BDBM371694 N-(5-fluoropyrimidin-2-yl)-4-(2-morpholino-4-(trifluoromethyl)phenyl)chroman-7-sulfonamide::US10239869, Example 120

SMILES Fc1cnc(NS(=O)(=O)c2ccc3[C@H](CCOc3c2)c2ccc(cc2N2CCOCC2)C(F)(F)F)nc1

InChI Key InChIKey=TUCOHLYYACEFAZ-GOSISDBHSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 371694   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

US Patent
LigandPNGBDBM371694(N-(5-fluoropyrimidin-2-yl)-4-(2-morpholino-4-(trif...)
Affinity DataIC50:  11nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

US Patent
LigandPNGBDBM371694(N-(5-fluoropyrimidin-2-yl)-4-(2-morpholino-4-(trif...)
Affinity DataIC50:  12nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Lupin

US Patent
LigandPNGBDBM371694(N-(5-fluoropyrimidin-2-yl)-4-(2-morpholino-4-(trif...)
Affinity DataIC50: >1.00E+4nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent