Compile Data Set for Download or QSAR
Report error Found 405 Enz. Inhib. hit(s) with all data for entry = 2566
LigandChemical structure of BindingDB Monomer ID 371616BDBM371616(US10239869, Example 40 | (R)-4-(2-(6-Fluoropyridin...)
Affinity DataIC50: 0.0400nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371648BDBM371648((R)-N-(6-Fluoropyridin-2-yl)-4-(2-(2-methyloxazol-...)
Affinity DataIC50: 0.200nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371618BDBM371618(US10239869, Example 42 | (R)-4-(2-(6-Fluoropyridin...)
Affinity DataIC50: 0.200nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371635BDBM371635(US10239869, Example 60 | (R)-4-(2-(1H-1,2,3-Triazo...)
Affinity DataIC50: 0.300nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371523BDBM371523((R)-N-(6-Fluoropyridin-2-yl)-4-(2-(1-methyl-1H-pyr...)
Affinity DataIC50: 0.300nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371774BDBM371774((R)-4-(2-(5-fluoropyridin-2-yl)-4-(trifluoromethyl...)
Affinity DataIC50: 0.5nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371776BDBM371776((R)-4-(2-(6-methylpyridin-3-yl)-4-(trifluoromethyl...)
Affinity DataIC50: 0.5nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371736BDBM371736(4-(2-(3-fluoropropyl)-4-(trifluoromethyl)phenyl)-N...)
Affinity DataIC50: 0.700nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371734BDBM371734(4-(2-(3-fluoropropyl)-4-(trifluoromethyl)phenyl)-N...)
Affinity DataIC50: 0.700nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371755BDBM371755((S)-N-(6-fluoropyridin-2-yl)-4-(2-(((S)-tetrahydro...)
Affinity DataIC50: 0.900nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371643BDBM371643(US10239869, Example 68 | (R)-4-(2-(2-Methylthiazol...)
Affinity DataIC50: 0.900nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371697BDBM371697(N-(6-fluoropyridin-2-yl)-4-(2-morpholino-4-(triflu...)
Affinity DataIC50: 1nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371540BDBM371540((R)-N-(4-Fluoropyridin-2-yl)-4-(2-(1-methyl-1H-pyr...)
Affinity DataIC50: 1nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371652BDBM371652((R)-4-(2-(2-methyloxazol-4-yl)-4-(trifluoromethyl)...)
Affinity DataIC50: 1nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371768BDBM371768((R)-4-(2-(5-fluoropyridin-2-yl)-4-(trifluoromethyl...)
Affinity DataIC50: 1nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371770BDBM371770((R)-4-(2-(5-fluoropyridin-2-yl)-4-(trifluoromethyl...)
Affinity DataIC50: 1nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371614BDBM371614(US10239869, Example 38 | (R)-4-(2-(6-Fluoropyridin...)
Affinity DataIC50: 2nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371788BDBM371788(4-(2-(3,3-difluoropropyl)-4-(trifluoromethyl)pheny...)
Affinity DataIC50: 2nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371668BDBM371668(N-(pyrimidin-4-yl)-4-(2-(thiazol-2-yl)-4-(trifluor...)
Affinity DataIC50: 3nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371639BDBM371639(US10239869, Example 64 | (R)-4-(2-(2-Methylthiazol...)
Affinity DataIC50: 3nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371584BDBM371584(US10239869, Example 10 | (R)-4-(2-(1-Methyl-1H-pyr...)
Affinity DataIC50: 3nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371695BDBM371695(4-(2-morpholino-4-(trifluoromethyl)phenyl)-N-(pyri...)
Affinity DataIC50: 3nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371667BDBM371667(N-(pyrimidin-2-yl)-4-(2-(thiazol-2-yl)-4-(trifluor...)
Affinity DataIC50: 4nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371729BDBM371729(4-(2-(2-fluoroethyl)-4-(trifluoromethyl)phenyl)-N-...)
Affinity DataIC50: 4nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371701BDBM371701(4-(2-(2-methoxyethoxy)-4-(trifluoromethyl)phenyl)-...)
Affinity DataIC50: 4nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371780BDBM371780(N-(6-fluoropyridin-2-yl)-4-(2-(6-methylpyridin-3-y...)
Affinity DataIC50: 4nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371739BDBM371739(4-(2-(4-fluorobutyl)-4-(trifluoromethyl)phenyl)-N-...)
Affinity DataIC50: 5nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371693BDBM371693((R)-4-(2-morpholino-4-(trifluoromethyl)phenyl)-N-(...)
Affinity DataIC50: 5nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371637BDBM371637(US10239869, Example 62 | (R)-N-(6-Fluoropyridin-2-...)
Affinity DataIC50: 5nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371777BDBM371777(N-(5-fluoropyrimidin-2-yl)-4-(2-(6-methylpyridin-3...)
Affinity DataIC50: 6nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371785BDBM371785(4-(2-(3,3-difluoropropyl)-4-(trifluoromethyl)pheny...)
Affinity DataIC50: 7nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371772BDBM371772((R)-4-(2-(5-fluoropyridin-2-yl)-4-(trifluoromethyl...)
Affinity DataIC50: 7nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371766BDBM371766(2'-(7-(N-(6-fluoropyridin-2-yl)sulfamoyl)chroman-4...)
Affinity DataIC50: 8nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371641BDBM371641(US10239869, Example 66 | (R)-N-(5-Fluoropyrimidin-...)
Affinity DataIC50: 8nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371670BDBM371670(N-(6-fluoropyridin-2-yl)-4-(2-(thiazol-2-yl)-4-(tr...)
Affinity DataIC50: 8nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371779BDBM371779(4-(2-(6-methylpyridin-3-yl)-4-(trifluoromethyl)phe...)
Affinity DataIC50: 8nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371778BDBM371778(4-(2-(6-methylpyridin-3-yl)-4-(trifluoromethyl)phe...)
Affinity DataIC50: 8nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371733BDBM371733(4-(2-(3-fluoropropyl)-4-(trifluoromethyl)phenyl)-N...)
Affinity DataIC50: 10nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371677BDBM371677(4-(2-(6-ethoxypyridin-3-yl)-4-(trifluoromethyl)phe...)
Affinity DataIC50: 10nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371669BDBM371669(N-(pyridazin-3-yl)-4-(2-(thiazol-2-yl)-4-(trifluor...)
Affinity DataIC50: 11nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371757BDBM371757(N-(pyrimidin-4-yl)-4-(2-(((S)-tetrahydrofuran-3-yl...)
Affinity DataIC50: 11nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371672BDBM371672((R)-4-(2-(6-isopropoxypyridin-3-yl)-4-(trifluorome...)
Affinity DataIC50: 11nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371751BDBM371751((S)-N-(6-fluoropyridin-2-yl)-4-(2-((tetrahydro-2H-...)
Affinity DataIC50: 11nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371666BDBM371666((R)-N-(5-fluoropyrimidin-2-yl)-4-(2-(thiazol-2-yl)...)
Affinity DataIC50: 11nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371694BDBM371694(N-(5-fluoropyrimidin-2-yl)-4-(2-morpholino-4-(trif...)
Affinity DataIC50: 11nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371612BDBM371612(US10239869, Example 36 | (R)-4-(2-(6-Fluoropyridin...)
Affinity DataIC50: 12nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371711BDBM371711(N-(6-fluoropyridin-2-yl)-4-(2-(2-methoxyethyl)-4-(...)
Affinity DataIC50: 12nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371747BDBM371747((S)-N-(pyrimidin-4-yl)-4-(2-((tetrahydro-2H-pyran-...)
Affinity DataIC50: 12nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371735BDBM371735(4-(2-(3-fluoropropyl)-4-(trifluoromethyl)phenyl)-N...)
Affinity DataIC50: 12nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 371799BDBM371799(4-(2-(5-fluoro-6-methylpyridin-2-yl)-4-(trifluorom...)
Affinity DataIC50: 12nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

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