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Found 6 Enz. Inhib. hit(s) with Target = 'Sodium channel protein type 9 subunit alpha' and Ligand = 'BDBM371612'
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

US Patent
LigandPNGBDBM371612((R)-4-(2-(6-Fluoropyridin-3-yl)-4-(trifluoromethyl...)
Affinity DataIC50:  12nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

US Patent
LigandPNGBDBM371612((R)-4-(2-(6-Fluoropyridin-3-yl)-4-(trifluoromethyl...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells assessed as V1/2 of slow inactivation at 10 Hz frequency at -120 mV holding potential by single ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

US Patent
LigandPNGBDBM371612((R)-4-(2-(6-Fluoropyridin-3-yl)-4-(trifluoromethyl...)
Affinity DataIC50:  21nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

US Patent
LigandPNGBDBM371612((R)-4-(2-(6-Fluoropyridin-3-yl)-4-(trifluoromethyl...)
Affinity DataIC50:  34nMAssay Description:Use-dependent inhibition of human Nav1.7 expressed in HEK293 cells at 25 pulse 10 Hz frequency at -120 mV holding potential by manual patch clamp ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

US Patent
LigandPNGBDBM371612((R)-4-(2-(6-Fluoropyridin-3-yl)-4-(trifluoromethyl...)
Affinity DataIC50:  44nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells assessed as V1/2 of fast inactivation at 10 Hz frequency at -120 mV holding potential by single ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

US Patent
LigandPNGBDBM371612((R)-4-(2-(6-Fluoropyridin-3-yl)-4-(trifluoromethyl...)
Affinity DataIC50:  2.28E+3nMAssay Description:Inhibition of human Nav1.7 at resting state expressed in HEK293 cells at -120 mV holding potential by 10 Hz single pulse protocol based manual patch ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed