5-(4-isopropyl-1H-imidazol-1-yl)-4-me...)
Affinity DataIC50:  2.70nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523894((R)-5-(4-Cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-...)
Affinity DataIC50:  2.90nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523897(N-(6-(6′,7′-Dihydrospiro[cyclopropane-...)
Affinity DataIC50:  3nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523882((S)-5-(4-Cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-...)
Affinity DataIC50:  3.5nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523887(5-(4-Cyclopropyl-1H-imidazol-1-yl)-N-(6-(5-ethynyl...)
Affinity DataIC50:  3.60nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523875((S)-5-(4-(tert-Butyl)-1H-imidazol-1-yl)-2-fluoro-4...)
Affinity DataIC50:  4.10nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523883((S)-5-(4-Cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-...)
Affinity DataIC50:  4.10nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523890((S)-5-(4-Cyclopropyl-1H-imidazol-1-yl)-2-fluoro-N-...)
Affinity DataIC50:  4.90nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523878(5-(4-Cyclopropyl-1H-imidazol-1-yl)-N-(6-(6,6-dimet...)
Affinity DataIC50:  4.90nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523869((S)-5-(4-Cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-...)
Affinity DataIC50:  5nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523893((S)-5-(4-Cyclopropyl-1H-imidazol-1-yl)-N-(6-(5-eth...)
Affinity DataIC50:  5nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523880((R)-5-(4-Cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-...)
Affinity DataIC50:  5.20nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523899(6-(4-Cyclopropyl-1H-imidazol-1-yl)-2-(6-(6′,...)
Affinity DataIC50:  5.5nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM504319(US11040968, Example 001 | US11136324, Example 1 | ...)
Affinity DataIC50:  6nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523888((S)—N-(6-(5-(Cyanomethyl)-6,7-dihydro-5H-pyrrolo[2...)
Affinity DataIC50:  6.10nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523895((S)-5-(4-Cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-...)
Affinity DataIC50:  6.60nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523879(5-(4-Cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-meth...)
Affinity DataIC50:  7.20nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523885(5-(4-Cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-meth...)
Affinity DataIC50:  7.70nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523891((R)-2-Chloro-5-(4-cyclopropyl-1H-imidazol-1-yl)-4-...)
Affinity DataIC50:  8.20nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523898(6-(4-Cyclopropyl-1H-imidazol-1-yl)-2-(6-(6,7-dihyd...)
Affinity DataIC50:  8.40nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523873((S)-2-Fluoro-5-(4-isopropyl-1H-imidazol-1-yl)-4-me...)
Affinity DataIC50:  9nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523881(5-(4-Cyclopropyl-1H-imidazol-1-yl)-2-fluoro-N-(6-(...)
Affinity DataIC50:  9.10nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523864(5-(4-Cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-meth...)
Affinity DataIC50:  9.30nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523900((S)-6-(4-Cyclopropyl-1H-imidazol-1-yl)-5-methyl-2-...)
Affinity DataIC50:  9.40nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523889((S)-5-(4-Cyclopropyl-1H-imidazol-1-yl)-2-fluoro-N-...)
Affinity DataIC50:  9.60nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523871((S)-5-(4-Cyclopropyl-1H-imidazol-1-yl)-2-fluoro-N-...)
Affinity DataIC50:  10.6nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523877(N-(6-(5′H,7′H-Spiro[cyclopropane-1,6&#...)
Affinity DataIC50:  10.9nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523876(5-(4-Cyclopropyl-1H-imidazol-1-yl)-N-(6-(6-cyclopr...)
Affinity DataIC50:  11.4nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM504320(US11040968, Example 002 | US11136324, Example 3 | ...)
Affinity DataIC50:  13.4nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523867(4-(4-Cyclopropyl-1H-imidazol-1-yl)-N-(3-(6,7-dihyd...)
Affinity DataIC50:  19.6nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523866(5-(4-Cyclopropyl-1H-imidazol-1-yl)-N-(6-(5,6-dihyd...)
Affinity DataIC50:  47.8nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent