BDBM371666 (R)-N-(5-fluoropyrimidin-2-yl)-4-(2-(thiazol-2-yl)-4-(trifluoromethyl)phenyl)chroman-7-sulfonamide::US10239869, Example 92

SMILES Fc1cnc(NS(=O)(=O)c2ccc3[C@H](CCOc3c2)c2ccc(cc2-c2nccs2)C(F)(F)F)nc1

InChI Key InChIKey=VZXRKGUEJHGCBI-QGZVFWFLSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 371666   

TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Lupin

US Patent
LigandPNGBDBM371666((R)-N-(5-fluoropyrimidin-2-yl)-4-(2-(thiazol-2-yl)...)
Affinity DataIC50: >1.00E+4nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

US Patent
LigandPNGBDBM371666((R)-N-(5-fluoropyrimidin-2-yl)-4-(2-(thiazol-2-yl)...)
Affinity DataIC50:  11nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent