BDBM371648 (R)-N-(6-Fluoropyridin-2-yl)-4-(2-(2-methyloxazol-4-yl)-4-(trifluoromethyl)phenyl)chroman-7-sulfonamide::US10239869, Example 74

SMILES Cc1nc(co1)-c1cc(ccc1[C@H]1CCOc2cc(ccc12)S(=O)(=O)Nc1cccc(F)n1)C(F)(F)F

InChI Key InChIKey=UKTHMRKYVPDRNS-GOSISDBHSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 371648   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL
LigandPNGBDBM371648((R)-N-(6-Fluoropyridin-2-yl)-4-(2-(2-methyloxazol-...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Lupin

Curated by ChEMBL
LigandPNGBDBM371648((R)-N-(6-Fluoropyridin-2-yl)-4-(2-(2-methyloxazol-...)
Affinity DataIC50:  0.200nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent